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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

European Journal of Cancer Prevention

Impact of screening compliance on gastric cancer risk and eligibility for endoscopic treatment: a nationwide population-based cohort study

Jinju Choi, Joo Hyun Lim, Kyungdo Han, Cheol Min Shin, Byung-Ha Jeon, Ho-Kyoung Lee, Eun Hyo Jin, Seung Joo Kang

To evaluate the association between compliance with the Korean national gastric cancer screening program and both gastric cancer incidence and eligibility for endoscopic treatment. Using the Korean National Health Insurance Service database, we conducted a nationwide cohort study of individuals who underwent screening endoscopy in 2012 and 2014 without prior gastric cancer. Participants were classified as high compliance, moderate compliance, or low compliance according to screening history from 2008 to 2014. Gastr …

27.08.2026journal-article

Oral Surgery

Chondrosarcoma of the Temporomandibular Joint: A Case Report

Thamyryz Rafaela Almeida Simões, Lais de Oliveira Melo, Marcio Tadashi Tino, Gilberto Fenelon das Neves

ABSTRACT Objective Tumours affecting the temporomandibular joint (TMJ) are rare and may mimic common temporomandibular disorders, leading to delayed diagnosis. This study reports a case of TMJ chondrosarcoma initially presenting with long‐standing TMJ symptoms. Methods A 56‐year‐old female presented with right preauricular pain during mouth opening, closing and mastication for approximately 10 years. Clinical examination revealed a maximum interincisal opening of 20 mm with pain in the right TMJ. Cone‐beam computed …

27.08.2026journal-article

Recycling

Life Cycle Assessment of Anaerobic Digestion Pathways for Winery Residues: Influence of Functional Unit Selection on Wastewater Treatment and Grape Pomace Valorization

Mara Silva, Vitor Coelho Barroso, José Pereira, Ana Catarina Faria

Winery activities generate large amounts of residues requiring sustainable management. Anaerobic digestion offers opportunities for resource recovery while reducing the environmental burdens associated with these residues. This study presents a gate-to-gate Life Cycle Assessment (LCA) of two anaerobic digestion pathways: winery wastewater treatment (Scenario A) and grape pomace valorization (Scenario B). Inventory data were obtained from pilot-scale operation and complemented with the Ecoinvent 3.10 database. Envir …

27.08.2026journal-article

Tijdschrift voor Urologie

Klinische kenmerken en chirurgische behandeling van urogenitale endometriose: een retrospectief cohortonderzoek

Hanzhe Dong, Eefje Oude Lohuis, Johanna M. A de Bruin, Bob Theodoor Merks

Samenvatting Endometriose kan verscheidene orgaansystemen aantasten. Urogenitale endometriose (UGE) is een zeldzame vorm van diepe endometriose met betrokkenheid van blaas en/of ureters. In dit retrospectieve cohortonderzoek werden 80 vrouwen met UGE geïdentificeerd onder 1.568 geopereerde patiënten met diepe endometriose (2018–2024), overeenkomend met een prevalentie van 5,1 %. Blaasendometriose kwam voor bij 34 patiënten, ureterbetrokkenheid bij 32 en gecombineerde ziekte bij 14. Dysurie trad vaker op bij blaasbe …

27.08.2026journal-article

Frontiers in Medicine

Day-4 antipseudomonal and anti-MRSA de-escalation was not associated with higher mortality in critically ill patients with sepsis

Yuhang Zhang, Guoying Liao, Jianli Song, Yinsheng Liao, Lulu Zhang

Background Broad empiric antibiotics are often appropriate at the start of intensive care unit (ICU) sepsis care; however, continued antipseudomonal or anti-methicillin-resistant Staphylococcus aureus (MRSA) coverage may no longer be justified by the day-4 reassessment. We examined antibiotic de-escalation at this clinical decision point. Materials and methods We emulated two parallel target trials in Medical Information Mart for Intensive Care IV (MIMIC-IV) v3.1 and conducted a supportive multicenter analysis in t …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Association of glucagon-like peptide-1 receptor agonists with atrial fibrillation recurrence after catheter ablation: a systematic review and meta-analysis

Dan He, Defu Lv, Jiaxin Tang, Xiaojuan Liao, Ping Mao, Zhu Tian

Background Current studies suggest a potential association between the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and atrial fibrillation (AF) recurrence after catheter ablation, but the findings remain controversial. Therefore, we conducted a meta-analysis to evaluate this association, aiming to provide evidence for clinical prevention and treatment. Methods We systematically searched PubMed, Embase, Web of Science, Cochrane Library, and four Chinese databases (CNKI, WanFang, VIP, and CBM) up to J …

27.08.2026journal-article

Small

Sequential Integration of Microenvironment Regulation Utilizing Aggregation‐Induced Emission Luminogen‐Based Carbon Dots for Diabetic Wound Treatment

Judun Zheng, Miaomiao Kang, Minghai Zhao, Shuang Guo, Qihu Xie, Zhijin Fan, Sitong Zhou, Zhijun Zhang, Qin Zeng, Zeyu Liu, Yinghui Liu, Jialin Huang, Xu Chen, Bowen Shu, Bin Li, Kexiang Rao, Hongfang Liu, Xiaoping Zhong, Ronghua Yang, Yunxia Wu, Dong Wang, Yuhui Liao

ABSTRACT Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re‐epithelialization. Herein, we propose a sequential integrating microenvironment regulation and re‐epithelialization promotion (SIMREP) strategy based on zinc‐doped glycyrrhizinate carbon dots loaded with aggregation‐induced emission luminoge …

27.08.2026journal-article

Clinical and Translational Gastroenterology

Diagnostic Performance of Six Tests for Helicobacter pylori Infection in Peptic Ulcer Bleeding: A Prospective Head-to-Head Comparison

Tanawat Geeratragool, Thanapat Atthakitmongkol, Supathep Tansirichaiya, Pubet Weeranawin, Somchai Leelakusolvong, Monthira Maneerattanaporn

Background: Rapid urease test (RUT) is widely used for diagnosing Helicobacter pylori (HP) because it is inexpensive and practical. However, its accuracy is reduced in peptic ulcer bleeding (PUB). We prospectively performed a head-to-head comparison of diagnostic tests in the same patients to evaluate their performance in this setting. Methods: After endoscopic hemostasis, gastric biopsies were obtained for RUT, histology, and PCR. Blood samples were collected for current infection marker (CIM) and anti-urease anti …

27.08.2026journal-article

JAMA Network Open

A Multilevel Intervention to Identify Individuals for Genetic Testing and Treatment

Kirsten A. Jorgensen, Nuria Agusti, Tara Coffin, Karla Barajas, Maria D. Iniesta, Erica M. Bednar, Alexa Kanbergs, Roni Nitecki Wilke, Isabel Beshar, Sara Pirzadeh-Miller, Sayoni Lahiri, Kathy Pratt, Kristofer Jennings, Heidy Bosch, Charles A. Leath, Beth Karlan, Melissa Frey, Ravi Sharaf, Karen Lu, J. Alejandro Rauh-Hain

Importance Cascade genetic testing (CGT) is a key strategy for cancer prevention in families with hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome (LS), yet uptake among at-risk relatives remains persistently low, particularly in medically underserved populations where structural and informational barriers limit access to genetic services. Objective To evaluate the feasibility and preliminary effects of IGNITE-TX (Identifying Individuals for Genetic Testing and Treatment), a scalable, bilingu …

27.08.2026journal-article

Journal of Occupational & Environmental Medicine

The Effectiveness of Ergonomic Training and Chiropractic Treatment in Industrial Workers with Nonspecific Chronic Neck Pain: A Randomized Controlled Trial

Deniz Balikçi, Beyzanur Dikmen Hoşbaş, Ömer Şevgin

OBJECTIVE: To evaluate whether adding chiropractic treatment to ergonomic training improves pain, function, and sleep in industrial workers with chronic nonspecific neck pain. METHODS: Forty-five male industrial workers were randomized (15 per group) to ergonomic training plus chiropractic treatment (CTG), plus sham manipulation (SMTG), or alone (CG) for four weeks. Pain (VAS), biopsychosocial impact (BNQ), disability (NDI), and sleep quality (PSQI) were assessed before and after. The group × time interaction was t …

27.08.2026journal-article

Journal of Clinical Medicine

Bad Ragaz Ring Method Versus Halliwick Method in Verbally Cooperative Children with Spastic Cerebral Palsy (GMFCS Levels I–II): A Pilot Comparison Study

Na-Yeon Ye, Eun-Ju Lee

Background/Objectives: Aquatic therapy is widely used for children with cerebral palsy (CP), but existing approaches such as the Halliwick method focus primarily on postural control and mobility with limited active resistance exercise. The Bad Ragaz Ring Method (BRRM) integrates proprioceptive neuromuscular facilitation (PNF) diagonal patterns with closed kinetic chain (CKC) exercise in the aquatic environment, yet its direct application to children with spastic CP has rarely been examined. This pilot study compare …

27.08.2026journal-article

Discover Oncology

Ovarian cancer tumor immune microenvironment and its clinical trial implications

Barbora Vavrušáková, Renata Bartošová, Michal Hendrych, Tomáš Kazda, Lukáš Moráň, Marek Svoboda

Abstract Ovarian cancer is the most lethal gynecologic malignancy, primarily because of late-stage diagnosis, rapid disease progression, and marked molecular and immunologic heterogeneity. It remains the leading cause of gynecologic cancer-related death, affecting approximately 1 in 70 women in developed countries over their lifetimes. Tumor development and progression are orchestrated within the tumor immune microenvironment, a dynamic and complex structural niche that supports malignant transformation and immune …

27.08.2026journal-article

Developmental Medicine & Child Neurology

Deep brain stimulation outcomes and management of childhood‐onset dystonia and associated hyperkinetic movements disorders

Sinead Barkey, Laura Ainaga, Eva Maria Navarrete Muñoz, Verity McClelland, Keyoumars Ashkan, Richard Selway, Harutomo Hasegawa, Daniel E Lumsden, Jean‐Pierre Lin, Hortensia Gimeno

Abstract Aim To examine longitudinal changes in self‐selected goals and dystonia severity over 1 year, 2 years, and 5 years after deep brain stimulation (DBS) in children and young people (CYP) with dystonia and other hyperkinetic movement disorders, using CYP and caregiver reports. Method The retrospective cohort study included follow‐up to 5 years after DBS, with the number of participants varying across time points. In the CYP group, 62 participants were included at the 1‐year follow‐up, 50 at 2 years, and 17 at …

27.08.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Availability and Pricing of Orthobiologic Knee Injections Vary by Practice Type but Not by Community Socioeconomic Vulnerability in Suburban New York

Tracy M. Tauro, Benjamin Hershfeld, Katharine Chen, Ran Lampert, Adam D. Bitterman, Randy M. Cohn, Nicholas A. Sgaglione

Purpose To assess the availability, price transparency, and pricing of platelet‐rich plasma (PRP), bone marrow aspirate concentration, and stem cell injections for knee osteoarthritis (OA) among orthopaedic sports medicine (OSM) practices and alternative clinics in suburban New York and to evaluate the impact of the economic status of a population on the availability and pricing of biologic injections. Methods Between July and September 2025, OSM practices and alternative clinics offering PRP, bone marrow aspirate …

27.08.2026journal-article

Physics in Medicine & Biology

MGTP-Seg: A Mask Guidance and Text Prompting Network for Gross Tumor Volume Segmentation in Esophageal Cancer Radiotherapy

Chengwei Chen, Hongfei Sun, Yuxuan Yao, Yao Zheng, Yuefei Feng, Qifeng Wang, Wencheng Zhang, Yang Liu, Lina Zhao, Dong Huang

Abstract Accurate delineation of the gross tumor volume (GTV) is critical for determining the efficacy of radiotherapy in esophageal cancer. Conventional segmentation methods either rely solely on end-to-end learning from imaging features, which often struggle to address small tumor volumes and ambiguous boundaries, or incorporate coarse masks as spatial priors but fail to integrate the pathological semantics essential for clinical decision-making. This disconnect can lead to segmentation results that are poorly al …

27.08.2026journal-article

Revista ft

Capacitação da equipe de clínica médica quanto às atualizações do manejo agudo hospitalar de fibrilação atrial de alta resposta ventricular

Victor Souza Nobre, Marilia Mendes de Saboya, Felipe de Araújo Lucena, Camila Amora Santos Albuquerque D’Alva, Natália Marinho Porto Lima, Luiza Targino Studart, José de Ribamar Barroso Jucá Neto

Atrial fibrillation with rapid ventricular response is a common condition in the hospital setting and requires prompt recognition, assessment of hemodynamic stability, and evidence-based therapeutic decision-making. Given the variability in clinical management and the need for professional updating, this study aims to train the Internal Medicine medical team on current recommendations for the acute hospital management of atrial fibrillation with rapid ventricular response, with the goal of standardizing clinical pr …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Long-term outcomes following successful treatment of acute mesenteric ischemic event: A population-based observational study

Karri Kase, Merli Koitmäe, Annika Reintam Blaser, Kadri Tamme, Peep Talving, Marko Murruste

BACKGROUND There is a lack of studies reporting long-term outcomes in patients surviving initial event of acute mesenteric ischemia (AMI). AIM To identify population-based outcomes and risk factors for mortality according to AMI subtypes. METHODS We performed overall survival analysis of all enrolled AMI patients and follow-up investigation on patients who survived beyond index admission. The demographics, diagnostic and management variables, in addition to causes of death, were accrued from the Estonian National E …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Severe postoperative infections following surgery for digestive system diseases

Ya Liu, Li Chen

BACKGROUND Postoperative infection following digestive system surgery is a critical complication that leads to high rates of morbidity and mortality. Current studies on the incidence and, more importantly, the risk and microbiological factors related to these infections in patients undergoing surgery on the digestive system are lacking. Identifying such factors can aid in detecting patients who may be at post-operative infection risk and enable the modification of perioperative practices. AIM To describe the incide …

27.08.2026journal-article

Light: Science & Applications

Label-free ovarian cancer histopathological diagnosis using two-photon autofluorescence microscopy with a joint denoising and segmentation framework

Zhengyuan Pan, Naikun Song, Shanshan Cheng, Wen Pang, Hongen Liao, Yu Wang, Bobo Gu

Abstract Two-photon autofluorescence (TPAF) microscopy is a promising modality for rapid, label-free assessment of unstained tissue, but is fundamentally limited by the poor visibility of nuclei, which are one of the gold-standard cancer biomarkers, due to their negative contrast nature. A restoration method capable of distinguishing these signal voids from stochastic noise to render quantitative pathology is lacking. Here, we proposed a deep learning framework of AFN-DeSeg (Auto-Fluorescence Nuclei Denoising and S …

27.08.2026journal-article

Journal of Veterinary Pharmacology and Therapeutics

Pharmacokinetics and Efficacy Assessment of Long‐Term Ivermectin Treatment in Canine Demodicosis: Drug Disposition and Clinical Outcomes Relationship

S. Martínez, M. J. Del Sole, L. Maté, S. Sánchez Bruni, A. Lifschitz, M. Ballent

ABSTRACT Canine demodicosis is an inflammatory skin disease caused by Demodex canis mites. While newer isoxazoline classes currently represent the standard of care where licensed and available, prolonged ivermectin treatment remains an effective and cost‐effective alternative under specific socioeconomic contexts or clinical challenges associated with specific presentations, such as refractory pododemodicosis. Prolonged ivermectin treatment remains the primary choice, especially in resource‐limited settings and cer …

27.08.2026journal-article

Environments

Role of a Wastewater Treatment Plant in the Dissemination and Control of Antimicrobial Resistance in Wastewater and Receiving Water

Vanesa Benito, Naroa Lopez-Herguedas, Maite Cabañas, Santos Paunero, Ane Rivas-Macho, Iker Alvarez-Mora, Manu Soto, Felipe Goñi-de-Cerio

Wastewater treatment plants (WWTPs) are key nodes in the environmental dissemination of antimicrobial resistance (AMR), although their net role as sources or barriers of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARG) under full-scale conditions remains insufficiently understood. This study evaluated the occurrence and dynamics of ARB and ARG in a full-scale urban WWTP and its receiving river over a two-year monitoring campaign. Samples were collected from the WWTP influent and effluent, a …

27.08.2026journal-article

Mathematics

A Condition-Disentangled Representation Optimization Framework for Domain Generalization Under Distribution Shift: Application to Fault Diagnosis

Shiqi Zhao, Yaqiong Lv, Xiaohu Zhang, Jian Hao

Domain generalization under distribution shift remains a fundamental challenge in representation learning, where predictive models trained on multiple source domains are expected to generalize to previously unseen operating conditions. For rotating machinery fault diagnosis, variations in operating conditions often introduce domain-specific characteristics that interfere with fault-related representations, resulting in significant performance degradation across unseen domains. To address this issue, this paper form …

27.08.2026journal-article

Clinical Orthopaedics & Related Research

Is Femoral Head Decentration Reversible After Periacetabular Osteotomy for the Treatment of Developmental Dysplasia of the Hip?

Florian Schmaranzer, Alexander F. Heimann, Michael B. Millis, Ata M. Kiapour, David Liu, Young-Jo Kim, Eduardo N. Novais

Background Femoral head decentration, seen on MRI as a fluid gap between the femoral head and acetabulum, has recently been introduced as a sign of hip instability. Although periacetabular osteotomy (PAO) effectively corrects bony morphology in developmental dysplasia of the hip (DDH), it is unknown whether femoral head decentration is reversible after acetabular reorientation or whether it persists because of factors such as femoral version or intraarticular degeneration. Questions/purposes (1) Does femoral head d …

27.08.2026journal-article

Journal of Clinical Medicine

Prevalence and Predictors of Self-Reported Swallowing Difficulty in Community-Dwelling Older Adults

Lana Fluk, Yuval Nachalon, Amit Shiff, Haya Fogel-Grinvald, Nogah Nativ-Zeltzer

Objectives: Dysphagia in older adults is associated with malnutrition, aspiration, and reduced quality of life. This study aimed to estimate the prevalence of self-reported swallowing difficulties among community-dwelling older adults in Israel and to identify demographic, medical, and socioeconomic predictors. Method: In this cross-sectional study, 1064 community-dwelling adults aged ≥ 60 years (mean 75.1 ± 7.5 years; 68.1% female) completed an online questionnaire capturing demographics, medical diagnoses, physic …