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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Oncology

Hypothermia and recovery outcomes before and after implementation of a multimodal perioperative temperature-management bundle in minimally invasive radical rectal cancer surgery

Qian Liu, Ling Liu, Chenxi Han, Chunmei Cao, Jiefang Ji, Aihua Zhu

Background Inadvertent perioperative hypothermia is common during minimally invasive rectal cancer surgery. We assessed whether a five-component multimodal temperature-management bundle was associated with improved perioperative outcomes. Methods This single-center retrospective before-and-after study included 247 adults undergoing laparoscopic or robot-assisted radical rectal cancer surgery from 2021 to 2025 (pre-implementation, n = 123; post-implementation, n = 124). The primary outcome was any intraoperative nas …

27.08.2026journal-article

Frontiers in Oncology

Construction and exploratory validation of a digital pathology prognostic model for stage II–III colorectal cancer based on contrastive learning and attention mechanisms

Yizhan Lu, Zhifeng Qu, Chongbao Sun, Bo Li, Xiaoyang Bai, Qingqing Zhao, Wenxin Zhang, Yandong Zhao, Wuteng Cao, Xuezhi Zhou

Introduction Although TNM staging is the standard framework for prognostic assessment in colorectal cancer (CRC), patients within the same stage can have heterogeneous outcomes. This study aimed to extract tumor-tissue features from whole-slide images (WSIs), develop an image-derived prognostic model for stage II–III CRC, and conduct an exploratory evaluation of its performance. Methods A transfer-learning tissue classifier was used to identify tumor regions in CRC WSIs. Self-supervised contrastive learning was use …

27.08.2026journal-article

Neuro-Oncology

118 Molecular and Immunological Landscape of the Pleomorphic Xanthoastrocytoma–Epithelioid Glioblastoma Spectrum

Iman Dandapath, Swati Mahajan, Jyotsna Singh, Mehar Chand Sharma, Chitra Sarkar, Vaishali Suri

Abstract Background Pleomorphic xanthoastrocytoma (PXA), especially PXAG3, exhibits considerable morphologic, molecular, and clinical overlap with epithelioid glioblastoma (eGB), raising questions regarding their biological relationship and progression dynamics. Although immune checkpoint pathways have been investigated in glioblastoma, comprehensive integration of immune profiling with transcriptomic signatures across the PXA–eGB spectrum remains inadequately defined. Methods Fifty-three tumors (PXAG2 n = 15, PXAG …

27.08.2026journal-article

Neuro-Oncology

109 Multi-omic integration reveals intra-tumour heterogeneity and identifies disulfiram and copper as a synergistic therapy in paediatric ependymoma

Alina Pandele, Alison Whitby, Sandra Martinez-Jarquin, Chiara Bastiancich, Donald Macarthur, Ian Kamaly-Asl, David Barrett, Richard Grundy, Dong-Hyun Kim, Ruman Rahman

Abstract Introduction Ependymoma (EPN) is the second most malignant paediatric brain tumour. The PF-A subgroup, associated with a hypoxic microenvironment, has a dismal survival rate of 50%, with clinical trials failing to demonstrate a significant survival advantage from chemotherapy to date. We present a multi-omic integration investigating whether spatially-distinct tumour microenvironments represent targetable metabolic niches in PF-A EPN. Methods Surgical sampling of spatially-distinct regions from eight PF-A …

27.08.2026journal-article

Neuro-Oncology

142 Arginine deprivation improves survival and activates the immune system in mouse models of diffuse midline glioma

Molly Brooks, Dani Chattenton, Huan Huang, Zehongru Xu, Richard Perryman, Maria Chatziathanasiadou, Nelofer Syed

Abstract Introduction Diffuse midline glioma (DMG) is a rare but fatal childhood brain tumour with no successful treatments. An inert immune microenvironment is a key factor in the failure to find suitable treatments. Arginine deprivation using ADI-PEG20 has been effective in treating a number of cancers, particularly those which cannot generate their own arginine. Our previous studies demonstrated that ADI-PEG20 combined with radiation eradicated GBM tumours and extended survival of animals indefinitely. ADI-PEG20 …

27.08.2026journal-article

International Journal of Pattern Recognition and Artificial Intelligence

Dense-RBF Grad-CAM: A Clinically Trustworthy AI Framework for early Breast Cancer Detection using mammography images

Rupali Patil, V.V. Dixit

Breast cancer continues to be the most common cause of cancer-related deaths in women globally. The earlier breast cancer is identified, the higher the chance of survival. In screening dense breast tissue, the standard diagnostic approach has essential limitations, including a relatively high false-negative rate and poor interpretability. This research introduces a Dense Radial Bias Functional Gradient-weighted Class Activation Mapping method optimized using the Revolution Optimization Algorithm (DRBF-GradCAM_ROA) …

27.08.2026journal-article

Frontiers in Immunology

Targeting splicing-derived neoantigens for precision cancer immunotherapy

Mutian Tang, H. Leighton Grimes, Nathan Salomonis

Aberrant pre-mRNA splicing in cancer generates protein sequences that are rare or absent in normal tissues, creating a rich source of tumor-specific neoantigens for immunotherapy. These splicing-derived neoantigens arise through diverse mechanisms, including recurrent somatic mutations in core spliceosome components ( SF3B1 , SRSF2 , U2AF1 , and ZRSR2 ), epigenetic derepression of transposable elements that give rise to chimeric exon-TE junctions, and coordinated dysregulation of splicing regulatory networks in can …

27.08.2026journal-article

Journal of Intensive Care Medicine

Modern Approaches to the Treatment of Respiratory Distress Syndrome in Children: The Role of Surfactant and Antenatal Prophylaxis

Aisuluu Omurzakova, Venera Azhikulova, Mairamkan Sharipova, Nargiza Kurbanova, Gulnura Zhunusbaeva

Background and Objective The aim of the study was to evaluate the multilevel impact of antenatal prophylaxis and modern non-invasive respiratory strategies on the course and outcomes of respiratory distress syndrome in new-borns. Methods A total of 4080 hospitalisations of preterm and full-term infants with confirmed respiratory failure, born between 1 January 2017 and 30 September 2024, who received care at the Osh Regional Clinical Maternity Hospital (Kyrgyzstan), were included in the retrospective cohort registr …

27.08.2026journal-article

International Journal of Molecular Sciences

Paclitaxel Nanomedicines: Molecular Mechanisms of Drug Resistance, Tumor Microenvironment-Responsive Delivery, and Translational Challenges

Dejun Cheng, Guowei Yang, Ruibin Kong, Qin Liu, Li Li, Yunpeng Luan, Qijiang Shu

Paclitaxel (PTX) remains a major component of treatment for solid tumors, but its clinical performance is limited by poor aqueous solubility, solvent-associated toxicity, heterogeneous tumor exposure, and multifactorial drug resistance. This narrative review examines PTX nanomedicines from a molecular pharmacology perspective, focusing on how carrier design interacts with resistance pathways, tumor microenvironment signals, and intracellular drug trafficking. We outline resistance mechanisms involving ATP-binding c …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Meta-analysis of surgical quality-related factors associated with local recurrence rate after rectal cancer surgery

Jin-Kai Wang, Chang-Tao Yu, Bai-Xue Qin, Hua-Bin Cheng

BACKGROUND Despite treatment advances, rectal cancer continues to pose a considerable global health burden, and local recurrence remains an important driver of long-term outcomes. Despite the evolution of surgical technique and multimodal therapy, local recurrence rates (LRRs) remain heterogeneous across institutions, thought to be related to differences in surgical quality. Local recurrence risk has been associated with several surgical quality indicators such as circumferential resection margin (CRM) involvement, …

27.08.2026journal-article

Oncologie

Curcumol and Oxaliplatin exhibit synergistic anti-tumor effect in colorectal cancer by co-targeting the KPNA2/c-Myc axis

Zhicheng Chen, Yanni Chen, Bo Zhang, Xingxin Zhou, Feng Gao

Abstract Objectives Curcumol is a natural product that has been demonstrated to exert antitumor effects in many tumor types. Oxaliplatin is one of the chemotherapeutic agents commonly employed in the treatment of colorectal cancer (CRC). In this study, we aimed to investigate the synergistic antitumor role of Curcumol and Oxaliplatin in CRC and explore the potential mechanisms. Methods The synergistic antitumor efficacy of Curcumol and Oxaliplatin in CRC cells was assessed by using CCK-8, flow cytometry, and colony …

27.08.2026journal-article

Frontiers in Pharmacology

Association between a regional reimbursement policy and treatment escalation in pulmonary arterial hypertension: a real-world cohort study with long-term Markov cost-effectiveness analysis

Yilin Xie, Yusi Chen, Jun Luo, Jingyuan Chen, Yingjie Tan, Tianyu Wang, Wenjie Chen, Jiang Li

Background Pulmonary arterial hypertension (PAH) requires long-term treatment with high-cost targeted therapies. However, evidence regarding the associations of reimbursement policies with real-world treatment escalation and long-term economic outcomes remains limited. Objectives To examine the association between implementation of a regional reimbursement policy and real-world treatment patterns and to evaluate the long-term cost-effectiveness of the observed post-policy treatment distribution compared with the pr …

27.08.2026journal-article

Frontiers in Oncology

Case Report: Prostate metastasis from pulmonary sarcomatoid carcinoma: the first reported case and clinical implications of palliative radiotherapy

Xueping Liu, Nai Mu, Guobo Du, Min Hou, Lang He

Pulmonary sarcomatoid carcinoma (PSC) is a highly aggressive lung cancer subtype. Prostate metastasis is extremely rare in lung cancer, and no PSC case with immunohistochemical confirmation has been reported. We report a 68-year-old man diagnosed with left upper lobe carcinosarcoma (myogenic differentiation) on pathological biopsy. He underwent multimodal treatment, including radical resection, adjuvant chemotherapy, anlotinib targeted therapy, and local thoracic radiotherapy. Eight months later, he developed progr …

27.08.2026journal-article

Macromol

Preclinical Efficacy and Structural Gaps of Ganoderma lucidum Polysaccharides in Cancer: A Systematic Review

Jean Felipe dos Santos, Karien Sauruk da Silva, Hellen Abreu, Alex Leandro dos Santos de Sá, Daniele Maria-Ferreira, Fhernanda Ribeiro Smiderle

Ganoderma lucidum’s anticancer potential is largely attributed to its polysaccharides, yet their preclinical translation requires rigorous systematization. Following PRISMA 2020 guidelines, this systematic review evaluated the anticancer efficacy of G. lucidum polysaccharides (GLPs) in preclinical models (PROSPERO: CRD42021296200). Systematic searches spanning 2011 to 2026 were conducted in PubMed, Embase, and Scopus. Eligible peer-reviewed articles investigated GLPs in cancer cell lines or animal models. The Cochr …

27.08.2026journal-article

Cancer Discovery

EML4−ALK Mediates Resistance to KRASG12C Inhibition and Induces an Oncogenic Dependency by Rewiring Signaling through the Wild-Type RAS Pathway

Pietro Scaparone, Alessia Mira, Taek-Chin Cheong, Enrico Patrucco, Biagio Ricciuti, Riccardo Gribaudo, Edoardo Garbo, Rossella Scardaci, Ilenia Savinelli, Sandra Vietti Michelina, Igor Odintsov, Elliott J. Brea, Roberto Mignacco, Rafael B. Blasco, David Santamaría, Claudia Voena, Marco H. Hofmann, Ernest Nadal, Silvia Novello, Mark M. Awad, Roberto Chiarle, Chiara Ambrogio

Abstract KRAS mutations are common oncogenic drivers in human cancers, with the KRASG12C variant being a key target in lung adenocarcinoma. Despite the FDA approval of KRASG12C-selective inhibitors, their clinical efficacy has been limited, as evidenced by trials showing modest response rates and resistance development through the selection of acquired genomic alterations. Our study explores the mechanisms underlying acquired EML4–ALK fusion in KRASG12C-driven tumors developing resistance to KRASG12C inhibitors and …

1 Zitationen
27.08.2026journal-article

American Journal of Veterinary Research

Clinical presentation, diagnosis, and treatment of caudal mediastinal paraesophageal abscesses in dogs: a multi-institutional retrospective study

Kathryn Biehl, Rachel W. Williams, Emily Orr, Kelley Thieman Mankin, Hunter Piegols, Jordyn Blew, David E. Holt, Francesca P. Solari, Federico R. Vilaplana Grosso

Abstract Objective To describe the clinical presentation, diagnostic findings, management, and short- and long-term outcomes of dogs with caudal mediastinal paraesophageal abscesses (CMPA) in a multi-institutional retrospective cohort. Animals 12 client-owned dogs with CMPA confirmed on CT and/or surgery. Clinical Presentation The most common presenting complaints were inappetence and lethargy. Tachypnea and dyspnea were frequent physical examination findings at presentation. Results All 12 dogs underwent CT. The C …

27.08.2026journal-article

Neuro-Oncology

9 Development of a Rapid Lateral Flow Assay for Early Identification of Glioblastoma and Brain Metastases Using a Circulating Serum Biomarker

Carys Jordan, Xia Liu, Calum Haydon, Cristina Santi, M C Galan, Kathreena Kurian

Abstract Introduction Rapid diagnostic tools could improve the early detection of glioblastoma (GBM) and brain metastases (BM). Lateral flow assays (LFAs) offer a simple, point-of-care testing platform. Glial fibrillary acidic protein (GFAP) has previously been reported as a circulating marker associated with blood–brain barrier disruption in brain tumours. This study aimed to develop and evaluate an LFA capable of detecting GFAP in the serum of patients with GBM and BM. Methods Detection antibodies were conjugated …

27.08.2026journal-article

Neuro-Oncology

129 Electroactive drug delivery for local glioblastoma treatment

Joshua Killilea, Immi Van Der Auweraert, Gary Shaw, Harveena Padda, Holly Briggs, Une Kontrimaite, Leire Landeira Suquia, Rosalie De Ferm, Lucia Moreno Gimeno, Phoebe McCrorie, Estelle Cuttaz, Aaron Lee, Giovanni Carlo Miceli, Stuart Smith, Dong-Hyun Kim, Ruman Rahman, Juanita Lopez, Roberto Portillo Lara, Josef Goding, Heiko Wurdak, Ryan Mathew, Christopher Chapman, Rylie Green

Abstract Introduction Despite recent advances in cancer therapeutics, the prognosis for glioblastoma remains exceptionally poor, stemming from the limited ability of systemically administered chemotherapeutics to cross the blood brain barrier (BBB). Mechanically circumventing the BBB represents a promising avenue. However, biomaterials previously used for local delivery suffer from low control over drug release, further limiting their translation. To address this, an implantable bioelectronic drug delivery device w …

27.08.2026journal-article

Neuro-Oncology

19 Age Related Presentation Characteristics and MRI Volumetric Associations in Glioblastoma IDHwt

Dominic van Loan, Sophie Williams, Olamide Rominiyi, Safiyyah Hussain, Danielle Madamba

Abstract Introduction Glioblastoma IDHwt is most common in adults aged ≥65 years, who often present with atypical symptoms, potentially impacting diagnostic pathways. We aimed to characterize presenting clinical features and MRI volumetric parameters in older adults with glioblastoma IDHwt at a single tertiary neurosurgical centre. Methods Clinical data were retrospectively collected for a continuous case series of patients diagnosed with glioblastoma IDHwt between 2020-2024 at Sheffield Teaching Hospitals Foundati …

27.08.2026journal-article

Neuro-Oncology

136 Tessa Jowell BRAIN MATRIX interim analysis: surgical and oncology outcomes in glioblastoma patients

Vassili Crispi, Lucy Abell, Joshua Savage, Rhys Mant, Amanda Kirkham, Lucinda Billingham, Vinton Cheng, Victoria Wykes, Colin Watts

Abstract Introduction The Tessa Jowell BRAIN MATRIX (TJBM) is a programme of work aimed at improving the knowledge of and treatment for glioma, comprising a platform study with subsequent interventional clinical trials. Methods Interim analysis of first 500 patients from 11 specialist neurosurgical UK centres recruited to the TJBM study (14/Dec/2020-31/Jan/2025) with recruitment and data cleaning ongoing. Data snapshot 20/Feb/2026. Analysis conducted in R version 4.3.1. Results Amongst GBMs (n = 141), median age is …

27.08.2026journal-article

Pediatric Blood & Cancer

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton

ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations enrolled in the North American SDS Registry to characterize neuropsychological, psychiatric, educational, functional, and neuroimaging outcomes. Medical records were …

27.08.2026journal-article

World Journal of Hepatology

Second-line treatment of primary biliary cholangitis: To whom, which molecule, and when

Sylvia Drazilova, Peter Jarcuska, Tomas Koky, Martin Harhovsky, Slavomira Komarova, Jan Vasil, Martin Janicko

Ursodeoxycholic acid (UDCA) is the first-line treatment of primary biliary cholangitis (PBC). Approximately two-thirds of patients have a biochemical response to UDCA, but only one-third of treated patients achieve a complete biochemical response. UDCA nonresponse is associated with hepatic decompensation and higher liver-related mortality; therefore, UDCA nonresponders should be considered for second-line PBC treatment. Nonfibrate peroxisome proliferator-activated receptor (PPAR) agonists elafibranor and seladelpa …

27.08.2026journal-article

Hepatology Research

On‐Treatment Reassessment of Type IV Collagen 7S and M2BPGi‐Qt Improves Long‐Term Hepatocellular Carcinoma Risk Stratification in Chronic Hepatitis B

Kazumi Yamasaki, Hideko Kozuru, Tomoko Sato, Tomoyuki Suehiro, Yasuhide Motoyoshi, Yuki Kugiyama, Akira Saeki, Shinya Nagaoka, Atsumasa Komori, Hiroshi Yatsuhashi

ABSTRACT Aims Hepatocellular carcinoma (HCC) remains a major complication in patients with chronic hepatitis B receiving nucleos(t)ide analogue (NA) therapy despite effective viral suppression. Although on‐treatment assessment of indirect fibrosis indices has been associated with HCC risk, the prognostic value of direct fibrosis markers, particularly type IV collagen 7S (4COL7S), during antiviral therapy remains poorly defined. We investigated whether on‐treatment 4COL7S predicts HCC development, with M2BPGi‐Qt eva …