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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Clinical Journal of Health Sciences

The Relationship Between Water Scarcity, Climate Change, and Mental Health: A Systematic Review

İlknur Taşkıran, Hatice Sinem Şenli, Begüm Arıtan

The aim of this study is to examine the relationship between water scarcity, climate change, and mental health through a systematic review. Water scarcity is defined as the long-term inadequate management of available water resources and the failure to meet increasing demand; climate change, in turn, is a fundamental driver that both accelerates and deepens this scarcity through drought, heat waves, and disruptions to the water regime. In recent years, it has increasingly been emphasized that these environmental pr …

27.08.2026journal-article

Frontiers in Medicine

AI-driven diagnostic and prognostic models for metabolic dysfunction-associated steatotic liver disease: insights from clinical, imaging, and multi-omics studies—a scoping review

M. Sujana, G. N. Vivekananda

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is the most common chronic liver disease around the world, affecting 33.6% of the adult population (95% CI: 28.1%–39.5%; I 2 = 99.9%), or roughly one in three. The extent of the liver damage is variable, from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH), cirrhosis and hepatocellular carcinoma (HCC). Early diagnosis is essential to prevent seriou …

27.08.2026journal-article

Journal of Eating Disorders

Mentalization-based treatment for eating disorders: a systematic review and narrative synthesis

Katie Gabrielle Salucci, Sela Scott, Amelia Austin

Abstract Background Mentalization-based treatment (MBT) targets difficulties in reflective functioning, emotion regulation and interpersonal relationships, which may contribute to the development and maintenance of eating disorders (EDs). This systematic review synthesised the available quantitative evidence on the outcomes of MBT or MBT-informed interventions for people with EDs. Methods A protocol was prospectively registered with PROSPERO (CRD42024421136) and the review was conducted in accordance with PRISMA gu …

27.08.2026journal-article

International Journal of Pharmacy Practice

Medicine shortages in an Austrian community pharmacy: quantification and pharmacist intervention—a prospective observational study on shortage extent, patient support, and associated predictive factors

Alexander Schmidt-Ilsinger, Thomas Arzt, Petra Riegler, Trudi McIntosh

Abstract Background Medicine shortages increasingly challenge community pharmacies, affecting patient safety, increasing pharmacist workload, and straining healthcare systems. Little is known about shortages in Austrian community pharmacy settings. Aim To estimate the prevalence of medicine shortages in a community pharmacy in Austria, and describe how frequently pharmaceutical interventions were provided to mitigate their impact on patients. Methods This prospective, single-centre study was conducted over 8 weeks …

27.08.2026journal-article

Journal of Bone and Joint Surgery

Distal Radial Fracture as an Early Marker of Bone Fragility

Ryutaro Shibata, Yoko Sato, Yoshihiro Tanaka

Background: Distal radial fractures (DRFs) are common fragility fractures in older adults and often indicate skeletal deterioration. However, whether DRFs reflect underlying systemic frailty or occur predominantly in relatively active individuals with preserved physical function remains unclear. Methods: This retrospective cohort study analyzed data from the Shizuoka Kokuho Database, which includes the health and long-term care (LTC) claims of 2.4 million residents. Individuals aged 65 to 89 years who were newly di …

27.08.2026journal-article

Karya Journal of Health Science

ANTIMICROBIAL RESISTANCE AND CLINICAL OUTCOMES OF BLOODSTREAM INFECTIONS IN A CARDIOVASCULAR SURGERY DEPARTMENT

Tayfun Özdem, Mehmet Emin Varol, Ali Can Korkmaz, Ilgaz Kazaz, Tuna Demirkıran, Işil Taşöz, Furkan Burak Akyol, Ertan Demirdaş, Gökhan Erol, Tuğrul Hoşbul, Hakan Kartal

Objective: Bloodstream infections (BSIs) following cardiovascular surgery and cardiovascular interventions are major postoperative complications associated with substantial morbidity and mortality. Although antimicrobial resistance (AMR) has become an increasingly important global public health concern, this study aimed to clarify its impact on clinical outcomes in patients who develop postoperative BSIs.Method: This retrospective study included 139 adult patients who developed BSIs after cardiovascular surgery or …

27.08.2026journal-article

Biotechnology and Bioprocess Engineering

Enhancing TGF-β1 production in CHO cells via MS-275 treatment, Bax/Bak knockout, and PACEsol overexpression

Kyungsoo Kim, Kyoung Eun Baek, Gyun Min Lee

Abstract Efficient production of recombinant human transforming growth factor-β1 (rhTGF-β1) in Chinese hamster ovary (CHO) cells is limited by low yields and inefficient precursor processing. Here, we developed an integrated strategy combining chemical and genetic engineering. Screening of additives revealed that the histone deacetylase inhibitor MS-275 increased specific productivity ( q hTGF−β1 ) but inhibited growth, without affecting precursor processing. To counteract this, Bax and Bak double knockout cells we …

27.08.2026journal-article

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

Evaluation of Endometriosis-Associated Pain Scores and Complications after Laparoscopic Surgery in Patients Unresponsive to Medical Treatment

Hale Ankara Aktaş, Murat Levent Dereli, Gülfem Başol, Fatih Şanlıkan, Yasmin Aboalhasan Yoldaş, Esra Keles, Gazi Yıldız, Emre Mat

Endometriosis is a chronic gynecologic disorder characterized by the presence of endometrial-like tissue outside the uterus, often associated with pelvic pain and infertility. Although several medical treatments exist, many patients experience persistent symptoms that require surgical management. Painful pelvic symptoms are the main reason why women with endometriosis who do not respond to medical options seek treatment. This study aimed to evaluate changes in pelvic pain symptoms before and after laparoscopic endo …

27.08.2026journal-article

International Journal of Biology and Life Sciences

Multi-Layer Computational Design of Small-Molecule Inhibitors Targeting Nck1 for Autoimmune Disease Treatment

Junyuan Chen

The adaptor protein Nck1 involved in the T cell CD3 signaling pathway is a promising therapeutic target for the treatment of immune system-related diseases. This study established a multi-layer virtual screening pipeline that integrates compound library generation, molecular docking, pan-assay inference compounds (PAINS) filtration, and free energy calculation from molecular dynamics (MD) simulation to design and sequentially identify promising novel small molecule inhibitors (SMIs) for autoimmune diseases treatmen …

27.08.2026journal-article

Current Opinion in Cardiology

Diagnostic performance and clinical impact of photon-counting detector computed tomography in coronary artery disease

Roosha Parikh, Doosup Shin, Ziad A. Ali, Omar K. Khalique

Purpose of review Photon-counting detector computed tomography (PCD-CT) is an emerging technology that addresses key limitations of conventional coronary CT angiography, including calcium blooming, stent-related artifacts, and limited spatial resolution. This review summarizes recent evidence regarding the diagnostic performance and clinical impact of PCD-CT in the evaluation of coronary artery disease (CAD) and discusses its potential role in contemporary cardiovascular imaging. Recent findings Recent studies demo …

27.08.2026journal-article

JMIR Formative Research

Teaching the Atomic Sentence Method for Source-Verified, AI-Assisted Literature Synthesis to Clinical Health Care Professionals: Single-Cohort Feasibility and Acceptability Study

Sung-Wei Liu, Shao-Yin Chu, Hung-Che Wang, Ming-Shinn Lee

Abstract Background Generative AI can reduce the academic-writing burden on clinical health care professionals, but unsupervised use introduces citation hallucination (the confident fabrication or misattribution of references), which threatens research integrity. When a machine invents a source, it is termed “hallucination,” and when a person does it, it is termed “fabrication,” yet both are equally unacceptable. Existing health professions education writing workshops have rarely translated this concern into a conc …

27.08.2026journal-article

Strategy Science

Unique Strategies and Average Treatment Effects

Jason Snyder, Robert Wuebker, Todd Zenger

What explains the increasing disconnect between empirical strategy research and real-world strategy? Although empirical methods have evolved, notably in the use of techniques that support causal identification, we argue that empirical strategy’s focus on estimating well-identified average treatment effects from a population-level model of performance is fundamentally misaligned with the strategist’s need for firm-specific insights about how to build firm-specific models that guide strategic decision making. This mi …

27.08.2026journal-article

Journal of Clinical Pathology

ALK overexpression without rearrangement widely exists in EWSR1 / FUS -rearranged soft tissue tumours

Lihong Li, Lihua Gong

Aims Anaplastic lymphoma kinase (ALK) is implicated in ALK fusion-positive non-small cell lung cancer and inflammatory myofibroblastic tumours. Based on prior studies and our observations, ALK overexpression appears to be associated with FET ( FUS / EWSR1 / TAF15 ) family rearrangements ( EWSR1 and FUS ). Methods In this study, we analysed 119 FET-rearranged tumours spanning 20 tumour types. Using ALK D5F3 immunohistochemistry (IHC), ALK overexpression was defined as positive only for scores of 2+ or 3+. Cases with …

27.08.2026journal-article

Journal of Intensive Care Medicine

Association of Statin Use With Short- and Long-Term Mortality in Critically Ill Patients With Aortic Stenosis: A Retrospective Cohort Study

Yue Yu, Sanshuai Chang, Ke Shang, Yuemiao Jiao, Yang Li, Liuyang Tian, Guangyuan Song, Chengqian Yin

Background Statins have not been shown to modify valvular disease progression in relatively stable aortic stenosis populations, but their prognostic relevance during critical illness remains unclear. Methods We conducted a retrospective cohort study using the MIMIC-IV database. Adult patients with aortic stenosis were included at their first ICU stay if the ICU length of stay was at least 24 h. In-hospital statin prescription exposure was identified from prescription records. The primary outcome was 30-day all-caus …

27.08.2026journal-article

Journal of Neonatal-Perinatal Medicine

Impact of structured antenatal breastfeeding counselling on early initiation of breastfeeding: A comparative study from Central India

Priyanshi Panwar, Bharati P. Choubey, Sharmila Ramteke, Anukrati Khare, Manjusha Goel

Objectives To determine the effectiveness of structured antenatal breastfeeding counselling on early initiation of breastfeeding (EIBF) within 1 hour of birth and its determinants among mothers delivering at a tertiary-care hospital in central India. Methods A prospective, non-randomized (quasi-experimental) study was conducted in the Department of Pediatrics, Bhopal, from June 2024 to September 2025. The intervention group included third-trimester antenatal women who received one to three structured counselling se …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Postoperative gastrointestinal dysfunction and gastrointestinal tumors: A review and a point of view

Jia-Bing Liu, Cai-Wen Yan, Zhi-Jun Chen, Liang Zong

Gastrointestinal (GI) dysfunction following surgery for GI tumors is a common complication that significantly impacts patient recovery, prolongs hospital stays, and increases healthcare burdens. This review of recent research systematically examines the risk factors, predictive model development, and clinical prognostic value associated with this postoperative condition. We delve into key risk determinants including patient age, tumor stage, operation duration, and nutritional indices. We focus on the clinical sign …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Precision and function preservation in gastrointestinal surgery: Integrating minimally invasive techniques, enhanced recovery, and metabolic interventions

Yun Wang, Yang Wang, Yao-Yu Jin, Yu-Xuan Zhou, Jie Wu, Yan Li

Gastrointestinal surgery is shifting from pursuing radical oncology to emphasizing precision, functionalization, and rapid recovery. How to integrate laparoscopic and robotic surgery, enhanced recovery after surgery protocols, and metabolic regulatory mechanisms of bariatric surgery is a key issue in optimizing patient outcomes. This review focuses on three areas: (1) Short- and long-term outcomes of minimally invasive techniques for colorectal and gastric cancer, as well as surgical strategies for special populati …

27.08.2026journal-article

Frontiers in Oncology

PD-1/PD-L1 inhibitor-related cystitis: clinical features, diagnostic exclusion, and outcomes in one definite and seven probable cases with an updated literature review

Wei Ding, Heqian Liu, Lin Li, Yingqing Liu, Jiawei Wang, Zhonglang Wang, Lingsong Tao, Xiansheng Zhang

Background PD-1/PD-L1 inhibitor-related cystitis (PD-(L)1-RC) is an uncommon urinary immune-related adverse event that may be mistaken for bacterial cystitis, tumor progression, radiation injury, stone disease, or chemotherapy-related hemorrhagic cystitis. This study describes the clinical phenotype, diagnostic exclusion process, treatment response, and updated literature context of PD-(L)1-RC. Methods We retrospectively reviewed eight patients who developed new lower urinary tract symptoms after PD-1/PD-L1 inhibit …

27.08.2026journal-article

Frontiers in Nutrition

Preoperative prognostic nutritional index and in-hospital mortality in neonates undergoing cardiac surgery for congenital heart disease: a single-center retrospective study

Heqi Zhang, Haoju Dong, Taibing Fan, Weijie Liang

Background Neonates undergoing cardiac surgery for congenital heart disease (CHD) represent one of the highest-risk subpopulations in pediatric cardiac surgery. Preoperative nutritional and immune reserve may substantially influence perioperative resilience, yet practical neonatal-specific nutritional risk markers remain insufficiently defined. Objective To evaluate the association between preoperative prognostic nutritional index (PNI) and in-hospital mortality in neonates undergoing cardiac surgery for CHD, and t …

27.08.2026journal-article

Clinical Transplantation

Survival and Outcomes of Lung‐Kidney and Lung‐Liver Transplants Using a Large National Cohort

John A. Treffalls, Kelly Pennington, Cassie C. Kennedy, Julie K. Heimbach, Carrie A. Schinstock, Mauricio A. Villavicencio, Sahar A. Saddoughi

ABSTRACT Background We used a national cohort to compare post‐transplant outcomes of lung‐kidney and lung‐liver transplantation to isolated lung transplantation. Methods The United Network for Organ Sharing database was queried for all lung transplants performed from 1/1/2010‐9/30/2024. Heart‐lung and three‐organ transplants were excluded. Patients undergoing isolated lung transplantation were compared with those undergoing simultaneous lung‐kidney or lung‐liver transplantation. Cox proportional hazards models asse …

27.08.2026journal-article

Journal of Clinical Medicine

Targeting Inflammation Across the Myocardial Infarction Continuum: Biomarkers, Imaging, and Emerging Therapies

Kristi Hoxha, Isabella Maccaferri, Francesco Paparazzo, Alberto Sarti, Giorgio Sciaramenti, Giovanni Camaiti, Pierpaolo Cioci, Cristina Rizza, Renè Tezze, Ludovica Rita Vocale, Elisabetta Tonet, Federico Marchini, Gianluca Campo, Rita Pavasini

Background: Myocardial infarction (MI) remains a leading cause of morbidity and mortality despite major advances in reperfusion and secondary prevention. Inflammation contributes throughout the MI continuum, from atherosclerotic plaque development and destabilization to myocardial injury, adverse ventricular remodeling, and recurrent cardiovascular events. Objective: This narrative review summarizes current evidence on inflammation across the MI continuum, focusing on inflammatory biomarkers, cardiovascular imaging …

27.08.2026journal-article

Frontiers in Medicine

Nomogram integrating BRAF V600E, serum biomarkers, and ultrasound features for malignancy risk stratification in C-TIRADS category 3 and 4 thyroid nodules

Yu Gao, Wenran Zhang, Jingmin Li, Jiaqing Dou

Background For patients with C-TIRADS 3 or 4 nodules who have undergone fine-needle aspiration cytology (FNAC), subsequent management decisions remain challenging, especially when cytological results are discordant with imaging findings or indeterminate. We built a nomogram incorporating BRAF V600E, serum biomarkers, and ultrasound features to provide an individualized risk estimate of malignancy for these nodules. Methods We retrospectively included 300 patients with C-TIRADS 3 or 4 nodules. All nodules were confi …

27.08.2026journal-article

Frontiers in Medicine

Rising burden of early-onset lung cancer among Chinese adolescents and young adults (1990–2023): a Bayesian age-period-cohort analysis with projections to 2038

Yi Dong, Yongjie Guan, Maosen Zhao, Shuang Feng, Xiaowei Wang, Mingming Wang, Maoyong Fu, Jiayu Shang, Ke Gao

Background Early-onset lung cancer (diagnosed at age 15–39 years) remains uncommon, yet incidence is rising in several world regions. China—the largest contributor to global lung cancer mortality—has not had its youth burden comprehensively characterized or projected. Methods Using the Global Burden of Disease Study 2023 (GBD 2023), we extracted annual incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) for Chinese adolescents and young adults (AYA) aged 15–39 years from 1990 to 2023. Joinp …

27.08.2026journal-article

Oral and Maxillofacial Surgery

A new radiological classification of the mental foramen in the edentulous mandible: clinical and surgical implications

Bruno Scognamiglio, Alfonso Acerra, Mario Caggiano, Isabella De Rubertis, Francesco Giordano

Abstract Background The purpose of this cross-sectional study was to classify different patterns of mental nerve emergence (MNE) in edentulous mandible using cone beam computed tomography (CBCT) scans. Methods Seventy-five consecutive patients, each contributing with one hemimandible and candidates for implant surgery, were recruited at Dental Unit of University Hospital of Salerno. CBCT scans were analyzed by two calibrated examiners to assess the distance between the bone crest and the mental foramen (BC–MF), man …