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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Toxins

Aflatoxin B1, Gut Microbiota Dysbiosis, and the Intestinal Barrier: Implications for the Gut–Liver Axis and Extrahepatic Cancer Risk

Charbel Sleilaty, Marilyn Hnein, Teddy Lattouf, Thea Gemayel, Fouad Attieh, Tia Kreidy, Kevin Sarkis, May Bark, Maha Hoteit, Alain Chebly, Marwan Ghosn, André El Khoury, Jad Chémali

Aflatoxin B1 (AFB1) is a potent foodborne mycotoxin classified as a Group 1 human carcinogen by the International Agency for Research on Cancer (IARC) and is widely recognized for its causal role in hepatocellular carcinoma (HCC). Beyond its well-established hepatotoxicity, increasing evidence indicates that AFB1 also disrupts intestinal homeostasis by impairing epithelial barrier integrity, reducing mucus production, altering gut microbial composition, and disturbing microbial metabolism. These changes promote inc …

24.08.2026journal-article

European Journal of Applied Sciences

Tetracarpidium conophorum for Fibroid Treatment in Southeastern Nigeria

N. E. Ahajumobi, J. C. Asika

Background: Gynecological uterine leiomyomas commonly called uterine fibroids are smooth muscle benign tumors of the uterus that occur in women of reproductive age. Prevalence is estimated at 20-80% globally, depending on geographical location, diagnostic methods, age, race and ethnicity, and modern treatment is beyond the reach of the poor and middle class. Objectives: To determine evidence and separate myths from facts, clear the air about superstition, encourage appropriate use, and make summary evidence availab …

24.08.2026journal-article

Case Reports in Gastroenterology

Neoadjuvant Chemotherapy after Plasmapheresis in Borderline Resectable Pancreatic Cancer: A Case Report

Yoshihiro Uehara, Tatsunori Satoh, Shinya Kawaguchi, Eri Asahina, Shinya Endo, Kazuya Ohno

Introduction: Persistent jaundice may occasionally occur even after technically successful biliary drainage, posing a considerable challenge in patients requiring early systemic therapy. In borderline resectable pancreatic cancer (BR-PC), timely initiation of neoadjuvant chemotherapy (NAC) is critical for optimizing treatment outcomes, but hyperbilirubinemia often delays therapy. Although plasmapheresis has been reported as a potential option for refractory hyperbilirubinemia, its use for facilitating initiation of …

24.08.2026journal-article

Frontiers in Public Health

Safety and quality of public chatbots for lung cancer prognostic information: a comparative evaluation

Yanru Jiang, Qianyun Wang, Liang Zheng, Lei Zhang, Bo Jiang, Jingjuan Xu, Jun Wang, Jiaying Zhu, Zhishui Wu

Objective To compare the safety, accuracy, empathy, reliability, information quality, and readability of five publicly accessible large language model chatbots when answering patient-facing lung cancer prognostic questions under standardized single-turn English prompting. Methods In this Chatbot Health Advice Reporting Transparency-guided cross-sectional evaluation, 53 standardized English prompts were submitted once to ChatGPT, Gemini, Copilot, DeepSeek, and Doubao through official web interfaces during April 1–21 …

24.08.2026journal-article

Frontiers in Oncology

Pretreatment TyG-BMI predicts CD19 CAR-T persistence and prognosis in diffuse large B-cell lymphoma

Zelin Liu, Ruijun Yang, Jiawen Chen, Ziyu Liu, Yangyang Ding, Keke Huang, Ya Liao, Linhui Hu, Lianfang Pu, Lujie Liu, Jiyu Wang, Qianshan Tao, Shudao Xiong

Background Although CD19 CAR-T cell therapy has improved outcomes in relapsed or refractory diffuse large B-cell lymphoma (DLBCL), responses are variable and predictive biomarkers are lacking. The triglyceride glucose-body mass index (TyG-BMI)—a surrogate of insulin resistance—has shown prognostic value in solid tumors, but its relevance to DLBCL and CAR-T efficacy remains unknown. Methods We retrospectively analyzed 204 newly diagnosed DLBCL patients treated with rituximab-containing regimens, stratified by median …

24.08.2026journal-article

Periodica Polytechnica Chemical Engineering

Hydrothermal Cetyltrimethylammonium Bromide Modified Palm Oil Fuel Ash as a Mesostructured Silica-Based Adsorbent for Produced Water Treatment

Tutuk Djoko Kusworo, Meitri Bella Puspa, Ahmad Fauzi Ismail, Andri Cahyo Kumoro

This study evaluates the adsorption performance of hydrothermally modified palm oil fuel ash (POFA) for the removal of chemical oxygen demand (COD) and ammonia nitrogen (NH3–N) from produced water, while identifying the dominant equilibrium mechanisms governing pollutant uptake. The novelty of this work lies in the utilization of cetyltrimethylammonium bromide (CTAB)-assisted hydrothermal modification to enhance the mesostructural characteristics, surface functionality and adsorption selectivity of industrial POFA …

24.08.2026journal-article

Frontiers in Psychiatry

Factors associated with successful psychiatric intensive home treatment – a quasi-experimental study

Stefan Weinmann, Konstantinos Nikolaidis, Gerhard Längle, Sebastian von Peter, Peter Brieger, Juergen E. Timm, Lasse Fischer, Morten Dreher, Svenja Raschmann, Martin Holzke, Julian Schwarz, Olaf Hardt, Constance Hirschmeier, Uwe Herwig, Stefan Klingberg, Reinhold Kilian, Johanna Baumgardt, Johannes Hamann, Andreas Bechdolf

Background With more and more Home Treatment (HT) teams being implemented worldwide as well as high variations in models and intensity of care and target groups, there is a need to look at factors associated with its success and relative effectiveness compared to inpatient treatment (IT). For doing so, we used data from the quasi-experimental evaluation of the German highly regulated model of intensive HT (IHT). Methods Within a propensity-score matched study we compared 200 patients treated by IHT in ten psychiatr …

24.08.2026journal-article

Cancer

Gynecologic cancers in low‐ and middle‐income countries: Bridging the survival gap

Dewi Setiawati, Wachyudi Muchsin, Alfi Sophan

Abstract Gynecologic malignancies—including cervical, endometrial, ovarian, vaginal, and vulvar cancers—represent a major and largely preventable source of mortality in low‐ and middle‐income countries (LMICs). In 2022, an estimated 1.47 million new cases and over 680,000 deaths were reported globally, with mortality disproportionately concentrated in resource‐constrained settings. The survival gap between LMICs and high‐income countries (HICs) remains profound, reflecting systemic policy and health system failures …

24.08.2026journal-article

Indian Journal of Ophthalmology

New pharmacological and biotechnological approaches for the treatment of neurotrophic keratopathy: From growth factors to gene therapy

Mukaddes Damla Ciftci, Mehmet Gurdal, Ozlem B Selver

Neurotrophic keratopathy (NK) is a serious ocular surface disease that develops due to a reduction or loss of corneal innervation. Conventional therapeutic approaches, such as the use of artificial tears and autologous serum, primarily serve as symptomatic relief measures and do not target the underlying neurodegenerative process. The introduction of recombinant human nerve growth factor (rhNGF, cenegermin) has marked the first disease-modifying pharmacological therapy for NK, providing evidence of enhanced epithel …

24.08.2026journal-article

Journal of Cell Communication and Signaling

Rapid normal fibroblast‐tumor crosstalk promotes cancer‐associated fibroblast‐like activation and attenuates mitomycin C cytotoxicity in bladder cancer

Jinhui Gao, Cindy Xinyu Ji, Ci Ren, John Hines, Eleanor Stride, Richard T. Bryan, Jennifer L. Rohn

Abstract Normal fibroblasts (NFs) are among the earliest stromal cells encountered by bladder cancer cells during invasion into the lamina propria, yet their contribution to tumor progression and intravesical chemotherapy response remains poorly defined. Here, we investigated whether NFs are passive stromal bystanders or active participants in early bladder cancer microenvironmental remodeling. Analysis of an early‐stage non‐muscle‐invasive bladder cancer transcriptomic cohort revealed that fibroblast‐associated sc …

24.08.2026journal-article

Frontiers in Public Health

The impact of migrant-inclusive policy on Botswana’s universal HIV treatment program: a retrospective analysis of the national HIV treatment program data (2016–2022)

Patrick T. Mokgethi, Ontlametse T. Choga, Wonderful T. Choga, Dorcas Maruapula, Natasha O. Moraka, Graceful Mulenga, Terence Mohammed, Kesaobaka Molebatsi, Catherine K. Koofhethile, Sununguko W. Mpoloka, Tafireyi Marukutira, Sikhulile Moyo, Simani Gaseitsiwe

Background Botswana has made substantial progress toward the Joint United Nations Programme on Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) (UNAIDS) 95-95-95 targets. However, migrants were historically excluded from free antiretroviral therapy (ART). In December 2019, Botswana extended free HIV testing and treatment to migrants. Population-level data on ART coverage, viral load testing, and virologic suppression among migrants remain limited. Therefore, the study intends to assess the …

24.08.2026journal-article

World Journal of Clinical Oncology

Targeting tumor metabolism through precision nutrition: A therapeutic strategy to improve cancer outcomes

Debdeep Chattopadhyay, Anushka Saha, Durva Tendulkar, Trisha Banerjee, Souvik Roy, Lopamudra Choudhury, Ramya Lakshmi Rajendran, Prakash Gangadaran, Byeong-Cheol Ahn

Modern cancer therapies include chemotherapy, immunotherapy, radiation therapy, hormone therapy and newer methods like oncolytic viruses and chimeric antigen receptor T-cell therapy. These therapies are commonly used to manage cancer, but many patients face serious side effects such as cachexia and treatment related anorexia which can lead to a lower quality of life and a reduced ability to tolerate treatment. This review explores nutrition-based approaches that might help reduce these side effects and improve the …

24.08.2026journal-article

International Journal of Biology and Life Sciences

Protein Phase Separation and Regulatory Mechanisms of Transcriptional Programming in Tumor Microenvironment in Stress Response

Xingjian Luo

Malignant tumor evolution is governed by its symbiotic relationship with the tumor microenvironment, which features steep oxygen and acidity gradients that drive malignant progression. Traditional biochemical frameworks fail to adequately explain the rapid, coordinated genomic alterations under such stresses. This review focuses on liquid-liquid phase separation (LLPS), which acts as a biophysical switch regulating transcriptional programming. The study demonstrates that tumor microenvironmental stress directly mod …

24.08.2026journal-article

Frontiers in Oncology

Trends in cervical cancer incidence and mortality in Mongolia, 2014–2024: a population-based analysis of pandemic-related disruptions

Nomin-Erdene Tsogtgerel, Dolgorkhand Adiyadorj, Gan-Erdene Ganbaatar, Amy Elizabeth Parry, María José González Méndez, You Lin Qiao

Background Cervical cancer remains a major public health concern in Mongolia, where screening coverage is estimated at approximately 38%, well below recommended levels, and access to timely diagnosis varies. This study examined temporal trends in incidence and mortality and assessed the impact of COVID-19–related disruptions on cancer detection. Methods A nationwide population-based study was conducted using data from Mongolia’s national health information system (H-Info). All cervical cancer cases (ICD-10: C53.0-C …

24.08.2026journal-article

Asia-Pacific Journal of Clinical Oncology

Impact of Prior Immune Checkpoint Inhibitor Treatment on the Efficacy of Weekly Paclitaxel and Cetuximab in Recurrent or Metastatic Head and Neck Cancer

Shohei Tsutsumi, Shunsuke Miyamoto, Kaho Momiyama, Kohei Hagiwara, Taku Yamashita

ABSTRACT Aim The optimal treatment sequence involving immune checkpoint inhibitors (ICIs) and chemotherapy for recurrent or metastatic head and neck cancer remains unclear. This study aimed to evaluate the efficacy of weekly paclitaxel and cetuximab (PTX + Cmab) following prior ICI treatment. Methods We retrospectively analyzed 52 patients with unresectable recurrent or metastatic head and neck cancer who received PTX + Cmab. Patients were divided into two groups according to prior ICI treatment status. Treatment o …

24.08.2026journal-article

Advanced Science

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You

ABSTRACT Paclitaxel (PTX) chemotherapy is constrained by an “immunomodulatory paradox,” where antitumor Type I Interferon (IFN‐I) activation is coupled with detrimental pro‐inflammatory cascades. To address this challenge, we developed Deep Learning for Innate Immunity Modulatory Potential (DLINP), a Transformer‐based framework designed to identify precision immunomodulators that uncouple IFN‐I induction from deleterious inflammatory signaling. Screening 123 million entities identified Co68—an organometallic PNP‐pi …

24.08.2026journal-article

Medinformatics

Mutational Landscape and Regulatory Network Analysis of TP53 and FOXA1 in Prostate Cancer

Shrijee Lakshkar, Pratha Tiwari, Heenal Bhatt, Vipin Ranga, Narendra Kumar Sharma, Tikam Chand Dakal

Prostate cancer is a major global health burden. According to GLOBOCAN 2022 estimates, it accounts for nearly 396,792 deaths and 1,466,680 cases annually. Despite advances in immunotherapy, hormone therapy, radiation, chemotherapy, and surgery, improved biomarkers for early detection and targeted treatment remain urgently needed. In this study, cancer genomics data from cBioPortal were analyzed to identify key gene mutations associated with prostate cancer progression. Examination of 12,741 nonoverlapping samples a …

24.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Concurrent chemotherapy and external radiation therapy (ConCERT): phase 3 noninferiority randomized clinical trial of cisplatin weekly vs every 3 weeks in locally advanced squamous cell carcinoma of the head and neck

Atul Sharma, Manish Kumar Choudhary, Suman Bhasker, Akash Kumar, Alok Thakar, Raja Pramanik, Ahitagni Biswas, Kapil Sikka, Surya V S Deo, Ashok Kumar, Supriya Mallick, Amit Chirom Singh, Pooja Sethi, Amit Sehrawat, Vishnubhatla Sreenivas, Rajeev Kumar, Saphalata Baghmar, Aanchal Kakkar, Vinod Sharma, Babita Kataria, Ranjit Sahoo, Aman Sharma, Prasanth Ganesan, Sudhir Kumar, Amol Patel, Smriti Panda, Sanjay Thulkar, Sandeep Seth, Shikha Halder, Manoj Gupta, Ashish Dutt Upadhyay

Abstract Introduction Concurrent chemoradiotherapy with cisplatin (100 mg/m² every three weeks) is the standard for locally advanced head and neck squamous cell carcinoma (LA-HNSCC), but it is uncertain if weekly cisplatin (40 mg/m²) is non-inferior. Method This open-label, multicentre, phase III non-inferiority trial randomised patients with non-nasopharyngeal LA-HNSCC in a ratio of 1 1 to receive either the standard cisplatin regimen (100 mg/m² every three weeks) or the experimental weekly regimen (40 mg/m²), bot …

24.08.2026journal-article

Advanced Science

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li

ABSTRACT Triple‐negative breast cancer (TNBC) derives limited benefit from immune checkpoint blockade, largely owing to primary resistance shaped by the tumor immune microenvironment. Here, baseline transcriptomic profiling of a neoadjuvant chemoimmunotherapy cohort identified carbohydrate sulfotransferase 1 (CHST1) as a candidate resistance‐associated gene. High CHST1 expression was associated with poor immunotherapy response and inferior clinical outcome across clinical datasets. Functionally, CHST1/Chst1 had min …

24.08.2026journal-article

Pharmaceuticals

Narciclasine Exerts Anticancer Activity in Colorectal Cancer Cells in Association with HELLS Downregulation and DNA Damage-Associated Responses

Yoon-Mi Lee, Sumin Han, Gyun Seok Park, Judy Gopal, Jae-Wook Oh

Background/Objectives: Colorectal cancer (CRC) remains a major cause of cancer-related mortality worldwide, largely owing to metastasis, recurrence, and resistance to conventional therapies. Natural-product-derived compounds represent an important source of anticancer drug candidates. This study investigated the anticancer activity of purified narciclasine, which was tentatively annotated as a major detected constituent of Lycoris sanguinea extract, and examined its association with HELLS-associated DNA damage resp …

27.08.2026journal-article

Nucleic Acids Research

PCNA–RECQL5–RPRD1B recruit repair components to stressed replication forks to promote survival of BRCA1-deficient cancer cells

Manh Tien Tran, Elizabeth A Williamson, Aruna S Jaiswal, Dominic Arris, Nhat Nguyen, Andrew Carrillo, Shaun Olsen, Kimi Kong, Montasser Shaheen, Doraid Sadadeen, Daohong Zhou, Yaxia Yuan, Shahrez Syed, Youngho Kwon, Sameer Salunkhe, Patrick Sung, Robert Hromas

Abstract Given their defect in homologous recombination, BRCA1-deficient cancers use polymerase theta (POLQ) microhomology-mediated end joining (MMEJ) for repair of stressed replication forks. We found that BRCA1-deficient cells repress microRNA (miR) 4485-3p, and reconstituting expression of this miR resulted in the death of BRCA1-deficient cells. In our interrogation of the mechanism of this synthetic lethality, we discovered that miR-4485-3p suppresses expression of RPRD1B protein. Depletion of RPRD1B led to sel …

24.08.2026journal-article

Journal of The Society of Obstetricians and Gynaecologists of Pakistan

Assessing the Utilization of Preoperative Ultrasound Guided Skin Marking for Tumor Localization in Post-Neoadjuvant Breast Cancer - A Single-Centre Study

Eisha Tahir, Maimoona Gulshan, Maham Abid

Objective: This study compares the cost-effective use of ultrasound-guided skin surface marking (USGSSM) with wire-guided localization (WGL) for tumor localization in breast cancer surgery at Shalamar Hospital.Materials and Methods: A retrospective study was conducted at Shalamar Hospital, Lahore, between July 2023 and December 2023. The records of breast cancer patients including age, localization technique, sonographic and pathological tumor size, histologic type/grade, margin status, chemotherapy, and axillary d …

24.08.2026journal-article

Frontiers in Oncology

Sertoli cell tumor in familial adenomatous polyposis: a case report

Chandra Kakarala, Katie Bussing, Reema Patel, Jessica Moss, Zin W. Myint

Familial adenomatous polyposis is known to progress into colorectal cancer, and extra-intestinal malignancies have also been reported. However, testicular sex cord stromal tumors are very rarely noted in association. In this study, we report the case of a 50-year-old man with genetically confirmed FAP and adenocarcinoma of the colon who was incidentally found to have a testicular lesion. Radial orchiectomy was performed, and histopathologic examination confirmed a Sertoli cell tumor without high-risk features. This …

24.08.2026journal-article

Frontiers in Oncology

Differential analysis of urinary stable downregulated proteins in male patients after colorectal cancer surgery

Lupeng Wang, Qian Meng, Mei Hu, Man Zhang

Background Colorectal cancer is a common malignant tumor that threatens men’s health, and there are currently ineffective biomarkers for noninvasive monitoring of postoperative tumor changes in clinical practice. Urine is an easily accessible sample that can reveal physiological and pathological changes in the body. To identify specific proteins stably downregulated postoperatively and thereby provide novel potential biomarkers for colorectal cancer following surgery monitoring, this study analyzed urinary proteomi …