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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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22 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Approach to the Patient: Ethics Cases in Pediatric Endocrinology and Their Management

Jennifer M Ladd, Meaghann S Weaver, Rohan K Henry

Abstract Context With advancing technologies and expanding indications for existing therapies, ethical dilemmas increasingly arise in pediatric endocrinology practice. Aim This article presents practical, case-based scenarios to guide clinicians in navigating common ethical challenges in pediatric endocrinology. Cases We present four case vignettes which present ethical dilemmas regarding (1) growth hormone treatment prescribed for idiopathic short stature, (2) precocious puberty management in a child with neurodev …

27.08.2026journal-article

Frontiers in Psychology

Clinical risk stratification of stroke caregiver distress: an interpretable nonlinear model of caregiving-load categories

Yingjie Zheng, Shailing Ma, Xiaohui Liu, Yuyan Yang, Ru Gan, Jiajia Lai, Yijia Qi, Jing Li, Lijun Wang, Miaomiao Chen

Background Family caregivers of stroke survivors frequently experience psychological distress. Social support and active coping may be protective, but their associations can vary across levels of caregiving load. Interpretable machine learning may help characterize such nonlinear patterns without assuming a constant linear association. Methods This multicenter cross-sectional study included 506 family caregivers. High psychological distress was defined as a Hospital Anxiety and Depression Scale (HADS) total score ≥ …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Case Report: Interventricular septal hematoma after ventricular septal defect repair with persistent left ventricular communication: 10-year follow-up

Anna Rudek-Budzyńska, Aleksandra Morka, Tomasz Mroczek

Interventricular septal hematoma is a rare complication of congenital heart surgery with unpredictable clinical course and limited data guiding management. We report a female infant who developed a giant interventricular septal hematoma after surgical closure of a perimembranous ventricular septal defect at 4 months of age. Early postoperative imaging demonstrated a large intraseptal cavity without ventricular communication, followed by development of multiple small fistulous connections with the left ventricular l …

27.08.2026journal-article

Frontiers in Oral Health

Periodontal management in patients with diabetes: the impact of periodontal treatment on cardiometabolic biomarkers

Alicia Morales, Gustavo Sáenz-Ravello, Loreto Matamala, Mauricio Baeza, Patricia Hernández-Ríos

Introduction Type II Diabetes Mellitus (T2DM) and periodontitis present an independent bidirectional relationship. While T2DM is associated with a higher prevalence, incidence, and severity of periodontitis, periodontitis might worsen glycemic control and inflammatory biomarker levels in diabetics. Although there is no standardized therapy for the treatment of diabetic patients with periodontitis, different periodontal interventions report improvements in clinical and cardiometabolic parameters. Objective To summar …

27.08.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

From metrological comparability to clinical continuity: authorising laboratory result reporting when changing measurement procedures

Raúl Rigo-Bonnin, David Ceacero-Marín, Míriam Valbuena-Asensio, Virgínia Mas-Bosch, Aurora Blanco-Font

Abstract Objectives To develop and apply an operational framework integrating metrological, analytical, clinical and risk evidence to authorise an output-specific reporting rule after a change in measurement procedure. Methods Four measurement procedure changes were evaluated: alanine aminotransferase (ALT) procedures with and without pyridoxal-5′-phosphate activation; follicle-stimulating hormone (FSH) reagent replacement; routine vs. short-turnaround-time (STAT) parathyroid hormone (PTH) procedures; and tacrolimu …

27.08.2026journal-article

Biological Products. Prevention, Diagnosis, Treatment

Inactivation of Mycoplasma gallisepticum and Mycoplasma synoviae during influenza vaccine production

N. N. Savina, M. Sh. Aliev, A. I. Reutskiy, T. V. Gorokhova, O. S. Babkina, S. V. Pankratov, N. Yu. Serova

INTRODUCTION. The use of chicken embryos in influenza vaccine production carries the risk of contaminating the final product with the avian mycoplasmas, Mycoplasma gallisepticum and M. synoviae , which pose a potential hazard to humans. Therefore, evaluating the effectiveness of inactivating these contaminants in influenza vaccine intermediates using inactivators (β-propiolactone, ultraviolet irradiation) and detergents is important. AIM. This study aimed to evaluate the inactivation dynamics of M. gallisepticum an …

27.08.2026journal-article

Genes

Insights on Prevalence of Hereditary Aortic Thoracic Disease and Impact on Family Screening in Routine Clinical Cardiothoracic Surgery Care

Simone Gasser, Michael Graber, Nikolaos Bonaros, Michael Grimm, Julia Dumfarth

Objective: Heritable thoracic aortic disease (HTAD) is an important cause of thoracic aortic aneurysm and dissection, yet remains underdiagnosed. We aimed to summarize the prevalence of syndromic and non-syndromic HTAD, describe variants of uncertain significance (VUS), and evaluate the impact of family screening in a contemporary cardiothoracic surgical cohort. Methods: Between 2018 and 2026, 163 patients underwent genetic testing for suspected HTAD at our institution. A total of 139 patients with completed geneti …

27.08.2026journal-article

Frontiers in Medicine

Enhancing nurses’ competence in mechanical ventilation: a quasi-experimental study and its association with patient severity using APACHE II

Noha Mohammed Ibrahim, Samia Eaid Elgazzar, Amany Ibrahim Ezz Eldin, Abdo Mansoor Alhusami, Mona Metwally El-Sayed, Mohamed Goda Elbqry, Fatma Mohamed Elmansy, Shereen Ahmed A. Qalawa, Nasiru Mohammed Abdullahi, Saddam Ahmed Al-Ahdal, Hanadi Dakhilallah, Sheren Ebrahim El-Hag El-Tahry

Background Mechanical ventilation is a cornerstone of intensive care, requiring ICU nurses to have adequate knowledge, competence, and skills to provide safe, evidence-based care. Although educational programs improve nurses’ preparedness, evidence of their impact on patient outcomes remains limited. Aim To assess ICU nurses’ knowledge, professional competence, and clinical practice related to mechanical ventilation following participation in a structured educational program, and to explore the association between …

27.08.2026journal-article

Journal of Palliative Medicine

Patient and Caregiver Perspectives on Communication Quality in Tele-Palliative Care

Julia I. Bandini, Elaine Li, Dio Kavalieratos, Natalie C. Ernecoff, Kimberly Curseen, Jordan Harrison

Background: Tele-palliative care has become a well-established practice following its rapid expansion in the outpatient setting during the COVID-19 pandemic. Despite sustained integration of tele-palliative care, questions remain about patients’ and family caregivers’ experiences with it and its potential impact on the quality of communication during palliative care visits. Objective: To qualitatively explore patient and family caregiver experiences with telehealth and in-person visits for outpatient palliative car …

27.08.2026journal-article

Journal of Scientific Innovation in Medicine

Bridging the Knowledge, Usage, and Regulation Gap for Artificial Intelligence in Medicine: A Cross-Sectional Survey of Spanish Clinicians and Trainees

Jorge García Condado, Enric Cristòbal Cóppulo, Mireia Gamundi, Irene Martínez-Menéndez, Andrea Portaña Sanz, Luis Merino Ulizarna, María del Carmen Cortés Navarro, Francine Klein Milla Palacios, Ámbar C. Almaraz Valdez, Mikel Rueda-Etxebarria

Objective: Artificial intelligence (AI) is rapidly transforming healthcare, offering opportunities to improve diagnostics, optimize workflows, and reduce medical errors. Effective integration requires not only technological innovation but also clinician engagement and education. This study explores the perceptions, knowledge, and experiences of Spanish medical professionals and students regarding AI in healthcare. Methods: A cross-sectional online survey was conducted between October and December 2024, yielding 167 …

27.08.2026journal-article

Medicine & Science in Sports & Exercise

Photobiomodulation Does Not Increase Mitochondrial Respiration in Skeletal Muscle or Skin Tissue in Humans

Thorben Aussieker, Heather L. Petrick, Lisa M.E. Kuin, Jeremias Kaiser, Cas J. Fuchs, Esther Kornips, Kostas Tsintzas, Scott Cooper, Sandra Lammers, Stephan Praet, Tim Snijders, Luc J.C. van Loon

Purpose: Low-level laser therapy, also referred to as photobiomodulation (PBM), is rapidly gaining popularity as a non-invasive treatment for various conditions and as a means to enhance health and performance. PBM has been proposed to directly increase mitochondrial activity in skin and skeletal muscle and activate various molecular signalling pathways. However, evidence for the proposed properties of PBM in vivo in humans is lacking. Methods: In a within-participant study design, 12 healthy men and women (6/6 m/f …

27.08.2026journal-article

Medicine & Science in Sports & Exercise

Ketone Ester Intake Did Not Improve Performance, Neither Cognitive Function or Sleep, During an 8-Day Simulated Cycling Race

Louise Engelbrecht, Wout Lauriks, Ruben Robberechts, Myrthe Stalmans, Monique Ramaekers, Elmarie Terblanche, Katrien Koppo, Chiel Poffé

Purpose: Physiological strain, mental exhaustion, and sleep deprivation are key elements that hinder performance during multi-day endurance activities. Ketone monoester supplementation (KE) may enhance post-exercise recovery, preserve cognitive function, and increase both sleep quantity and quality. Therefore, we simulated an 8-day cycling stage race to assess the effect of KE on physiological strain, mental fatigue, exercise performance, and sleep. Methods: In a double-blind, placebo-controlled, parallel trial, ei …

27.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

Real-world pathogen spectrum, clinical actionability, and host correlates of first-time mNGS testing in hospitalized patients with hematologic diseases

Ziyi Li, ZiHui Dong, LeMin Jiao, YuDie Cai, YangMiao Zhang, HaiTing Wei, TianQi Fang, ZiYang Zhang, Hang Liu

Background Patients with hematologic diseases are highly susceptible to infection. Conventional tests often have low sensitivity. Metagenomic next-generation sequencing (mNGS) can detect many pathogens at once, but its clinical value depends on how the results are interpreted. It is often hard to tell true infection from colonization or contamination. Methods We retrospectively studied hospitalized hematologic patients Only adult patients (≥18 years) who received mNGS for the first time. Detected organisms were rec …

27.08.2026journal-article

Frontiers in Medicine

Effectiveness and renal safety of dupilumab in the treatment of moderate-to-severe atopic dermatitis patients with chronic kidney disease stages 4–5: a real-world cohort study in China

Gang Hu, Quanhong Zhang, Luoyao Yang, Yanglin Hu, Jinbo Chen

Background While dupilumab is widely used for atopic dermatitis (AD), its safety and effectiveness in patients with severe renal failure remain insufficiently studied. Objective To evaluate the real-world effectiveness and renal safety of dupilumab in this population. Methods This cohort study included 30 adult moderate-to-severe AD patients with Chronic Kidney Disease (CKD) stages 4–5. Patients were divided into a dupilumab-treated group ( n = 17) and a control group ( n = 13) receiving conventional therapy. Effec …

27.08.2026journal-article

Frontiers in Dental Medicine

Oral dysbiosis in children with renal failure: a systematic review

Juan Antonio Ruiz-Roca, María Pilar Pecci-Lloret, Antonio Romano, Francesco Carinci, Dorina Lauritano, Nuria Pérez-Guzmán, Alberta Lucchese

Introduction The oral microbiome plays an important role in maintaining host homeostasis and may interact with systemic diseases through the oral–systemic axis. Chronic kidney disease (CKD) in childhood is associated with chronic inflammation, metabolic alterations, and immune dysfunction, which may influence microbial ecosystems. While intestinal dysbiosis has been widely studied in paediatric CKD, alterations in the oral microbiome remain less well understood. The aim of this study was to qualitatively synthesize …

27.08.2026journal-article

Frontiers in Membrane Science and Technology

Phosphate-rich municipal wastewater treatment using magnetite nanoparticles dispersed oakwood biochar-assisted pretreatment followed by air-gap membrane distillation

Prashan M. Rodrigo, Bishweshwar Pant, Sunith B. Madduri, Raghava R. Kommalapati

An integrated approach combining Fe 3 O 4 nanoparticle-loaded biochar-assisted pretreatment and air-gap membrane desalination (AGMD) was investigated for treating phosphate-rich wastewater. This study addresses key limitations of conventional coagulants, such as residual chemical load and limited removal efficiency. Fe 3 O 4 nanoparticles were co-precipitated on oakwood biochar (Fe 3 O 4 /BC). The Fe 3 O 4 /BC composite acts as a coagulant that can be rapidly separated under an applied magnetic field. This study sy …

27.08.2026journal-article

Journal of Intensive Care Medicine

Oxygen Delivery in the Adult Intensive Care Unit with a Focus on Hyperoxic Acute Lung Injury Pathogenesis and Clinical Manifestations

Zachary M. Harris, Edward P. Manning

High oxygen damages human lung, called hyperoxic acute lung injury (HALI). HALI pathogenesis involves formation of reactive oxygen species (ROS) which overwhelm antioxidant mechanisms and lead to alveolar epithelial and endothelial cell death and interstitial inflammation. Resultant alveolar flooding causes ventilation-perfusion (V/Q) mismatch, hypoxic respiratory failure, and death. 12–16 h of severe hyperoxic exposure potentiates symptoms that include substernal chest discomfort, cough, and sore throat. Alteratio …

27.08.2026journal-article

Gynecology Obstetrics & Reproductive Medicine

Systemic Thiol-Disulfide Homeostasis and Contemporaneous Menstrual Pain Intensity in Primary Dysmenorrhea: A Prospective Observational Study

Gonca Turker Engin, Mert Ishak Kaya, Duygu Tugrul Ersak, Ugurcan Zorlu, Raziye Toksoz, Elcin Islek Secen, Goktug Okyar, Salim Neselioglu

OBJECTIVE: Primary dysmenorrhea (PD) is associated with prostaglandin-mediated uterine hypercontractility, transient ischemia, inflammation, and oxidative stress. Whether systemic redox biomarkers reflect menstrual pain intensity at a specific clinical time point remains uncertain. This study evaluated the associations of thiol-disulfide homeostasis parameters and ischemia-modified albumin (IMA) with contemporaneous menstrual pain intensity among women with PD. STUDY DESIGN: This prospective observational study inc …

27.08.2026journal-article

Langenbeck's Archives of Surgery

A Validated, explainable machine learning–based preoperative risk model for microvascular invasion in hepatocellular carcinoma

Liu-Xin Zhou, Jin-Hong Cai, Chang-Ren Zhu, Tian-Ci Luo, Tian-Ming Gao, Kun-Qing Xiao, Sheng Ding, Chen Chen, Bao-Yu Wan, Hao Dong, Song-Song Fan, Dou-Sheng Bai, De-Cai Yu, Guo-Qing Jiang

Abstract Purpose This investigation aimed to develop and validate a diagnostic algorithm for preoperatively assessing the likelihood of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC). Methods Clinical and pathological information of patients with HCC who underwent curative resection was collected from two medical centers. Data from Nanjing Drum Tower Hospital were randomly split into training (80%) and internal validation (20%) cohorts, while data from Northern Jiangsu People’s Hospita …

27.08.2026journal-article

Neuro-Oncology

40 Retrospective analysis of Alopecia in patient receiving Proton Beam Radiotherapy in Neuro-oncology – Single centre experience

Hasti Barot, Vandana Kushwaha, Mithushanaa Nesarajah, Adila Amariyil, Karthica Indramohan, Michelle Newman, Michael Kosmin, Naomi Fersht

Abstract Introduction Alopecia is a common and cosmetically distressing adverse effect of cranial irradiation that significantly affect quality of life in patients. Radiation induced alopecia can be short term or long term or can rarely be permanent. This study aims to evaluate the incidence of acute (≤90 days after completion) and long-term (>90 days) and permanent alopecia in brain tumour patients treated with proton beam therapy in our centre and to establish if the incidence or severity correlates with the s …

27.08.2026journal-article

Neuro-Oncology

17 Psychological and holistic consequences of delays in molecular diagnosis after neuro-oncological surgery: a qualitative study

Jay Kotecha, Shahzaib Ahmed, Kelly Dawson, Anna Mycock, Emily Lockyer, Andrew Dapaah, Simon Paine, Michael Baliousis, Stuart Smith

Abstract Introduction The 2021 WHO Classification of Tumours of the Central Nervous System supports an integrated diagnosis combining histological, immunohistochemical and molecular parameters. Advanced molecular techniques such as DNA methylome arrays and Whole Genome/Next Generation Sequencing are now required to identify certain tumour entities confidently as well as sometimes determining eligibility for clinical trials. Complex molecular analysis however can lead to extended turnaround times and significant del …

27.08.2026journal-article

Journal of Clinical Cardiology

The Balance Between Choice, Initial Prosthetic Valve Selection, and Future Transcatheter Success: A Patient-Centered Strategic Perspective

Caio Cesar Cardoso, José de Lima Oliveira Jr, SO Cardoso

The emergence of transcatheter valve-in-valve (ViV) procedures has fundamentally changed the management of bioprosthetic valve degeneration, providing a less invasive alternative to high-risk surgical reoperation. However, the long-term clinical success of future transcatheter interventions is largely predetermined at the time of the initial surgical valve replacement. This commentary discusses how initial prosthetic choice—type, design, and intraoperative sizing—impacts the patient’s lifelong therapeutic journey. …