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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
18.08.2026journal-article

Theoretical and Natural Science

How Cancer Cells Exploit Unfolded Protein Response Signaling for Survival, Metastasis, and Therapy Resistance

Zihe Zhou

The unfolded protein response (UPR) is a homeostatic protective mechanism activated in response to endoplasmic reticulum (ER) stress. However, once co-opted by cancer cells, its function extends far beyond maintaining proteostasis and becomes an important regulator of tumor progression. This review summarizes how the three canonical UPR branches establish a persistent adaptive state under chronic ER stress. It discusses the molecular mechanisms by which UPR signaling maintains proteostasis, reprograms cellular meta …

18.08.2026journal-article

Neurology, Neuropsychiatry, Psychosomatics

A multimodal approach to the correction of equinovarus foot deformity in patients following focal lesions of the brain and spinal cord: integration of local botulinum therapy and surgical interventions on the capsuloligamentous and musculotendinous apparatus

S. E. Khatkova, D. S. Bobrov, A. S. Larin, O. S. Pavlyuchenkova, A. V. Golovanova, Yu. S. Krainova, A. V. Lychagin, A. Andr. Gritsyuk, K. Kh. Tomboidi, A. A. Gritsyuk, E. Yu. Tselishcheva, R. Kh. Yavlieva

Equinovarus foot deformity is one of the most common orthopaedic sequelae/patterns in patients with spastic paresis of the lower limb following focal lesions of the brain and spinal cord. The effectiveness of comprehensive rehabilitation for patients with spastic paresis of the lower limb and equinovarus foot, incorporating local administration of botulinum toxin type A (BTA) and surgical intervention on the capsuloligamentous and musculotendinous apparatus, has been little studied. Objective: to develop and evalua …

18.08.2026journal-article

Neurology, Neuropsychiatry, Psychosomatics

Personalized therapy of chronic pain syndromes in patients with multiple sclerosis

N. N. Spirin, D. V. Kiselev, E. G. Shipova, N. S. Baranova

In patients with multiple sclerosis (MS), chronic pain syndromes (CPS), which vary in terms of their etiology, clinical symptoms and localization, occur with high frequency even in the early stages of the disease. As a rule, these are pathogenetically linked to the underlying disease and result from focal lesions in the central nervous system and/or the neurological disorders developing in patients. CPS significantly reduce quality of life, impair social adaptation and exacerbate disability in patients with MS. Thi …

18.08.2026journal-article

Journal of Gastroenterology and Hepatology

Consolidation Therapy of Probiotics With Rifaximin Prevent Relapse in Rifaximin‐Responsive Diarrhea‐Predominant Irritable Bowel Syndrome: A Multicenter Randomized Clinical Trial

Jing Zhong, Zhengyang Xu, Wenwen Chen, Yao Jiang, Qiwei Ge, Yanyong Deng, Weili He, Xinli Mao, Yabi Zhu, Jianzhong Sang, Peifen Zheng, Linhua Yao, Feng Han, Huaqiang You, Shujie Chen, Liangjing Wang

ABSTRACT Background and Aim Although rifaximin treatment achieves high remission rates in diarrhea‐predominant irritable bowel syndrome (IBS‐D), current therapeutic approaches remain ineffective in preventing disease recurrence. This study aimed to evaluate the relapse rates with Rifaximin after consolidation course with live Bacillus subtilis and Enterococcus faecium capsules (Medilac‐S) and explore gut microbiota changes in these IBS‐D patients. Methods We performed a multicenter, open‐label, randomized trial. Pa …

18.08.2026journal-article

Frontiers in Digital Health

Self-reported pain on a digital workplace assessment: identifying the score that flags desk-based workers for earlier occupational health review

Tsz Ling Nicola Tik

Introduction Musculoskeletal pain is common among desk-based workers and reduces productivity, increases healthcare use, and contributes to work disability. Digital workplace platforms now record self-reported pain at scale, offering a way to use a single score to flag workers for earlier review, yet evidence on the lowest score at which pain is consistently associated with functional impact across multiple domains is lacking. This study aimed to identify that point. Methods Retrospective cross-sectional analysis o …

18.08.2026journal-article

Journal of Head Trauma Rehabilitation

Foundation Model Forecasting of Headache Days in People With Persisting Postconcussion Symptoms

Antonios Danelakis, Gøril Storvig, Marte Helene Bjørk, Daniela Contreras, Manjit Matharu, Parashkev Nachev, Bendik Slagsvold Winsvold, Erling Tronvik, Anker Stubberud, Alexander Olsen

Objectives: We aimed to forecast headache in individuals with persisting postconcussion symptoms using foundation machine learning (ML) models and multimodal longitudinal data. Methods: This was an ML analysis of data from the Digital Solutions for Concussion (DiSCo) study, a research project assessing the usability and feasibility of 2 mobile health apps for individuals with persisting postconcussion symptoms. The participants completed daily symptom registrations and daily biofeedback sessions measuring heart rat …

18.08.2026journal-article

The Mental Lexicon

Episodic memory abilities predict lexical diversity in spontaneous speech across languages and the adult lifespan

Phillip Hamrick, John Gunstad, Katelyn L. McClure, Miguel Arce Rentería, Jet M. J. Vonk, Jennifer J. Manly, Adam M. Brickman

Abstract Previous research has linked episodic memory to word learning and processing, but its role in broader lexical behaviors, such as lexical diversity, is still not well-understood. The present study leveraged existing data from a community-based sample of 564 adults (ages 27–89) who completed an episodic memory task and provided spontaneous speech in English or Spanish. Episodic memory abilities were measured on an immediate and delayed test and lexical diversity in spontaneous speech was measured using root …

18.08.2026journal-article

Jurnal Persatuan Perawat Nasional Indonesia (JPPNI)

Implementation of Coloring and Puzzle Play Therapy to Reduce Hospitalization Anxiety in Preschoolers: A Case Study

Diah Ayu Agustin, Shofiyyul Izhan, Ika Melasari, Bambang Sucipto

Deterioration in physical condition, environmental changes, medical treatment, loss of control over activities can cause anxiety in preschool children hospitalized with bronchopneumonia. The aim of the study: to determine the results of the application of puzzle and coloring therapy in 2 children who experienced anxiety during hospitalization. Method: Descriptive case study. Coloring therapy in patient 1 (N) and puzzle therapy in patient 2 (A) was carried out once a day for 30 minutes, for three days of treatment. …

18.08.2026journal-article

Current Oncology

Standard Therapy Plus Adjunctive Vegan Lifestyle Intervention in Metastatic Prostate Cancer: A Case Report

Boštjan Jakše, Zlatko Fras, Anno Graser, Katharina Wirnitzer

Prostate cancer is among the most frequently diagnosed cancers in men globally, with metastatic disease contributing substantially to morbidity and mortality. While conventional therapies remain the standard of care, dietary and lifestyle behaviors are increasingly explored as potentially modifiable factors influencing clinical outcomes, although their role in advanced disease is not well established. We report a 60-year-old, physically active male, lifelong non-smoker without significant comorbidities, diagnosed w …

18.08.2026journal-article

Child Language Teaching and Therapy

Let's read together: An examination of augmentative and alternative communication supported interactive reading in the classroom

Nathalie Thomas, Pascale Grevesse, Angélique Spyropoulos

Background This study examines the impact of an adapted version of the “Tell Me Program-AAC in the Preschool Classroom” on emergent literacy and vocabulary development in children with intellectual and developmental disabilities, autism spectrum disorder, and complex communication needs. Method Fourteen French-speaking children aged 6 to 16 participated in a five-week interactive reading intervention supported by augmentative and alternative communication (AAC). Sessions were led by teachers or speech and language …

18.08.2026journal-article

Bioconjugate Chemistry

Interfacially Engineered Hafnium-Doped Hollow Prussian Blue Nanoreactors for Hypoxia-Relieved Synergistic Radio-Chemo-Photothermal Therapy

Jia Xu, Yufang Chen, Conglong Chen, Baohui Liu, Chaowei Hong, Xinying Liu, Xinyang Zhao, Zhen Zheng, Minxia Wu, Wei Chen, Ye Kuang

Abstract Radiotherapy (RT), a cornerstone of modern oncology, is often hindered by the hypoxic tumor microenvironment (TME), inherent radioresistance, and collateral damage to surrounding healthy tissues. To circumvent these limitations, we developed a biomimetic, interfacially engineered nanoplatform (CMHHND) designed for precision synergistic therapy. The nanoplatform features hafnium-doped hollow Prussian blue (HHPB) nanocatalysts as a functional core, which are loaded with nuclear-targeted doxorubicin and encap …

18.08.2026journal-article

Frontiers in Audiology and Otology

Artificial intelligence and machine learning in cochlear implant rehabilitation: a narrative review of outcome prediction, speech enhancement, and therapy-support applications

Amulya Sathish, Hanna Ehlert

Artificial intelligence (AI) and machine learning (ML) are increasingly influencing clinical decision-making and rehabilitation strategies for cochlear implant (CI) users. This narrative review synthesizes representative research examining how AI- and ML-based approaches have been applied in CI rehabilitation, with particular emphasis on prediction modeling, speech enhancement, and therapy-oriented digital tools relevant to hearing and speech outcomes. Existing literature suggests that ML-based prediction models ca …

18.08.2026journal-article

Journal of Advances in Medicine and Medical Research

Blood Pressure Control Following Fixed-dose Combination Antihypertensive Therapy in a Private Nigerian Cardiology Setting: A Retrospective Descriptive Study

Tosin Majekodunmi, Moses C. Nnamdi, Ebubechukwu Ezeh, Nzekwe Joy Ijeoma, Amina Rabiu

Background: Hypertension is a leading modifiable risk factor for cardiovascular morbidity and mortality, with a disproportionate burden in low- and middle-income countries, including Nigeria. Questions remain regarding real-world prescribing patterns, blood pressure responses, and follow-up control rates among patients receiving combination antihypertensive therapy in Nigerian private clinical settings. Aim: To evaluate antihypertensive prescribing patterns, blood pressure changes, control rates, and documented tre …

18.08.2026journal-article

International Journal of Scientific Reports

A cognitive behavioural therapy-based intervention for an adolescent experiencing social anxiety and stuttering: a clinical case study

Rati Khurana, Priyanka Malhotra

Stuttering is frequently associated with social anxiety, resulting in avoidance, negative self-evaluation, and impaired social functioning. This case study describes the assessment and cognitive behavioral therapy (CBT)-based treatment of a 17-year-old adolescent presenting with stuttering and severe social anxiety. Case formulation and intervention were guided by Rapee and Heimberg’s cognitive model of social anxiety. Treatment included psychoeducation, development of a hierarchy of feared situations, cognitive re …

18.08.2026journal-article

Turkish Journal of Chemistry

Folic acid-targeted polymeric complex imprinted with doxorubicin and quercetin for controlled drug delivery in cancer therapy

CEREN TÜRKCAN, EMİRHAN İŞERİ

​Cancer therapy is often limited by the systemic toxicity and dose-dependent adverse effects of conventional chemotherapeutic agents such as doxorubicin (DOX). In this study, a folic acid-functionalized molecularly imprinted polymeric complex based on poly(HEMA) crosslinked with ethylene glycol dimethacrylate was synthesized for the controlled release of DOX in combination with quercetin (QUE), a flavonoid known for its antioxidant and chemosensitizing properties. The aim of this work was to develop and physicochem …

18.08.2026journal-article

Anaesthesiology Intensive Therapy

Opioid-sparing and opioid-free anaesthesia: concepts, rationale, evidence, and practical implications

Justyna Karolina Danel, Maja Magdalena Copik, Szymon Zdanowski, Małgorzata Reysner, Wiktoria Smyła-Gruca, Szymon Białka

Opioids have long been central to perioperative analgesia, but their well-recognised adverse effects, including postoperative nausea and vomiting, respiratory depression, ileus, and the risk of persistent postoperative use, have increased interest in strategies that reduce perioperative opioid exposure. This narrative review examines two such strategies, opioid-sparing anaesthesia and opioid-free anaesthesia (OFA), and presents them as related points along a continuum of opioid minimisation rather than as opposing …

18.08.2026journal-article

Cancer Immunology, Immunotherapy

Microwave ablation combined with anti-LAG-3 therapy enhances anti-tumor immunity in hepatocellular carcinoma mice by regulating CXCL10/CXCR3-mediated CD8+ T cell activation

Zhilan Zhang, Jiangshan Zhang, Shan Wei, Yeliu Fu, Zhongju Li, Weifang Zhang, Minhui Xin, Ping Zhou

Abstract Background The therapeutic potential of combining microwave ablation (MWA) with lymphocyte-activation gene 3 (LAG-3) blockade has been demonstrated in various cancers, while its specific efficacy and molecular mechanisms in hepatocellular carcinoma (HCC) remain unclear. Methods LAG-3 expression in clinical samples was investigated. LAG-3 expression in tumor-infiltrating lymphocytes (TILs) was further explored using HCC-bearing mice treated with MWA. Moreover, the survival rate, tumor growth, TIL recruitmen …

18.08.2026journal-article

Journal of Oral Rehabilitation

Comparison of Two Disc Repositioning Techniques Based on Jaw Motion Analysis—An Ambispective Cohort Study

Jiangshan Hua, Jieyun Zhao, Chuan Lu, Xin Nie, Dongmei He

ABSTRACT Background Temporomandibular joint (TMJ) disc repositioning (DR) is an effective treatment for anterior disc displacement (ADD). However, postoperative joint motion lacks comprehensive objective evaluation and comparison between different surgical methods. Materials and Methods Patients who need TMJ DR surgery at our center between November 2023 and September 2024 were enrolled and divided into 2 groups for comparison: arthroscopic group (AS) and open suturing (OSu) group. Mandibular and condyle movement, …

18.08.2026journal-article

International Journal of Innovative Technologies in Social Science

CAR-T CELL THERAPY IN ONCOLOGY AND RHEUMATOLOGY

Kornelia Tyczka, Marcin Szczepanik, Maria Nowakowska, Jakub Senko, Joanna Kulpa, Zofia Suchanek

Background: CAR-T cell therapy is a highly personalized form of treatment. it involves modifying T cells extracted from the patients white blood cells during cell collection. Genetic modification of said T cells allows for the extraction of chimeric antigen receptor (CAR), which are later multiplied and infused into the recipients organism. The use of such a highly personalized method yields promising results in both oncology and hematology where relapses and the severity of conditions require precise therapy. Aim: …

18.08.2026journal-article

NeuroRehabilitation

Effectiveness of Telerehabilitation Versus Conventional Rehabilitation on Motor Function and Activities of Daily Living After Stroke: A Systematic Review of Randomized Controlled Trials

Kainat Shehzadi, Tiberiu Tătaru

Background Although telerehabilitation is an increasingly popular method for delivering physiotherapy remotely, its efficacy compared with traditional in person therapy for stroke patients remains uncertain. Objective This systematic review evaluates the effectiveness of telerehabilitation compared with conventional physiotherapy on motor function (Fugl-Meyer Assessment, FMA) and activities of daily living (Barthel Index) in stroke patients. Results Four trials involving 226 randomized participants were included. C …

18.08.2026journal-article

International Journal of Ophthalmology

Effect of active vision therapy on contrast sensitivity in bilateral amblyopia

Department of Optometry, School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran 16169-13111, Iran, Saeed Rahmani, Cirous Dehghani, Discipline of Optometry and Vision Science, University of Canberra, ACT 2617, Australia, Ebrahim Jafarzadehpour, Department of Optometry, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran 14496-14535, Iran, Haleh Kangari, Jeffery Cooper, SUNY College of Optometry, New York, NY 10036, USA, Mohammad Reza Talebnejad, Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71348-45794, Iran, Ali Reza Akbarzadeh Baghban, Proteomics Research Center, Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran 19716-53313, Iran, Enayatollah Osroosh

AIM: To evaluate the effectiveness of combining patching with active vision therapy, compared to patching with placebo training on contrast sensitivity (CS) in pediatric participants with bilateral refractive amblyopia. METHODS: In this double-blind, clinical trial, 43 participants aged 5–8 with bilateral refractive amblyopia, unresponsive to spectacles, were randomly assigned to either the experimental group (active vision therapy plus patching) or the control group (placebo treatment with patching) for four month …

18.08.2026journal-article

Journal of Occupational & Environmental Medicine

Resilience and lifestyle behaviours as determinants of future work ability in university students: a cross-sectional study

Antonio Di Lorenzo, Luigi De Maria, Giuseppe Delvecchio, Antonio Caputi, Stefano Sole, Alessandra Sindaco, Silvio Giannuzzi, Silvio Tafuri, Luigi Vimercati, Luigi Di Lorenzo

Objectives. Resilience is a key psychological resource for work ability, especially in medical students confronting cognitive and emotional pressures. Aim of the study is to assess resilience in university students and examine its associations with physical activity, sleep quality, and Mediterranean diet. Methods. A cross-sectional study involved 331 medical students at University of Bari. Resilience was measured using the Dispositional Resilience Scale-15 (DRS-15); lifestyle through PREDIMED, IPAQ, and PSQI. Pears …

17.08.2026journal-article

Veterinary World

Effectiveness of underwater treadmill rehabilitation following femoral head and neck ostectomy in dogs: A prospective controlled pilot study

Nichanan Maneeganondh, Naruepon Kampa, Thanikul Srithunyarat, Pongsatorn Tuchpramuk, Phimrawee Ngampring, Parichat Naknil, Somphong Hoisang

Background and Aim: Femoral head and neck ostectomy (FHO) is a widely performed salvage procedure for canine coxofemoral disorders; however, postoperative recovery is frequently limited by reduced weight bearing, persistent lameness, muscle atrophy, and restricted hip mobility. Although underwater treadmill (UWTM) rehabilitation has been used for various orthopedic conditions, objective evidence supporting its effectiveness after FHO remains limited. This study aimed to evaluate the effectiveness of a standardized …

17.08.2026journal-article

Occupational and Environmental Medicine

Associations of employment characteristics and psychosocial work factors with severe menopausal symptoms among working women: a longitudinal study

Miho Iida, Ryota Toki, Atsuko Miyake, Minako Matsumoto, Aya Hirata, Shun Edagawa, Naoko Miyagawa, Sei Harada, Toru Takebayashi

Objectives To investigate whether employment characteristics and psychosocial work factors are associated with the development of severe menopausal symptoms among working women. Methods We longitudinally analysed 648 working women aged 35–55 years without menopausal symptoms interfering with daily life at baseline (2012–2014). Employment characteristics included employment status, managerial position, shift work and working hours. Psychosocial work factors included workload, job control, job strain and effort-rewar …