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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Journal of Clinical Medicine

Predicting Primary Refractory Diffuse Large B-Cell Lymphoma: A Comparison of Machine Learning Models with the IPI Score

Cosmin-Daniel Minciuna, Dorina Minciuna, Ingrid-Andrada Vasilache, Lucian Miron

Background/Objectives: Diffuse large B-cell lymphoma (DLBCL) remains clinically heterogeneous despite standard first-line immunochemotherapy. We evaluated whether machine learning (ML) models using routinely available diagnostic variables could predict primary refractory DLBCL. Materials and Methods: We performed a retrospective single-center study of 369 patients with DLBCL treated between 2015 and 2023. Primary refractory disease was defined as failure to achieve at least a partial response after first-line thera …

27.08.2026journal-article

Journal of Clinical Cardiology

The Balance Between Choice, Initial Prosthetic Valve Selection, and Future Transcatheter Success: A Patient-Centered Strategic Perspective

Caio Cesar Cardoso, José de Lima Oliveira Jr, SO Cardoso

The emergence of transcatheter valve-in-valve (ViV) procedures has fundamentally changed the management of bioprosthetic valve degeneration, providing a less invasive alternative to high-risk surgical reoperation. However, the long-term clinical success of future transcatheter interventions is largely predetermined at the time of the initial surgical valve replacement. This commentary discusses how initial prosthetic choice—type, design, and intraoperative sizing—impacts the patient’s lifelong therapeutic journey. …

27.08.2026journal-article

Indonesian Journal of Global Health Research

The Effectiveness of Scenario-Based Simulation Training for Perianesthetic Emergencies on Anesthesia Nurses’ Preparedness and Accuracy of Clinical Interventions

Dewi Kartika Sari, Aric Frendy Andriyan, Elisa Ayudia, Binuri Nisya Fi Amanillah

Although anesthesia nurses play a crucial role in managing perianesthetic emergencies, various reports continue to indicate delays and inaccuracies in clinical interventions due to limited clinical experience and suboptimal training methods. This study aimed to determine the effectiveness of perianesthetic emergency scenario-based simulation training on the preparedness and accuracy of anesthesia nurses’ clinical interventions This study employed a quasi-experimental design with a one-group pretest–posttest approac …

27.08.2026journal-article

Frontiers in Medicine

A risk-stratified framework for in-house PLA 3D printing of non-critical medical device spare parts: a cost-effectiveness analysis

Kun Li, Xinghua Ma, Lei Su, Yinyan Sun, Qian Mu, Dingmeng Luo, Jing Cheng

Background Procurement of non-critical medical device spare parts faces major challenges. These include high costs, long lead times, and supply chain fragility. In-house additive manufacturing (AM), specifically Polylactic Acid (PLA) Fused Deposition Modeling (FDM), offers a potential solution but lacks systematic safety and economic validation. Objective This study aimed to establish a risk-stratified framework for identifying suitable non-critical spare parts and to evaluate the engineering feasibility, economic …

27.08.2026journal-article

Sensors

Cross-Condition Fault Diagnosis of Crane Slewing Bearings Based on a Lightweight Domain-Adaptive Graph Convolutional Network

Wuben Yang, Qiangyin Wu, Anding Wu, Lipeng Su, Yifan Lou, Jiafu Wu, Zhaoyi Wang, Cancan Yi

Cross-condition fault identification for crane slewing bearings is difficult because low rotational speed, heavy loading, and operating-condition variation jointly weaken fault-induced impulses and alter the distribution of monitoring data. In addition, vibration and acoustic emission signals describe different aspects of bearing degradation, making fixed multi-sensor fusion insufficient when sensor sensitivity changes across fault states. This study proposes a Lightweight Domain-Adaptive Graph Convolutional Networ …

27.08.2026journal-article

Diabetes, Obesity and Metabolism

Increasing Trends in Hospitalisation With Diabetic Ketoacidosis at Type 1 Diabetes Diagnosis Among Children and Youth in the United States and England, 2002–2020

Chintan V. Dave, Kristen Lloyd, Abner Nyandege, Jason Roy, Raquel López‐Díez, Sally Radovick, Brian L. Strom

ABSTRACT Background There is a paucity of population‐level data evaluating trends in the proportion of children and youth hospitalised with diabetic ketoacidosis (DKA) at the time of Type 1 diabetes (T1D) diagnosis. Methods National Medicaid (US publicly insured claims), MarketScan (US commercially insured claims) and Clinical Practice Research Datalink (CPRD) (English electronic health record) data were used to create cohorts of children with incident T1D. DKA at diagnosis was defined as a DKA hospitalisation occu …

27.08.2026journal-article

The Journal of Dermatology

Economic Burden and Treatment Patterns Among Patients Diagnosed With Vitiligo in Japan: An Observational Retrospective Cohort Study

Naoki Oiso, Kent A. Hanson, Ahmed M. Soliman, Chao Li, Manabu Taura, Daniel Mercer, Andrew Rava, Danielle Bynoe, Haiyan Sun, Tamio Suzuki

ABSTRACT Vitiligo, a common and chronic depigmentation disorder, significantly impacts patients' quality of life and exerts a substantial economic burden. The deleterious impact of vitiligo can be exacerbated by comorbid conditions, including psychiatric and autoimmune conditions. Treatment may vary across geographic regions, and there is sparse evidence of treatment patterns for vitiligo in Japan. Evaluations of healthcare costs are also needed to help underline unmet needs, including data on the influence of como …

27.08.2026journal-article

Cosmetics

Combined Fractional Radiofrequency Microneedling and High-Intensity Focused Ultrasound with Focus Dual for Facial Skin Rejuvenation: A 37-Patient Case Series

Ornella Rossi, Giovanna Perrotti, Massimo Del Fabbro, Tiziano Testori

Background: Non-invasive energy-based technologies, including high-intensity focused ultrasound (HIFU) and fractional radiofrequency microneedling (RF-MN), are increasingly used for facial rejuvenation due to their ability to induce dermal remodeling and neocollagenesis, although evidence on combined protocols remains limited. Objective: To evaluate the clinical outcomes and safety of a combined treatment protocol using HIFU and RF-MN delivered via the Focus Dual® device for facial skin rejuvenation in patients wit …

27.08.2026journal-article

Journal of Advances in Medicine and Medical Research

Gut Microbiota and Paediatric Endocrine-metabolic Disease: A Critical Appraisal of the Evidence in Childhood Obesity, Type 1 Diabetes, Steatotic Liver Disease and Growth Disorders

Ashraf Soliman, Fawzia Alyafei, Nada Alaaraj, Shayma Elsayed, Noor Hamed, Shayma Ahmed, Moataz Derbala

The intestinal microbial community assembles during the same developmental window in which adiposity, islet autoimmunity, hepatic lipid handling and linear growth are established, and this temporal coincidence has encouraged the view that microbial variation is a modifiable determinant of paediatric endocrine-metabolic disease. Evidence supporting that view is unevenly distributed across disorders and rests on designs of very different inferential strength. This critical narrative review evaluates the state of know …

27.08.2026journal-article

Neuro-Oncology

2 Age-Related Disparities in Clinical Characteristics and Survival Outcomes of High-Grade Spinal Cord Gliomas: A Retrospective Analysis of 219 Patients

Khalid Sarhan, Mohammed A Azab

Abstract Introduction High-grade spinal cord gliomas exhibit significant age-dependent disparities in survival and clinical management. This study evaluates how age influences prognosis and the utilization of treatment modalities like radiation and chemotherapy. Methods A retrospective analysis was conducted on 219 patient records, categorized into four age groups: Children (N = 41), AYA (N = 71), Older adults (N = 76), and Elderly (N = 31). Statistical measures included median survival, 1, 3, and 5-year survival r …

27.08.2026journal-article

Clinical Otolaryngology

Survey of National Approaches to Practice in Local Anaesthetic Rhinology Surgery ( SNAP ‐ LARS ): A United Kingdom National Cross‐Sectional Collaborative Survey

Dhruv Patel, Behrad Barmayehvar, Shayan Shahidi, Tharsika Myuran, Ding Yang, Vikas Acharya, Miran Pankhania, Raj K. Bhalla, Ashok Rokade, BRSJ collaborators

ABSTRACT Introduction Local anaesthetic rhinology surgery (LARS) offers a safe and cost‐effective alternative to procedures traditionally performed under general anaesthesia. Despite publication of British Rhinological Society guidance in 2022, the landscape of LARS provision in the United Kingdom (UK) remains unclear. This study aimed to characterise current practice, whilst highlighting variations and perceived barriers to LARS. Methods A cross‐sectional national multi‐centre collaborative survey was conducted be …

27.08.2026journal-article

Autism Research

Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population‐Based Cohort Study Using Clinical Practice Research Datalink Aurum

Aws Sadik, Golam M. Khandaker, Antonio F. Pardiñas, Michael Lundberg, Brian K. Lee, Cecilia Magnusson, Dheeraj Rai, Paul Madley‐Dowd

ABSTRACT Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non‐autistic males and females in the United Kingdom (UK) from 1997 to 2023. Using population‐representative UK primary care records, we defined three autistic groups—autistic adults with intellectual disability (ID), autistic adults without ID and all autistic adults—and four non‐autistic groups. In each cale …

27.08.2026journal-article

Journal of Advances in Medical and Pharmaceutical Sciences

Reducing False Positives and False Negatives in Artificial Intelligence-assisted Imaging Screening: A Critical Review of Accuracy, Error Mechanisms and Clinical Translation

Musa Shamaki Ibrahim, Enock Kumi Ackaah, Charity Benewa Acheampong, Bukola E Shasere, Susana Owusu-Ansah, Godliver Awonlie Alangyam, Emmanuel Arhin

Imaging-based screening programmes are constrained by two opposing failures: false-positive results that generate unnecessary recall, anxiety, further imaging and biopsy, and false-negative results that permit disease to progress undetected until the next screening round or until symptoms appear. Artificial intelligence applied to medical images has been presented as a means of relaxing this constraint by improving detection without expanding the recalled population. This critical review evaluates whether that clai …

27.08.2026journal-article

Transactions of The Royal Society of Tropical Medicine and Hygiene

Renal histopathology in acute kidney injury following haemotoxic snake envenomation

P Sai Kameshwar Rao, Chanaveerappa Bammigatti, P S Priyamvada, Bheemanathi Hanuman Srinivas

Abstract Objectives Snakebite envenomation is a major cause of acute kidney injury (AKI) in tropical regions. While acute tubular necrosis (ATN) and acute cortical necrosis have traditionally been described as predominant renal lesions, multiple factors, including recent improvements in early access to antivenom, may have altered the histopathological spectrum. This study aimed to evaluate renal histopathology in snakebite envenomation-associated AKI (SBE-AKI) and its clinicopathological correlates. Methods In this …

27.08.2026journal-article

Vaccines

HPV Genotype Distribution, Vaccine Protection Gaps, and Co-Infection Network Centrality Among 8515 Clinical Women in Wuxi, China: A Retrospective Cross-Sectional Study

Baocai Ran, Han Wu, Fengjuan Zhang

Background/Objectives: Regional HPV genotype data for the Yangtze River Delta remain scarce, limiting evidence-based vaccine and screening policies. This study characterised the HPV genotype distribution, the vaccine protection gaps, and the co-infection network structure among clinical women in Wuxi, a prefecture-level city in the Yangtze River Delta region of Jiangsu Province, China. Methods: We retrospectively analysed all 8515 cervical HPV genotyping records from Xishan People’s Hospital of Wuxi City (January 2 …

27.08.2026journal-article

Journal of Clinical Medicine

Arrhythmias in Cardiac Sarcoidosis: Pathophysiology, Diagnostic Strategies, Risk Stratification for Sudden Cardiac Death, and Contemporary Management—A Narrative Review

Mehdi Guedira, Jaouad Nguadi, Damien Poindron, Nicolas Lellouche, Cyrus Moini

Background: Cardiac sarcoidosis (CS) is a potentially life-threatening manifestation of systemic granulomatous disease, characterized by a heterogeneous spectrum of arrhythmic and conduction disorders that represent the leading cause of CS-related sudden cardiac death (SCD). Clinical cardiac involvement is estimated at 5% of sarcoidosis patients, while silent myocardial infiltration is detected in 20–25% of autopsy series. Diagnosis is difficult because the disease frequently runs a subclinical course and no single …

27.08.2026journal-article

Pediatric Transplantation

Treatment Adaptation to Surgical Timing in Pediatric Hepatoblastoma: A 19‐Year Single‐Center Experience With Resection and Liver Transplantation

Claudia Pellegrinelli, Laura Cavalleri, Michela Bravi, Paolo Marra, Clarissa Valle, Lisa Licini, Domenico Pinelli, Massimo Provenzi, Sandro Sironi, Lorenzo D'Antiga

ABSTRACT Background The management of hepatoblastoma (HB) relies on chemotherapy combined with surgery, either liver resection (LR) or liver transplantation (LT), with reported overall survival (OS) of 80%, cardiac toxicity of 6%, nephrotoxicity of 21%, ototoxicity of 32%–46%. In clinical practice, deviations from protocol‐defined chemotherapy are often required to achieve resectability or bridge to transplantation. We aimed to evaluate the impact of treatment adaptation to surgical timing on OS and toxicity in a s …

27.08.2026journal-article

Frontiers in Nutrition

Non-nutritive sweeteners and body weight in children with type 1 and type 2 diabetes: a critical narrative review of current evidence, methodological challenges, biological mechanisms, and clinical implications

Sousana K. Papadopoulou, Exakousti-Petroula Angelakou, Theodosios Koimtsidis, Eleni Pavlidou, Dimitrios Tasoulas, Constantinos Giaginis

Introduction Body weight management is an important component of pediatric diabetes care, although its clinical relevance differs between type 1 diabetes (T1D) and type 2 diabetes (T2D) because of distinct pathophysiology, insulin physiology, and therapeutic goals. Non-nutritive sweeteners (NNSs) are widely used to replace added sugars, reducing glycaemic load and, in some settings, energy intake. However, their long-term effects on body weight in children with diabetes remain controversial. This narrative review e …

27.08.2026journal-article

Clinical and Translational Gastroenterology

Dupilumab Improves Endoscopic Features in Adult and Adolescent Patients With Eosinophilic Esophagitis: Post Hoc Analysis of LIBERTY EoE TREET Study

Evan S. Dellon, Margaret H. Collins, Kathryn Peterson, Xian Sun, Bram P. Raphael, Margee Louisias, Allen Radin

INTRODUCTION: Endoscopic features are critical for monitoring treatment response in eosinophilic esophagitis (EoE). This post hoc analysis assessed dupilumab’s efficacy on endoscopic features of EoE in adults and adolescents in the phase 3 LIBERTY EoE TREET study (NCT03633617). METHODS: Data were pooled from 2 study arms in which patients with active EoE were randomized to dupilumab 300 mg weekly or placebo for 24 weeks (Parts A/B), followed by dupilumab 300 mg weekly to week (W) 52 (Parts A–C/B–C). EoE Endoscopic …

27.08.2026journal-article

Scientific Reports

A rapid hybridization-free LAMP–LFB assay for the clinical detection of Neisseria gonorrhoeae in urine specimens

Jutturong Ckumdee, Somchai Santiwatanakul, Rossaphorn Kittiyaowamarn, Thongchai Kaewphinit

Abstract Neisseria gonorrhoeae remains a critical global public health challenge, particularly in regions where access to rapid molecular diagnostics is constrained. In this study, we developed and clinically validated a hybridization-free loop-mediated isothermal amplification-lateral flow biosensor (LAMP-LFB) assay for the rapid detection of N. gonorrhoeae in urine specimens. The hybridization-free format is achieved through dual-labeled LAMP primers, in which biotin and fluorescein isothiocyanate (FITC) labels a …

27.08.2026journal-article

PLOS One

Public social trust and acceptance of task shifting to hospital paramedics as a response to physician shortages

Satoshi Kondo, Shuhei Ichikawa, Shuji Hashimoto, Masashi Izumiya, Masato Eto

Background Physician shortage is a crucial global issue. Some countries have introduced task shifting to expand paramedics’ roles. This expansion requires citizens’ social trust in paramedics in general. During medical emergencies, citizens must allow treatment by paramedics, with whom they often have no prior relationship. Although social trust is vital in medical emergencies, its level among hospital paramedics is unclear. This study aimed to evaluate citizens’ social trust in hospital paramedics and their accept …

27.08.2026journal-article

Sports Health: A Multidisciplinary Approach

Oral Contraceptive Use at the Time of ACL Reconstruction Decreases Risk of Revision Surgery

Sujay Garlapati, Rajit Agarwal, Meghan Bishop

Background: Anterior cruciate ligament (ACL) reconstruction is associated with a significant risk of revision surgery. Oral contraceptive pills (OCPs) suppress endogenous estrogen and progesterone levels and have been associated with reducing the risk of primary ACL injuries in women. Hypothesis: OCP use at the time of initial ACL reconstruction is associated with a reduced risk of subsequent ipsilateral procedures in female patients and an elevated risk of venous thromboembolism (VTE). Study Design: Cohort study. …

27.08.2026journal-article

Frontiers in Medicine

Rapid scale-up of hospital-at-home services during wartime: lessons learned from the Sheba Medical Center experience

Anat Ekka Zohar, Boris Fizdel, Liat Aroshass, Liron Vaserman, Galia Barkai, Shani Edelman, Rachel Sarafraz, Eyal Leshem, Matan Peri, Asaf Biber, Yael Frenkel Nir, Gad Segal

Background Sheba BEYOND, the telemedicine-governed hospital within the Sheba medical center includes a unique telemedicine-based service for internal-medicine patients suffering from acute illness since 2020, serving as a viable alternative to in-hospital stay. During March 2026, amid an Israeli war on two fronts, Iran and Lebanon, the urgent need to transfer over 1,900 (in-hospital) patients to underground facilities under continuous missile attacks necessitated immediate, massive fortification of our HaH services …

27.08.2026journal-article

Archives of Pathology & Laboratory Medicine

False Results in Urine Drug Screen for Amphetamine, Methamphetamine, and Ecstasy: A Systematic Review

Zahra Babazadeh Igdir, Mohammad Delirrad, Adel Ghorani-Azam

Context.— Amphetamines and methamphetamines are used for their hallucinogenic and euphoric effects. Owing to structural similarity of the drugs and lack of specificity in antibody-based drug screening methods, these tests are associated with false results, which can lead to misinterpretation with catastrophic consequences. Objective.— To summarize all drugs and chemicals that can lead to false-positive and false-negative test results for amphetamine and methamphetamine. Data Sources.— A systematic literature search …