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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Advanced Science

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan

ABSTRACT Butyrate (BA) is essential for intestinal health, but its intestinal therapeutic applications are hindered by its malodorous nature, premature gastric absorption, and rapid intestinal metabolism. To address these challenges, an inodorous macromolecule β‐glucan‐BA (GLU‐BA) is synthesized via one‐step esterification, allowing for BA production in the intestine with burst yet gradual dynamics. After oral administration, GLU‐BA self‐assembles into nanomicelles, preventing premature gastric absorption. Upon rea …

27.08.2026journal-article

Plants

From Traditional Remedy to Evidence-Based Phytotherapeutic Agent: Hedera helix L. in Respiratory Medicine

Agata Maria Pawłowska

Hedera helix L. leaf extracts are regulated expectorants for productive cough, yet their evidence is dispersed across pharmaceutical quality, nonclinical pharmacology, disposition, toxicology, clinical pharmacology, efficacy, safety, and regulatory assessment. This review integrates those domains in a single study-level account and explicitly distinguishes isolated constituents, incompletely specified extracts, defined monograph preparations, proprietary extracts, and combination products. Hederacoside C is the pha …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Perioperative management based on the enhanced recovery after surgery concept in elderly patients undergoing laparoscopic common bile duct exploration plus laparoscopic cholecystectomy

Long-Xiang Wang, Yan-Hong Jiang, Yong Ding, Hai-Tao Wu

BACKGROUND Choledocholithiasis is highly prevalent among the elderly, with laparoscopic common bile duct exploration (LCBDE) plus laparoscopic cholecystectomy (LC) serving as a key minimally invasive treatment. However, elderly patients often face increased surgical risks and prolonged recovery due to reduced physiological reserve and comorbidities. The enhanced recovery after surgery (ERAS) protocol has proven effective in optimizing perioperative outcomes across multiple surgical disciplines, yet its specific app …

27.08.2026journal-article

Bone Research

Multidisciplinary expert consensus on clinical diagnosis and therapies for low back pain

Bo Gao, Rundong Chai, Guanyi Wang, Yanfang Song, Lei Shang, Jinghui Huang, Xu Cao, Yong Hai, Zhuojing Luo, Chinese Society for the Study of the Lumbar Spine, Chinese Association of Spine, Zhongqiang Chen, Shiqing Feng, Jianyuan Jiang, Fang Li, Li Li, Yueming Song, Zhaomin Zheng, Jun Ao, Yunbing Chang, Bohua Chen, Deyu Chen, Jianting Chen, Liang Chen, Qixin Chen, Shaoqian Cui, Shucai Deng, Huiqiang Ding, Guiyou Feng, Yanzheng Gao, Tao Guo, Zhaoqing Guo, Qing He, Baorong He, Shisheng He, Yi Hong, Zhenghua Hong, Congren Huang, Han Jiang, Dianming Jiang, Bo Li

Abstract Low back pain (LBP) is one of the most frequently encountered conditions in orthopedics, physical therapy and rehabilitation, and pain medicine. Its etiology is multifactorial and its management options are diverse. However, a unified, standardized, and evidence-based clinical pathway for LBP remains lacking, leading to substantial variation in diagnostic reasoning, treatment selection, outcome assessment, and long-term care across healthcare settings and professional disciplines. To address this gap, Chin …

27.08.2026journal-article

Internal and Emergency Medicine

⁠From liver to cardiovascular system: the MASLD–ASCVD continuum

Andrea Boccatonda, Antonella Bray, Marialuisa Sveva Marozzi, Alessia Cipollone, Gianfranco Lauletta, Damiano D’Ardes, Sebastiano Cicco, Francesco Cipollone

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide and is increasingly recognized as a systemic cardiometabolic disorder. Atherosclerotic cardiovascular disease (ASCVD) represents the leading cause of mortality in patients with MASLD. This review aims to summarize current evidence on the epidemiology, pathophysiological mechanisms, and clinical impact of MASLD on cardiovascular outcomes. We reviewed epidemiological studies, mechanistic inv …

27.08.2026journal-article

Knee Surgery, Sports Traumatology, Arthroscopy

Progressive lateral femoral condyle lengthening in total knee arthroplasty produces dose‐dependent increases in patellofemoral joint loading and alters patellar tracking

Jobe Shatrov, Mounir Boudali, Koki Abe, David Parker, William Walter, Elizabeth Clarke

Abstract Purpose To examine the biomechanical effects of progressive lateral femoral condyle lengthening on patellofemoral joint (PFJ) kinematics and kinetics following total knee arthroplasty (TKA), and to determine whether lateral condyle distalisation produces measurable, dose‐dependent alterations in PFJ loading and patellar tracking. Methods Eight fresh‐frozen cadaveric knees were implanted with a cruciate‐retaining TKA and tested in four states: Native (unresurfaced), Neutral (resurfaced to native thickness), …

27.08.2026journal-article

Optics

Machine-Learning Augmented Optical Tissue Sensing for Intraoperative Guidance in Spine Surgery: A Systematic Review and Meta-Analysis

Samer G. Salman, Rohan A. Phadke, Rahul Kumar, Neil Panwalker, Zane G. Salman, Ryan Zeitouny, Sai Sarnala, Alireza Tavakkoli, Ethan Waisberg, Joshua Ong, Sainyam Galhotra, Ajay Tripuraneni, James Rizkalla

Background: Pedicle-screw malposition and canal breach can cause major neurologic and vascular complications. Fluoroscopy, navigation, and robotics guide trajectory, but they do not directly identify the tissue in front of the instrument. We evaluated machine learning (ML)-augmented optical sensing for tissue discrimination in spine-relevant settings. Methods: We conducted a PRISMA-DTA systematic review under a prospectively registered PROSPERO protocol and searched five databases. Classification accuracy was poole …

27.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Clinical and Electrophysiological Effects of Downhill Treadmill Walking in Patients With Ischemic Stroke

Burak Yıldız, İpek Midi, Evrim Karadağ-Sayg, Özge Keniş-Coşkun

Objective: To evaluate the clinical and electrophysiological effects of downhill treadmill walking performed at different inclines in patients with stroke. Design: Thirty-five patients with stroke were randomized to level treadmill walking (control), −7.5% downhill walking, or −15% downhill walking. In this assessor-blinded trial, the intervention consisted of five sessions delivered over 5 consecutive days. Clinical outcomes assessed before and after the intervention were the Modified Ashworth Scale, Fugl-Meyer Lo …

27.08.2026journal-article

International Journal of Cancer

Comparison of Healthcare Utilization Before Diagnosis Between Non‐Advanced and Advanced Lung Cancer Patients: A Study Among 72,851 Cases in Germany

Josephine Küsel‐Kanbach, Oliver Riedel, Ulrike Haug

ABSTRACT There is no study from Germany on the association between stage of lung cancer (LC) and patient characteristics. We aimed to compare advanced versus non‐advanced LC cases regarding indicators of healthcare utilization. Using claims data covering 20% of the German population, we included LC patients diagnosed between 2013 and 2019. Stratified by stage (advanced vs. non‐advanced), we assessed comorbidities, hospitalizations, outpatient physician contacts and utilization of preventive measures before LC diagn …

27.08.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Approach to the Patient: Ethics Cases in Pediatric Endocrinology and Their Management

Jennifer M Ladd, Meaghann S Weaver, Rohan K Henry

Abstract Context With advancing technologies and expanding indications for existing therapies, ethical dilemmas increasingly arise in pediatric endocrinology practice. Aim This article presents practical, case-based scenarios to guide clinicians in navigating common ethical challenges in pediatric endocrinology. Cases We present four case vignettes which present ethical dilemmas regarding (1) growth hormone treatment prescribed for idiopathic short stature, (2) precocious puberty management in a child with neurodev …

27.08.2026journal-article

Frontiers in Psychology

Clinical risk stratification of stroke caregiver distress: an interpretable nonlinear model of caregiving-load categories

Yingjie Zheng, Shailing Ma, Xiaohui Liu, Yuyan Yang, Ru Gan, Jiajia Lai, Yijia Qi, Jing Li, Lijun Wang, Miaomiao Chen

Background Family caregivers of stroke survivors frequently experience psychological distress. Social support and active coping may be protective, but their associations can vary across levels of caregiving load. Interpretable machine learning may help characterize such nonlinear patterns without assuming a constant linear association. Methods This multicenter cross-sectional study included 506 family caregivers. High psychological distress was defined as a Hospital Anxiety and Depression Scale (HADS) total score ≥ …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Case Report: Interventricular septal hematoma after ventricular septal defect repair with persistent left ventricular communication: 10-year follow-up

Anna Rudek-Budzyńska, Aleksandra Morka, Tomasz Mroczek

Interventricular septal hematoma is a rare complication of congenital heart surgery with unpredictable clinical course and limited data guiding management. We report a female infant who developed a giant interventricular septal hematoma after surgical closure of a perimembranous ventricular septal defect at 4 months of age. Early postoperative imaging demonstrated a large intraseptal cavity without ventricular communication, followed by development of multiple small fistulous connections with the left ventricular l …

27.08.2026journal-article

Frontiers in Oral Health

Periodontal management in patients with diabetes: the impact of periodontal treatment on cardiometabolic biomarkers

Alicia Morales, Gustavo Sáenz-Ravello, Loreto Matamala, Mauricio Baeza, Patricia Hernández-Ríos

Introduction Type II Diabetes Mellitus (T2DM) and periodontitis present an independent bidirectional relationship. While T2DM is associated with a higher prevalence, incidence, and severity of periodontitis, periodontitis might worsen glycemic control and inflammatory biomarker levels in diabetics. Although there is no standardized therapy for the treatment of diabetic patients with periodontitis, different periodontal interventions report improvements in clinical and cardiometabolic parameters. Objective To summar …

27.08.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

From metrological comparability to clinical continuity: authorising laboratory result reporting when changing measurement procedures

Raúl Rigo-Bonnin, David Ceacero-Marín, Míriam Valbuena-Asensio, Virgínia Mas-Bosch, Aurora Blanco-Font

Abstract Objectives To develop and apply an operational framework integrating metrological, analytical, clinical and risk evidence to authorise an output-specific reporting rule after a change in measurement procedure. Methods Four measurement procedure changes were evaluated: alanine aminotransferase (ALT) procedures with and without pyridoxal-5′-phosphate activation; follicle-stimulating hormone (FSH) reagent replacement; routine vs. short-turnaround-time (STAT) parathyroid hormone (PTH) procedures; and tacrolimu …

27.08.2026journal-article

Biological Products. Prevention, Diagnosis, Treatment

Inactivation of Mycoplasma gallisepticum and Mycoplasma synoviae during influenza vaccine production

N. N. Savina, M. Sh. Aliev, A. I. Reutskiy, T. V. Gorokhova, O. S. Babkina, S. V. Pankratov, N. Yu. Serova

INTRODUCTION. The use of chicken embryos in influenza vaccine production carries the risk of contaminating the final product with the avian mycoplasmas, Mycoplasma gallisepticum and M. synoviae , which pose a potential hazard to humans. Therefore, evaluating the effectiveness of inactivating these contaminants in influenza vaccine intermediates using inactivators (β-propiolactone, ultraviolet irradiation) and detergents is important. AIM. This study aimed to evaluate the inactivation dynamics of M. gallisepticum an …

27.08.2026journal-article

Genes

Insights on Prevalence of Hereditary Aortic Thoracic Disease and Impact on Family Screening in Routine Clinical Cardiothoracic Surgery Care

Simone Gasser, Michael Graber, Nikolaos Bonaros, Michael Grimm, Julia Dumfarth

Objective: Heritable thoracic aortic disease (HTAD) is an important cause of thoracic aortic aneurysm and dissection, yet remains underdiagnosed. We aimed to summarize the prevalence of syndromic and non-syndromic HTAD, describe variants of uncertain significance (VUS), and evaluate the impact of family screening in a contemporary cardiothoracic surgical cohort. Methods: Between 2018 and 2026, 163 patients underwent genetic testing for suspected HTAD at our institution. A total of 139 patients with completed geneti …

27.08.2026journal-article

Frontiers in Medicine

Enhancing nurses’ competence in mechanical ventilation: a quasi-experimental study and its association with patient severity using APACHE II

Noha Mohammed Ibrahim, Samia Eaid Elgazzar, Amany Ibrahim Ezz Eldin, Abdo Mansoor Alhusami, Mona Metwally El-Sayed, Mohamed Goda Elbqry, Fatma Mohamed Elmansy, Shereen Ahmed A. Qalawa, Nasiru Mohammed Abdullahi, Saddam Ahmed Al-Ahdal, Hanadi Dakhilallah, Sheren Ebrahim El-Hag El-Tahry

Background Mechanical ventilation is a cornerstone of intensive care, requiring ICU nurses to have adequate knowledge, competence, and skills to provide safe, evidence-based care. Although educational programs improve nurses’ preparedness, evidence of their impact on patient outcomes remains limited. Aim To assess ICU nurses’ knowledge, professional competence, and clinical practice related to mechanical ventilation following participation in a structured educational program, and to explore the association between …

27.08.2026journal-article

Journal of Palliative Medicine

Patient and Caregiver Perspectives on Communication Quality in Tele-Palliative Care

Julia I. Bandini, Elaine Li, Dio Kavalieratos, Natalie C. Ernecoff, Kimberly Curseen, Jordan Harrison

Background: Tele-palliative care has become a well-established practice following its rapid expansion in the outpatient setting during the COVID-19 pandemic. Despite sustained integration of tele-palliative care, questions remain about patients’ and family caregivers’ experiences with it and its potential impact on the quality of communication during palliative care visits. Objective: To qualitatively explore patient and family caregiver experiences with telehealth and in-person visits for outpatient palliative car …

27.08.2026journal-article

Frontiers in Membrane Science and Technology

Phosphate-rich municipal wastewater treatment using magnetite nanoparticles dispersed oakwood biochar-assisted pretreatment followed by air-gap membrane distillation

Prashan M. Rodrigo, Bishweshwar Pant, Sunith B. Madduri, Raghava R. Kommalapati

An integrated approach combining Fe 3 O 4 nanoparticle-loaded biochar-assisted pretreatment and air-gap membrane desalination (AGMD) was investigated for treating phosphate-rich wastewater. This study addresses key limitations of conventional coagulants, such as residual chemical load and limited removal efficiency. Fe 3 O 4 nanoparticles were co-precipitated on oakwood biochar (Fe 3 O 4 /BC). The Fe 3 O 4 /BC composite acts as a coagulant that can be rapidly separated under an applied magnetic field. This study sy …

27.08.2026journal-article

Neuro-Oncology

40 Retrospective analysis of Alopecia in patient receiving Proton Beam Radiotherapy in Neuro-oncology – Single centre experience

Hasti Barot, Vandana Kushwaha, Mithushanaa Nesarajah, Adila Amariyil, Karthica Indramohan, Michelle Newman, Michael Kosmin, Naomi Fersht

Abstract Introduction Alopecia is a common and cosmetically distressing adverse effect of cranial irradiation that significantly affect quality of life in patients. Radiation induced alopecia can be short term or long term or can rarely be permanent. This study aims to evaluate the incidence of acute (≤90 days after completion) and long-term (>90 days) and permanent alopecia in brain tumour patients treated with proton beam therapy in our centre and to establish if the incidence or severity correlates with the s …

27.08.2026journal-article

Neuro-Oncology

17 Psychological and holistic consequences of delays in molecular diagnosis after neuro-oncological surgery: a qualitative study

Jay Kotecha, Shahzaib Ahmed, Kelly Dawson, Anna Mycock, Emily Lockyer, Andrew Dapaah, Simon Paine, Michael Baliousis, Stuart Smith

Abstract Introduction The 2021 WHO Classification of Tumours of the Central Nervous System supports an integrated diagnosis combining histological, immunohistochemical and molecular parameters. Advanced molecular techniques such as DNA methylome arrays and Whole Genome/Next Generation Sequencing are now required to identify certain tumour entities confidently as well as sometimes determining eligibility for clinical trials. Complex molecular analysis however can lead to extended turnaround times and significant del …

27.08.2026journal-article

Medicine & Science in Sports & Exercise

Photobiomodulation Does Not Increase Mitochondrial Respiration in Skeletal Muscle or Skin Tissue in Humans

Thorben Aussieker, Heather L. Petrick, Lisa M.E. Kuin, Jeremias Kaiser, Cas J. Fuchs, Esther Kornips, Kostas Tsintzas, Scott Cooper, Sandra Lammers, Stephan Praet, Tim Snijders, Luc J.C. van Loon

Purpose: Low-level laser therapy, also referred to as photobiomodulation (PBM), is rapidly gaining popularity as a non-invasive treatment for various conditions and as a means to enhance health and performance. PBM has been proposed to directly increase mitochondrial activity in skin and skeletal muscle and activate various molecular signalling pathways. However, evidence for the proposed properties of PBM in vivo in humans is lacking. Methods: In a within-participant study design, 12 healthy men and women (6/6 m/f …

27.08.2026journal-article

Medicine & Science in Sports & Exercise

Ketone Ester Intake Did Not Improve Performance, Neither Cognitive Function or Sleep, During an 8-Day Simulated Cycling Race

Louise Engelbrecht, Wout Lauriks, Ruben Robberechts, Myrthe Stalmans, Monique Ramaekers, Elmarie Terblanche, Katrien Koppo, Chiel Poffé

Purpose: Physiological strain, mental exhaustion, and sleep deprivation are key elements that hinder performance during multi-day endurance activities. Ketone monoester supplementation (KE) may enhance post-exercise recovery, preserve cognitive function, and increase both sleep quantity and quality. Therefore, we simulated an 8-day cycling stage race to assess the effect of KE on physiological strain, mental fatigue, exercise performance, and sleep. Methods: In a double-blind, placebo-controlled, parallel trial, ei …