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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Postoperative gastrointestinal dysfunction and gastrointestinal tumors: A review and a point of view

Jia-Bing Liu, Cai-Wen Yan, Zhi-Jun Chen, Liang Zong

Gastrointestinal (GI) dysfunction following surgery for GI tumors is a common complication that significantly impacts patient recovery, prolongs hospital stays, and increases healthcare burdens. This review of recent research systematically examines the risk factors, predictive model development, and clinical prognostic value associated with this postoperative condition. We delve into key risk determinants including patient age, tumor stage, operation duration, and nutritional indices. We focus on the clinical sign …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Precision and function preservation in gastrointestinal surgery: Integrating minimally invasive techniques, enhanced recovery, and metabolic interventions

Yun Wang, Yang Wang, Yao-Yu Jin, Yu-Xuan Zhou, Jie Wu, Yan Li

Gastrointestinal surgery is shifting from pursuing radical oncology to emphasizing precision, functionalization, and rapid recovery. How to integrate laparoscopic and robotic surgery, enhanced recovery after surgery protocols, and metabolic regulatory mechanisms of bariatric surgery is a key issue in optimizing patient outcomes. This review focuses on three areas: (1) Short- and long-term outcomes of minimally invasive techniques for colorectal and gastric cancer, as well as surgical strategies for special populati …

27.08.2026journal-article

Frontiers in Oncology

PD-1/PD-L1 inhibitor-related cystitis: clinical features, diagnostic exclusion, and outcomes in one definite and seven probable cases with an updated literature review

Wei Ding, Heqian Liu, Lin Li, Yingqing Liu, Jiawei Wang, Zhonglang Wang, Lingsong Tao, Xiansheng Zhang

Background PD-1/PD-L1 inhibitor-related cystitis (PD-(L)1-RC) is an uncommon urinary immune-related adverse event that may be mistaken for bacterial cystitis, tumor progression, radiation injury, stone disease, or chemotherapy-related hemorrhagic cystitis. This study describes the clinical phenotype, diagnostic exclusion process, treatment response, and updated literature context of PD-(L)1-RC. Methods We retrospectively reviewed eight patients who developed new lower urinary tract symptoms after PD-1/PD-L1 inhibit …

27.08.2026journal-article

Frontiers in Nutrition

Preoperative prognostic nutritional index and in-hospital mortality in neonates undergoing cardiac surgery for congenital heart disease: a single-center retrospective study

Heqi Zhang, Haoju Dong, Taibing Fan, Weijie Liang

Background Neonates undergoing cardiac surgery for congenital heart disease (CHD) represent one of the highest-risk subpopulations in pediatric cardiac surgery. Preoperative nutritional and immune reserve may substantially influence perioperative resilience, yet practical neonatal-specific nutritional risk markers remain insufficiently defined. Objective To evaluate the association between preoperative prognostic nutritional index (PNI) and in-hospital mortality in neonates undergoing cardiac surgery for CHD, and t …

27.08.2026journal-article

MEDICUS

MODIFIABLE RISK FACTORS FOR CHRONIC NONCOMMUNICABLE DISEASES AND THEIR CORRECTION IN CITIZENS DURING CLINICAL EXAMINATION OF THE ADULT POPULATION IN THE CITY POLYCLINIC IN 2025

Saksena Ishita, E.I. Demina, E.V. Krug

The article discusses the issues of medical examination of certain groups of the adult population in the city clinic. The objective was to identify modifiable risk factors in patients and prioritize lifestyle modifications for preventive risk factor management counseling. Identification of risk factors was carried out in citizens of working age and older than working age. All necessary studies were carried out in accordance with the order of the Ministry of Health of the Russian Federation No. 404n, 2021, depending …

27.08.2026journal-article

Clinical Transplantation

Survival and Outcomes of Lung‐Kidney and Lung‐Liver Transplants Using a Large National Cohort

John A. Treffalls, Kelly Pennington, Cassie C. Kennedy, Julie K. Heimbach, Carrie A. Schinstock, Mauricio A. Villavicencio, Sahar A. Saddoughi

ABSTRACT Background We used a national cohort to compare post‐transplant outcomes of lung‐kidney and lung‐liver transplantation to isolated lung transplantation. Methods The United Network for Organ Sharing database was queried for all lung transplants performed from 1/1/2010‐9/30/2024. Heart‐lung and three‐organ transplants were excluded. Patients undergoing isolated lung transplantation were compared with those undergoing simultaneous lung‐kidney or lung‐liver transplantation. Cox proportional hazards models asse …

27.08.2026journal-article

Oral and Maxillofacial Surgery

A new radiological classification of the mental foramen in the edentulous mandible: clinical and surgical implications

Bruno Scognamiglio, Alfonso Acerra, Mario Caggiano, Isabella De Rubertis, Francesco Giordano

Abstract Background The purpose of this cross-sectional study was to classify different patterns of mental nerve emergence (MNE) in edentulous mandible using cone beam computed tomography (CBCT) scans. Methods Seventy-five consecutive patients, each contributing with one hemimandible and candidates for implant surgery, were recruited at Dental Unit of University Hospital of Salerno. CBCT scans were analyzed by two calibrated examiners to assess the distance between the bone crest and the mental foramen (BC–MF), man …

27.08.2026journal-article

Frontiers in Medicine

Rising burden of early-onset lung cancer among Chinese adolescents and young adults (1990–2023): a Bayesian age-period-cohort analysis with projections to 2038

Yi Dong, Yongjie Guan, Maosen Zhao, Shuang Feng, Xiaowei Wang, Mingming Wang, Maoyong Fu, Jiayu Shang, Ke Gao

Background Early-onset lung cancer (diagnosed at age 15–39 years) remains uncommon, yet incidence is rising in several world regions. China—the largest contributor to global lung cancer mortality—has not had its youth burden comprehensively characterized or projected. Methods Using the Global Burden of Disease Study 2023 (GBD 2023), we extracted annual incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) for Chinese adolescents and young adults (AYA) aged 15–39 years from 1990 to 2023. Joinp …

27.08.2026journal-article

Frontiers in Medicine

Nomogram integrating BRAF V600E, serum biomarkers, and ultrasound features for malignancy risk stratification in C-TIRADS category 3 and 4 thyroid nodules

Yu Gao, Wenran Zhang, Jingmin Li, Jiaqing Dou

Background For patients with C-TIRADS 3 or 4 nodules who have undergone fine-needle aspiration cytology (FNAC), subsequent management decisions remain challenging, especially when cytological results are discordant with imaging findings or indeterminate. We built a nomogram incorporating BRAF V600E, serum biomarkers, and ultrasound features to provide an individualized risk estimate of malignancy for these nodules. Methods We retrospectively included 300 patients with C-TIRADS 3 or 4 nodules. All nodules were confi …

27.08.2026journal-article

Journal of Clinical Medicine

Targeting Inflammation Across the Myocardial Infarction Continuum: Biomarkers, Imaging, and Emerging Therapies

Kristi Hoxha, Isabella Maccaferri, Francesco Paparazzo, Alberto Sarti, Giorgio Sciaramenti, Giovanni Camaiti, Pierpaolo Cioci, Cristina Rizza, Renè Tezze, Ludovica Rita Vocale, Elisabetta Tonet, Federico Marchini, Gianluca Campo, Rita Pavasini

Background: Myocardial infarction (MI) remains a leading cause of morbidity and mortality despite major advances in reperfusion and secondary prevention. Inflammation contributes throughout the MI continuum, from atherosclerotic plaque development and destabilization to myocardial injury, adverse ventricular remodeling, and recurrent cardiovascular events. Objective: This narrative review summarizes current evidence on inflammation across the MI continuum, focusing on inflammatory biomarkers, cardiovascular imaging …

27.08.2026journal-article

European Respiratory Journal

The Role of Inflammation in the Pathogenesis of Pulmonary Fibrosis: Mechanisms and Treatment Implications

Nazanin Nazemi, Bruno Crestani, Doumet Georges Helou, Oliver Distler, Janine Gote-Schniering, Anna-Maria Hoffmann Vold, Carlos Machahua, Martin Kolb, Manuela Funke-Chambour

Fibrotic interstitial lung diseases (fILDs) encompass a heterogeneous group of interstitial lung diseases (ILDs) and may arise from persistent inflammation caused by systemic disease or environmental exposures. Idiopathic pulmonary fibrosis (IPF), the prototypical fILD, is characterized by progressive fibrosis, limited inflammation, and a high mortality rate. In contrast, other fILDs display variable contributions of fibrosis and inflammation that are only partially determined by the underlying diagnosis. Within mo …

27.08.2026journal-article

BMC Surgery

Prophylactic endoluminal vacuum-assisted therapy in high-risk ultra-low rectal anastomoses: a retrospective comparative study of feasibility and clinical outcomes

Nour Alkhanji, Eslam Elmaghraby, Saleh Lahes, Mohammed Abdulla, Wolfram Trudo Kneofel, Nadja C Lehwald-Tywuschik

Abstract Background Anastomotic leakage (AL) remains a major cause of morbidity and mortality after ultra-low anterior resection (uLAR) for rectal cancer, when the anastomosis is located ≤ 5 cm from the anal verge, in patients with additionally risk factors. This study proposes the prophylactic endoluminal vacuum-assisted therapy (pEVAT) as a feasible strategy that may reduce AL incidence and promote healing in this subgroup of patients. Methods Thirty-three patients multiple established risk factors for AL who und …

27.08.2026journal-article

Advanced Science

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan

ABSTRACT Butyrate (BA) is essential for intestinal health, but its intestinal therapeutic applications are hindered by its malodorous nature, premature gastric absorption, and rapid intestinal metabolism. To address these challenges, an inodorous macromolecule β‐glucan‐BA (GLU‐BA) is synthesized via one‐step esterification, allowing for BA production in the intestine with burst yet gradual dynamics. After oral administration, GLU‐BA self‐assembles into nanomicelles, preventing premature gastric absorption. Upon rea …

27.08.2026journal-article

Plants

From Traditional Remedy to Evidence-Based Phytotherapeutic Agent: Hedera helix L. in Respiratory Medicine

Agata Maria Pawłowska

Hedera helix L. leaf extracts are regulated expectorants for productive cough, yet their evidence is dispersed across pharmaceutical quality, nonclinical pharmacology, disposition, toxicology, clinical pharmacology, efficacy, safety, and regulatory assessment. This review integrates those domains in a single study-level account and explicitly distinguishes isolated constituents, incompletely specified extracts, defined monograph preparations, proprietary extracts, and combination products. Hederacoside C is the pha …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Perioperative management based on the enhanced recovery after surgery concept in elderly patients undergoing laparoscopic common bile duct exploration plus laparoscopic cholecystectomy

Long-Xiang Wang, Yan-Hong Jiang, Yong Ding, Hai-Tao Wu

BACKGROUND Choledocholithiasis is highly prevalent among the elderly, with laparoscopic common bile duct exploration (LCBDE) plus laparoscopic cholecystectomy (LC) serving as a key minimally invasive treatment. However, elderly patients often face increased surgical risks and prolonged recovery due to reduced physiological reserve and comorbidities. The enhanced recovery after surgery (ERAS) protocol has proven effective in optimizing perioperative outcomes across multiple surgical disciplines, yet its specific app …

27.08.2026journal-article

Bone Research

Multidisciplinary expert consensus on clinical diagnosis and therapies for low back pain

Bo Gao, Rundong Chai, Guanyi Wang, Yanfang Song, Lei Shang, Jinghui Huang, Xu Cao, Yong Hai, Zhuojing Luo, Chinese Society for the Study of the Lumbar Spine, Chinese Association of Spine, Zhongqiang Chen, Shiqing Feng, Jianyuan Jiang, Fang Li, Li Li, Yueming Song, Zhaomin Zheng, Jun Ao, Yunbing Chang, Bohua Chen, Deyu Chen, Jianting Chen, Liang Chen, Qixin Chen, Shaoqian Cui, Shucai Deng, Huiqiang Ding, Guiyou Feng, Yanzheng Gao, Tao Guo, Zhaoqing Guo, Qing He, Baorong He, Shisheng He, Yi Hong, Zhenghua Hong, Congren Huang, Han Jiang, Dianming Jiang, Bo Li

Abstract Low back pain (LBP) is one of the most frequently encountered conditions in orthopedics, physical therapy and rehabilitation, and pain medicine. Its etiology is multifactorial and its management options are diverse. However, a unified, standardized, and evidence-based clinical pathway for LBP remains lacking, leading to substantial variation in diagnostic reasoning, treatment selection, outcome assessment, and long-term care across healthcare settings and professional disciplines. To address this gap, Chin …

27.08.2026journal-article

Internal and Emergency Medicine

⁠From liver to cardiovascular system: the MASLD–ASCVD continuum

Andrea Boccatonda, Antonella Bray, Marialuisa Sveva Marozzi, Alessia Cipollone, Gianfranco Lauletta, Damiano D’Ardes, Sebastiano Cicco, Francesco Cipollone

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide and is increasingly recognized as a systemic cardiometabolic disorder. Atherosclerotic cardiovascular disease (ASCVD) represents the leading cause of mortality in patients with MASLD. This review aims to summarize current evidence on the epidemiology, pathophysiological mechanisms, and clinical impact of MASLD on cardiovascular outcomes. We reviewed epidemiological studies, mechanistic inv …

27.08.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Approach to the Patient: Ethics Cases in Pediatric Endocrinology and Their Management

Jennifer M Ladd, Meaghann S Weaver, Rohan K Henry

Abstract Context With advancing technologies and expanding indications for existing therapies, ethical dilemmas increasingly arise in pediatric endocrinology practice. Aim This article presents practical, case-based scenarios to guide clinicians in navigating common ethical challenges in pediatric endocrinology. Cases We present four case vignettes which present ethical dilemmas regarding (1) growth hormone treatment prescribed for idiopathic short stature, (2) precocious puberty management in a child with neurodev …

27.08.2026journal-article

International Journal of Cancer

Comparison of Healthcare Utilization Before Diagnosis Between Non‐Advanced and Advanced Lung Cancer Patients: A Study Among 72,851 Cases in Germany

Josephine Küsel‐Kanbach, Oliver Riedel, Ulrike Haug

ABSTRACT There is no study from Germany on the association between stage of lung cancer (LC) and patient characteristics. We aimed to compare advanced versus non‐advanced LC cases regarding indicators of healthcare utilization. Using claims data covering 20% of the German population, we included LC patients diagnosed between 2013 and 2019. Stratified by stage (advanced vs. non‐advanced), we assessed comorbidities, hospitalizations, outpatient physician contacts and utilization of preventive measures before LC diagn …

27.08.2026journal-article

Frontiers in Psychology

Clinical risk stratification of stroke caregiver distress: an interpretable nonlinear model of caregiving-load categories

Yingjie Zheng, Shailing Ma, Xiaohui Liu, Yuyan Yang, Ru Gan, Jiajia Lai, Yijia Qi, Jing Li, Lijun Wang, Miaomiao Chen

Background Family caregivers of stroke survivors frequently experience psychological distress. Social support and active coping may be protective, but their associations can vary across levels of caregiving load. Interpretable machine learning may help characterize such nonlinear patterns without assuming a constant linear association. Methods This multicenter cross-sectional study included 506 family caregivers. High psychological distress was defined as a Hospital Anxiety and Depression Scale (HADS) total score ≥ …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Case Report: Interventricular septal hematoma after ventricular septal defect repair with persistent left ventricular communication: 10-year follow-up

Anna Rudek-Budzyńska, Aleksandra Morka, Tomasz Mroczek

Interventricular septal hematoma is a rare complication of congenital heart surgery with unpredictable clinical course and limited data guiding management. We report a female infant who developed a giant interventricular septal hematoma after surgical closure of a perimembranous ventricular septal defect at 4 months of age. Early postoperative imaging demonstrated a large intraseptal cavity without ventricular communication, followed by development of multiple small fistulous connections with the left ventricular l …

27.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Clinical and Electrophysiological Effects of Downhill Treadmill Walking in Patients With Ischemic Stroke

Burak Yıldız, İpek Midi, Evrim Karadağ-Sayg, Özge Keniş-Coşkun

Objective: To evaluate the clinical and electrophysiological effects of downhill treadmill walking performed at different inclines in patients with stroke. Design: Thirty-five patients with stroke were randomized to level treadmill walking (control), −7.5% downhill walking, or −15% downhill walking. In this assessor-blinded trial, the intervention consisted of five sessions delivered over 5 consecutive days. Clinical outcomes assessed before and after the intervention were the Modified Ashworth Scale, Fugl-Meyer Lo …

27.08.2026journal-article

Frontiers in Medicine

Enhancing nurses’ competence in mechanical ventilation: a quasi-experimental study and its association with patient severity using APACHE II

Noha Mohammed Ibrahim, Samia Eaid Elgazzar, Amany Ibrahim Ezz Eldin, Abdo Mansoor Alhusami, Mona Metwally El-Sayed, Mohamed Goda Elbqry, Fatma Mohamed Elmansy, Shereen Ahmed A. Qalawa, Nasiru Mohammed Abdullahi, Saddam Ahmed Al-Ahdal, Hanadi Dakhilallah, Sheren Ebrahim El-Hag El-Tahry

Background Mechanical ventilation is a cornerstone of intensive care, requiring ICU nurses to have adequate knowledge, competence, and skills to provide safe, evidence-based care. Although educational programs improve nurses’ preparedness, evidence of their impact on patient outcomes remains limited. Aim To assess ICU nurses’ knowledge, professional competence, and clinical practice related to mechanical ventilation following participation in a structured educational program, and to explore the association between …