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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Neuro-Oncology

21 Adult ependymoma in England: Incidence, treatment, and outcomes from GlioCova

Kerlann Le Calvez, Radvile Mauricaite, Peter Treasure, Thomas C Booth, Stephen J Price, Andrew Brodbelt, Jonathan J Gregory, Seema Dadhania, Lillie Pakzad-Shahabi, Maureen Dumba, Ingela Oberg, Sally Vernon, Jawad Basharat, Matt Williams

Abstract Introduction England has a long-running system for national cancer data collection. In this work we present data on incidence, treatment and survival in all adult ependymoma patients in England diagnosed between 2013 and 2018. Methods Gliocova uses a linked pseudo-anonymised data set of all adult patients in England diagnosed with a primary brain tumour between 2013 and 2018. We identified all adult patients with an ependymoma based on ICD-10 diagnosis and tumour morphology. Results In the 6-year period of …

27.08.2026journal-article

Neuro-Oncology

38 Building Research Capacity: The Impact of The Brain Tumour Charity’s Future Leaders Funding Programme

Lucy Grist, Simon Newman, Emma Thompson

Abstract Introduction Brain tumours remain one of the most challenging cancers, and progress is slowed by a shortage of researchers entering and remaining in the field. To build capacity, ensure research excellence and drive innovation, The Brain Tumour Charity established the Future Leaders Programme to identify talented early‑career researchers and support them to become leaders in brain tumour research. Methods The programme uses a staged funding model. Researchers undertake a three‑year Postdoctoral Fellowship, …

27.08.2026journal-article

Molecular Cancer Therapeutics

Dual-Targeting of EGFR and HER2 by a Bispecific Antibody–Drug Conjugate Demonstrates Broad Antitumor Activity in Multiple Solid Tumors

Xiaojuan Chai, Fu Li, Hongmei Xie, Hanxi Yu, Xiaojing Huang, Yihui Lin, Yuting Lu, Nan Li, Tete Li, Qiangqiang Deng, Weiming He, Wenqiang Zhai, Shu Zhang, Xiaozhen Wang, Haizhou Zhang, Fanglong Yang, Siqin Wang, Lei Jin, John L. Xu

Abstract While HER2-directed antibody–drug conjugates (ADC), such as ENHERTU (DS-8201), represent a major therapeutic advance, treatment options for tumors with low HER2 expression remain limited, and acquired resistance continues to pose a significant clinical challenge. Given the frequent co-expression of EGFR and HER2 across multiple tumor types, we hypothesized that dual-targeting could improve therapeutic efficacy and overcome resistance mechanisms. This approach may achieve broader tumor coverage, synergistic …

27.08.2026journal-article

Philosophical Transactions of the Royal Society B: Biological Sciences

Piecing together the structure of epidermal growth factor receptor complexes: a journey from crystals to cells and its impact on cancer therapy

Selene Roberts, Dave Clarke, Ioannis Galdadas, Marisa Martin-Fernandez

Abstract The epidermal growth factor receptor (EGFR) was cloned and identified as an oncogene 40 years ago, and since then has become the poster child for receptor tyrosine kinases in physiological and pathophysiological settings. Cell surface EGFRs bind growth factors secreted by adjacent cells and undergo conformational changes that transduce normal or dysregulated growth and division signals across the plasma membrane. It took more than two decades for atomic resolution of partial structures to become available, …

27.08.2026journal-article

Frontiers in Oncology

Feasibility, reliability, and clinical value of genomic assay on pre-therapeutic biopsy for endocrine receptor-positive HER2-negative early breast cancer

Gilles Houvenaeghel, Maxime Souquet Bressand, Valérie Juhan Duguet, Monique Cohen, Catherine Bouteille, Laura Sabiani, Julien Barrou, Loic Juquel, Véronique Brunel, Olivia Quilichini

Endocrine receptor-positive (ER+) and HER2-negative breast cancer (BC) represents approximately 80% of all BCs. Most patients are treated with upfront surgery; however, 15%–30% will develop late recurrences. Genomic assay indication is usually based on postoperative pathological data including histology subtype, tumor size, lymph node status, SBR grade, and Ki67. Performing genomic testing on core needle biopsy specimens prior to surgery may offer several advantages. In this manuscript, we assess the feasibility, r …

27.08.2026journal-article

Clinics and Practice

Scientific Clinical Trial Publication Productivity in Medical Oncology: A Comparative Analysis and Data Review of Northern and Southern Italy

Vittorio Gebbia, Sergio Rizzo, Dario Piazza, Daniela Sambataro, Giuseppa Scandurra, Maria Rosaria Valerio

Background: Italy exhibits a socioeconomic divide between its northern and southern regions, which extends into healthcare delivery and biomedical research. Medical oncology is particularly affected by this structural imbalance. This paper examines geographic disparities in clinical trial scientific publication output, citation impact, research funding, and collaboration networks in medical oncology between northern and southern Italy. Methods: A narrative bibliometric analysis was conducted using data from PubMed …

27.08.2026journal-article

Med Research

Organoid Coculture Models for Cancer Research and Immunotherapy

Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen

ABSTRACT Three‐dimensional cancer organoids cultured in vitro closely recapitulate the phenotypic and genetic features of parental tumor tissues, making them powerful tools for cancer research, drug screening, and personalized medicine. However, traditional organoid cultures lack key components of the tumor microenvironment (TME), including cancer‐associated fibroblasts, immune cells, vascular networks, and dynamic physicochemical cues, such as fluid flow and oxygen gradients. These deficiencies limit the ability t …

27.08.2026journal-article

Frontiers in Oncology

Epigenetic profiling of circulating cell-free DNA for early detection and minimal residual disease assessment in lung cancer: a focus on DNA methylation

Tancredi Didier Bazan Russo, Valerio Gristina, Marco Donatello Delcuratolo, Leonardo Tamburi, Francesco Delli Muti, Filomena Mangiacotti, Clarissa Mujacic, Daniele Fanale, Antonio Galvano, Stefania Gori, Lorena Incorvaia, Antonio Giordano, Francesco Pepe, Umberto Malapelle, Antonio Russo, Lucia Anna Muscarella, Federico Pio Fabrizio

Lung Cancer (LC) continues to be the biggest cause of cancer-related deaths around the world, mostly because of delayed diagnosis. Even if tissue biopsies and circulating tumor DNA (ctDNA) tests have revolutionized clinical management of LC patients, their effectiveness is restricted in settings with lower tumor burden, molecular heterogeneity, and bias in sampling approaches. In this scenario, the epigenetic profiling of cell-free DNA (cfDNA) stands out as a promising, less invasive approach, accurately detect can …

27.08.2026journal-article

Discover Oncology

Cellular and transcriptomic responses to a PDE4DIP-directed siRNA in MDA-MB-231 breast cancer cells

Cong Wang, Chunjing Bian, Zhe Wang, Tao Luo

Abstract PDE4DIP/myomegalin is a Golgi- and centrosome-associated scaffold encoded by a complex, alternatively spliced gene. We examined cellular and transcriptomic responses of MDA-MB-231 cells to a PDE4DIP-directed siRNA. Its 21-nt target site occurs in 40 of 49 protein-coding transcripts under the current RefSeq annotation, including transcript variant 34, which encodes MMG8/SMYLE, and is therefore not unique to the MMG8/SMYLE transcript. The principal 443M-reactive species was an approximately 150-kDa band cons …

27.08.2026journal-article

Crystals

A Review of Fatigue Performance Research on Aluminum Alloy Forming, Heat Treatment, Additive Manufacturing and Surface Modification Technologies

Baicheng Liu, Hongliang Zhang, Shenghan Li, Yurii Luhovskyi, Zhisheng Nong

Aluminum alloy is a lightweight, high-strength material based on aluminum matrix with the addition of elements such as copper, magnesium, silicon, zinc, manganese, or lithium. Featuring low density, high specific strength, excellent formability, and outstanding corrosion resistance, it is widely applied in the fields of aerospace, rail transit, automotive lightweighting, and additive manufacturing. In the aerospace sector, fatigue failure constitutes the primary failure mode of load-bearing components. This paper r …

27.08.2026journal-article

International Journal of Pattern Recognition and Artificial Intelligence

Dense-RBF Grad-CAM: A Clinically Trustworthy AI Framework for early Breast Cancer Detection using mammography images

Rupali Patil, V.V. Dixit

Breast cancer continues to be the most common cause of cancer-related deaths in women globally. The earlier breast cancer is identified, the higher the chance of survival. In screening dense breast tissue, the standard diagnostic approach has essential limitations, including a relatively high false-negative rate and poor interpretability. This research introduces a Dense Radial Bias Functional Gradient-weighted Class Activation Mapping method optimized using the Revolution Optimization Algorithm (DRBF-GradCAM_ROA) …

27.08.2026journal-article

Frontiers in Immunology

Targeting splicing-derived neoantigens for precision cancer immunotherapy

Mutian Tang, H. Leighton Grimes, Nathan Salomonis

Aberrant pre-mRNA splicing in cancer generates protein sequences that are rare or absent in normal tissues, creating a rich source of tumor-specific neoantigens for immunotherapy. These splicing-derived neoantigens arise through diverse mechanisms, including recurrent somatic mutations in core spliceosome components ( SF3B1 , SRSF2 , U2AF1 , and ZRSR2 ), epigenetic derepression of transposable elements that give rise to chimeric exon-TE junctions, and coordinated dysregulation of splicing regulatory networks in can …

27.08.2026journal-article

International Journal of Molecular Sciences

Paclitaxel Nanomedicines: Molecular Mechanisms of Drug Resistance, Tumor Microenvironment-Responsive Delivery, and Translational Challenges

Dejun Cheng, Guowei Yang, Ruibin Kong, Qin Liu, Li Li, Yunpeng Luan, Qijiang Shu

Paclitaxel (PTX) remains a major component of treatment for solid tumors, but its clinical performance is limited by poor aqueous solubility, solvent-associated toxicity, heterogeneous tumor exposure, and multifactorial drug resistance. This narrative review examines PTX nanomedicines from a molecular pharmacology perspective, focusing on how carrier design interacts with resistance pathways, tumor microenvironment signals, and intracellular drug trafficking. We outline resistance mechanisms involving ATP-binding c …

27.08.2026journal-article

Journal of Intensive Care Medicine

Modern Approaches to the Treatment of Respiratory Distress Syndrome in Children: The Role of Surfactant and Antenatal Prophylaxis

Aisuluu Omurzakova, Venera Azhikulova, Mairamkan Sharipova, Nargiza Kurbanova, Gulnura Zhunusbaeva

Background and Objective The aim of the study was to evaluate the multilevel impact of antenatal prophylaxis and modern non-invasive respiratory strategies on the course and outcomes of respiratory distress syndrome in new-borns. Methods A total of 4080 hospitalisations of preterm and full-term infants with confirmed respiratory failure, born between 1 January 2017 and 30 September 2024, who received care at the Osh Regional Clinical Maternity Hospital (Kyrgyzstan), were included in the retrospective cohort registr …

27.08.2026journal-article

Frontiers in Oncology

Hypothermia and recovery outcomes before and after implementation of a multimodal perioperative temperature-management bundle in minimally invasive radical rectal cancer surgery

Qian Liu, Ling Liu, Chenxi Han, Chunmei Cao, Jiefang Ji, Aihua Zhu

Background Inadvertent perioperative hypothermia is common during minimally invasive rectal cancer surgery. We assessed whether a five-component multimodal temperature-management bundle was associated with improved perioperative outcomes. Methods This single-center retrospective before-and-after study included 247 adults undergoing laparoscopic or robot-assisted radical rectal cancer surgery from 2021 to 2025 (pre-implementation, n = 123; post-implementation, n = 124). The primary outcome was any intraoperative nas …

27.08.2026journal-article

Frontiers in Oncology

Construction and exploratory validation of a digital pathology prognostic model for stage II–III colorectal cancer based on contrastive learning and attention mechanisms

Yizhan Lu, Zhifeng Qu, Chongbao Sun, Bo Li, Xiaoyang Bai, Qingqing Zhao, Wenxin Zhang, Yandong Zhao, Wuteng Cao, Xuezhi Zhou

Introduction Although TNM staging is the standard framework for prognostic assessment in colorectal cancer (CRC), patients within the same stage can have heterogeneous outcomes. This study aimed to extract tumor-tissue features from whole-slide images (WSIs), develop an image-derived prognostic model for stage II–III CRC, and conduct an exploratory evaluation of its performance. Methods A transfer-learning tissue classifier was used to identify tumor regions in CRC WSIs. Self-supervised contrastive learning was use …

27.08.2026journal-article

Neuro-Oncology

118 Molecular and Immunological Landscape of the Pleomorphic Xanthoastrocytoma–Epithelioid Glioblastoma Spectrum

Iman Dandapath, Swati Mahajan, Jyotsna Singh, Mehar Chand Sharma, Chitra Sarkar, Vaishali Suri

Abstract Background Pleomorphic xanthoastrocytoma (PXA), especially PXAG3, exhibits considerable morphologic, molecular, and clinical overlap with epithelioid glioblastoma (eGB), raising questions regarding their biological relationship and progression dynamics. Although immune checkpoint pathways have been investigated in glioblastoma, comprehensive integration of immune profiling with transcriptomic signatures across the PXA–eGB spectrum remains inadequately defined. Methods Fifty-three tumors (PXAG2 n = 15, PXAG …

27.08.2026journal-article

Neuro-Oncology

109 Multi-omic integration reveals intra-tumour heterogeneity and identifies disulfiram and copper as a synergistic therapy in paediatric ependymoma

Alina Pandele, Alison Whitby, Sandra Martinez-Jarquin, Chiara Bastiancich, Donald Macarthur, Ian Kamaly-Asl, David Barrett, Richard Grundy, Dong-Hyun Kim, Ruman Rahman

Abstract Introduction Ependymoma (EPN) is the second most malignant paediatric brain tumour. The PF-A subgroup, associated with a hypoxic microenvironment, has a dismal survival rate of 50%, with clinical trials failing to demonstrate a significant survival advantage from chemotherapy to date. We present a multi-omic integration investigating whether spatially-distinct tumour microenvironments represent targetable metabolic niches in PF-A EPN. Methods Surgical sampling of spatially-distinct regions from eight PF-A …

27.08.2026journal-article

Neuro-Oncology

142 Arginine deprivation improves survival and activates the immune system in mouse models of diffuse midline glioma

Molly Brooks, Dani Chattenton, Huan Huang, Zehongru Xu, Richard Perryman, Maria Chatziathanasiadou, Nelofer Syed

Abstract Introduction Diffuse midline glioma (DMG) is a rare but fatal childhood brain tumour with no successful treatments. An inert immune microenvironment is a key factor in the failure to find suitable treatments. Arginine deprivation using ADI-PEG20 has been effective in treating a number of cancers, particularly those which cannot generate their own arginine. Our previous studies demonstrated that ADI-PEG20 combined with radiation eradicated GBM tumours and extended survival of animals indefinitely. ADI-PEG20 …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Meta-analysis of surgical quality-related factors associated with local recurrence rate after rectal cancer surgery

Jin-Kai Wang, Chang-Tao Yu, Bai-Xue Qin, Hua-Bin Cheng

BACKGROUND Despite treatment advances, rectal cancer continues to pose a considerable global health burden, and local recurrence remains an important driver of long-term outcomes. Despite the evolution of surgical technique and multimodal therapy, local recurrence rates (LRRs) remain heterogeneous across institutions, thought to be related to differences in surgical quality. Local recurrence risk has been associated with several surgical quality indicators such as circumferential resection margin (CRM) involvement, …

27.08.2026journal-article

Macromol

Preclinical Efficacy and Structural Gaps of Ganoderma lucidum Polysaccharides in Cancer: A Systematic Review

Jean Felipe dos Santos, Karien Sauruk da Silva, Hellen Abreu, Alex Leandro dos Santos de Sá, Daniele Maria-Ferreira, Fhernanda Ribeiro Smiderle

Ganoderma lucidum’s anticancer potential is largely attributed to its polysaccharides, yet their preclinical translation requires rigorous systematization. Following PRISMA 2020 guidelines, this systematic review evaluated the anticancer efficacy of G. lucidum polysaccharides (GLPs) in preclinical models (PROSPERO: CRD42021296200). Systematic searches spanning 2011 to 2026 were conducted in PubMed, Embase, and Scopus. Eligible peer-reviewed articles investigated GLPs in cancer cell lines or animal models. The Cochr …

27.08.2026journal-article

Neuro-Oncology

9 Development of a Rapid Lateral Flow Assay for Early Identification of Glioblastoma and Brain Metastases Using a Circulating Serum Biomarker

Carys Jordan, Xia Liu, Calum Haydon, Cristina Santi, M C Galan, Kathreena Kurian

Abstract Introduction Rapid diagnostic tools could improve the early detection of glioblastoma (GBM) and brain metastases (BM). Lateral flow assays (LFAs) offer a simple, point-of-care testing platform. Glial fibrillary acidic protein (GFAP) has previously been reported as a circulating marker associated with blood–brain barrier disruption in brain tumours. This study aimed to develop and evaluate an LFA capable of detecting GFAP in the serum of patients with GBM and BM. Methods Detection antibodies were conjugated …

27.08.2026journal-article

Neuro-Oncology

129 Electroactive drug delivery for local glioblastoma treatment

Joshua Killilea, Immi Van Der Auweraert, Gary Shaw, Harveena Padda, Holly Briggs, Une Kontrimaite, Leire Landeira Suquia, Rosalie De Ferm, Lucia Moreno Gimeno, Phoebe McCrorie, Estelle Cuttaz, Aaron Lee, Giovanni Carlo Miceli, Stuart Smith, Dong-Hyun Kim, Ruman Rahman, Juanita Lopez, Roberto Portillo Lara, Josef Goding, Heiko Wurdak, Ryan Mathew, Christopher Chapman, Rylie Green

Abstract Introduction Despite recent advances in cancer therapeutics, the prognosis for glioblastoma remains exceptionally poor, stemming from the limited ability of systemically administered chemotherapeutics to cross the blood brain barrier (BBB). Mechanically circumventing the BBB represents a promising avenue. However, biomaterials previously used for local delivery suffer from low control over drug release, further limiting their translation. To address this, an implantable bioelectronic drug delivery device w …

27.08.2026journal-article

Neuro-Oncology

19 Age Related Presentation Characteristics and MRI Volumetric Associations in Glioblastoma IDHwt

Dominic van Loan, Sophie Williams, Olamide Rominiyi, Safiyyah Hussain, Danielle Madamba

Abstract Introduction Glioblastoma IDHwt is most common in adults aged ≥65 years, who often present with atypical symptoms, potentially impacting diagnostic pathways. We aimed to characterize presenting clinical features and MRI volumetric parameters in older adults with glioblastoma IDHwt at a single tertiary neurosurgical centre. Methods Clinical data were retrospectively collected for a continuous case series of patients diagnosed with glioblastoma IDHwt between 2020-2024 at Sheffield Teaching Hospitals Foundati …