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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

American Journal of Clinical Oncology

Combining Statistical Modeling and Machine Learning for Prognostic Feature Selection in Cervical Cancer

Reyanguli Dawuti, Lili Yao, Mayila Wutikuer, Xiaoshan Liu, Dongrui Zhang, Tingting Qi

Objectives: Cervical cancer is a leading female malignancy with high global morbidity/mortality, and remains high recurrence risk after standard treatment. Accurate prognostic feature identification is critical for personalized therapy and patient survival improvement, while traditional indicators and single biomarkers lack sufficient accuracy in prognostic prediction. Methods: In this population-based retrospective study, we analyzed 5392 patients with cervical squamous cell carcinoma from the surveillance, epidem …

24.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Periductal myxoid stroma identifies ductal carcinoma in situ at risk of invasive recurrence

Aglaia Schiza, Viktoria Thurfjell, Erik Holmberg, Troy Bremer, Patrick Micke, Per Karlsson, Fredrik Wärnberg, Carina Strell

Abstract Overtreatment of breast ductal carcinoma in situ (DCIS) remains a major clinical problem because clinicopathologic criteria are insufficient to define the invasive potential. We evaluated whether periductal stromal morphology in diagnostic hematoxylin-eosin sections predicts invasive recurrence among 711 DCIS patients from the randomized SweDCIS trial, who underwent breast-conserving surgery with or without radiotherapy. Two raters scored the proportion of DCIS ducts surrounded by myxoid stroma. Eighty pat …

24.08.2026journal-article

Holistic Integrative Oncology

CACA Guidelines for holistic integrative assessment (2025)

Hongyan Zhang, Qiuling Shi, Xiaomei Li, Qian Li, Yong Liu, Hongmei Zhang, Rongbo Lin, Wenli Zhou, Qian Chu, Jie Min, Jin Zheng, Bo Liu, Xiaobing Chen, Yi He, Lei Ni, Min Li, Minghua Cong, Feng Liang, Xiaowen Wang, Zhi Guo, Guibin Qiao, Jinghui Bai, Hongxia Li, Beibei Chen, Fei Wang, Jizong Jiang, Duanqi Liu

Abstract The complexity and heterogeneity of malignant tumors necessitate a paradigm shift from a disease-centric to a patient-centric model of care. Cancer holistic integrative assessment (CHIA) is a multidimensional evaluation process that forms the cornerstone of personalized oncology. CHIA is characterized by four core principles: integrative philosophy, multidimensionality, dynamic individualization, and multidisciplinary collaboration. Key assessment domains include: 1) General status (performance status, phy …

24.08.2026journal-article

Clinical Cancer Research

Circulating Thymidine Kinase Activity Predicts Survival and Optimal Treatment Sequencing in BRAF-Mutated Metastatic Melanoma in the SECOMBIT Trial

Hildur Helgadottir, Mariaelena Capone, Laura Ridolfi, Alberto Zambelli, Luisa Piccin, Helen Gogas, Marco Tucci, Pietro Quaglino, Michele Del Vecchio, Alessandro Marco Minisini, Francesco Spagnolo, Piotr Rutkowski, Virginia Ferraresi, Ana Arance, Michele Guida, Evaristo Maiello, Céleste Lebbé, Jenny Bulgarelli, Vanna Chiarion Sileni, Miriam Paone, Ignacio Melero, Claudia Trojaniello, Mattias Bergqvist, Reinhard Dummer, Diana Giannarelli, Giuseppe Palmieri, Paolo A. Ascierto

Abstract Purpose: Although immune checkpoint inhibitors (ICI) are generally the preferred first-line treatment for metastatic BRAF V600–mutated melanoma, a subgroup that remains incompletely defined requires initial tumor control with BRAF/MEK-targeted therapy (TT). The purpose of this study was to evaluate circulating thymidine kinase activity (TKa), a blood-based marker of cellular proliferation, as a biomarker of outcome and treatment sequencing in patients enrolled in the randomized phase II SECOMBIT trial (NCT …

24.08.2026journal-article

Frontiers in Oncology

Global pattern and evolution of PPARγ in breast cancer: a 25-Year bibliometric and visualized knowledge map analysis

Xiaotian Zhang, Juan Jin, Yuan Cai, Xiaohui Luo, Qing She

Bibliometric methods were employed to visually examine the global trends and progression of PPARγ in the breast with the aim of clarifying the evolution of significant academic contributions, collaborative networks, foundational disciplines, and key terms. A comprehensive search was conducted on publications related to PPARγ in breast cancer research using the Web of Science Core Collection database (WOSCC) and PubMed. The reference types for the WOSCC database were restricted to articles and reviews published in E …

24.08.2026journal-article

World Journal of Clinical Oncology

Advancing interleukin-21 in cancer immunotherapy: Mechanisms of action and clinical translation

Jin-Xiang Wu, Yu-Meng Jin, Wen-Jie Shen, Zi-Hao Chen, Dian-Bao Zuo, Guo-Ping Chen, Kang-Kang Ji

Interleukin-21 (IL-21) is a pleiotropic cytokine that coordinates both adaptive and innate immune responses. It enhances the cytotoxic activity of CD8+ T cells and natural killer cells, regulates the suppressive function of regulatory T cells, and promotes B cell-mediated antibody production, thereby showing therapeutic potential in antitumor immunity. Current evidence suggests that IL-21 can postpone or reverse T cell depletion by downregulating inhibitory receptors such as programmed cell death protein 1 and T ce …

24.08.2026journal-article

Cancers

Mechanism-Driven Evolution of Fertility-Sparing Treatment and Precision Management of Special Populations in Endometrial Cancer: A Review

Kai-Bing Qu, Chun-Lin Pan, Ming-Yue Zhang, Zhuo-Ying Du, Sheng-Qian Wang, Shu-Li Yang, Yu-Mei Wu, Jian-Dong Wang, Yue He

Endometrial cancer is increasingly diagnosed in patients who have not yet completed childbearing. For carefully selected patients with grade 1 endometrioid endometrial carcinoma confined to the endometrium, fertility-sparing treatment (FST) can preserve reproductive potential but requires rigorous histologic surveillance. In eligible patients, oral progestins and/or the levonorgestrel-releasing intrauterine system (LNG-IUS) remain the mainstay of fertility-sparing treatment, with hysteroscopic lesion resection inco …

24.08.2026journal-article

Journal of Orthopedic and Spine Trauma

Treatment and Outcomes of Radial Head and Neck Fractures with the "Tripod Technique": A Case Series

Mohammad Ali Okhovatpour, Atousa Jelvani, Parviz Ahangar, Reza Zandi

Background: Fractures of the radial head and neck are the most common elbow fractures, which can cause elbow dysfunction and reduced quality of life (QOL). The "tripod technique" is a new, less invasive method for fixing these fractures. The objective of this study was to assess the functional outcomes of tripod technique for treatment of radial head and neck fractures. Methods: This case series was performed on eight patients with radial head and neck fractures who were admitted to Taleghani Hospital in Tehran Cit …

24.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Expanding the phenotype of hereditary renal cell carcinoma syndromes: Implications for surveillance and management

Maria I Carlo, Andrew Schroeder, Jie Liu, Vignesh Ravichandran, Nikita Mehta, Yelena Kemel, Grace Zong, Ying Liu, Alicia Latham, Neil Shah, Darren Feldman, Martin H Voss, Ritesh Kotecha, Zsofia K Stadler, Mark E Robson, Miika Mehine, Chaitanya Bandlamudi, Michael F Berger, Yingbei Chen, Diana Mandelker, Kelly Bolton, Semanti Mukherjee, Kenneth Offit, Robert Motzer

Abstract Background Approximately 5% of renal cell carcinoma (RCC) occurs in the setting of a hereditary RCC syndrome, but accurate phenotype and cancer risk estimates remain limited by ascertainment bias in reported series. Methods We analyzed 32,728 cancer patients who underwent paired tumor-normal sequencing with MSK-IMPACT for germline pathogenic variants (PVs) in RCC hereditary syndrome genes VHL, FLCN, BAP1, MET, SDHB, FH, and proposed RCC risk variants MITF E318K and FH K477dup. We integrated clinical, tumor …

24.08.2026journal-article

Frontiers in Oncology

Adenosine signaling in tumor immune escape: metabolic checkpoints, myeloid suppression, and combination immunotherapy

Rui Li, Shengbiao Li, Tongtong Zhang

Adenosine is a central metabolic regulator of tumor immune escape, shaping the tumor microenvironment (TME) through suppression of effector lymphocytes and reprogramming of myeloid populations. Extracellular adenosine is generated primarily via the ectonucleotidases CD39 and CD73 and signals through A2A (A2AR) and A2B (A2BR) receptors on T cells, NK cells, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and dendritic cells. This pathway promotes T-cell exhaustion, inhibits cytotoxicit …

24.08.2026journal-article

Frontiers in Oncology

Role of health digital twins in oncology drug development - a primer

Maria Garcia Requesens, Arun K. Mankan, Luca Cantini, Marco Calabresi, Laura Vidal, Joan Brown, Steven Lang, Bobby Kaura, Kirill Veselkov, Ioannis Xenarios, Kamal S. Saini

Health Digital Twins (HDTs) have attracted increasing interest as a potential tool for improving both patient care and clinical research, particularly in oncology where clinical trials remain slow, costly, and operationally complex. This primer introduces the concept of digital twins in a form accessible to professionals involved in oncology clinical research and outlines the main components of health digital twins, describes how these systems are generated, and highlights their potential relevance to oncology tria …

24.08.2026journal-article

Current Opinion in Obstetrics & Gynecology

Evaluation of vaginitis and its treatment

Sara A. McKinney, Erin A. Gross

Purpose of review Vaginitis is one of the most common reasons a patient will present for care in both the ambulatory and urgent care settings. The objective of this review is to summarize traditional methods of evaluation and treatment for the most commonly seen vaginitis and vaginosis, but also to present updated literature and future management directions for this common and sometimes resilient medical problem. Recent findings A randomized controlled trial of partners in monogamous heterosexual relationships and …

24.08.2026journal-article

Journal of Endovascular Therapy

A Multicentre Experience of Inner-Branched Endovascular Aneurysm Repair for Treatment of Type Ia Endoleak After EVAR

Rens Jorn Oosterveld, Arjan W. J. Hoksbergen, Chrissy van Wely, Mathieu Lacquet, Lee H. Bouwman, Ozan Yazar

Purpose: To evaluate the outcomes of inner-branched endovascular aneurysm repair (iBEVAR) for the treatment of type Ia endoleak after infrarenal endovascular aneurysm repair (EVAR). Materials and Methods: This multicentre study retrospectively analyzed all consecutive patients who underwent elective revision using iBEVAR for type Ia endoleak after previous infrarenal EVAR. The primary outcome was technical success, and the secondary outcome was clinical success at 30 days. Outcomes during further follow-up were mor …

24.08.2026journal-article

International Journal of Surgery Case Reports

Treatment of tunica albuginea defect using double-breasted corporoplasty (Alei’s technique) and small intestinal submucosa graft

Sara Lagioni, Ioana Alexandra Iachimovsky, Michele Rizzo, Tommaso Cai, Alessandro Zucchi, Giovanni Liguori

Introduction and importance: An isolated, spontaneous defect of the tunica albuginea is an exceptionally rare condition characterized by localized thinning of its layers and herniation of cavernous tissue. Given the very limited number of reported cases and the absence of standardized management, each report contributes valuable insights into diagnostic and surgical strategies. This case highlights a reconstructive approach aimed at preserving both functional and cosmetic outcomes. Case presentation: A 26-year-old …

24.08.2026journal-article

Cells

A Proposed Microneedle–Small Extracellular Vesicle System for Localized Adjunctive Treatment of Established Oral Squamous Cell Carcinoma: A Narrative Review and Preclinical Development Perspective

Hai He, Zishuai Chen, Hengxiang Liu, Xiaohua Zhang, Zhiqiang Li, Heqiang Yang, Xiaoyong Chen, Yufei Yang, Zifan Wang

Established oral squamous cell carcinoma (OSCC) remains constrained by local recurrence, inadequate lesion exposure, systemic toxicity, and therapy resistance. This narrative review evaluates a proposed microneedle–small extracellular vesicle (sEV) system for localized adjunctive treatment in three preclinical contexts: postoperative residual-disease control, local immunomodulation/checkpoint combination, and chemoradiotherapy sensitization. Direct evidence for the combined microneedle–sEV system in OSCC is not yet …

24.08.2026journal-article

Frontiers in Oncology

Comorbidity patterns and risk of breast cancer: a case–control study exploring interaction with BMI using latent class analysis

Yaling Zhang, Bei Zhao, Xinchun Zhang, Na Cui, Lanhua Wu, Ling Chen

Background Most studies to date have examined individual comorbidities in relation to breast cancer risk but have largely ignored that these conditions often cluster in the same person. Looking at comorbidity patterns rather than isolated diseases may therefore offer a better understanding of breast cancer risk. Methods In this case–control study, latent class analysis (LCA) was performed in the pooled case–control sample based on 10 comorbidities/conditions, including diabetes mellitus, hypertension, coronary hear …

24.08.2026journal-article

Frontiers in Oncology

18F-FDG PET/CT metabolic network connectivity in clinical staging of diffuse large B-cell lymphoma

Jinhai Zou, Han Zou, Chang Liu, Chen Liang, Yufei Liang, Meiyu Zheng, Chunying Li

Introduction Diffuse large B-cell lymphoma (DLBCL) is the most common and highly heterogeneous subtype of non-Hodgkin lymphoma, and accurate staging is essential for treatment planning and prognosis. This study explored the value of 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) metabolic network connectivity for the clinical staging of DLBCL. Methods Forty-two previously untreated patients (23 males, 19 females; aged 30-82 years) diagnosed as de novo DLBCL, not ot …

24.08.2026journal-article

Frontiers in Pharmacology

Dual MAO A and HSP90 inhibitors enhance anti-PD-1 therapy and suppress colorectal cancer

Hui-Ju Tseng, Yueh-Lin Wu, Yan-Ling Chen, Chien-Hua Wang, Suddhasatwa Banerjee, Jing-Ping Liou

Introduction Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, yet their efficacy remains limited by tumor resistance, immune-related adverse events, and poor response in microsatellite stable colorectal cancer (CRC). To address these challenges, dual monoamine oxidase A (MAO-A) and heat shock protein 90 (HSP90) inhibitors, MPT1B098 and MPT1B099, were developed and evaluated for their therapeutic potential and immune-modulatory efficacy in CRC. Methods Human and murine CRC cell lines were trea …

24.08.2026journal-article

BMC Medicine

Associations of CLivD score with dementia, cardiovascular disease, cancer, and mortality in the general population from the UK biobank

Guozhe Sun, Jie Chen, Hongmei Yang, Caiyu Zhang, Chenhua He, Ying Zhou, Lin Guan, Shiyu Zhou, Yao Yu, Jun Wang, Xiangyu Tan, Yangzhi Yin, Ziyi Xie, Wei Miao, Wenhang Li, Yifei Chen, Xiaoxuan Tian, Tianhao Li, Xiaobing Zhou, Mengling Lu, Guangxiao Li, Xiaofan Guo

Abstract Background The Chronic Liver Disease (CLivD) score is a non-invasive marker of advanced liver disease risk. We evaluated its associations with dementia, cardiovascular disease (CVD), cancer, and all-cause mortality. Methods This prospective cohort study included UK Biobank participants with calculable CLivD scores at baseline (2006–2010). Two previously validated versions of the score were calculated: a laboratory-based CLivD (CLivD lab ), incorporating age, sex, waist-hip ratio, alcohol consumption, diabe …

24.08.2026journal-article

Discovery Medicine

Integrative Transcriptomic Analysis Identifies Glycolysis/Ferroptosis-Associated Candidate Genes in Gastric Cancer

Yongting Lan, Xin Zhou, Yongfen Ma, Jingmei Cao

Background: The crosstalk between glycolysis, ferroptosis and the gastric cancer (GC) immune microenvironment remains poorly defined. This study aims to uncover glycolysis/ferroptosis-related regulators of the GC immune microenvironment.Methods: Transcriptomic datasets from The Cancer Genome Atlas (TCGA)-Stomach adenocarcinoma (TCGA-STAD) and Gene Expression Omnibus (GEO) were integrated to screen glycolysis/ferroptosis-related differentially expressed genes (DEGs). We evaluated univariate prognostic associations o …

24.08.2026journal-article

Cancer Immunology, Immunotherapy

A phase 1 study of VAC85135, a neoantigen vaccine regimen targeting calreticulin and JAK2 mutations, in combination with ipilimumab in patients with myeloproliferative neoplasms

Salman Otoukesh, Bethan Psaila, Andrew Kuykendall, Aaron T. Gerds, Ahmed Abdulgawad, Prithviraj Bose, Charlotte Van Bogaert, Jennifer Bishop, Patrick Wilkinson, Baolian Liu, Tianxiang Kevin Han, Busola Sanusi, Jaymala Patel, Katelyn D. Miller, Denis Smirnov, John T. Loffredo, M. Alejandro Sepulveda, Ricardo Attar, Kim Staquet, Charles G. Drake, Nikki Daskalakis, Claire Harrison

Abstract Disease-specific somatic mutations (mut) in calreticulin ( CALR ) and JAK2 ( JAK2V617F ) are drivers of myeloproliferative neoplasms (MPNs), causing generation of immunogenic peptide epitopes hypothesized to be vaccine-targetable neoantigens. VAC85135, a heterologous prime-boost vaccine regimen comprising adenoviral and vaccinia vectors encoding polypeptides specific to mutCALR and JAK2V617F , concurrent with anti-CTLA-4, ipilimumab, was investigated in a phase 1 study. Fourteen (myelofibrosis [MF], n = 10 …

24.08.2026journal-article

Hormone Research in Paediatrics

Failure to thrive (FTT) in infants with Prader-Willi syndrome and long-term effects of GH-treatment on FTT

Demi J. Trueba-Timmermans, Gerthe F. Kerkhof, Lionne N. Grootjen, Edmond H.H.M. Rings, Anita C.S. Hokken-Koelega

Context: Failure to thrive (FTT) with feeding difficulties and hypotonia are well-known features in infants with Prader-Willi syndrome (PWS). Limited studies reported the percentage of infants with FTT and it is unknown whether growth hormone (GH)-treatment affects body composition of infants with or without FTT differently. Objective: To evaluate the percentage of infants with PWS with FTT from birth to age 6 months and to investigate the 5-year GH effects on body composition in infants with or without FTT at GH-s …

24.08.2026journal-article

Endocrine-Related Cancer

Tumor-infiltrating lymphocytes differ across MammaPrint® classifications in breast cancer

Carmen Ariño-Palao, Irene Carretero-Barrio, Sara Martos-Meléndez, Tamara Caniego-Casas, Marta Rosas, Noelia Martínez-Jañez, María Fernández-Abad, María Concepción Sánchez, Teresa Presa-Abos, Javier Zamora, Juan Martínez-Aedo Castro, María J Ledesma-Carbayo, José Palacios, Belén Pérez- Mies

Abstract MammaPrint® refines risk stratification in early oestrogen receptor-positive, HER2-negative breast cancer, evolving from a binary to a four-tier classification (UltraLow, Low, High-Risk1, High-Risk2). The relationship between routine histopathological features, immune infiltration and genomic risk within this framework remains incompletely characterised in luminal disease. We retrospectively analysed 492 luminal breast carcinomas with available MammaPrint® results. Clinicopathological variables (including …

24.08.2026journal-article

Frontiers in Medicine

Family history of cancer and risk of lung cancer: a retrospective cohort study in a Chinese population

Hongjun Song, Xinlu Men, Jun Cheng, Liangliang Zhang, Shuang Zhao

Background Family history of cancer is an established risk factor for lung cancer, but its association with the probability of malignancy among patients evaluated for pulmonary nodules—rather than with population-level lung cancer incidence—remains poorly characterized in Chinese populations. Methods We conducted a retrospective cohort study of 3,850 consecutive patients evaluated for pulmonary nodules at a tertiary teaching hospital between January 2018 and December 2021, of whom 1,257 (32.6%) underwent surgical r …