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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Med Phoenix

Etiological Clinical and Laboratory Profile of Children admitted with Febrile Seizures in a Tertiary Care Hospital of Western Nepal

Laxman Paudel, Arun Pokhrel, Sumina Shrestha, Dipim Gautam

Introduction: Febrile seizures are the most common seizure disorder in childhood and are a frequent cause of hospital admission. Information regarding the demographic, clinical, etiological, and laboratory characteristics of febrile seizures in Nepal remains limited. This study aimed to evaluate the demographic, etiological, clinical, and laboratory profile of children admitted with febrile seizures in a tertiary care hospital in Western Nepal.Materials and Methods: A hospital-based prospective observational study …

27.08.2026journal-article

Transactions of The Royal Society of Tropical Medicine and Hygiene

Out-of-pocket expenditure and catastrophic health expenditure in patients of leprosy at a tertiary care center in India

Kavita Kavita, Sukhdeep Singh, Kittu Malhi, Manisha Upreti, Sushma Saini, Arushi Ghai, Ritin Mohindra, Tarun Narang, Sunil Dogra

Abstract Objectives Leprosy continues to impose a significant clinical and socioeconomic burden. Despite free multidrug therapy, patients incur substantial out-of-pocket expenditure (OOPE), leading to catastrophic health expenditure (CHE). Evidence on the economic burden of leprosy in India remains limited. Methods A pilot prospective observational study was conducted at a tertiary care center in North India, enrolling 56 patients with leprosy. Data on sociodemographic characteristics, direct and indirect healthcar …

27.08.2026journal-article

Journal of Perinatal Medicine

Multidimensional compliance and outcomes in gestational diabetes

Weili Zhang, Qingqing Gong, Yan Zhu

Abstract Objectives To investigate the association between a composite multidimensional compliance score and glycemic control, maternal complications, and neonatal outcomes in women with gestational diabetes mellitus (GDM), and to evaluate these associations after adjusting for potential confounders. Methods This retrospective cohort study included 360 women with GDM, diagnosed between October 2023 and January 2026 at Guiyang Second People’s Hospital. A weighted compliance score (1–3) was calculated based on blood …

27.08.2026journal-article

Experimental Biology and Medicine

The interaction between oxidative stress and Schwann cells

Sihan Yang, Zijun Zhang, Qing Liao, Qipeng Ouyang, Yongyou Ye, Wei Lu, Zhendong Jiang

After peripheral nerve injury (PNI), a moderate increase in reactive oxygen species (ROS) levels can promote the proliferation and differentiation of Schwann cells (SCs) and participate in signal transduction. However, excessive ROS can trigger oxidative stress, and its harmful effects can overshadow the beneficial ones, such as inducing apoptosis, activating inflammation, disrupting environmental stability, and severely hindering neural processes. Therefore, if the damage caused by oxidative stress to SCs can be e …

27.08.2026journal-article

Journal of Clinical Medicine

Self-Reported Prevalence of Functional Ankle Instability and Associated Factors Among Male Football Players in Southwestern Saudi Arabia

Abdulaziz Mohammed Y Alfaya, Ahmad Alanazi, Msaad Alzhrani, Sultan A. Alanazi, Ateef Mahamed

Background/Objectives: Rapid changes, jumping, and high-intensity movements are common among football players and are vulnerable to ankle sprains and functional ankle instability (FAI). This study aimed to determine the prevalence of FAI and assess the correlation with related factors among male football players in southwestern Saudi Arabia. Methods: A cross-sectional observational study was conducted among 364 male football players aged ≥18 years in southwestern Saudi Arabia. Participants completed the Arabic vers …

27.08.2026journal-article

Research Methods in Medicine & Health Sciences

Quantifying the state of the art: A random appraisal-weighted method for clinical evaluation under EU MDR

George Miller

Background The European Union Medical Device Regulation (EU MDR) requires manufacturers to establish quantitative, state of the art parameters for clinical evaluation. Because most available evidence is heterogeneous and uncontrolled, conventional meta-analytic methods provide limited support for deriving device level benchmarks. Methods A methodological framework was developed using synthetic datasets reflecting typical real-world evidence. Study means, variances and standard errors were combined using fixed effec …

27.08.2026journal-article

Statistics in Medicine

Forest Kernel Balancing Weights: Outcome‐Guided Features for Causal Inference

Andy A. Shen, Eli Ben‐Michael, Avi Feller, Luke Keele, Jared Murray

ABSTRACT While balancing covariates between groups is central for observational causal inference, selecting which features to balance remains a challenging problem. Kernel balancing is a promising approach that first estimates a kernel that captures similarity across units and then balances a (possibly low‐dimensional) summary of that kernel, indirectly learning important features to balance. In this paper, we propose forest kernel balancing , which leverages the underappreciated fact that tree‐based machine learni …

27.08.2026journal-article

Retina

Predictive factors for visual acuity and metamorphopsia after epiretinal membrane surgery

Navid Johannigmann-Malek, Karolin Deichl, Leonard Coulibaly, Mathias Maier, Peter Charbel Issa, FEBO, Niklas Wiederholt, Katharina Gabka, Katharina Kirchmair, Stephen B Kaye, Carmen Baumann

Purpose: To identify predictive parameters of best-corrected visual acuity (BCVA) and metamorphopsia following epiretinal membrane (ERM) surgery. Methods: In this prospective consecutive case series, BCVA, vertical (VM-score) and horizontal M-Charts scores (HM-score) were measured preoperatively and at 2, 6 and 12 months postoperatively. Optical coherence tomography (OCT) features analyzed included central subfoveal thickness (CSFT), ectopic inner foveal layer thickness (EIFLT), inner macular cysts (IMC), ellipsoid …

27.08.2026journal-article

Cancer Medicine

Adjusted Risk Stratification of Indeterminate Thyroid Nodules Using the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI‐RADS)

Jessica Zhao, Rita Abi‐Raad, Sara I. Pai, Jonathan Langdon, Minhua Wang, Guoping Cai, John Sinard, Adebowale J. Adeniran, Sanhong Yu

ABSTRACT Background The TI‐RADS guides the initial management of thyroid nodules, but the malignancy risk across different categories of cytologically indeterminate thyroid nodules (CITNs), particularly AUS and FN, remains unclear. Methods We reviewed thyroid FNA specimens diagnosed as AUS or FN with TI‐RADS scores of 3, 4, or 5 from 2017 to 2025. Clinical data, molecular results, and surgical outcomes were analyzed. Results A total of 919 CITNs were identified: 304 with TI‐RADS 3, 454 with TI‐RADS 4, and 161 with …

27.08.2026journal-article

EPISTEMUS

Hidrogeles biomédicos y su papel en la medicina del futuro.

Lady Mar Gastélum Rodríguez, Daniel Fernández-Quiroz, Ma. Araceli Correa-Murrieta, Paul Zavala-Rivera, Carmen Sarai Rochín Wong

Los hidrogeles biomédicos son alternativas para mejorar terapias donde los materiales convencionales presentan limitaciones de adaptabilidad, control de liberación y compatibilidad con los tejidos. Este artículo ofrece una visión general de su comportamiento, sus usos principales y los avances recientes que han ampliado su potencial clínico. La evidencia indica que la difusión es el mecanismo dominante en la liberación de fármacos, permitiendo mantener niveles terapéuticos estables. En el tratamiento de heridas, es …

27.08.2026journal-article

Journal of Human Hypertension

Antihypertensive treatment and adverse psychiatric reactions in primary health care

Emina Curic, Henrik Ohlsson, Kenneth Kendler, Jan Sundquist, Kristina Sundquist, Margareta Reis, Bengt Zöller

Abstract Antihypertensive treatment (AHT) has been associated with adverse psychiatric reactions (APRs), but existing data are conflicting. The aim of the present study was to determine the risk for seven different APRs in drug-naive patients with newly diagnosed hypertension in primary health care. This cohort study analyzed registry data of individuals aged 40–70 with a newly diagnosed untreated hypertension without previous psychiatric or cardiovascular comorbidities in Swedish primary healthcare from 2006 and o …

27.08.2026journal-article

Frontiers in Medicine

Endoscopic drainage and one-stage titanium clip closure for appendiceal root abscess mimicking cecal submucosal tumor: a case report

Yanping Dai, Yang Liu, Jun Ye

Periappendiceal abscess stands as a frequent complication stemming from acute appendicitis. One rare variant presents as a submucosal mass at the root of the appendix and cecum. Clinicians often misdiagnose this form at alarmingly high rates. Conventional management brings substantial surgical trauma. It also prolongs patients’ recovery periods. Whether minimally invasive endoscopic intervention works well for this distinct abscess subtype still lacks solid clinical proof. Whether minimally invasive endoscopic inte …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Group C Orthobunyavirus Infection in a Patient from the Amazon Putumayo Region of Colombia During an Oropouche Fever Epidemic

Sully Márquez, Lizeth Salazar, John Collins, Victoria Nipaz, Vanessa Dávila Campos, Jacob Van der Ende, J. Kenneth Wickiser, Thomas Briese, Josefina Coloma

ABSTRACT. Orthobunyaviruses, one of the largest and most diverse genera of viruses, include numerous reassortant viruses and present diagnostic challenges due to similar clinical presentations with other arboviral infections. The detection and isolation of a group C orthobunyavirus from a patient with acute febrile illness from Puerto Ospina, Putumayo Department, Colombia during the 2023–2024 Latin American Oropouche fever regional outbreaks are reported in the present study. Using a vertebrate virus-focused metage …

27.08.2026journal-article

BMC Medicine

Healthy lifestyle is associated with lower infection incidence in type 2 diabetes: A prospective cohort study with multi-omics mediation analysis

Mingming Li, Haojun Zhai, Xiaoqiu Dai, Juan Ye, Xiaoqi Ye, Yebei Liang, Siyu Chen

Abstract Background Individuals with type 2 diabetes mellitus (T2DM) are at substantially increased risk of infections, yet effective strategies for infection prevention remain limited. Although adherence to healthy lifestyles has been associated with lower infection risk in the general population, whether these benefits extend to individuals with T2DM remains unclear. Moreover, the association between the American Heart Association’s Life’s Essential 8 (LE8) metrics and infection risk has not been investigated. Th …

27.08.2026journal-article

Communications Medicine

Immune checkpoint molecules as biomarkers of Staphylococcus aureus bone infection and clinical outcome

Motoo Saito, Katya A. McDonald, Alex K. Grier, Himanshu Meghwani, Javier Rangel-Moreno, H. Mark Kenney, Enrique Becerril-Villanueva, Armando Gamboa-Dominguez, Jennifer Bruno, Christopher A. Beck, Richard A. Proctor, Stephen L. Kates, Edward M. Schwarz, Gowrishankar Muthukrishnan

Abstract Background Staphylococcus aureus prosthetic joint infections (PJIs) are broadly considered incurable, and clinical diagnostics that guide conservative vs. aggressive surgical treatments don’t exist. Understanding the human T cell response to chronic S. aureus osteomyelitis may lead to improved patient outcomes and inform new therapeutic strategies. Methods We performed multi-omics studies, including flow cytometry, scRNA-seq, and immunofluorescence in a humanized NSG-SGM3 BLT mouse model and with human cli …

27.08.2026journal-article

Journal of Clinical Oncology

Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS / BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial

Yu Sunakawa, Manabu Shiozawa, Takanori Watanabe, Hirofumi Ota, Hisateru Yasui, Taichi Yabuno, Mitsuyoshi Tei, Mitsugu Kochi, Dai Manaka, Hisatsugu Ohori, Tatsuro Yamaguchi, Tamotsu Sagawa, Masahito Kotaka, Yutaro Kubota, Takashi Sekikawa, Masato Nakamura, Masahiro Takeuchi, Wataru Ichikawa, Masashi Fujii, Akihito Tsuji

The randomized phase II DEEPER trial (jRCTs061180022) previously reported superior depth of response with modified 5-fluorouracil, leucovorin, oxaliplatin and irinotecan (m-FOLFOXIRI) plus cetuximab versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer (mCRC). Here, we report updated final survival outcomes and exploratory subgroup analyses focusing on RAS / BRAF wild-type and left-sided tumors. Final overall survival (OS) and progression-free survival (PFS) were analyzed in the per-protoco …

27.08.2026journal-article

Energies

Incipient Interturn Short-Circuit Fault Diagnosis of Permanent Magnet Motors Based on Multiscale Entropy and Topological Data Analysis

Zhaoyu Mao, Jien Ma, Shangke Li, Lin Qiu, Youtong Fang

Incipient stator interturn short-circuit faults in permanent magnet synchronous motors produce only weak changes in the terminal currents, which limits the sensitivity of conventional amplitude- and unbalance-based indicators. This paper proposes a phase-wise diagnostic framework that combines multiscale sample entropy (MSE), topological data analysis (TDA), and a Gaussian mixture model (GMM). For each three-period current window, ten scale-dependent sample-entropy components and two persistent-entropy components a …

27.08.2026journal-article

Journal of Occupational & Environmental Medicine

Mismatch Between Exposure Risk and Protection: Occupational Inequities in COVID-19 Prevention Among Field-Based Utility Workers in South Africa

Tanusha Singh, Patrick Zibaya

Objective: Field-based workers faced unique occupational risks during the COVID-19 pandemic. This study assessed occupational disparities in COVID-19 exposure, vaccination uptake, PPE adequacy and implementation of preventive measures among utility workers. Methods: A cross-sectional analytical study was conducted among 154 South African workers in a power distribution company. Data were collected using a questionnaire and analysed using multivariable logistic regression to estimate adjusted odds ratios. Results: T …

27.08.2026journal-article

Frontiers in Medicine

Dynamic analysis of 22 serum biomarkers following pneumothorax

Jirui Chen, Qiang Lyu, Cheng Wang, Qianyu Han, Yuanyuan Wang, Mingwei Jiang, Lei Xue, Yuxiang Jin

Background Pneumothorax is a common respiratory emergency. Current diagnosis primarily relies on imaging examinations, but these have insufficient sensitivity for early or occult cases, and there is a lack of highly specific molecular markers. Investigating the dynamic changes in serum biomarkers is of great significance for the early diagnosis and intervention of pneumothorax. Methods A rat pneumothorax model was established. Serum was collected before modeling and at 1, 2, 6, 12, 24, and 48 h after modeling. Usin …

27.08.2026journal-article

BMC Surgery

Outpatient Total Extraperitoneal (TEP) for inguinal hernia repair following federal German outpatient operation procedure reform: a preliminary single-center descriptive study of same-day discharge, unplanned admission, and patient-reported outcomes

Julia Michel, Krzysztof Nowakowski, Fabian Nimczewski, Jens Hoeppner, Zsolt Madarasz

Abstract Background Outpatient hernia repair is becoming increasingly important, particularly with the adoption of minimally invasive techniques such as total extraperitoneal repair (TEP). Following the 2022 reform of the federal German outpatient operation procedure (AOP) catalog, our institution implemented a planned outpatient TEP pathway for selected patients with unilateral inguinal hernia. Methods This preliminary retrospective single-center study included a core cohort of 108 patients who were successfully d …

27.08.2026journal-article

PLOS Medicine

Adherence to smartphone-delivered antimicrobial prescribing guidelines in hospitals in Lao PDR: A stepped-wedge cluster randomized controlled trial

Vilada Chansamouth, Danoy Chommanam, Sue J. Lee, Susath Vongphachanh, Manivanh Vongsouvath, Sommay Keomany, Viladeth Paphasiri, Chanthala Phamisith, Siho Sengsavang, Phouvieng Douangdala, Khamsay Detleuxay, Sommana Rattana, Bandith Soumphonphakdy, Valy Keoluangkhot, Mavuto Mukaka, Nicholas P. J. Day, H. Rogier van Doorn, Paul Turner, Mayfong Mayxay, Paul N. Newton, Elizabeth A. Ashley

Background Prescribing guidelines are a cornerstone of antimicrobial stewardship programs. Smartphone applications can increase access in low-and middle-income countries (LMICs). Following the release of the Lao national antimicrobial prescribing guidelines in 2021, this trial compared adherence to these guidelines delivered by a smartphone application versus the paper-based version among hospitalized patients and outpatients in six hospitals in Laos. Methods and findings An open cohort stepped-wedge cluster random …

27.08.2026journal-article

Frontiers in Nutrition

Farming as food as medicine in Tanzania: reviving traditional knowledge for health, nutrition, and sustainability

Leonard R. Ndibalema, Joseph Kalonga

Tanzania faces a complex nutrition and public health challenge characterized by persistent undernutrition, micronutrient deficiencies, and an increasing burden of diet-related non-communicable diseases. At the same time, traditional farming systems that historically supplied diverse, nutrient-dense foods are being weakened by urbanization, climate variability, market pressures, and dietary transitions. This narrative review examines farming as food as medicine in Tanzania by synthesizing literature on indigenous cr …

27.08.2026journal-article

Haematologica

Treatment for relapsed pediatric acute myeloid leukemia: variability and comparative effectiveness of current approaches to re-induction

Caitlin W. Elgarten, Lei Wang, Yimei Li, Alix E. Seif, Regina M. Myers, Daniel J. Zheng, Kira Bona, Emi H. Caywood, Taumoha Ghosh, M. Monica Gramatges, Meret Henry, Tamara P. Miller, Arunkumar Modi, Rajen Mody, Caroline Smith, Jamie Stokke, Naomi Winick, Jennifer J. Wilkes, Victor Wong, Brian T. Fisher, Kelly D. Getz, Richard Aplenc

Post-relapse survival of pediatric acute myeloid leukemia (AML) remains poor and there is a paucity of data to inform relapse regimen selection. We sought to describe the treatment landscape for first AML relapse and compare effectiveness of prevalent salvage regimens. To do this, we conducted a retrospective cohort study using the REAL-AML dataset including pediatric patients with first relapse of AML treated at 13 US pediatric institutions from 2011–2023. Primary analyses compared overall survival (OS) by regimen …