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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Cancers

Mechanism-Driven Evolution of Fertility-Sparing Treatment and Precision Management of Special Populations in Endometrial Cancer: A Review

Kai-Bing Qu, Chun-Lin Pan, Ming-Yue Zhang, Zhuo-Ying Du, Sheng-Qian Wang, Shu-Li Yang, Yu-Mei Wu, Jian-Dong Wang, Yue He

Endometrial cancer is increasingly diagnosed in patients who have not yet completed childbearing. For carefully selected patients with grade 1 endometrioid endometrial carcinoma confined to the endometrium, fertility-sparing treatment (FST) can preserve reproductive potential but requires rigorous histologic surveillance. In eligible patients, oral progestins and/or the levonorgestrel-releasing intrauterine system (LNG-IUS) remain the mainstay of fertility-sparing treatment, with hysteroscopic lesion resection inco …

24.08.2026journal-article

Journal of Orthopedic and Spine Trauma

Treatment and Outcomes of Radial Head and Neck Fractures with the "Tripod Technique": A Case Series

Mohammad Ali Okhovatpour, Atousa Jelvani, Parviz Ahangar, Reza Zandi

Background: Fractures of the radial head and neck are the most common elbow fractures, which can cause elbow dysfunction and reduced quality of life (QOL). The "tripod technique" is a new, less invasive method for fixing these fractures. The objective of this study was to assess the functional outcomes of tripod technique for treatment of radial head and neck fractures. Methods: This case series was performed on eight patients with radial head and neck fractures who were admitted to Taleghani Hospital in Tehran Cit …

24.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Expanding the phenotype of hereditary renal cell carcinoma syndromes: Implications for surveillance and management

Maria I Carlo, Andrew Schroeder, Jie Liu, Vignesh Ravichandran, Nikita Mehta, Yelena Kemel, Grace Zong, Ying Liu, Alicia Latham, Neil Shah, Darren Feldman, Martin H Voss, Ritesh Kotecha, Zsofia K Stadler, Mark E Robson, Miika Mehine, Chaitanya Bandlamudi, Michael F Berger, Yingbei Chen, Diana Mandelker, Kelly Bolton, Semanti Mukherjee, Kenneth Offit, Robert Motzer

Abstract Background Approximately 5% of renal cell carcinoma (RCC) occurs in the setting of a hereditary RCC syndrome, but accurate phenotype and cancer risk estimates remain limited by ascertainment bias in reported series. Methods We analyzed 32,728 cancer patients who underwent paired tumor-normal sequencing with MSK-IMPACT for germline pathogenic variants (PVs) in RCC hereditary syndrome genes VHL, FLCN, BAP1, MET, SDHB, FH, and proposed RCC risk variants MITF E318K and FH K477dup. We integrated clinical, tumor …

24.08.2026journal-article

Frontiers in Oncology

Adenosine signaling in tumor immune escape: metabolic checkpoints, myeloid suppression, and combination immunotherapy

Rui Li, Shengbiao Li, Tongtong Zhang

Adenosine is a central metabolic regulator of tumor immune escape, shaping the tumor microenvironment (TME) through suppression of effector lymphocytes and reprogramming of myeloid populations. Extracellular adenosine is generated primarily via the ectonucleotidases CD39 and CD73 and signals through A2A (A2AR) and A2B (A2BR) receptors on T cells, NK cells, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and dendritic cells. This pathway promotes T-cell exhaustion, inhibits cytotoxicit …

24.08.2026journal-article

Frontiers in Oncology

Role of health digital twins in oncology drug development - a primer

Maria Garcia Requesens, Arun K. Mankan, Luca Cantini, Marco Calabresi, Laura Vidal, Joan Brown, Steven Lang, Bobby Kaura, Kirill Veselkov, Ioannis Xenarios, Kamal S. Saini

Health Digital Twins (HDTs) have attracted increasing interest as a potential tool for improving both patient care and clinical research, particularly in oncology where clinical trials remain slow, costly, and operationally complex. This primer introduces the concept of digital twins in a form accessible to professionals involved in oncology clinical research and outlines the main components of health digital twins, describes how these systems are generated, and highlights their potential relevance to oncology tria …

24.08.2026journal-article

Current Opinion in Obstetrics & Gynecology

Evaluation of vaginitis and its treatment

Sara A. McKinney, Erin A. Gross

Purpose of review Vaginitis is one of the most common reasons a patient will present for care in both the ambulatory and urgent care settings. The objective of this review is to summarize traditional methods of evaluation and treatment for the most commonly seen vaginitis and vaginosis, but also to present updated literature and future management directions for this common and sometimes resilient medical problem. Recent findings A randomized controlled trial of partners in monogamous heterosexual relationships and …

24.08.2026journal-article

Journal of Endovascular Therapy

A Multicentre Experience of Inner-Branched Endovascular Aneurysm Repair for Treatment of Type Ia Endoleak After EVAR

Rens Jorn Oosterveld, Arjan W. J. Hoksbergen, Chrissy van Wely, Mathieu Lacquet, Lee H. Bouwman, Ozan Yazar

Purpose: To evaluate the outcomes of inner-branched endovascular aneurysm repair (iBEVAR) for the treatment of type Ia endoleak after infrarenal endovascular aneurysm repair (EVAR). Materials and Methods: This multicentre study retrospectively analyzed all consecutive patients who underwent elective revision using iBEVAR for type Ia endoleak after previous infrarenal EVAR. The primary outcome was technical success, and the secondary outcome was clinical success at 30 days. Outcomes during further follow-up were mor …

24.08.2026journal-article

International Journal of Surgery Case Reports

Treatment of tunica albuginea defect using double-breasted corporoplasty (Alei’s technique) and small intestinal submucosa graft

Sara Lagioni, Ioana Alexandra Iachimovsky, Michele Rizzo, Tommaso Cai, Alessandro Zucchi, Giovanni Liguori

Introduction and importance: An isolated, spontaneous defect of the tunica albuginea is an exceptionally rare condition characterized by localized thinning of its layers and herniation of cavernous tissue. Given the very limited number of reported cases and the absence of standardized management, each report contributes valuable insights into diagnostic and surgical strategies. This case highlights a reconstructive approach aimed at preserving both functional and cosmetic outcomes. Case presentation: A 26-year-old …

24.08.2026journal-article

Cells

A Proposed Microneedle–Small Extracellular Vesicle System for Localized Adjunctive Treatment of Established Oral Squamous Cell Carcinoma: A Narrative Review and Preclinical Development Perspective

Hai He, Zishuai Chen, Hengxiang Liu, Xiaohua Zhang, Zhiqiang Li, Heqiang Yang, Xiaoyong Chen, Yufei Yang, Zifan Wang

Established oral squamous cell carcinoma (OSCC) remains constrained by local recurrence, inadequate lesion exposure, systemic toxicity, and therapy resistance. This narrative review evaluates a proposed microneedle–small extracellular vesicle (sEV) system for localized adjunctive treatment in three preclinical contexts: postoperative residual-disease control, local immunomodulation/checkpoint combination, and chemoradiotherapy sensitization. Direct evidence for the combined microneedle–sEV system in OSCC is not yet …

24.08.2026journal-article

Frontiers in Oncology

Comorbidity patterns and risk of breast cancer: a case–control study exploring interaction with BMI using latent class analysis

Yaling Zhang, Bei Zhao, Xinchun Zhang, Na Cui, Lanhua Wu, Ling Chen

Background Most studies to date have examined individual comorbidities in relation to breast cancer risk but have largely ignored that these conditions often cluster in the same person. Looking at comorbidity patterns rather than isolated diseases may therefore offer a better understanding of breast cancer risk. Methods In this case–control study, latent class analysis (LCA) was performed in the pooled case–control sample based on 10 comorbidities/conditions, including diabetes mellitus, hypertension, coronary hear …

24.08.2026journal-article

Frontiers in Oncology

18F-FDG PET/CT metabolic network connectivity in clinical staging of diffuse large B-cell lymphoma

Jinhai Zou, Han Zou, Chang Liu, Chen Liang, Yufei Liang, Meiyu Zheng, Chunying Li

Introduction Diffuse large B-cell lymphoma (DLBCL) is the most common and highly heterogeneous subtype of non-Hodgkin lymphoma, and accurate staging is essential for treatment planning and prognosis. This study explored the value of 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) metabolic network connectivity for the clinical staging of DLBCL. Methods Forty-two previously untreated patients (23 males, 19 females; aged 30-82 years) diagnosed as de novo DLBCL, not ot …

24.08.2026journal-article

Frontiers in Pharmacology

Dual MAO A and HSP90 inhibitors enhance anti-PD-1 therapy and suppress colorectal cancer

Hui-Ju Tseng, Yueh-Lin Wu, Yan-Ling Chen, Chien-Hua Wang, Suddhasatwa Banerjee, Jing-Ping Liou

Introduction Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, yet their efficacy remains limited by tumor resistance, immune-related adverse events, and poor response in microsatellite stable colorectal cancer (CRC). To address these challenges, dual monoamine oxidase A (MAO-A) and heat shock protein 90 (HSP90) inhibitors, MPT1B098 and MPT1B099, were developed and evaluated for their therapeutic potential and immune-modulatory efficacy in CRC. Methods Human and murine CRC cell lines were trea …

24.08.2026journal-article

BMC Medicine

Associations of CLivD score with dementia, cardiovascular disease, cancer, and mortality in the general population from the UK biobank

Guozhe Sun, Jie Chen, Hongmei Yang, Caiyu Zhang, Chenhua He, Ying Zhou, Lin Guan, Shiyu Zhou, Yao Yu, Jun Wang, Xiangyu Tan, Yangzhi Yin, Ziyi Xie, Wei Miao, Wenhang Li, Yifei Chen, Xiaoxuan Tian, Tianhao Li, Xiaobing Zhou, Mengling Lu, Guangxiao Li, Xiaofan Guo

Abstract Background The Chronic Liver Disease (CLivD) score is a non-invasive marker of advanced liver disease risk. We evaluated its associations with dementia, cardiovascular disease (CVD), cancer, and all-cause mortality. Methods This prospective cohort study included UK Biobank participants with calculable CLivD scores at baseline (2006–2010). Two previously validated versions of the score were calculated: a laboratory-based CLivD (CLivD lab ), incorporating age, sex, waist-hip ratio, alcohol consumption, diabe …

24.08.2026journal-article

Discovery Medicine

Integrative Transcriptomic Analysis Identifies Glycolysis/Ferroptosis-Associated Candidate Genes in Gastric Cancer

Yongting Lan, Xin Zhou, Yongfen Ma, Jingmei Cao

Background: The crosstalk between glycolysis, ferroptosis and the gastric cancer (GC) immune microenvironment remains poorly defined. This study aims to uncover glycolysis/ferroptosis-related regulators of the GC immune microenvironment.Methods: Transcriptomic datasets from The Cancer Genome Atlas (TCGA)-Stomach adenocarcinoma (TCGA-STAD) and Gene Expression Omnibus (GEO) were integrated to screen glycolysis/ferroptosis-related differentially expressed genes (DEGs). We evaluated univariate prognostic associations o …

24.08.2026journal-article

Cancer Immunology, Immunotherapy

A phase 1 study of VAC85135, a neoantigen vaccine regimen targeting calreticulin and JAK2 mutations, in combination with ipilimumab in patients with myeloproliferative neoplasms

Salman Otoukesh, Bethan Psaila, Andrew Kuykendall, Aaron T. Gerds, Ahmed Abdulgawad, Prithviraj Bose, Charlotte Van Bogaert, Jennifer Bishop, Patrick Wilkinson, Baolian Liu, Tianxiang Kevin Han, Busola Sanusi, Jaymala Patel, Katelyn D. Miller, Denis Smirnov, John T. Loffredo, M. Alejandro Sepulveda, Ricardo Attar, Kim Staquet, Charles G. Drake, Nikki Daskalakis, Claire Harrison

Abstract Disease-specific somatic mutations (mut) in calreticulin ( CALR ) and JAK2 ( JAK2V617F ) are drivers of myeloproliferative neoplasms (MPNs), causing generation of immunogenic peptide epitopes hypothesized to be vaccine-targetable neoantigens. VAC85135, a heterologous prime-boost vaccine regimen comprising adenoviral and vaccinia vectors encoding polypeptides specific to mutCALR and JAK2V617F , concurrent with anti-CTLA-4, ipilimumab, was investigated in a phase 1 study. Fourteen (myelofibrosis [MF], n = 10 …

24.08.2026journal-article

Hormone Research in Paediatrics

Failure to thrive (FTT) in infants with Prader-Willi syndrome and long-term effects of GH-treatment on FTT

Demi J. Trueba-Timmermans, Gerthe F. Kerkhof, Lionne N. Grootjen, Edmond H.H.M. Rings, Anita C.S. Hokken-Koelega

Context: Failure to thrive (FTT) with feeding difficulties and hypotonia are well-known features in infants with Prader-Willi syndrome (PWS). Limited studies reported the percentage of infants with FTT and it is unknown whether growth hormone (GH)-treatment affects body composition of infants with or without FTT differently. Objective: To evaluate the percentage of infants with PWS with FTT from birth to age 6 months and to investigate the 5-year GH effects on body composition in infants with or without FTT at GH-s …

24.08.2026journal-article

Endocrine-Related Cancer

Tumor-infiltrating lymphocytes differ across MammaPrint® classifications in breast cancer

Carmen Ariño-Palao, Irene Carretero-Barrio, Sara Martos-Meléndez, Tamara Caniego-Casas, Marta Rosas, Noelia Martínez-Jañez, María Fernández-Abad, María Concepción Sánchez, Teresa Presa-Abos, Javier Zamora, Juan Martínez-Aedo Castro, María J Ledesma-Carbayo, José Palacios, Belén Pérez- Mies

Abstract MammaPrint® refines risk stratification in early oestrogen receptor-positive, HER2-negative breast cancer, evolving from a binary to a four-tier classification (UltraLow, Low, High-Risk1, High-Risk2). The relationship between routine histopathological features, immune infiltration and genomic risk within this framework remains incompletely characterised in luminal disease. We retrospectively analysed 492 luminal breast carcinomas with available MammaPrint® results. Clinicopathological variables (including …

24.08.2026journal-article

Frontiers in Medicine

Family history of cancer and risk of lung cancer: a retrospective cohort study in a Chinese population

Hongjun Song, Xinlu Men, Jun Cheng, Liangliang Zhang, Shuang Zhao

Background Family history of cancer is an established risk factor for lung cancer, but its association with the probability of malignancy among patients evaluated for pulmonary nodules—rather than with population-level lung cancer incidence—remains poorly characterized in Chinese populations. Methods We conducted a retrospective cohort study of 3,850 consecutive patients evaluated for pulmonary nodules at a tertiary teaching hospital between January 2018 and December 2021, of whom 1,257 (32.6%) underwent surgical r …

24.08.2026journal-article

Frontiers in Oncology

KRAS mutations as architects of the tumor immune microenvironment: implications for combination therapies

Vasudevan Ramachandran, Haily Liduin Koyou, Siddarth Raajasekar, Mohd Hazmi Bin Mohamed, Liyana Najwa Binti Inche Mat, Venkataramanan Swaminathan, Mohd Nazil Salleh, Muhammad Evy Prastiyanto, Nurul Aini Binti Ahmad

Oncogenic KRAS mutations rank among the most prevalent driver alterations in human malignancies, reaching near-universal frequency (~98%) in pancreatic ductal adenocarcinoma (PDAC) and high prevalence in colorectal cancer (CRC, ~52%) and lung adenocarcinoma (LAC, ~32%). Beyond their canonical roles in promoting cell-intrinsic proliferation and survival through the MAPK/ERK and PI3K/AKT cascades, KRAS mutations actively sculpt a profoundly immunosuppressive tumor microenvironment (TME), which constitutes a major bar …

24.08.2026journal-article

Gaceta Científica

Inequidades territoriales en la mortalidad por cáncer y gestión sanitaria en Huánuco, Perú

César López Godoy, Paulo César López Barrientos, Carmen Rosa Caballero Castillo, Karin Estacio Laguna, Nelly Adela Hilario Porras, David Chi-Hon León Chiang, Ana María Soto Rueda

Objective: To analyze territorial inequalities in mortality from cervical, gastric, and colorectal cancer in the provinces of the Department of Huanuco, Peru, and their relevance to territorial sanitary management. Materials and methods: A cross-sectional ecological study was conducted across the 11 provinces of Huanuco during the 2018–2023 period. Mortality records from the National Death Information System and population projections from the National Institute of Statistics and Informatics were used. Mortality ra …

24.08.2026journal-article

Selcuk Dental Journal

Multidisciplinary Management of Eagle Syndrome: From Diagnosis to Treatment

İremnur Sambur, Hilal Peker Öztürk

AbstractBackground:Eagle syndrome is a rare clinical entity characterized by a wide spectrum of symptoms, most commonly orofacial pain, dysphagia, and cervical discomfort. These symptoms result from compression and irritation of adjacent neurovascular and soft tissue structures caused by elongation and/or calcification of the styloid process. Despite the importance of a detailed medical history, careful clinical examination, and appropriate imaging modalities, the variability and nonspecific nature of clinical find …

24.08.2026journal-article

Frontiers in Microbiology

Therapeutic regulation of gut microbiota in gastric cancer: mechanisms, strategies, and clinical prospects

Zicheng Liu, Mingyue Bai, lichao Han, Zeguang Li

Gastric cancer (GC) is a highly prevalent malignancy associated with substantial mortality worldwide. Dysbiosis of the gut microbiota is closely linked to the pathogenesis, clinical characteristics, and therapeutic responses of GC, making it a central focus of research in the field of tumor microecology. However, existing reviews mainly focus on microbial compositional features, individual mechanisms, or specific microbiota-based interventions, while lacking an integrated theoretical framework that incorporates Hel …

24.08.2026journal-article

International Journal of Science, Strategic Management and Technology

Breast Cancer Classification in Ultrasound Images Using Two-Phase EfficientNetB7 Transfer Learning

Madishetti Kavya, Dr.G. Thirupati

Breast cancer is a leading cause of cancer morbidity and mortality among women globally, emphasizing the need for accurate and timely diagnostic methods. A systematic but innovative two phases transfer learning based deep learning classification framework is developed using popular EfficientNetB7 architecture architecture for breast cancer classification. Breast ultrasound imaging proves a high degree of complexity to extract features with limited available medical datasets to address it and the proposed methodolog …

24.08.2026journal-article

Discover Public Health

Current policies and practices for testing and treatment of chronic hepatitis B and C infection in high-burden countries in the WHO European region

Machiko Otani, Marcelo Contardo Moscoso Naveira, Stela Bivol

Abstract Chronic hepatitis B and C remain major public health concerns in the WHO European Region, with an estimated 10.6 million people living with HBV and 7.7 million with HCV in 2022. Despite this burden, diagnosis and treatment coverage remain low, challenging progress toward the 2030 elimination goal. To map national policies and reported service availability for hepatitis testing and treatment. , the WHO Regional Office for Europe surveyed nine high-burden countries, receiving responses from eight: Armenia, A …