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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
17.08.2026journal-article

Multiple Sclerosis Journal

Automated speech analysis reveals progressive linguistic changes associated with subsequent gray matter loss in multiple sclerosis

Martin Šubert, Tereza Tykalová, Michal Novotný, Barbora Srpová, Jiří Motýl, Jan Krásenský, Matěj Kudrna, Manuela Vaněčková, Dana Horáková, Tomáš Uher, Jan Rusz

Background: The utility of high-level linguistic analysis for longitudinal monitoring of multiple sclerosis (MS) and its relationship with progressive brain volume loss remains largely unexplored. Objective: To characterize longitudinal changes in lexical and syntactic features in MS and determine whether linguistic alterations are associated with subsequent brain volume loss. Methods: Ninety-seven patients with MS and 80 age- and sex-matched healthy controls completed story narration tasks at baseline and 2-year f …

17.08.2026journal-article

Pediatrics

Early Antiviral Therapy in Pediatric Outpatients and Risk of Influenza-Related Hospitalization

Ya-Ning Huang, Chia-Jung Chang, Yu-Ling Dai, Yen-Hsin Kung, Ching-Ying Huang, Daniel Tsung-Ning Huang, Chien-Yu Lin, Lung Chang, Wan-Yu Lin, Luan-Yin Chang, Chi-Tai Fang, Hsin Chi, Nan-Chang Chiu, Fu-Yuan Huang

OBJECTIVES Evidence on the effectiveness of antiviral therapy in preventing influenza-related severe illness and hospitalization among children remains limited. We hypothesized that early administration of antiviral therapy within 48 hours of symptom onset would significantly reduce the risk of subsequent influenza-related severe illness and hospitalization. METHODS This multicenter, age- and season-matched, retrospective case-control study included all pediatric outpatients with laboratory-confirmed influenza who …

17.08.2026journal-article

Cells

A Novel Chorioallantoic Membrane (CAM) Setup to Investigate Angiogenic Effects of Extracorporeal Shock Wave Therapy (ESWT)

Lorenz Faihs, Jonas Flatscher, Cyrill Slezak, Bardia Firouz, Nassim Ghaffari Tabrizi-Wizsy, Kurt Schicho, Paul Slezak, Peter Dungel

Extracorporeal shock wave therapy (ESWT) is a well-known biophysical therapy that offers several beneficial effects, including a presumed increase in the growth of blood vessels. The chorioallantoic membrane (CAM) assay is a well-established in vivo model for studying angiogenesis. The aim of this study was to develop an experimental setup to apply ESWT to CAM in a three-step process and investigate the vascular response. First, we conducted virtual simulations of various shock-wave application setups to CAM and su …

17.08.2026journal-article

Frontiers in Psychology

Sustaining physical activity following participation in a joint pain exercise and education rehabilitation programme; a qualitative longitudinal study

Panayiotis Michael, Sheree A. McCormick, Jenny Alexanders, Aidan Quinn Innes, Amy Elizabeth Harwood, Francis Fatoye, Patrick Doherty, Nigel Timothy Cable, Davina Deniszczyc, Gillian Yeowell

Background Musculoskeletal conditions are leading contributors to global disability and place a significant economic burden on health systems. Optimal physical activity is a key recommended strategy for managing musculoskeletal conditions, yet many individuals struggle to sustain activity levels following the completion of exercise rehabilitation programmes. Identifying and understanding the factors that influence sustained physical activity may aid intervention design and benefit future patients. The aim of the st …

17.08.2026journal-article

World Journal of Otorhinolaryngology - Head and Neck Surgery

Speech Recognition Deficits in Presbyacusis: Links to Cortical Structural and Functional Alterations

Xiao‐Qian Ren, Lan Lan, Xiao‐Long Li, Xiang‐Bing Bian, Jin Li, Lan Yu, Dan‐Yang Li, Xin Lou, Qiu‐Ju Wang

ABSTRACT Objective To characterize speech recognition in presbyacusis and its associated neurophysiological and cortical structural features, and to explore structure‐function‐behavior relationships within the presbyacusis phenotype. Methods Thirty elderly patients with presbyacusis(HI) and thirty‐three healthy young controls(NH) completed a behavioral task involving Putonghua monosyllabic word recognition. Additionally, mismatch negativity (MMN) responses using the oddball paradigm to assess neurophysiological sen …

17.08.2026journal-article

Journal of Public Health and Primary Care

Tuberculosis Preventive Therapy in the Era of Primary Drug Resistance: A Primum Non Nocere Reappraisal

Sunil Kumar Raina

Abstract The assumption that anti-TB drugs function purely as bactericidal agents, with immune function as a passive benefit, reflects neither the known pharmacology of these compounds nor the dynamic biology of the latent state. Together, these realities invoke the oldest and most fundamental principle of medical ethics: primum non nocere; first, do no harm. It is the argument of this paper that TPT, as currently deployed in high-resistance settings, may, in a biologically definable and clinically significant subs …

17.08.2026journal-article

Russian Journal of Skin and Venereal Diseases

Skin Microbiome in Hidradenitis Suppurativa: Current Concepts and Perspectives of Personalized Therapy

S. Alferova, Natalia P. Teplyuk, Nune O. Vartanova, Elena O. Kravtsova, Oxana A. Svitich, E. Chelobanova

Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disease characterized by the formation of painful inflammatory nodules, abscesses, infiltrates, and sinus tracts, predominantly affecting intertriginous areas, including the axillary, inguinal, and anogenital regions. The disease is associated with a marked impairment in patients’ quality of life, chronic pain syndrome, the development of scarring, and frequently leads to significant social and psychological maladaptation. Despite substantial p …

17.08.2026journal-article

American Journal of Physiology-Cell Physiology

Combination therapy of RAS inhibition and glucagon-like peptide-1 receptor agonist improves a marker of kidney fibrosis in people with type 2 diabetes

Alexandra L. Møller, Stefanie Thöni, Felix Keller, Samir Sharifli, Federica Genovese, Morten Karsdal, Daniel G. K. Rasmussen, Gert Mayer

In type 2 diabetes (T2D), kidney fibrosis drives the progression of chronic kidney disease (CKD) and kidney failure. Lower urinary levels of collagen type III degradation (C3M), a biomarker of extracellular matrix (ECM) turnover, have been associated with CKD progression. We investigated the effect of combination therapy with renin-angiotensin system inhibition (RASi) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) on urinary C3M levels in people with T2D. Urinary C3M was measured using the nordicC3M™ ELISA …

17.08.2026journal-article

National Science Review

Muco-infiltrating prodrug coacervates with prolonged colonic retention enhance IBD-associated depression therapy

Fengming Tan, Bo Yi, Lizhi Wang, Kaixin Guan, Jinhong Qin, Mingxin Lin, Weitong Huang, Sirong Chen, Xiayi Xu, Pengchao Zhao, Liming Bian

Abstract Oral delivery of small-molecule drugs to the distal intestine is often hindered by short colonic retention, a key requirement for ensuring sustained colonic drug availability. Herein, we developed a library of minimalist, muco-infiltrating prodrug coacervates by exploiting the interfacial physics of liquid–liquid phase separation (LLPS). By systematically tuning the length of poly(ethylene glycol) (PEG) spacer and the hydrophobicity of drug stickers in PEG–drug conjugates, we precisely modulated the molecu …

17.08.2026journal-article

Teaching and Learning in Communication Sciences & Disorders

Targeted Interprofessional Education (IPE) Curriculum for First-Year Speech-Language Pathology (SLP) Graduate Students

Cody Marie Busch

ASHA requires that SLP graduate programs facilitate opportunities for interprofessional collaborative practice (IPCP). Research suggests that IPCP initiatives should be integrated throughout the curriculum, rather than isolated interprofessional education (IPE) experiences. 15 first-year SLP graduate students participated in a year-long IPE curriculum focused on the IPEC Core Competencies. Quantitative and qualitative data revealed improved perception of IPCP and appreciation of opportunities to interact with other …

17.08.2026journal-article

Journal of Civil, Construction and Environmental Engineering

Comparison of Field Tests and Methods of Rehabilitation for Flexible and Rigid Pavement Infrastructures in Egypt and Saudi Arabia: A Comprehensive Review

Mostafa Hassan

Roads are a vital infrastructure that links cities and countries and facilitates trade between countries. The impact of severe climate change is increasing significantly all over the world and influences its effect on vital roads with respect to changes in temperature that induce significant thermal stresses, relative humidity, and extreme floods these days. Different mix designs, field tests, and materials utilized for flexible (Asphalt) and rigid pavement (Concrete) in Egypt and Saudi Arabia will be discussed in …

17.08.2026journal-article

Journal of Applied Microbiology

Evaluation of Sequential Phage-Antibiotic Therapy Reveals Enhanced Biofilm Control with Meropenem and Colistin in Clinical MDR Hypervirulent Klebsiella pneumoniae Strain

Ramya Juliet, Madhumathi Irulappan, Balaji Veeraraghavan, Ramesh Nachimuthu

Abstract Aims The convergence of multidrug resistance and hypervirulence in Klebsiella pneumoniae (MDR-HvKp) has narrowed treatment options. Despite growing interest in phage-antibiotic synergy (PAS), this study evaluates the underexplored combinatorial effects of phage and antibiotics, including drug-specific interactions and sequence dependency, against the biofilm-forming MDR-HvKp clinical strain. Methods and Results A T5-like Klebsiella bacteriophage, Round, within the genus Webervirus, was therapeutically and …

17.08.2026journal-article

Journal of Oral Rehabilitation

Eccentric Occlusal Loads Remodel the Dentoalveolar and Temporomandibular Biomechanical Unit in Rats

Haochen Ci, Umama Ali, Zhiyuan Yang, Ayush Bakandi, Nhu Huynh, Christine Nguyen, Brandon Lee, Youngho Seo, Robert Flavell, Alireza Hatamifar, Rishi J. Gupta, Rebeka Silva, Yongmei Wang, Bo Wang, Sunita P. Ho

ABSTRACT Background Altered occlusal mechanics are critical regulators of the structure and function of the dentoalveolar and temporomandibular joints (DAJ, TMJ); however, the multiscale biological and mechanical consequences of sustained occlusal rise on the TMJ are not understood. Objective This study establishes a proof‐of‐concept for using an occlusal rise (OR) to investigate how the resulting chronic eccentric loading influences the DAJ and TMJ across mechanical, structural, and metabolic domains. Methods Rats …

17.08.2026journal-article

PLOS One

Occupational safety and health risks among plumbers: A qualitative study of workplace hazards, safety practices, and system-level gaps in Texas

Mary Conger, Avishek Choudhury

Background The plumbing trade exposes workers to ongoing workplace hazards that pose significant health risks. This issue is well known but remains unresolved. A key question remains: why have current safety measures, such as training programs, regulatory standards, and personal protective equipment (PPE) requirements, failed to reduce injury rates or significantly improve safety in the plumbing field. Objectives Despite well-documented hazards in plumbing work, qualitative research examining why existing safety me …

17.08.2026journal-article

Frontiers in Psychology

Psychometric refinement and validation of the Entrepreneurial Personality Inventory across distinct occupational groups

Mariela Pavalache-Ilie, Ana-Maria Cazan, Camelia Truța, Denisa Elena Tomulescu, Marcela Rodica Luca

Introduction Entrepreneurial personality is associated with entrepreneurial intention and business-related behavior, yet existing measures remain fragmented and insufficiently validated across occupational groups. The present study aimed to psychometrically refine and validate the Entrepreneurial Personality Inventory (EPI) across distinct occupational groups. Methods The study included 897 Romanian participants distributed across four groups: students enrolled in entrepreneurial education programs, matched student …

17.08.2026journal-article

Hong Kong Physiotherapy Journal

Effects of robotic glove-assisted task-oriented mirror therapy on hand motor function in sub-acute stroke patients: Randomised controlled trial

Abdul Rehman, Furqan Ahmed Siddiqi, Saman Shaukat

Background: The incidence of stroke has increased globally, leading to mortality and disability. Approximately 30–66% of stroke survivors are unable to regain motor functions in the affected hand throughout their lives, which significantly impacts their functionality and daily activities. Objective: This study aimed to determine the effects of robotic glove-assisted task-oriented mirror therapy in comparison with task-oriented mirror therapy on the motor functions of the hand in sub-acute stroke. Methods: This was …

17.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Factors affecting job stress among health workers and support staff: A case study of an affiliated private hospital in Thailand

Sanpatchaya Sirisawasd, Darika Wortong, Chakrapan Wisedsammapan, Chalobon Treesak, Paiboon Eksaengsri, Dhanoo Lawbundis, Rachata Lumkul

Background Managing an affiliated private hospital through various hospital groups in Thailand may increase job stress among health workers and support staff. Objectives To determine the prevalence and identify the factors affecting job stress among 2242 health workers and support staff in an affiliated private hospital in Thailand. Methods This cross-sectional analytical study included, via convenience sampling, health workers and support staff who worked at seven hospitals of an affiliated private hospital locate …

17.08.2026journal-article

Per Musi

Análisis del impacto de técnicas musicoterapéuticas en el bienestar emocional, calidad de vida y ansiedad de alumnos de un Conservatorio Profesional de Música

Mayte Sancho Herreros, Manuel Sequera Martín, Vicente Alejandro March Luján

La ansiedad escénica constituye una problemática prevalente entre estudiantes de conservatorios profesionales de música, afectando significativamente su rendimiento y bienestar emocional. El presente estudio analiza el impacto de técnicas musicoterapéuticas en el bienestar emocional, calidad de vida y ansiedad de 39 alumnos de un Conservatorio Profesional de Música mediante un diseño cuasi experimental. Los participantes se distribuyeron en grupo experimental (19 estudiantes) que recibió intervención musicoterapéut …

17.08.2026journal-article

Journal of Rational-Emotive & Cognitive-Behavior Therapy

Appraisals and Positive Irrational Beliefs in Dysfunctional Positive Feelings: Appraisal Vulnerabilities for Positive Emotion Disturbance

Marius Drugaș, Alexandru Tiba, Simona Trip, Bogdan Vlad

Abstract Positive emotion disturbance (PED) - high-arousal, high-intensity dysfunctional positive emotions - is thought to play a key role in bipolar disorder (BD). Yet its underlying cognitive processes remain poorly understood. In two samples, we explore whether rigid and extreme positive appraisals such as positive irrational beliefs (PIBs) function as emotion-specific appraisals associated with dysfunctional positive emotions beyond domain-general appraisals. In Study 1 ( N = 120), we demonstrate that domain-ge …

17.08.2026journal-article

Physiotherapy Research International

Acute Foot Warming Enhances Plantar Tactile Sensitivity With Limited Postural Control Effects in Obese Older Adults

Mathias Sosa Machado, Lissandra dos Santos Gonçalves, Amanda Carolina Paim Camponogara, Marieli Miranda Paz, Álvaro Sosa Machado, Felipe P. Carpes

ABSTRACT Background and Purpose Interventions to enhance tactile sensitivity, such as warming the feet, positively affect skin sensitivity with varying influence on postural control. Here, we hypothesize that foot warming may benefit tactile sensitivity and postural control in older adults, particularly those with obesity. Methods Fifty participants divided into 16 middle‐aged adults (14 women, mean ± standard deviation: age 40.29 ± 3.73 years, body mass index, BMI, 24.51 ± 1.70 kg/m 2 ), 17 non‐obese older adults …

17.08.2026journal-article

Arthritis Care & Research

Facial cosmetic therapy use amongst patients with systemic sclerosis: an Australian cohort study

Zachary Warren, Diane Apostolopoulos, Gene‐Siew Ngian, Amanda M Saracino, Laura Ross, Nava Ferdowsi, Jennifer Walker, Cindy Hall, Kim Griggs, Susanna Proudman, Wendy Stevens, Joanne Sahhar

Objective Systemic sclerosis (SSc) is associated with numerous facial manifestations for which patients may engage in cosmetic therapies. It is unclear how patients with SSc use these therapies. This study sought to characterise patient engagement and experiences with cosmetic therapies for SSc‐related and non‐SSc‐related facial changes. Methods SSc patients enrolled in the Australian Scleroderma Cohort Study at three Australian public tertiary hospitals and one private practice were invited to complete a de‐identi …

17.08.2026journal-article

Prenatal Diagnosis

Maternal Sirolimus Therapy for Fetal Extensive Lymphatic Cystic Malformation: Selection Criteria, Management, and Outcomes in a Series of Six Cases

L. Guibaud, M. Bordas‐Fournel, S. Cabet, C. Le Vaillant, A. Bruel, T. Lefrançois, C. Megier, A. Benachi, M. Sohier, Y. Gallois, T. Somon, J.‐M. Jouannic, G. Canaud, A. Guilhem, A. Atallah, A. Fraissenon

ABSTRACT Objective Maternal sirolimus therapy has emerged as a potential prenatal treatment for extensive fetal lymphatic malformations, particularly when associated with the risk of neonatal airway compromise. Data on prenatal indications, pharmacokinetics, and outcomes remain limited. We aimed to describe patient selection, treatment management, maternal and fetal safety, and early outcomes. Methods Between December 2023 and May 2025, 15 fetuses with extensive cystic or mixed vascular anomalies suggestive of lymp …

17.08.2026journal-article

Adolescência e Saúde

Shifting the Paradigm in GDM Care: A Randomized Controlled Trial of Midwifery-Led Versus Standard Care on Birth and Emergency Complication Preparedness Performance

Debajani Nayak, Pravati Tripathy, Prasant Kumar Nayak

Background: Gestational Diabetes Mellitus (GDM) is a high-risk illness linked to poor maternal and newborn outcomes. Adequate birth preparedness and complication readiness (BPCR) are critical components of safe motherhood, especially for women with GDM. Midwifery-led forms of care have demonstrated the ability to improve maternal outcomes via ongoing support, education, and empowerment. Objective: The objective is to assess the impact of a midwifery-led care paradigm on birth preparedness and complication readiness …

17.08.2026journal-article

Research, Society and Development

Fisioterapia após Acidente Vascular Cerebral: Recuperação da marcha, independência funcional e prevenção de incapacidade

Matheus Antônio dos Santos Araújo, Thelkia de Araujo Oliveira, Renan Soares e Silva, Ana Carolina Gazzola Braga, Sara Saba Faria

O Acidente Vascular Cerebral (AVC) constitui uma das principais causas de incapacidade adquirida em adultos e representa um importante problema de saúde pública devido ao seu impacto na funcionalidade, na qualidade de vida e nos custos dos sistemas de saúde. A fisioterapia desempenha papel essencial na recuperação motora e na promoção da reintegração social dos indivíduos acometidos. Esta revisão objetivou analisar as evidências científicas sobre a eficácia da fisioterapia na recuperação da marcha, no ganho de inde …