Medizin: neue Gesundheitspublikationen – Seite 84

27.08.2026journal-article

Cancers

Deconstructing Exceptional Responses to Immune Checkpoint Inhibition in Recurrent or Metastatic Head and Neck Carcinoma: A Site-Specific Clinical–Biological Synthesis

Giovanni Motta, Piero Giuseppe Meliante, Pasquale Capasso, Francesco Chiari, Giuseppe Tortoriello

Background: Recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is an aggressive malignancy with a historically poor prognosis. Although immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have established a new first-line standard of care, durable clinical benefit is restricted to a minority of patients, while primary or acquired resistance remains a major clinical challenge. This narrative review aims to provide a conceptual clinical–biological synthesis of immunotherapy in R/M …

27.08.2026journal-article

Diagnostics

Clinical and CSF Measurements for Identification of Leptomeningeal Metastasis in Lung Adenocarcinoma

Qichao Wu, Beihe Cao, Lei Qiu, Juan An, Yutong Zheng, Yufeng Shi, Xiaoyan Li

Background/Objectives: Because brain MRI and initial CSF cytology have limited sensitivity, suspected leptomeningeal metastasis (LM) may remain unresolved. We developed a model using clinical and CSF measurements available in source records to support identification of current LM in patients with lung adenocarcinoma undergoing CSF evaluation. Methods: This single-center retrospective cohort included 533 patients with lung adenocarcinoma and CNS metastases: 366 with a retrospectively verified reference diagnosis of …

27.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

The mediating role of social appearance anxiety in the relationship between instagram social comparison and cosmetic surgery acceptance: Implications for workplace wellbeing

Hatice Balci

Background Visually oriented social media use has increased social comparison processes and appearance-related concerns, potentially affecting psychosocial well-being, job burnout, and attitudes toward cosmetic surgery in professional settings. Objective This study examined the effects of Instagram-based social comparison, social media addiction, and social appearance anxiety on cosmetic surgery acceptance, with a focus on testing the mediating role of social appearance anxiety and investigating differences across …

27.08.2026journal-article

World Journal for Pediatric and Congenital Heart Surgery

Resection and Reimplantation of a Nearly Atretic Left Main Coronary Artery in an Adolescent

Robert McRae, Benjamin Hammond, Spencer Barfuss, Aaron Pennie, Collin Cowley, John Doty, Reilly Hobbs

Congenital coronary artery stenosis is a rare coronary anomaly with significant variability in presentation and management. We present a case of severe left main coronary artery stenosis in a young female. A 14-year-old female was referred to the Cardiology Clinic for multiple episodes of syncope and presyncope with activity that began in early childhood. Diagnostic imaging revealed near atresia of the proximal left main coronary artery. The patient underwent surgical repair with resection of the stenotic coronary …

27.08.2026journal-article

Revista Científica Saúde Global

Strategies in the Prevention and Treatment of Obesity

Ieda Carla Candido, Gisele Nicchio Rocha Buzzo, Matheus Rodrigues Dos Santos, Rafaela Crystina Vieira Bonfim, Fernanda Aparecida Vicente Magalhães, Karine Oltramari, Paulo Cesar Franzini, Angélica Sbrolini Marques Mincache, Greice Westphal-Nardo, Nelson Nardo Júnior Nardo Júnior

Objective: This study aims to present the most recent advances and the challenges encountered in the provision of pharmacological, surgical, and multidisciplinary programs for the treatment of obesity. Methods: This is a narrative literature review with a qualitative and exploratory approach, conducted in July 2025. The theoretical framework was based on studies published between 2020 and 2025, focusing on strategies for obesity prevention and treatment, particularly pharmacological therapies, bariatric surgery, an …

27.08.2026journal-article

Journal of Orthopaedic Experience & Innovation

Tibial Plafond Fractures and the Impact of Social Media Support Groups on Patient Perceptions

Alexandra F. Flaherty, Dana Perim, Annie Waite, Alvarho Guzman, Ernest N. Chisena

Background Tibial plafond fractures are severe injuries that often result in a prolonged treatment and recovery process, as well as poor outcomes and high complication rates. Given this, an online support group exists for patients to gain support and advice from a community of patients with the same injury. Similar groups exist for other chronic medical conditions and traumatic injuries; such groups have been studied to determine the impact on the affected patients. There have been no prior studies specifically inv …

27.08.2026journal-article

Frontiers in Medicine

Association between preprocedural information and anxiety in patients undergoing gastrointestinal endoscopy with sedation: a prospective observational study

Roberto Quirós-Zamorano, Raquel Romero-Tejedor, Miriam Álvarez-Villarreal, Francisco Javier García-Sánchez

Background Preprocedural anxiety is common among patients undergoing gastrointestinal endoscopy and may be influenced by the quality of information provided before the procedure. However, real-world evidence on the relationship between information delivery and anxiety levels remains limited. Methods A prospective observational cross-sectional study was conducted in the endoscopy unit of a tertiary hospital between June and September 2024. A total of 351 adult patients scheduled for elective gastroscopy or colonosco …

27.08.2026journal-article

Frontiers in Endocrinology

Case Report: Development of a thyrotropinoma in a patient with thyroid hemiagenesis

Emil Bartosz Rozenek, Mark Gurnell, Jacek Kunicki, Maria Maksymowicz, Marta Korbonits, Wojciech Zgliczyński, Maria Stelmachowska-Banaś

Thyroid hemiagenesis (THA) is a relatively rare disorder in which one thyroid lobe fails to develop. Although most individuals remain clinically euthyroid, they typically exhibit higher thyrotropin (TSH) concentrations than those with a bilobed thyroid gland, possibly reflecting reduced thyroidal reserve and a chronic compensatory response by pituitary thyrotrophs. While pituitary hyperplasia has been reported in the setting of hypothyroidism in THA, a TSH-secreting pituitary neuroendocrine tumor (thyrotropinoma) h …

27.08.2026journal-article

Frontiers in Medicine

Rheumatoid arthritis and cardiovascular disease in relation to cytomegalovirus infection: a pilot cross-sectional study

Mohammed Ahmed Al-Kaif, Laith A. I. K. Al-Kaif, Zaid Saad Madhi, Dalya Talal Fathi Al-Azzawi, Wael Rasheed Obaead Alfatlawi, Sarah Kassab Shandaway Al-Zamali, Fatin Alaa Abdul Ameer Mahdi, Haibo Liu

Background Patients with rheumatoid arthritis (RA) face increased cardiovascular disease (CVD) risk not fully explained by traditional factors. Chronic cytomegalovirus (CMV) infection may contribute through immune activation and vascular inflammation. This pilot study investigated associations between CMV serostatus, vascular endothelial growth factor A (VEGF-A), and inflammatory markers in patients with RA and/or CVD. Methods This cross-sectional study enrolled 76 participants (CVD = 40, RA = 18, RA+CVD = 18). Ser …

27.08.2026journal-article

Journal of Academic Ophthalmology

Clinical appropriateness of ChatGPT-4.0 and ChatGPT-4.0-mini for patient-facing ophthalmic procedure information

Nicholas Joseph DeLuca, Belen Wertheimer, Soumil Prasad, Matthew McSoley, Piero Carletti, Zubair Ansari

Background: Patients increasingly turn to large language models (LLMs), such as ChatGPT, for medical guidance, yet their reliability in ophthalmology remains understudied. Prior work has addressed readability and patient handout generation, but a comprehensive evaluation of ChatGPT’s procedural accuracy is lacking. Purpose: To evaluate the accuracy, clinical appropriateness, and readability of ChatGPT-4.0 and ChatGPT-4.0-mini in responding to patient-centered questions about six common ophthalmologic procedures. Me …

27.08.2026journal-article

Clinical Science

Resolvin D5 limits inflammatory lung injury and enhances antibacterial host defense in severe pneumococcal pneumonia

Henry H. Gong, Stephanie Pons, Jasmine Ji, Robert Nshimiyimana, Charles N. Serhan, Luciana P. Tavares, Bruce D. Levy

Abstract Streptococcus pneumoniae remains a leading cause of lower respiratory tract infections and pneumonia-related mortality worldwide. Although neutrophil recruitment is essential for pneumococcal containment, excessive and dysregulated neutrophilic inflammation can drive severe lung injury and acute respiratory distress syndrome. Specialized pro-resolving mediators, such as Resolvin D5 (7S,17S-dihydroxy-4Z,8E,10Z,13Z,15E,19Z-docosahexaenoic acid; RvD5), are produced in the lungs and have the potential to promo …

27.08.2026journal-article

Journal of Clinical Medicine

EZH2 Expression and Clinical Outcomes in Non-Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors: A Real-World Retrospective Cohort Study

Esra Asarkaya, Hatice Asoglu, Abdurrahman Aykut, Gunes Dorukhan Cavusoglu, Yasemin Aydınalp, Sendag Yaslıkaya, Suheda Atas Ipek, Fatma Calkan, Emine Kilic Bagir, Derya Gumurdulu, Hulya Binokay, Tolga Koseci, Ismail Oguz Kara, Berksoy Sahin, Ertugrul Bayram

Background: Lung cancer remains the leading cause of cancer-related mortality, with non-small cell lung cancer (NSCLC) accounting for approximately 85% of cases. Over the past decade, immune checkpoint inhibitors have become a core component of first-line treatment for advanced-stage NSCLC lacking driver mutations. Programmed death-ligand 1 (PD-L1) expression is currently used as the standard biomarker, yet its predictive value remains limited, and in most immunotherapy trials, treatment efficacy has been observed …

27.08.2026journal-article

Clinical Infectious Diseases

Does acute pyelonephritis skew outcomes in registrational trials of novel antibiotics for complicated urinary tract infections? A systematic review and meta-analysis

Giovanni Mori, Tommaso Ceccato, Simone Botti, Simone Giuliano, Carlo Tascini, Stefania Stefani, Massimiliano Lanzafame, Truls Erik Bjerklund Johansen, Tommaso Cai

Abstract Background Acute pyelonephritis (AP) and complicated urinary tract infections (cUTIs) are pooled in registrational RCTs of new antibiotics. We assessed whether outcomes differ between subtypes and which component of the composite endpoint drives any difference. Methods Across ten registrational RCTs we estimated the AP-versus-cUTI treatment effect on the composite primary endpoint (clinical cure plus microbiologic eradication at test-of-cure ) using random-effects risk ratios, with risk-difference, odds-ra …

27.08.2026journal-article

Sakarya Üniversitesi Holistik Sağlık Dergisi

Does Clinical Practice in Psychiatric Nursing Change Students’ Perspectives on Psychiatric Nursing and Mental Illnesses?: A Qualitative Study

Ferhan Açıkgöz, Aysel Karaca

Objective: This study aims to examine students’ perspectives on individuals with mental disorders and psychiatric nursing before and after the psychiatric nursing clinical course, as well as their thoughts and experiences regarding the clinical practice, using a qualitative approach.Methods: A qualitative research method was employed in this study, and data were collected through focus group interviews. In this study, three separate focus group interviews were conducted, each consisting of 10 participants. The data …

27.08.2026journal-article

Cancer Medicine

UTMD Suppresses CSF ‐1 to Drive Macrophage‐Mediated Ferroptosis in Papillary Thyroid Carcinoma

Yanqiang Niu, Zhenqiang Yao, Minghua Zhang, Jiayan Zhang, Yushan Li, Jinhui Xie, Zubang Zhou

ABSTRACT The tumor microenvironment (TME) of Papillary Thyroid Carcinoma (PTC), particularly the role of tumor‐associated macrophages (TAMs), contributes to therapeutic resistance. This study investigated whether ultrasound‐targeted microbubble destruction (UTMD), a non‐invasive physical modality, could reprogram the TME through modulation of TAMs and induction of ferroptosis. Transcriptomic profiling identified CSF‐1 as a top target suppressed by UTMD, which was validated by ELISA, Western blot, and qRT‐PCR. UTMD …

27.08.2026journal-article

Archivos Peruanos de Cardiología y Cirugía Cardiovascular

Trasplante cardiaco en paciente adulto con circulación de Fontan disfuncionante en un centro de alta complejidad cardiovascular en el Perú: reporte de caso

Roger Yoel Conde Moncada, Víctor Robles Velarde, Romel Zamudio Silva, Edwin Amado Masabel Chicoma, Sergio Martín Zavala Castillo, Franz Ronald Soplopuco Palacios

Fontan circulation failure represents a progressive condition associated with multiorgan dysfunction and increased morbidity and mortality. In this context, heart transplantation has become the definitive treatment for this subgroup of patients. Reported survival rates after heart transplantation in patients with Fontan circulation are approximately 80% at 1 year, 74% at 5 years, and 59% at 10 years. We present the case of a 46-year-old patient with a history of Ebstein anomaly who underwent intracardiac Fontan sur …

27.08.2026journal-article

Med Phoenix

Etiological Clinical and Laboratory Profile of Children admitted with Febrile Seizures in a Tertiary Care Hospital of Western Nepal

Laxman Paudel, Arun Pokhrel, Sumina Shrestha, Dipim Gautam

Introduction: Febrile seizures are the most common seizure disorder in childhood and are a frequent cause of hospital admission. Information regarding the demographic, clinical, etiological, and laboratory characteristics of febrile seizures in Nepal remains limited. This study aimed to evaluate the demographic, etiological, clinical, and laboratory profile of children admitted with febrile seizures in a tertiary care hospital in Western Nepal.Materials and Methods: A hospital-based prospective observational study …

27.08.2026journal-article

Transactions of The Royal Society of Tropical Medicine and Hygiene

Out-of-pocket expenditure and catastrophic health expenditure in patients of leprosy at a tertiary care center in India

Kavita Kavita, Sukhdeep Singh, Kittu Malhi, Manisha Upreti, Sushma Saini, Arushi Ghai, Ritin Mohindra, Tarun Narang, Sunil Dogra

Abstract Objectives Leprosy continues to impose a significant clinical and socioeconomic burden. Despite free multidrug therapy, patients incur substantial out-of-pocket expenditure (OOPE), leading to catastrophic health expenditure (CHE). Evidence on the economic burden of leprosy in India remains limited. Methods A pilot prospective observational study was conducted at a tertiary care center in North India, enrolling 56 patients with leprosy. Data on sociodemographic characteristics, direct and indirect healthcar …

27.08.2026journal-article

Journal of Perinatal Medicine

Multidimensional compliance and outcomes in gestational diabetes

Weili Zhang, Qingqing Gong, Yan Zhu

Abstract Objectives To investigate the association between a composite multidimensional compliance score and glycemic control, maternal complications, and neonatal outcomes in women with gestational diabetes mellitus (GDM), and to evaluate these associations after adjusting for potential confounders. Methods This retrospective cohort study included 360 women with GDM, diagnosed between October 2023 and January 2026 at Guiyang Second People’s Hospital. A weighted compliance score (1–3) was calculated based on blood …

27.08.2026journal-article

Experimental Biology and Medicine

The interaction between oxidative stress and Schwann cells

Sihan Yang, Zijun Zhang, Qing Liao, Qipeng Ouyang, Yongyou Ye, Wei Lu, Zhendong Jiang

After peripheral nerve injury (PNI), a moderate increase in reactive oxygen species (ROS) levels can promote the proliferation and differentiation of Schwann cells (SCs) and participate in signal transduction. However, excessive ROS can trigger oxidative stress, and its harmful effects can overshadow the beneficial ones, such as inducing apoptosis, activating inflammation, disrupting environmental stability, and severely hindering neural processes. Therefore, if the damage caused by oxidative stress to SCs can be e …

27.08.2026journal-article

Journal of Clinical Medicine

Self-Reported Prevalence of Functional Ankle Instability and Associated Factors Among Male Football Players in Southwestern Saudi Arabia

Abdulaziz Mohammed Y Alfaya, Ahmad Alanazi, Msaad Alzhrani, Sultan A. Alanazi, Ateef Mahamed

Background/Objectives: Rapid changes, jumping, and high-intensity movements are common among football players and are vulnerable to ankle sprains and functional ankle instability (FAI). This study aimed to determine the prevalence of FAI and assess the correlation with related factors among male football players in southwestern Saudi Arabia. Methods: A cross-sectional observational study was conducted among 364 male football players aged ≥18 years in southwestern Saudi Arabia. Participants completed the Arabic vers …

27.08.2026journal-article

Research Methods in Medicine & Health Sciences

Quantifying the state of the art: A random appraisal-weighted method for clinical evaluation under EU MDR

George Miller

Background The European Union Medical Device Regulation (EU MDR) requires manufacturers to establish quantitative, state of the art parameters for clinical evaluation. Because most available evidence is heterogeneous and uncontrolled, conventional meta-analytic methods provide limited support for deriving device level benchmarks. Methods A methodological framework was developed using synthetic datasets reflecting typical real-world evidence. Study means, variances and standard errors were combined using fixed effec …

27.08.2026journal-article

Frontiers in Medicine

Endoscopic drainage and one-stage titanium clip closure for appendiceal root abscess mimicking cecal submucosal tumor: a case report

Yanping Dai, Yang Liu, Jun Ye

Periappendiceal abscess stands as a frequent complication stemming from acute appendicitis. One rare variant presents as a submucosal mass at the root of the appendix and cecum. Clinicians often misdiagnose this form at alarmingly high rates. Conventional management brings substantial surgical trauma. It also prolongs patients’ recovery periods. Whether minimally invasive endoscopic intervention works well for this distinct abscess subtype still lacks solid clinical proof. Whether minimally invasive endoscopic inte …

27.08.2026journal-article

Journal of Human Hypertension

Antihypertensive treatment and adverse psychiatric reactions in primary health care

Emina Curic, Henrik Ohlsson, Kenneth Kendler, Jan Sundquist, Kristina Sundquist, Margareta Reis, Bengt Zöller

Abstract Antihypertensive treatment (AHT) has been associated with adverse psychiatric reactions (APRs), but existing data are conflicting. The aim of the present study was to determine the risk for seven different APRs in drug-naive patients with newly diagnosed hypertension in primary health care. This cohort study analyzed registry data of individuals aged 40–70 with a newly diagnosed untreated hypertension without previous psychiatric or cardiovascular comorbidities in Swedish primary healthcare from 2006 and o …

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Aktuelle Forschung nach Fachgebiet

Deconstructing Exceptional Responses to Immune Checkpoint Inhibition in Recurrent or Metastatic Head and Neck Carcinoma: A Site-Specific Clinical–Biological Synthesis

Clinical and CSF Measurements for Identification of Leptomeningeal Metastasis in Lung Adenocarcinoma

The mediating role of social appearance anxiety in the relationship between instagram social comparison and cosmetic surgery acceptance: Implications for workplace wellbeing

Resection and Reimplantation of a Nearly Atretic Left Main Coronary Artery in an Adolescent

Strategies in the Prevention and Treatment of Obesity

Tibial Plafond Fractures and the Impact of Social Media Support Groups on Patient Perceptions

Association between preprocedural information and anxiety in patients undergoing gastrointestinal endoscopy with sedation: a prospective observational study

Case Report: Development of a thyrotropinoma in a patient with thyroid hemiagenesis

Rheumatoid arthritis and cardiovascular disease in relation to cytomegalovirus infection: a pilot cross-sectional study

Clinical appropriateness of ChatGPT-4.0 and ChatGPT-4.0-mini for patient-facing ophthalmic procedure information

Resolvin D5 limits inflammatory lung injury and enhances antibacterial host defense in severe pneumococcal pneumonia

EZH2 Expression and Clinical Outcomes in Non-Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors: A Real-World Retrospective Cohort Study

Does acute pyelonephritis skew outcomes in registrational trials of novel antibiotics for complicated urinary tract infections? A systematic review and meta-analysis

Does Clinical Practice in Psychiatric Nursing Change Students’ Perspectives on Psychiatric Nursing and Mental Illnesses?: A Qualitative Study

UTMD Suppresses CSF ‐1 to Drive Macrophage‐Mediated Ferroptosis in Papillary Thyroid Carcinoma

Trasplante cardiaco en paciente adulto con circulación de Fontan disfuncionante en un centro de alta complejidad cardiovascular en el Perú: reporte de caso

Etiological Clinical and Laboratory Profile of Children admitted with Febrile Seizures in a Tertiary Care Hospital of Western Nepal

Out-of-pocket expenditure and catastrophic health expenditure in patients of leprosy at a tertiary care center in India

Multidimensional compliance and outcomes in gestational diabetes

The interaction between oxidative stress and Schwann cells

Self-Reported Prevalence of Functional Ankle Instability and Associated Factors Among Male Football Players in Southwestern Saudi Arabia

Quantifying the state of the art: A random appraisal-weighted method for clinical evaluation under EU MDR

Endoscopic drainage and one-stage titanium clip closure for appendiceal root abscess mimicking cecal submucosal tumor: a case report

Antihypertensive treatment and adverse psychiatric reactions in primary health care