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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
17.08.2026journal-article

International Journal of Language & Communication Disorders

Building Knowledge and Confidence: Student Speech Pathologists' Perspectives on Learning About Cognitive‐Communication Disorders and the Potential of Implementing Convers‐ABI‐lity on Placement

Ashna Nadan, Petra Avramović, Leanne Togher, Annie Chan, Rachael Rietdijk

ABSTRACT Background Cognitive‐communication disorders (CCDs) are common after acquired brain injury (ABI). People with CCD experience communication breakdowns, significantly impacting long‐term social, familial, and vocational outcomes. Convers‐ABI‐lity, a web‐based communication partner training intervention, was co‐designed with key stakeholders, including people with ABI, their family members, speech pathologists, and other allied health professionals, to address communication breakdowns in everyday interactions …

17.08.2026journal-article

Proceedings of the National Academy of Sciences

CXCR4-targeted dual softener for inducing senescence therapy in hepatic fibrosis

Junmei Mu, Jingwen Dong, Jiahui Chen, Panle Sima, Yinuo Fan, Xunyi Gong, Junjie Zhou, Xue Yang, Zhanwei Zhou, Minjie Sun

Hepatic fibrosis is a central pathological driver of chronic liver diseases, including metabolic dysfunction-associated steatotic liver disease and alcohol-related liver disease, which collectively impose a growing global health burden. Fibrosis is primarily mediated by persistent activation of hepatic stellate cells (aHSCs) and excessive deposition of stiff extracellular matrix (ECM). The dense and rigid ECM-aHSCs network severely hinders drug delivery and penetration, posing a major challenge for effective antifi …

17.08.2026journal-article

Frontiers in Neurology

Application of musculoskeletal ultrasound in quantitative assessment and rehabilitation of lower leg muscles in stroke patients

Chengrui Ma, Liansong Liu, Rongxing Yang, Ping Yao

Objective To investigate the application of musculoskeletal ultrasound in the quantitative assessment of lower leg muscles and its value in stratifying rehabilitation outcomes in patients with stroke. Methods A single-center retrospective study was conducted, including 152 patients with stroke. Based on predefined composite functional criteria at 6 months after rehabilitation, patients were classified into favorable outcome ( n = 105) and poor outcome ( n = 47) groups. Baseline clinical characteristics (FMAS, Barth …

17.08.2026journal-article

MedComm

Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances

Yihong Dong, Moran Chen, Xupeng Hou, Xiaoya Tang, Xiaoli Yu, Jing Liu

ABSTRACT The abscopal effect is a systemic antitumor response to localized radiotherapy (RT) that has emerged as a central focus in the era of immunotherapy. Clinical evidence demonstrates that local RT can induce regression of distant, nonirradiated metastases, including cases of complete remission. However, the effect remains unpredictable, with marked variation in clinical outcomes ranging from complete regression to paradoxical progression. The mechanistic basis for this heterogeneity and optimal strategies to …

17.08.2026journal-article

Current Pharmaceutical Design

Melittin in Aggressive Breast Cancer Therapy: Mechanisms, Delivery Systems, and Clinical Potential

Yashika, Sachin Yadav, Anish Arora, Amandeep Singh

Introduction: Aggressive breast cancer subtypes, including Triple-Negative Breast Cancer (TNBC) and HER2-positive tumours, remain clinically challenging due to poor prognosis, high therapeutic resistance, and limited targeted treatment options, highlighting the urgent need for novel and more effective therapeutic strategies. Methods: This study presents a narrative review of preclinical and mechanistic studies evaluating the anticancer potential of melittin, a bioactive peptide derived from bee venom, with emphasis …

17.08.2026journal-article

Frontiers in Medicine

Bronchoscopic local instillation of amphotericin B deoxycholate as adjunctive therapy for pulmonary mucormycosis with inadequate response to posaconazole: a retrospective case series

Liyan Qiu, Binyue Liang, Hua Zhou

Background Pulmonary mucormycosis is a life-threatening invasive fungal infection, most often affecting immunocompromised patients. Liposomal amphotericin B is the preferred first-line therapy, but amphotericin B formulations may be poorly tolerated. When endobronchial obstruction and tissue necrosis are present, pulmonary lesions may progress despite systemic antifungal therapy. Methods We retrospectively reviewed patients with documented pulmonary mucormycosis who received posaconazole-based therapy at the First …

17.08.2026journal-article

International Journal of Cancer

Anthracycline‐Free Neoadjuvant Therapy With Nab‐Paclitaxel and Carboplatin in Non‐Luminal Breast Cancer: A Single‐Arm Clinical Trial

Jiayi Wu, Deyue Liu, Mengdi Chen, Caijin Lin, Shuning Ding, Jin Hong, Weiqi Gao, Siji Zhu, Xiaosong Chen, Ou Huang, Jianrong He, Weiguo Chen, Yafen Li, Kunwei Shen, Li Zhu

ABSTRACT Anthracycline‐free regimens have attracted growing interest because of less cardiac toxicity, especially in HER2‐positive breast cancer when used in combination with trastuzumab and pertuzumab. This prospective, single‐center trial (NEOPATH) aimed to assess the efficacy and safety of nab‐paclitaxel combined with carboplatin in the neoadjuvant therapy of non‐luminal breast cancer. The study was conducted in Ruijin Hospital between April 2019 and October 2021. Patients who had stage II–III TNBC or HER2‐posit …

17.08.2026journal-article

Child Language Teaching and Therapy

From space and voice to audience and influence: Methodological approaches to inclusive co-research with young children

Kathy Cologon

This paper presents a methodological reflection on an arts-based practitioner inquiry project conducted in an inclusive early childhood setting in Australia. Drawing on Lundy's model of participation, describing space, voice, audience and influence, the paper explores how research with young children can move from tokenistic towards meaningful collaboration. The study involved 26 children aged three to six years and six practitioners (two teachers and four educators), working collaboratively with a university-based …

17.08.2026journal-article

Frontiers in Oncology

The impact of different exercise modalities on health-related quality of life in patients with prostate cancer undergoing androgen deprivation therapy: a systematic review and network meta-analysis

Wang Li, Xiaoqin Huang, Xin Huang, Yiqin Shi, Feng Wang, Liping Pu, Mingyan He, Huiwen Tan

Background Androgen deprivation therapy (ADT) for prostate cancer is associated with adverse effects including fatigue, muscle weakness, adiposity, and impaired health-related quality of life (HRQoL). Exercise interventions may mitigate these side effects, but the comparative efficacy of different exercise modalities remains unclear. Purpose To determine the effects of various exercise programs on HRQoL and physical functioning in prostate cancer patients undergoing ADT, and to provide evidence-based recommendation …

17.08.2026journal-article

Clinical and Experimental Dermatology

Topical delgocitinib in severe chronic hand eczema: an alternative to systemic therapy with practical considerations and economic impact

Emily House, Anna B Chapman

Chronic hand eczema can cause major functional and occupational impairment and may be difficult to manage when systemic therapies are contraindicated. We report the use of topical delgocitinib in severe, treatment-refractory disease, demonstrating rapid clinical improvement, return to work and reduced monitoring burden compared with systemic therapy. This case series experience supports topical delgocitinib as an effective and practical therapeutic option in selected patients.

17.08.2026journal-article

Brazilian Journal of Music Therapy

Music Therapy in Down Syndrome:

Fernando Miranda Baumgartner, Luciana Castilho Razabone, Paula Martins-Said

Music therapy has been increasingly reported in the literature involving individuals with Down syndrome. However, its conceptualization, professional implementation, and reporting practices vary widely. This scoping review followed PRISMA-ScR guidelines to map how interventions self-identified as music therapy in individuals with Down syndrome have been conceptualized and reported in the scientific literature. Thirteen electronic databases were searched without restrictions on publication year or language. Studies …

17.08.2026journal-article

Dhaka Shishu (Children) Hospital Journal

Pancreatic Enzyme Eeplacement Therapy in paediatric care:Global insights and gaps in Bangladesh

Rahat Bin Habib, A R M Luthful Kabir

Pancreatic Enzyme Replacement Therapy (PERT) remains the cornerstone of managing exocrine pancreatic insufficiency (EPI), especially in children with Cystic Fibrosis (CF). Globally, Pancrelipase a high-potency, enteric-coated pancreatic enzyme is widely recommended for effective symptom control and nutritional requirements. However, in Bangladesh, a critical gap exists in both the availability of Pancrelipase and awareness regarding its appropriate use. Clinicians often rely on low-potency, non-enteric-coated enzym …

17.08.2026journal-article

Diabetes, Obesity and Metabolism

Body Composition Remodelling During GLP ‐1‐Based Therapy: A Systematic Review and Meta‐Analysis Using a Hierarchical Physiological Framework

Maria Luizza Lopes Menezes, Maria Eduarda Güntzel Chiappa, Rodrigo Fuentes Kloss, Marcelo Tuesta, Paula Santos, Alberto Souza Sá Filho, Gaspar R. Chiappa

ABSTRACT Background Body composition changes during glucagon‐like peptide‐1 (GLP‐1)‐based therapy remain incompletely characterized, particularly regarding their effects on adiposity, muscle quantity, and muscle quality. We conducted a systematic review and meta‐analysis using a predefined physiological framework to evaluate body composition remodelling during GLP‐1‐based therapy. Methods We searched PubMed, Embase, and Cochrane CENTRAL from inception through May 2026 for studies evaluating GLP‐1 receptor agonists …

17.08.2026journal-article

Teaching and Learning in Communication Sciences & Disorders

Equity in Evaluation: Examining Grading Practices and Student Experiences in Speech-Language Pathology Education

Jennifer Essig

Traditional grading practices remain the norm in communication sciences and disorders (CSD) education, despite evidence these systems may exacerbate inequities and affect motivation and perceptions of learning. This study examined how traditional and alternative grading practices are experienced by undergraduate and graduate students enrolled in CSD programs. Using a convergent mixed-methods design, survey data were collected from 73 students regarding perceptions of grading, motivation to learn, and emotional resp …

17.08.2026journal-article

Journal of Rehabilitation Medicine

Mapping the commonalities of rehabilitation: using GUIDE-rehab to open the black box of programmes across diverse health conditions

Stefano Negrini, Helena Burger, Paolo Capodaglio, Maria Gabriella Ceravolo, Lisa Hoogendam, Esther Janssen, Greta Jurenaite, Calogero Malfitano, Federico Pennestri, Ruud Selles, Gianluca Martino Tartaglia, Charlotte Kiekens

Objective: Rehabilitation is a health strategy implemented with specific programmes across multiple health conditions. This study aimed to identify rehabilitation programmes’ commonalities among health conditions and partners, as required by the PREPARE (Personalised REhabilitation via Novel AI PAtient StRatification StratEgies) project. Design: Qualitative study. Subjects/Patients: Seven rehabilitation programmes in Europe covering diverse health conditions were chosen according to PREPARE research needs for their …

17.08.2026journal-article

East African Journal of Agriculture and Biotechnology

Effects of Agricultural Rehabilitation Programme on Enhanced Value Chain: The Roles of Farmers’ Willingness and Commitment to Participate

Emmanuel Agyekum, Wiiliam Mills Abbey, Gloria Pokuaa-Duah

This study investigates the impact of the Cocoa Rehabilitation Programme (CRP) on the Enhanced Value Chain (EVC) within the Ghanaian cocoa sector. Central to this inquiry is the role of human agency, specifically examining how Farmers’ Willingness to Participate (FWP) and Farmers’ Commitment to Participate (FCP) function as psychological and behavioural mediators between institutional interventions and value chain optimisation. Drawing on the Theory of Planned Behaviour (TPB) and Value Chain Theory, the research de …

17.08.2026journal-article

The Egyptian Journal of Critical Care Medicine

Vitamin C deficiency and its effect as adjuvant therapy in sepsis patients

Eslam Abdelhady, Mohammed Ashraf Shawky, Mahmoud Khaled Nour, Farouk Mostafa Fares

Abstract Background Sepsis causes high mortality and organ failure; vitamin C deficiency is common and may worsen inflammation and shock, supporting its role as an adjunctive therapy. Objectives To evaluate plasma vitamin C levels in sepsis and septic shock and assess the effects of high-dose intravenous vitamin C on inflammation, hemodynamics, organ dysfunction, and clinical outcomes. Methods This prospective, interventional, non-randomized controlled cohort study was conducted in the 25-bed Critical Care Departme …

17.08.2026journal-article

Journal of Asian Pacific Society of Cardiology

Current Diagnostic Practices and Management Strategies for Cancer Therapy-related Cardiac Dysfunction: An Exploratory Multicentre Survey in Indonesia

Feny Junaidy, Mefri Yanni, Citra Kiki Krevani, Hirowati Ali

Background: Cancer therapy-related cardiac dysfunction (CTRCD) has emerged as a major complication of modern cancer therapy, particularly as cancer survival continues to improve. Although international guidelines provide standardised recommendations for CTRCD surveillance and management, real-world implementation remains highly variable, especially in low- and middle-income settings. Key diagnostic modalities include left ventricular ejection fraction and global longitudinal strain, ideally integrated within a mult …

17.08.2026journal-article

Biomacromolecules

Mucoadhesive Carboxymethyl Chitosan Hydrogel Eyedrops via Dual Dynamic Covalent Chemistry for Long-Acting Glaucoma Therapy

Jin Pan, Huangkun Gong, Qiuyun Shao, Xuehan Zhang, Ravin Narain, Kaihui Nan, Yangjun Chen

Abstract Glaucoma, a leading cause of irreversible blindness, is commonly treated with topical eye drops that reduce intraocular pressure (IOP), but their efficacy is limited by rapid precorneal clearance. To address this, we developed a dynamic hydrogel (CSFP) via Schiff base bonding between carboxymethyl chitosan (CMCS) and 4-formylphenylboronic acid (FPBA) as an advanced delivery vehicle for brimonidine (BRI) and timolol (TIM), two common IOP-lowering agents. The mechanical properties were tunable by adjusting C …

17.08.2026journal-article

JMIR Mental Health

Interpretable Topic Modeling of Spontaneous Speech in Depression Using Large Language Models: Multilingual Four-Cohort Study

Gustave Cortal, Sélim Benjamin Guessoum, Xuan-Nga Cao, Santiago de Leon-Martinez, Enrique Baca-García, Rachid Riad

Abstract Background Depression is underdiagnosed worldwide, and clinicians rely on interpreting patients’ subjective speech. Qualitative analysis of patient language does not scale, and existing computational approaches describe topics with keyword lists that miss clinical nuance. Objective We evaluated whether clustering spontaneous speech transcripts with large language models (LLMs) yields clusters whose membership is associated with validated clinical scales across multilingual cohorts, and whether LLMs can ren …

17.08.2026journal-article

Frontiers in Urology

Use of androgen suppression therapy at salvage radiotherapy in recurrent prostate cancer: a systematic review with meta-analysis

Maria Juliana Chaves Medina, Rodolfo Varela Ramírez, Wilfredo Donoso Donoso, Jaime Moreno-Chaparro, Javier Eslava-Schmalbach

Introduction Salvage radiotherapy (SRT) is one of the treatment options after progression following surgical management, with effectiveness varying according to patient risk and clinical-pathological characteristics. Objective To compare the effectiveness of SRT alone versus SRT combined with androgen deprivation therapy (ADT) in men with biochemical recurrence. Methods We conducted a systematic review with advanced searches in MEDLINE (PubMed), EMBASE, SCOPUS, Cochrane CENTRAL, and LILACS for the period 1990–2024. …

17.08.2026journal-article

Pacing and Clinical Electrophysiology

Non‐Invasive Methods for Identifying Electrical Responders to Conduction System Pacing Cardiac Resynchronization Therapy

Jack W. Samways, Nadine Ali, Ahran D. Arnold, Ji‐Jian Chow, Matthew Shun‐Shin, Jagdeep Singh Mohal, Akriti Naraen, Keenan Saleh, Nandita Kaza, Chetanya Sharma, Pavel Leinveber, Pavel Jurák, Daniel Keene, Yixiu Liang, Nicholas S. Peters, Prapa Kanagaratnam, James P. Howard, Norman Qureshi, Fu Siong Ng, Nick W. Linton, David C. Lefroy, Darrel P. Francis, P. Boon Lim, Mark A. Tanner, Amal Muthumala, Frits W. Prinzen, Judith M. Lubrecht, Karol Čurila, Graham Cole, Zachary Whinnett

ABSTRACT Background Conduction system pacing (CSP) is an emerging alternative modality of cardiac resynchronization therapy (CRT). However, not all patients obtain electrical resynchronization with CSP, there is a clinical need for reliable non‐invasive predictors of response. We aimed to assess the ability of several non‐invasive modalities to predict electrical resynchronization with CSP‐CRT. Methods Patients with standard heart failure CRT indications (excluding right‐bundle branch block) underwent CSP‐CRT using …

17.08.2026journal-article

Occupational and Environmental Medicine

Increased risk of occupational falls among cancer survivors: Japanese nationwide cohort

Kazuhiko Watanabe, Ichiro Kawachi, Takahiro Tabuchi, Masayoshi Zaitsu

Objectives Despite declining incidence rates for some cancers, the ageing workforce and improved survival have increased the number of workers with a history of cancer. Cancer treatment can affect strength, balance and bone health, thereby increasing fall risk among cancer survivors. However, an association between a history of cancer and occupational falls has not been reported. We aimed to investigate whether a history of cancer was associated with occupational falls and fall-related fractures among workers in Ja …

17.08.2026journal-article

ACS Biomaterials Science & Engineering

ROS-Responsive, Water–Oil Biphasic Hydrogel-Based Separable Microneedle System for Intra-Articular Delivery in Osteoarthritis Therapy

Xian Zhang, Na Li, ChengRong Zhang, XiaoQing Zhang, Yanhong Ma, Huan Ye, Xin Wang, Guoqing Yan

Abstract Osteoarthritis (OA) is characterized by a chronic inflammatory microenvironment with excessive reactive oxygen species (ROS) and progressive cartilage degeneration. To address these challenges, we developed a ROS-responsive, water–oil biphasic separable microneedle patch (CKCA MN) for transdermal therapy. This microneedle utilizes hyaluronic acid (HA) as a rapidly dissolving substrate, and its needle tip comprises a coordination-crosslinked hydrogel formed by Ce3+ and alendronate (Aln), loaded with cinnama …