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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
17.08.2026journal-article

International Journal of Innovative Science and Research Technology

Physiotherapy Management of Chronic Temporomandibular Joint Dysfunction in a Cricket Player: A Case Report

Anoli Gupta, Sneha Ganu

Background: Temporomandibular dysfunction (TMJ) is a commonly seen maxillofacial disorder in athletes, with a predominance in females. Contact sports are a contributing factor to TMJ dysfunction, such as blows to the jaw. In recent years, physiotherapy has had excellent outcomes.  Case Presentation: A 19-year-old male cricket player came in with a complaint of limited jaw opening and a click on jaw movements after suffering a blow to the jaw. Based on clinical examination, he was diagnosed with Internal derangemen …

17.08.2026journal-article

PHAGE: Therapy, Applications, and Research

Prevalence of Biofilm-Forming Pseudomonas aeruginosa from Clinical Samples in Africa: A Systematic Review and Meta-Analysis

Assefa Sisay, Zelalem Asmare, Ermias Getachew, Birhanu Kassanew, Ephrem Tamrat, Yalewayker Gashaw, Melese Abate Reta

Background: Biofilms help Pseudomonas aeruginosa adhere to surfaces and form an extracellular polymeric matrix. P. aeruginosa infections are increasingly difficult to treat due to biofilm formation. This study seeks to ascertain the overall prevalence of biofilm-forming P. aeruginosa clinical isolates in Africa. Methods: All studies published from January 1, 2010, to December 30, 2024, were systematically obtained from electronic databases, including PubMed, ScienceDirect, and Scopus, as well as via the Google Scho …

17.08.2026journal-article

Journal of Clinical Medicine

Theranostics in Radiation Medicine: Integrating Radiopharmaceutical Therapy and External-Beam Radiotherapy

Senthamizhchelvan Srinivasan, Joseph A. Moore, Sarah Han-Oh

Theranostics has transformed nuclear medicine from an imaging-focused discipline into a data-rich radiation medicine platform in which target expression, pharmacokinetics, tumor dose, and response can be measured in the same patient. This critical narrative review evaluates patient-specific integration of radiopharmaceutical therapy (RPT) with external-beam radiotherapy (EBRT), with emphasis on quantitative imaging, absorbed-dose estimation, spatial registration, biological interpretation, adaptation thresholds, an …

17.08.2026journal-article

Adolescência e Saúde

Eosinophil-Guided Therapy In Chronic Obstructive Pulmonary Disease: Evaluating Blood Eosinophils As Predictors Of Inhaled-Corticosteroids Response

Dr Selva Nandha Kumaran K K, Dr Suresh A, Dr Veena Charishma RP, Dr Ghanshyam Verma

Background-Aim:Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide and is characterized by persistent airflow limitation and recurrent exacerbations. Although inhaled corticosteroids (ICS) are recommended for patients with frequent exacerbations, the response to therapy varies. Blood eosinophil count has emerged as a potential biomarker for identifying patients who may benefit from ICS-containing regimens. This study evaluated the role of baseline blood eosinophil coun …

17.08.2026journal-article

Viruses

Virological Failure and Mortality Among People Living with HIV Transitioned to Second- or Third-Line Antiretroviral Therapy in Rwanda: A Competing-Risks Survival Analysis of National Case-Based Surveillance Data, 2019–2025

Gallican N. Rwibasira, Jean Claude Kwizera, Tafadzwa Dzinamarira, Steven Karera, Gatete Gaetan, Albert Tuyishime, Eric Remera, Daniel Henry Paris, Tracy R. Glass

Background: Despite Rwanda’s achievement of the UNAIDS 95–95–95 targets, national evidence on virological failure (VF) and mortality after transition to second- or third-line antiretroviral therapy (ART) remains limited. We estimated the incidence of these outcomes and examined associated factors among people living with HIV (PLWH) transitioned to second- or third-line ART in Rwanda between 2019 and 2025. Methods: We conducted a retrospective cohort study using Rwanda’s national HIV case-based surveillance (CBS) sy …

17.08.2026journal-article

Current Neuropharmacology

Differential Serum NGF and BDNF Levels in People Living with HIV According to Antiretroviral Therapy, Historical and Current Viroimmunological Condition: A Pilot Study

Luca Maddaloni, Pamela Rosso, Elena Fico, Letizia Santinelli, Carmen Falvino, Marco Ridolfi, Giampiero Ferraguti, Giancarlo Ceccarelli, Claudio Maria Mastroianni, Guido Antonelli, Carolina Scagnolari, Gabriella d'Ettorre, Marco Fiore

Introduction: Although HIV infection can now be kept under control in almost all people living with HIV (PLWH), these individuals are prone to developing several non-AIDS complications due to chronic immune impairments, such as HIV-associated neurocognitive disorders (HAND). Unfortunately, no marker has been identified to predict these conditions, but there is growing interest in neurotrophins, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Methods: In this pilot study, we evaluated …

17.08.2026journal-article

Frontiers in Immunology

URAT1 inhibition in hyperuricemia and gout: from transporter biology to clinical precision therapy

Guangtao Li, Yu Wang, Zhuoli Zhang

Impaired renal urate excretion is a major mechanism underlying hyperuricemia and gout, with urate transporter 1 (URAT1), encoded by SLC22A12, playing a central role in proximal tubular urate reabsorption. This review summarizes the biological relevance of URAT1, the pharmacological evolution of URAT1 inhibitors, and their clinical implications in urate-lowering therapy. Evidence from transporter biology, structural pharmacology, pharmacokinetic and pharmacodynamic studies, and clinical trials was narratively synthe …

17.08.2026journal-article

Journal of Clinical Oncology

Therapy for Stage IV Non-Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2026.3.3

Paul Wheatley Price, Nofisat Ismaila, Antonio Calles Blanco, Jeremy Cetnar, Terri Conneran, Parth A. Desai, Greg Durm, Hidehito Horinouchi, Humera Khurshid, Swati Kulkarni, Kristen Ashley Marrone, Kirstin Perdrizet, Lyudmila Bazhenova

This guideline has been updated. This ASCO Living Guideline is reviewed on an eight-week cycle. Please see the online dynamic version for the latest updates. Living guidelines are developed for selected topic areas with rapidly evolving evidence that drives frequent change in recommended clinical practice. Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the ASCO Guidelines Methodology Manual . ASC …

17.08.2026journal-article

Adolescência e Saúde

Methodological Confidence And Reported Certainty Of Evidence For Virtual Rehabilitation And Mirror Therapy In Post-Stroke Upper-Extremity Function: An Umbrella-Review Audit Using AMSTAR 2 And GRADE

Tumuluri S S Chandra Sekharendra Swamy, Dr. Payal Sharma, PT, Dr. Dipika Balala, PT, Dr. Deepak Lohar, PT, Dr. Jafar Khan, PT, K. M. Annamalai, Shradha Hariom Tiwari, Sneha Thakur Lund, Parul Sharma, Payal Padole

Background. Systematic reviews of virtual rehabilitation and mirror therapy for post-stroke upper-extremity function have expanded rapidly, but the methodological confidence and reporting practices of these reviews remain unclear. Objective. To audit the methodological confidence and reporting practices of systematic reviews examining virtual rehabilitation and mirror therapy for post-stroke upper-extremity function using AMSTAR 2. Methods. An umbrella-review audit of review methods was conducted. PubMed, Europe PM …

17.08.2026journal-article

BMEMat

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang

Abstract The dynamic interplay between intratumoral bacteria and cancer progression has unveiled new avenues for precision oncology, positioning bacteria as versatile, programmable platforms for targeted therapy. This review systematically explores the dual roles of tumor‐associated microbiota‐both promoting and suppressing malignancy‐and highlights the transformative potential of engineered bacterial systems in cancer treatment. Capitalizing on their innate tropism for hypoxic tumor cores, bacteria serve as self‐p …

17.08.2026journal-article

Small

Potentiating In Vivo Precision Cancer Therapy With Modularized Aptamer‐Chemotherapeutics Conjugates Based on DNA Tiling‐Mediated Structural Nanotechnology

Weijun Wang, Jingting Wu, Yuxi Yang, Xinru Yu, Wenhao Pan, Wenqing Lin, Zai‐Sheng Wu

ABSTRACT While DNA origami nanotubes have been often used in the biomedical field, the technical challenges in the assembly at large scale and the susceptibility to degradation limit their exploration for clinical application. In the current contribution, we propose a structural DNA nanotechnology (TMM) for the construction of a degradation‐resistant DNA nanotube (DNT) via periodically tiling two structural modules (M) into a modularized (M) tubular DNA nano‐architecture. The tube circumference is 118.6 nm, the tub …

17.08.2026journal-article

Clinical and Experimental Dermatology

Refractory livedoid vasculopathy successfully treated with CHAP therapy and punch grafts: two case reports

María del Señor Gómez Marín, Miguel Juan Cencerrado, Irene Suárez Vergne

Abstract Livedoid vasculopathy (LV) is a chronic thrombotic microangiopathy characterized by painful ulcerations that significantly impair quality of life. Management of refractory LV remains challenging as conventional therapies have limited efficacy. We report two female patients with chronic, painful ulcers unresponsive to multiple intravenous immunoglobulin cycles who achieved complete ulcer healing and rapid pain resolution following a combined regimen of CHAP therapy, comprising nifedipine, hydroxychloroquine …

17.08.2026journal-article

Human Systems: Therapy, Culture and Attachments

The we-dentity daisy approach for creating antidotes to life diminishing stories of identity; a CMM informed systemic narrative approach

Rachel Ames, Glenda Fredman

We share our personal and professional journeys through different identity discourses that have shaped our practice as clinical psychologists and systemic psychotherapists working with children, adults and older people within public physical and mental health services. Through examples of our work with children affected by illness and disability, we track the development of our understandings of identity from ‘internal states of self’ to understandings that are relational, distributed, performed, and fluid. Integra …

17.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

How digital leadership fosters employee proactive behavior: A dual-pathway model based on job demands and resources

Mingqi Huang, Wei Shao

Background Digital leadership is increasingly recognized as critical to organizational digital transformation. How digital leadership fosters employee proactive behavior through job characteristics remains insufficiently understood. Objective Drawing on Job Demands-Resources theory, this study develops and tests a dual-pathway model examining how digital leadership influences employee proactive behavior through digital job demands and digital job resources, with employee digital literacy as a boundary condition. Me …

17.08.2026journal-article

Adolescência e Saúde

Patient-Reported Barriers To Routine Dental Care And Postoperative Maxillofacial Prosthetic Rehabilitation In Head And Neck Cancer Patients: A Cross-Sectional Study

Sudhakar Vundavalli, Koya Srikanth, Radhika Doppalapudi, Aravind Muthukrishnan, Kaleswara Rao Atluri, MeignanaArumugham Indiran, Rakhi Issrani, Ravikanth Manyam

Background: Survivors of head and neck cancer require sustained oral healthcare after cancer therapy; few cases may additionally need specialized maxillofacial prosthetic rehabilitation. Objective: To assess patient-reported barriers to routine dental care among post-treatment head and neck cancer patients and, among those requiring a maxillofacial prosthesis, to characterize barriers to postoperative prosthetic rehabilitation. Methods: A cross-sectional survey was conducted among 194 post-treatment head and neck c …

17.08.2026journal-article

Adolescência e Saúde

Psychological Stress And Occupational Performance Among Seafarers: A Systematic Review Of Verified Empirical Evidence

Rashmi Sharma, Dr. Anurag Shakya

Background: Seafaring brings together several demanding features of work within a single occupation - long absences from family, cramped and shared living conditions, irregular sleep, mixed-nationality crews, and heavy workloads carried out with little outside support. A substantial body of research has examined how these conditions give rise to psychological stress, and how that stress in turn shapes seafarers' mental health, wellbeing, and ability to carry out their duties. Objectives: This review has two aims: f …

17.08.2026journal-article

Revista Árvore

Effect of the rehabilitation of bauxite mining areas on the infiltration and repellency of the soil to water

Henrique de Andrade Cenachi, Herly Carlos Teixeira Dias, Bernardo Fontes Grossi Lino, Bruna Queiroz de Souza, Paulo Cesar Marques Cordeiro, Juliana Marcela de Paiva, Rodolfo Soares de Almeida, Mônica de Abreu Azevedo, Hélio Garcia Leite

Brazil, the fourth-largest holder of bauxite reserves worldwide, plays a prominent role in global mineral production. However, open-pit mining can alter soil hydrological attributes due to vegetation removal and intensive soil disturbance. This study evaluated the effects of rehabilitation practices implemented by Companhia Brasileira de Alumínio (CBA) on water infiltration, unsaturated hydraulic conductivity, and soil water repellency. Six study areas were selected in the municipality of São Sebastião da Vargem Al …

17.08.2026journal-article

Revista de Geopolítica

A GAMETERAPIA ASSOCIADA À FISIOTERAPIA NO TRATAMENTO DE CRIANÇAS COM PARALISIA CEREBRAL: UMA REVISÃO INTEGRATIVA

Elane Tereza Oliveira Bandeira, Emanoel Pereira da Silva Neto, Gustavo Coringa de Lemos, Joelma Gomes da Silva Rocha, Rebeca Graziely Gomes de Melo, Frederico da Silva Jales, Andréa Raquel Fernandes Carlos da Costa, Lidiane Pinto de Mendonça Ferreira, Sirlene Batista Cavalcante, Natália Jéssica Barra Silva

Nos últimos anos o uso de recursos tecnológicos na área da saúde vem sendo utilizado como uma estratégia terapêutica, sendo esta reconhecida como Gameterapia. Dentre esses recursos destaca-se a Realidade Virtual (RV), a qual possibilita ao paciente se sentir inserido em uma realidade artificial criada digitalmente. Assim, no tratamento de crianças com Paralisia Cerebral (PC), a Fisioterapia e a Gameterapia podem estar associadas na tentativa de potencializar os resultados e proporcionar momentos de ludicidade. Dian …

17.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

THE INTEGRATION OF NEUROPSYCHOPEDAGOGY, MUSIC THERAPY, AND PSYCHOMOTOR THERAPY IN THE DEVELOPMENT OF CHILDREN WITH AUTISM SPECTRUM DISORDER: AN INTEGRATIVE LITERATURE REVIEW

Kevin Barbosa de Moraes Feitosa

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by persistent differences in communication and social interaction, associated with restricted and repetitive patterns of behavior and interests. Given the heterogeneity present within the autism spectrum, it is essential to adopt individualized intervention strategies based on each child’s needs, potential, and characteristics. In this context, the integration of neuropsychopedagogy, music therapy, and psychomotor therapy offers an inter …

17.08.2026journal-article

Frontiers in Medicine

Efficacy of ozone with steroid injection therapy in lumbar disc herniation: meta-analysis

Yi Zhou, Hongyu Yu

Background The efficacy of ozone combined with steroid injection for lumbar disc herniation remains uncertain. This systematic review and meta-analysis aimed to investigate the efficacy of Ozone with steroid injection therapy in the treatment of lumbar disc herniation. Methods PubMed, Embase, Web of Science, and Wanfang were searched from database inception to July 20, 2026. Comparative studies evaluating ozone combined with steroid injection in patients with lumbar disc herniation were included. Mean differences ( …

17.08.2026journal-article

International Journal of Molecular Sciences

Clinical Impact of a Common PDCD1 Germline Variant in DLBCL Patients Treated with CAR-T Cell Therapy

Katja Seipel, Marta Gonçalves Fonseca, Inna Shaforostova, Seok-Yun Lee, Ulrike Bacher, Thomas Pabst

Chimeric antigen receptor CAR T-cells are effective immunotherapies for patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) with overall response rates of 63–84% and complete response rates of 43–54%. Programmed cell death protein 1 (PD-1) is a cell surface receptor with immune check-point function. There are several common germline variants of the PDCD1 gene, including the linked single nucleotide polymorphisms (SNP) rs6710479 and rs2227981. Genetic variants of the immune-checkpoint regu …

17.08.2026journal-article

The Journal of ECT

Klazomania Refractory to Electroconvulsive Therapy

Vishwa Thakkar, Sagar Karia, Nilesh Shah

Klazomania is a rare phenomenon characterized by compulsive, uncontrollable shouting or yelling without an emotional trigger or reason. It has been reported to be associated with various psychiatric and neurological conditions. No specific treatment has been recommended as the etiology is not known. Trials of antipsychotics, antidepressants, and antiepileptic drugs have been used. Hereby, we report a case of Klazomania in a patient with Obsessive Compulsive Disorder who initially responded to Electroconvulsive Ther …

17.08.2026journal-article

Adolescência e Saúde

Freedom Of Speech And Expression In The Digital Age: A Critical Analysis Of Constitutional Rights, Social Media Regulation, And Emerging Technologies

Dr. Mamta Rani, Dr. Jitendra Yadav

Freedom of speech and expression constitutes one of the fundamental pillars of a democratic society. In India, Article 19(1)(a) of the Constitution guarantees every citizen the right to freedom of speech and expression, while Article 19(2) permits reasonable restrictions in the interests of sovereignty, security, public order, decency, morality, contempt of court, defamation, and incitement to an offence. The emergence of digital technologies, social media platforms, artificial intelligence (AI), algorithmic govern …