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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Frontiers in Public Health

Reframing the starting point of shared decision-making under algorithmic short-form video exposure: bone tumor care as a sentinel context

Jia-Wen Wang, Ying-Fa Feng, Zi-Bo Zhang

Short-form video platforms have become a major component of the pre-consultation information environment for patients with cancer in China and may create new challenges for clinical communication. Contemporary shared decision-making (SDM) and patient decision aids (PtDAs) do not explicitly assess or calibrate beliefs formed before consultation. Algorithmic recommendation and emotionally charged narratives may therefore contribute to pre-consultation cognitive anchoring and alter the conditions under which SDM occur …

24.08.2026journal-article

Journal of Translational Medicine

Targeting the metabolic dependencies of tumor-associated macrophages for cancer immunotherapy

Weifeng Yuan, Yiran Zhu, Yuxin Zhang, Jinping Gu, Liqiong Xue, Wencan Zhang, Xu Cao

Abstract Tumor-associated macrophages (TAMs) play a pivotal role in tumor progression and immune evasion, with recent evidence indicating that metabolic reprogramming is crucial in determining their functional phenotype. Alterations in glucose, amino acid, and lipid metabolism are central to the regulation of TAMs plasticity, driving the shift between pro-inflammatory (M1) and anti-inflammatory (M2) states. M1 macrophages predominantly rely on glycolysis and aerobic metabolism to support their pro-inflammatory func …

24.08.2026journal-article

Clinical Nuclear Medicine

Two Cases of Solitary Corpus Cavernosum Metastasis From Prostate Cancer Detected by 68Ga-PSMA PET Imaging

Guannan Li, Lixiang Yang, Minggang Su, Fanglan Li, Yueqi Wang

Solitary corpus cavernosum metastasis from prostate cancer is extremely rare, particularly as an isolated nodular lesion. We report 2 patients who developed rapid prostate-specific antigen (PSA) elevation following radical prostatectomy without prior evidence of metastatic disease. 68 Ga-PSMA PET revealed isolated PSMA-avid nodules in the corpus cavernosum (SUV max : 4.46 and 22.46, respectively). Following salvage radiotherapy, both patients showed a marked decline in PSA levels. These cases highlight the utility …

24.08.2026journal-article

Journal of Adolescent and Young Adult Oncology

Genetic Markers of Early Skeletal Muscle Loss in Adolescent and Young Adult Cancer Patients Treated with Anthracyclines

Savannah V. Rauschendorfer, Amanda Brandt, Behrang Amini, J. Andrew Livingston, Michael E. Roth, Eugenie S. Kleinerman, Michelle A.T. Hildebrandt

Purpose: Skeletal muscle (SM) loss occurs during early anthracycline treatment in adolescent and young adult (AYA) cancer patients. Identifying those at greatest risk is critical for prevention. This study aimed to determine if genetic variants previously associated with SM loss in the general population are also associated with SM loss in AYA cancer patients receiving anthracycline chemotherapy. Methods: SM change was quantified via computed tomography for 138 AYA cancer patients. The genome-wide association studi …

24.08.2026journal-article

Biomedicines

Photodynamic Therapy in Cancer: Mechanisms, Photosensitizer Technology, Vitamin Modulation, and Rational Combination Design

Ilaf Naser, Dorota Bartusik-Aebisher, Barbara Smolak, Klaudia Dynarowicz, Edward Kowalczyk, Wiesław Guz, David Aebisher, Gabriela Henrykowska

Photodynamic therapy (PDT) is a minimally invasive anticancer modality based on the interaction of a photosensitizer, light of an appropriate wavelength, and molecular oxygen, resulting in reactive oxygen species (ROS)-mediated tumor injury. This review discusses PDT as a mechanism-dependent therapeutic platform and evaluates how photosensitizers, vitamin A, vitamin D, nanotechnology, and combination strategies may influence its efficacy. The article synthesizes mechanistic and translational evidence concerning pho …

24.08.2026journal-article

Journal of Transcultural Nursing

Use of Complementary and Alternative Medicine for Fatigue and Pain Among Gastrointestinal Cancer Patients in Türkiye: A Cross-Sectional Study

Ayşegül Çelik, Özlem Kardaş Kin

Introduction: Gastrointestinal cancers are associated with pain and fatigue that impair quality of life; use of complementary and alternative medicine (CAM) for symptom management is increasing, yet data from Türkiye remain limited. Method: A descriptive, cross-sectional design was employed with 167 gastrointestinal cancer patients receiving treatment at a university hospital in Türkiye. Results: Liver cancer (33.5%) and gastric cancer (31.7%) were the most common diagnoses. The total mean holistic complementary an …

24.08.2026journal-article

Frontiers in Oncology

HAIC combined with atezolizumab and bevacizumab versus lenvatinib in advanced hepatocellular carcinoma: a multicenter propensity score matching analysis

Lei Zhao, Dan Liu, Chao Ma, Yue Hu, Shu Liu

Purpose This study aimed to evaluate the clinical efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) combined with atezolizumab and bevacizumab (HTA) versus HAIC combined with lenvatinib (HL) in the treatment of advanced hepatocellular carcinoma (HCC). Methods A multicenter retrospective study was conducted between June 2021 and June 2025, reviewing advanced HCC patients treated with either HTA or HL. To mitigate initial differences between the two groups, propensity score matching (PSM) was appli …

24.08.2026journal-article

IJEDO

Is a 20-Session Treatment Sufficient for Adult Anorexia Nervosa? A Critical Comparison of CBT-AN-20 with CBT-E

Simona Calugi, Riccardo Dalle Grave

The aim of this article is to describe the key theoretical differences between CBT-AN-20 and enhanced cognitive behaviour therapy (CBT-E), to compare briefly the findings from CBT-AN-20 with those of the principal outpatient CBT-E studies in adults with anorexia nervosa, and to examine the conceptual and clinical implications of the two approaches. The treatments differ in their theoretical foundations and strategies. CBT-AN-20, based on an anxiety model, promotes rapid behavioural change, exposure to feared foods, …

24.08.2026journal-article

Pharmaceuticals

Transcriptional Regulation of Receptor-Mediated Mitophagy in Sunitinib-Resistant Renal Cancer Cells: Response to Succinic Acid

Goksu Kasarci-Kavsara, Sinem Bireller, Baris Ertugrul, Bedia Cakmakoglu

Background/Objectives: Drug resistance is a major challenge in cancer therapy, and mitochondria contribute to this process by controlling both metabolic adaptability and cell survival signaling. Mitophagy, the selective lysosomal removal of dysfunctional mitochondria, has been implicated in therapy resistance, yet its role in sunitinib-resistant renal cancer remains poorly defined. Methods: In this study, acquired sunitinib resistance was established in ACHN renal cancer cells through eight months of stepwise dose …

24.08.2026journal-article

Cancers

Quality of Outcome Reporting for Older Subgroups in FDA Registration Gastroesophageal Cancer Trials (2010–2024): A Systematic Review

Ilse Trip, Martha Kormi, Elizabeth Smyth, Russell D. Petty, Mark A. Baxter

Background: Gastroesophageal adenocarcinoma is predominantly a disease of older adults. However, older adults are underrepresented in randomised controlled trials (RCTs), and outcomes specific to this subgroup are underreported. Clinicians therefore extrapolate data from younger, fitter trial populations, which can lead to over- and undertreatment of older cancer patients. This study examines the inclusion and completeness of outcome reporting for older patients in practice-changing trials in gastroesophageal cance …

24.08.2026journal-article

British Journal of Pharmacology

Single‐atom Pt‐N‐C nanozyme targets Rara/Wnt/β‐catenin axis for diabetic cardiomyopathy treatment

Lina Hao, Xiufen Qu

Abstract Background and Purpose Diabetic cardiomyopathy (DCM) lacks effective therapies because of complex mechanisms. This study aims to develop a single‐atom nanozyme for integrated antioxidant and signalling regulation in DCM. Experimental Approach A graphene quantum dot‐templated single‐atom Pt‐N‐C nanozyme (PtsaN‐C) was synthesised for all‐trans retinoic acid (ATRA) delivery (PtsaN‐C@ATRA). In vitro antioxidant activity and in vivo efficacy were evaluated in DCM mice, combined with scRNA‐seq for mechanistic an …

24.08.2026journal-article

Veterinary Dermatology

A Randomised Placebo‐Controlled Study to Evaluate the Efficacy and Safety of a Two‐Dose Topical Terbinafine and Betamethasone Gel for the Treatment of Yeast ( Malassezia pachydermatis ) Otitis Externa in Dogs

Zorica Zivkovic Baks, Hope Baird Heinz, Stephan Grundke, Caryn Thompson, Roberto Garcia

ABSTRACT Background Otitis externa (OE) with Malassezia pachydermatis overgrowth with limited bacterial involvement is common in dogs. Treatment with products containing antibiotics is unnecessary and not consistent with judicious use of antimicrobials. Objectives To evaluate the efficacy and safety of an otic gel containing 1% terbinafine and 0.1% betamethasone acetate for the treatment of yeast‐predominant canine OE. Animals 239 privately owned dogs were enrolled. Materials and Methods Inclusion criteria were an …

24.08.2026journal-article

Annals of Surgical Oncology

Increased Axillary Nodal Metastasis in Patients with Breast Cancer and Limited English Proficiency

Thomas Amburn, Daniel Louie, Shira Schwartz, Anita McFarlane, Joseph Ravenell, Kathie-Ann Joseph

Abstract Background Patients with breast cancer and limited English proficiency (LEP) experience barriers to care that may result in greater disease burden. We aim to evaluate breast cancer presentation and pathologic characteristics of patients with LEP compared with patients with English proficiency (EP). Patients and Methods We performed an institutional review board (IRB)-approved, retrospective review of prospectively collected patient-reported data among a multilingual population evaluated within a New York C …

24.08.2026journal-article

Endocrine-Related Cancer

Association between PD-1/PD-L1 Expression and Clinicopathological Parameters as well as Prognosis in Neuroendocrine Neoplasms of the Digestive System: A Systematic Review and Meta-Analysis

Qiming Zheng, Xinyue Xie, Qingjun Guo, Chiyi Chen, Wentao Jiang

Abstract Neuroendocrine neoplasms (NENs) are a highly heterogeneous group of tumors originating from the neuroendocrine system, predominantly occurring in the gastrointestinal tract and lungs. This meta-analysis aimed to clarify the association of programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) expression with clinicopathological parameters and prognosis in patients with digestive system NENs. A systematic literature search was performed in PubMed, Web of Science, Embase, the Cochrane Library, China Nat …

24.08.2026journal-article

Journal of Experimental & Clinical Cancer Research

SPATS2 triggers immune evasion and anti-PD-1 resistance of hepatocellular carcinoma by inducing dendritic cell phagocytic dysfunction

Bo Zhang, Xiangyu Wang, Baorui Tao, Chenhe Yi, Yan Geng, Yincheng Gu, Rui Zhang, Rongquan Sun, Senfeng Ying, Jing Lin, Jinhong Chen

Abstract Background The clinical efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma (HCC) remains limited due to the inherently immunosuppressive tumor microenvironment. This study aims to investigate the role of the spermatogenesis-associated serine-rich protein 2 (SPATS2) in mediating resistance to anti-PD-1 immunotherapy in HCC. Methods Five independent HCC anti-PD-1 therapy RNA-seq cohorts ( n = 105) were included to identify key genes driving anti-PD-1 resistance. Multiplex immunofluorescence stai …

24.08.2026journal-article

npj Breast Cancer

Upregulated mitophagy promotes the survival and aggressiveness of breast cancer upon apoptosis reversal

Lung Yiu, Yan Wah Chong, Yuk Wah Chan, Yiyue Xu, Peilan Guo, Lijun Zhou, Lin Peng, Zongwei Cai, Xiangdong Li, Suk Ying Tsang

Abstract A number of literature have documented the phenomenon of apoptosis reversal. We have previously reported that when cancer cells are treated with apoptosis inducer, if the inducer is withdrawn at an inappropriate time, some cells would undergo apoptosis reversal and survive with increased aggressiveness. However, the reasons underlying the increase in aggressiveness are unknown. Here, we aimed to investigate whether enhanced mitophagy is the underlying rescuing force. By qPCR and flow cytometry, mitophagy-r …

24.08.2026journal-article

Journal of Endovascular Therapy

Individual Patient Data Meta-Analysis of GORE VIABAHN Endoprosthesis with Heparin Bioactive Surface for Treatment of Femoro-Popliteal Arterial Disease (INSIGHT VSX)

Hilde Wetzels, Suzanne Holewijn, Stijn Zomer, Osamu Iida, Sho Nakao, Takao Ohki, Tanja Böhme, Florian Wolf, Richard Saxon, Michel M.P.J. Reijnen

Objective: This study aims to analyze available data on patients the latest-generation heparin-bonded Viabahn endoprosthesis in the femoropopliteal artery. Design: This study is an individual patient data (IPD) meta-analysis. Methods: This study incorporated all available cases from databases that reported outcomes of patients treated with the heparin-bonded Viabahn endoprosthesis in the femoropopliteal artery. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 IPD Guidelines were …

24.08.2026journal-article

Cancer Discovery

Diet-Induced Phospholipid Remodeling Dictates Ferroptosis Sensitivity and Tumorigenesis in the Pancreas

Christian Felipe Ruiz, Xiangyu Ge, Rylee McDonnell, Sherry S. Agabiti, Daniel C. McQuaid, Andy Tang, Meera Kharwa, Jennifer Goodell, Rocío del M. Saavedra-Peña, Allison Wing, Guangtao Li, Natasha Pinto Medici, Marie E. Robert, Rohan R. Varshney, Michael C. Rudolph, Fred S. Gorelick, John Wysolmerski, Daniel Canals, John D. Haley, Matthew S. Rodeheffer, Mandar Deepak Muzumdar

Abstract High-fat diet (HFD) intake has been linked to an increased risk of pancreatic ductal adenocarcinoma (PDAC), a lethal and therapy-resistant cancer. However, whether and how specific dietary fats drive cancer development remains unresolved. Leveraging an oncogenic Kras-driven mouse model that closely mimics human PDAC progression, we screened a dozen isocaloric HFDs differing solely in fat source and representing the diversity of human fat consumption. Unexpectedly, diets rich in oleic acid—a monounsaturated …

3 Zitationen
24.08.2026journal-article

Molecular Pharmaceutics

A Dual-Action CXCR4-Targeted Peptide−Drug Conjugate Engineered to Enhance Antitumor Efficacy and Mitigate Myelosuppression in Pancreatic Cancer

Ke Zhu, Xuanxin Liu, Dapeng Li, Tao Wang, Tao Wen, Xiaocui Fang, Yanlian Yang, Jian Liu, Jie Meng, Chen Wang, Haiyan Xu

Abstract Gemcitabine (GEM) is a first-line therapeutic option for pancreatic cancer; however, it has low efficacy due to rapidly developed drug resistance and severe dose-limiting myelosuppression. To enhance its therapeutic effect, this study developed a novel peptide−drug conjugate using a CXCR4 antagonistic peptide as the targeting head and gemcitabine as the drug payload, based on the characteristics of pancreatic tumor cells highly expressing CXCR4 that mediates immunosuppression and tumor progression through …

24.08.2026journal-article

Journal of Clinical Medicine

Clinical and Radiological Outcomes of Oral Bisphosphonate Therapy Combined with Conservative Treatment in Subchondral Bone Marrow Edema of the Knee: A Retrospective Cohort Study

Goker Yurdakul, Murat Korkmaz, Irfan Karadak, Abdullah Iyigun, Muhammed Kazez, Nezih Yayli, Mustafa Fatih Erkoc, Fatih Golgelioglu

Background/Objectives: Subchondral bone marrow edema (BME) of the knee often causes persistent pain despite conservative treatment, and evidence supporting oral bisphosphonates is limited. We compared conservative treatment alone with conservative treatment plus oral alendronate. Methods: This retrospective cohort study included 82 patients with MRI-confirmed subchondral BME of the knee treated between January 2020 and January 2025. Patients received conservative treatment alone (n = 44) or conservative treatment p …

24.08.2026journal-article

JEADV Clinical Practice

When Treatment Meets Natural History: Understanding Early Dermatitis‐Related Adverse Events in Systemic Atopic Dermatitis Trials

Diego Ruiz Dasilva, Alondra Soto‐Gonzalez, Haya Alkiswani, Graham H. Litchman, Harrison Nguyen, Gil Yosipovitch, Firas George Hougeir, Matthew Zirwas, David Cotter, Brad Glick, E. James Song, Christopher G. Bunick, Neal Bhatia, Adam Friedman, Leon Kircik, Mona Shahriari, Peter Lio, James Del Rosso

ABSTRACT Biologics and Janus kinase (JAK) inhibitors have transformed the management of atopic dermatitis (AD), yet some patients experience early worsening of disease activity during treatment initiation. In clinical trials, these events are typically recorded as treatment‐emergent adverse events (TEAEs), most commonly coded as “atopic dermatitis”. We conducted a structured narrative review of phase 3 randomized trials evaluating approved systemic therapies for AD used in combination with background topical therap …

24.08.2026journal-article

International Journal for Quality in Health Care

Assessment of Knowledge, Attitudes, and Practices around Cervical Cancer Screening in the Gulu District of Northern Uganda: A cross-sectional study

Tana Chongsuwat, Andre Nana, Aaliyah O Ibrahim, Ann E Evensen, James H Conway, Sumba O Pius, Ibrahim Sseddangira, Usman Iqbal, William Oloya

Abstract Background Cervical cancer is a global health issue, particularly Sub-Saharan Africa including Uganda, where it poses a severe burden. Despite the availability of screening methods, uptake remains low due to various barriers, such as limited resources and a lack of awareness. This study primarily aimed to assess the knowledge, attitudes, and practices related to cervical cancer screening among men and women in the Gulu District of Northern Uganda, with secondary objectives on understanding gender differenc …

24.08.2026journal-article

Current Oncology

Breast Cancer Patients’ Parenting Concerns User Personas: A Qualitative Analysis

Ying Zhang, Ming Liu, Xiaoning Fan, Hailing Tu, Yin Wang, Jingfang Hong

Breast cancer disproportionately affects young women raising minor children. Unresolved parenting concerns can impair patients mental health, reduce treatment adherence, and compromise long-term oncological outcomes. However, previous studies have paid limited attention to the heterogeneity of parenting concerns in this population and lack a theory-grounded classification framework for stratified supportive care. This descriptive qualitative study, framed by social role theory, recruited 17 Chinese breast cancer pa …

24.08.2026journal-article

World Journal of Clinical Oncology

Risk factors for surgical site infection after craniotomy for meningioma resection in a tertiary hospital in China

Hong Wang, Yu-Lu He, Yin Gao, Xing-Rong Gao, Li-Yuan Sun, Ji-Cheng Yan, Qun Lu, Kai-Wen Ni

BACKGROUND Meningioma is the most common intracranial neoplasm and carries a non-negligible surgical site infection (SSI) risk (reported incidence: 4%-6%) despite its clean-wound classification. Most existing studies enroll heterogeneous neurosurgical cohorts spanning vascular, traumatic, and biologically distinct tumor entities, even though meningioma itself is an independent SSI risk factor, which calls for disease-specific investigation. Preoperative host physiologic reserve indices have shown prognostic value a …