Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Onkologie · Seite 9

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Macromol

Preclinical Efficacy and Structural Gaps of Ganoderma lucidum Polysaccharides in Cancer: A Systematic Review

Jean Felipe dos Santos, Karien Sauruk da Silva, Hellen Abreu, Alex Leandro dos Santos de Sá, Daniele Maria-Ferreira, Fhernanda Ribeiro Smiderle

Ganoderma lucidum’s anticancer potential is largely attributed to its polysaccharides, yet their preclinical translation requires rigorous systematization. Following PRISMA 2020 guidelines, this systematic review evaluated the anticancer efficacy of G. lucidum polysaccharides (GLPs) in preclinical models (PROSPERO: CRD42021296200). Systematic searches spanning 2011 to 2026 were conducted in PubMed, Embase, and Scopus. Eligible peer-reviewed articles investigated GLPs in cancer cell lines or animal models. The Cochr …

27.08.2026journal-article

Neuro-Oncology

9 Development of a Rapid Lateral Flow Assay for Early Identification of Glioblastoma and Brain Metastases Using a Circulating Serum Biomarker

Carys Jordan, Xia Liu, Calum Haydon, Cristina Santi, M C Galan, Kathreena Kurian

Abstract Introduction Rapid diagnostic tools could improve the early detection of glioblastoma (GBM) and brain metastases (BM). Lateral flow assays (LFAs) offer a simple, point-of-care testing platform. Glial fibrillary acidic protein (GFAP) has previously been reported as a circulating marker associated with blood–brain barrier disruption in brain tumours. This study aimed to develop and evaluate an LFA capable of detecting GFAP in the serum of patients with GBM and BM. Methods Detection antibodies were conjugated …

27.08.2026journal-article

Neuro-Oncology

129 Electroactive drug delivery for local glioblastoma treatment

Joshua Killilea, Immi Van Der Auweraert, Gary Shaw, Harveena Padda, Holly Briggs, Une Kontrimaite, Leire Landeira Suquia, Rosalie De Ferm, Lucia Moreno Gimeno, Phoebe McCrorie, Estelle Cuttaz, Aaron Lee, Giovanni Carlo Miceli, Stuart Smith, Dong-Hyun Kim, Ruman Rahman, Juanita Lopez, Roberto Portillo Lara, Josef Goding, Heiko Wurdak, Ryan Mathew, Christopher Chapman, Rylie Green

Abstract Introduction Despite recent advances in cancer therapeutics, the prognosis for glioblastoma remains exceptionally poor, stemming from the limited ability of systemically administered chemotherapeutics to cross the blood brain barrier (BBB). Mechanically circumventing the BBB represents a promising avenue. However, biomaterials previously used for local delivery suffer from low control over drug release, further limiting their translation. To address this, an implantable bioelectronic drug delivery device w …

27.08.2026journal-article

Neuro-Oncology

19 Age Related Presentation Characteristics and MRI Volumetric Associations in Glioblastoma IDHwt

Dominic van Loan, Sophie Williams, Olamide Rominiyi, Safiyyah Hussain, Danielle Madamba

Abstract Introduction Glioblastoma IDHwt is most common in adults aged ≥65 years, who often present with atypical symptoms, potentially impacting diagnostic pathways. We aimed to characterize presenting clinical features and MRI volumetric parameters in older adults with glioblastoma IDHwt at a single tertiary neurosurgical centre. Methods Clinical data were retrospectively collected for a continuous case series of patients diagnosed with glioblastoma IDHwt between 2020-2024 at Sheffield Teaching Hospitals Foundati …

27.08.2026journal-article

Neuro-Oncology

136 Tessa Jowell BRAIN MATRIX interim analysis: surgical and oncology outcomes in glioblastoma patients

Vassili Crispi, Lucy Abell, Joshua Savage, Rhys Mant, Amanda Kirkham, Lucinda Billingham, Vinton Cheng, Victoria Wykes, Colin Watts

Abstract Introduction The Tessa Jowell BRAIN MATRIX (TJBM) is a programme of work aimed at improving the knowledge of and treatment for glioma, comprising a platform study with subsequent interventional clinical trials. Methods Interim analysis of first 500 patients from 11 specialist neurosurgical UK centres recruited to the TJBM study (14/Dec/2020-31/Jan/2025) with recruitment and data cleaning ongoing. Data snapshot 20/Feb/2026. Analysis conducted in R version 4.3.1. Results Amongst GBMs (n = 141), median age is …

27.08.2026journal-article

Oncologie

Curcumol and Oxaliplatin exhibit synergistic anti-tumor effect in colorectal cancer by co-targeting the KPNA2/c-Myc axis

Zhicheng Chen, Yanni Chen, Bo Zhang, Xingxin Zhou, Feng Gao

Abstract Objectives Curcumol is a natural product that has been demonstrated to exert antitumor effects in many tumor types. Oxaliplatin is one of the chemotherapeutic agents commonly employed in the treatment of colorectal cancer (CRC). In this study, we aimed to investigate the synergistic antitumor role of Curcumol and Oxaliplatin in CRC and explore the potential mechanisms. Methods The synergistic antitumor efficacy of Curcumol and Oxaliplatin in CRC cells was assessed by using CCK-8, flow cytometry, and colony …

27.08.2026journal-article

Frontiers in Pharmacology

Association between a regional reimbursement policy and treatment escalation in pulmonary arterial hypertension: a real-world cohort study with long-term Markov cost-effectiveness analysis

Yilin Xie, Yusi Chen, Jun Luo, Jingyuan Chen, Yingjie Tan, Tianyu Wang, Wenjie Chen, Jiang Li

Background Pulmonary arterial hypertension (PAH) requires long-term treatment with high-cost targeted therapies. However, evidence regarding the associations of reimbursement policies with real-world treatment escalation and long-term economic outcomes remains limited. Objectives To examine the association between implementation of a regional reimbursement policy and real-world treatment patterns and to evaluate the long-term cost-effectiveness of the observed post-policy treatment distribution compared with the pr …

27.08.2026journal-article

Frontiers in Oncology

Case Report: Prostate metastasis from pulmonary sarcomatoid carcinoma: the first reported case and clinical implications of palliative radiotherapy

Xueping Liu, Nai Mu, Guobo Du, Min Hou, Lang He

Pulmonary sarcomatoid carcinoma (PSC) is a highly aggressive lung cancer subtype. Prostate metastasis is extremely rare in lung cancer, and no PSC case with immunohistochemical confirmation has been reported. We report a 68-year-old man diagnosed with left upper lobe carcinosarcoma (myogenic differentiation) on pathological biopsy. He underwent multimodal treatment, including radical resection, adjuvant chemotherapy, anlotinib targeted therapy, and local thoracic radiotherapy. Eight months later, he developed progr …

27.08.2026journal-article

World Journal of Hepatology

Second-line treatment of primary biliary cholangitis: To whom, which molecule, and when

Sylvia Drazilova, Peter Jarcuska, Tomas Koky, Martin Harhovsky, Slavomira Komarova, Jan Vasil, Martin Janicko

Ursodeoxycholic acid (UDCA) is the first-line treatment of primary biliary cholangitis (PBC). Approximately two-thirds of patients have a biochemical response to UDCA, but only one-third of treated patients achieve a complete biochemical response. UDCA nonresponse is associated with hepatic decompensation and higher liver-related mortality; therefore, UDCA nonresponders should be considered for second-line PBC treatment. Nonfibrate peroxisome proliferator-activated receptor (PPAR) agonists elafibranor and seladelpa …

27.08.2026journal-article

Lifestyle Medicine

Systematic Review and Descriptive Synthesis of Behaviour Change Techniques in Physical Activity Interventions During and Beyond Breast Cancer

Alejandro Dominguez Garcia, Barbara A. Mullan, Kylie Hill, Lauren J. Breen, Chloe Maxwell‐Smith

ABSTRACT Purpose Many interventions aim to support women with and after a breast cancer diagnosis to increase physical activity; however, the behaviour change components supporting long‐term effectiveness remain unclear. This review examined the behaviour change techniques used in physical activity interventions in breast cancer populations that reported long‐term behavioural outcomes (≥12 weeks post‐intervention). Methods Six databases (CINAHL Ultimate, Medline, ProQuest, PsycINFO, Scopus, Web of Science) were sea …

27.08.2026journal-article

Healthcare

Knowledge, Attitudes, and Practices of Pulmonary Tuberculosis Patients Regarding Tuberculosis and Home-Based Treatment

Xuwen Fu, Jianjie Jiang, Yuanying Li, Jiajia Duan, Zhaojing Shi, Xiang Li

Objectives: To assess the knowledge, attitudes, and intended practices (KAP) of pulmonary tuberculosis (PTB) patients regarding the disease and home-based treatment. Methods: A cross-sectional study was conducted at the authors’ hospital from 1 September 2024 to 28 February 2025, using a self-designed KAP questionnaire. Differences in KAP scores across demographic subgroups were analyzed, and the associations among knowledge, attitude, and practice were examined. Results: A total of 509 valid responses were include …

27.08.2026journal-article

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

Comparison of Clinical Outcomes of Single and Double Soft Anchor Fixation in Arthroscopic Treatment of Anterior Bankart Lesions

Fatih İlker Can, Emre Gültaç, Burak Şener, Rodi Ertoğrul

The aim of this study was to compare the clinical, functional, and stability outcomes of arthroscopic Bankart repair performed using either a single or double soft anchor in patients with limited anterior Bankart lesions between the 1 and 5 o’clock positions. Our retrospective cohort included patients underwent arthroscopic Bankart repair for anterior shoulder instability between January 2018 and December 2023. Glenoid defects or other associated shoulder pathologies were excluded, and all patients had a minimum tw …

27.08.2026journal-article

JAMA Otolaryngology–Head & Neck Surgery

Imaging-Detected Extranodal Extension in p16-Positive Oropharyngeal Cancer

Christopher W. Fleming, Chandana A. Reddy, Sarah Stock, Jonathan Lee, Maura Gillison, Jimmy J. Caudell, Jessica L. Geiger, Dukagjin M. Blakaj, Greg A. Krempl, A. Dimitrios Colevas, Christopher U. Jones, Nabil F. Saba, Jack Phan, Thomas J. Galloway, Samantha Seaward, Sharon Spencer, Pedro Torres-Saavedra, Sue S. Yom, Quynh-Thu Le, Shlomo A. Koyfman

Importance Imaging-detected extranodal extension (iENE) has been included in the American Joint Committee on Cancer (AJCC) and Union for International Cancer Control (UICC) protocol tumor-node-metastasis 9th edition staging system (TNM9) for human papillomavirus (HPV)-mediated (p16-positive) oropharyngeal cancer (HPV-positive OPC). Objective To confirm the new TNM9 staging system on a prospective dataset. Design, Setting, and Participants This prognostic study included patients with HPV-positive OPC with clinically …

27.08.2026journal-article

Advanced Science

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang

ABSTRACT Lymph node metastasis (LN) represents a major clinical challenge in bladder cancer (BCa) and is associated with dismal prognosis; however, the underlying molecular drivers remain incompletely understood. Here, we demonstrate that DIX domain‐containing protein 1 (DIXDC1) is significantly upregulated in LN‐metastatic BCa tissues and is associated with unfavorable clinical outcomes. Functionally, DIXDC1 enhances BCa cell migration, invasion, proliferation, and lymph node dissemination in vivo. Mechanistically …

27.08.2026journal-article

QJM: An International Journal of Medicine

Lytic bone lesions in a patient diagnosed with breast cancer – Sarcoidosis

Ami Schattner, Ina Dubin, Yair Glick, Vladimir Kravtsov

Abstract Sarcoidosis is an inflammatory disease of unknown cause with protean manifestations and presentations which may affect almost any organ. Involvement of intra-thoracic organs (lungs, lymph nodes), reticuloendothelial system, skin, and eyes is predominant. The histological hallmark is non-necrotizing (noncaseating) granulomas. Bone involvement in sarcoidosis is noteworthy. We report a woman who developed crescendo back pain, with multiple lytic bone lesions. Since she had been recently diagnosed with locally …

27.08.2026journal-article

Hepatology Research

On‐Treatment Reassessment of Type IV Collagen 7S and M2BPGi‐Qt Improves Long‐Term Hepatocellular Carcinoma Risk Stratification in Chronic Hepatitis B

Kazumi Yamasaki, Hideko Kozuru, Tomoko Sato, Tomoyuki Suehiro, Yasuhide Motoyoshi, Yuki Kugiyama, Akira Saeki, Shinya Nagaoka, Atsumasa Komori, Hiroshi Yatsuhashi

ABSTRACT Aims Hepatocellular carcinoma (HCC) remains a major complication in patients with chronic hepatitis B receiving nucleos(t)ide analogue (NA) therapy despite effective viral suppression. Although on‐treatment assessment of indirect fibrosis indices has been associated with HCC risk, the prognostic value of direct fibrosis markers, particularly type IV collagen 7S (4COL7S), during antiviral therapy remains poorly defined. We investigated whether on‐treatment 4COL7S predicts HCC development, with M2BPGi‐Qt eva …

27.08.2026journal-article

PLOS One

CLIN-LLM: A safety-constrained hybrid framework for clinical diagnosis and treatment generation

Md. Mehedi Hasan, Md. Abir Hossain, Farman Hossain Sayem, Bikash Kumar Paul, Ziaur Rahman, Mohammad Shorif Uddin, Rafid Mostafiz

Accurate symptom-to-disease classification and clinically-grounded treatment recommendations remain challenging, particularly in heterogeneous patient settings with high diagnostic risk. Existing large language model (LLM)-based systems often lack medical grounding and fail to quantify uncertainty, resulting in unsafe outputs. We propose CLIN-LLM, a safety-constrained hybrid pipeline that integrates multimodal patient encoding, uncertainty-calibrated disease classification, and retrieval-augmented treatment generat …

27.08.2026journal-article

Journal of Molecular Pathology

Discrepancies in the Molecular Epidemiology of Druggable Genetic Alterations in Non-Small Cell Lung Cancer

Panagiotis Paliogiannis, Angelo Zinellu, Giuseppe Palmieri, Alessandro Giuseppe Fois

Non-small cell lung cancer (NSCLC) represents most lung cancer diagnoses worldwide and remains a leading cause of cancer-related mortality. The advent of precision oncology has transformed the therapeutic landscape of NSCLC through the identification of druggable genetic alterations, enabling the use of targeted therapies with significant clinical benefit. However, the reported prevalence of these alterations varies widely across studies and populations, raising important questions about the underlying determinants …

27.08.2026journal-article

Frontiers in Global Women's Health

Expanding treatment options for syphilis during pregnancy: a review of alternatives to penicillin

Claire L. Townsend, Lynne Mofenson, Sami Gottlieb, Remco P. H. Peters, Oriol Mitjà, Clara Pérez-Mañá, Elaine J. Abrams, Sinead Delany-Moretlwe, Shahin Lockman, Catriona Waitt, Kathryn Miele, Melanie M. Taylor, Françoise Renaud

Syphilis infection during pregnancy leads to around 390,000 adverse birth outcomes each year and is an important cause of preventable stillbirth. Although benzathine penicillin G is safe and effective during pregnancy for treating maternal and fetal infection, there are frequent global shortages and limited options for people with penicillin allergy. We conducted a review of potential alternatives to penicillin for treating syphilis during pregnancy when penicillin is not available or cannot be used, including ceft …

27.08.2026journal-article

Neuro-Oncology

34 Therapeutic Targeting of the SLC7A11-GCLM-GPX4 Axis Sensitizes Glioblastoma to Ferroptosis and Associates with Poor Survival

Minakshi Behera, Suvendu Purkait, Amit Ghosh, Rabi Narayan Sahu, Sandip Kumar Barik

Abstract Background Glioblastoma (GBM) is the most common malignant primary brain tumor with a dismal prognosis. The high proliferative activity of GBM is prone to generating oxidative stress, which must be counteracted to support cell survival and prevent ferroptotic cell death. Objective The present study evaluated the expression of the GPX-4 and GCLM involved in redox homeostasis in GBM and their possible implications for tumor biology, clinical outcome, and therapeutic potential. Methodology The mRNA and protei …

27.08.2026journal-article

Neuro-Oncology

32 A FLASH of Hope - Preventing Recurrent Glioblastoma

Riddhi Sharma, William Timbury, Sean Gettings, Raymond Shek, Stuart Smith, Ruman Rahman, Nora Bourbia

Abstract Introduction Glioblastoma (GBM) remains the most aggressive and lethal primary brain tumour, with a 5-year survival rate of only ∼13% and a recurrence rate approaching 90% within two years of diagnosis. Current treatment options include surgery followed by radiotherapy and chemotherapy, but these are limited by radioresistance and the inability to eliminate residual infiltrative cells. There is an urgent need for more effective, kinder treatment strategies that prevent recurrence. This project has, so far, …

27.08.2026journal-article

Neuro-Oncology

51 Does it matter where you are treated? Insights from a national review of NHS brain tumour services (2020-2026)

Jill Sokratous, Andrew Wright, Nicky Huskens, Camille Goetz

Abstract Introduction Despite advances in brain tumour care, evidence suggests that patients face variations in treatment, care and research opportunities. To further explore equity of care in the context of the United Kingdom (UK) and identify key challenges, we reviewed NHS brain tumour services. Method We collected data from 25 neuro-oncology centres (covering 90% of the UK population) in 2020–2022 and again in 2024–2026 through the Tessa Jowell Centre of Excellence, a UK-wide benchmarking and service improvemen …

27.08.2026journal-article

Neuro-Oncology

19 Developing a Teenage and Young Adult Brain Tumour Standard Operating Procedure in a UK Tertiary Neurosciences Centre

Aimee Goel, Natalia Koc, Sumbal Nawaz, Andrew Kay

Abstract Introduction Teenage and Young Adult (TYA) patients aged 16–24 years represent a biologically and clinically distinct cohort of central nervous system (CNS) tumour patients. Despite national standards for TYA cancer care, no dedicated management pathway for TYA brain tumours exists at Trust or national level. We developed a Trust-wide Standard Operating Procedure (SOP) for TYA CNS tumours at University Hospitals Birmingham (UHB), alongside an artificial intelligence (AI)-assisted framework for structured S …

27.08.2026journal-article

Neuro-Oncology

36 The cost of a brain tumour: The Economic Case for Urgent Action

Clair Thorstensen-Woll, Marcus Cahill-Evans, Katie Murray, Elana Greaves, Joe Goldbacher, Rob Malcolm, Matthew Taylor

Abstract Introduction Each year over 13,000 people are diagnosed with brain tumours in the UK and 5,400 people lose their lives. Brain tumours have a substantial impact on individual health and on wider society; however, little research has been conducted to estimate the overall burden that brain tumours have on society in the UK. Methods The lifetime burden of illness from brain tumours diagnosed in 2025 was calculated from several sources. There were two categories of impact: (i) financial costs and (ii) health i …