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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Pelvic floor rehabilitation improves anorectal function after sphincter-preserving surgery for low rectal cancer

Xiao-Jun Liu, Ming-Li Wei, Li-Li Liu, Jing-Jing Qin

BACKGROUND Sphincter-preserving surgery with prophylactic colostomy is the benchmark treatment for low rectal cancer, although postoperative anorectal dysfunction significantly reduces quality of life. Although pelvic floor muscle training seems effective in functional recovery, there is currently little systematic evidence regarding the efficacy of this therapy in this specific population. AIM To investigate whether structured pelvic floor muscle rehabilitation training provides better anorectal functioning than s …

27.08.2026journal-article

Current Oncology

Return to Intended Oncologic Therapy After Brain Metastasis Surgery: Mapping the Early Postoperative Pathway

Alexis Hadjiathanasiou, Martin Liebisch, Johanna Dahn, Johannes Lemcke, Patrick Schuss

Surgery for brain metastases (BM) is embedded in a multidisciplinary oncologic pathway. This study evaluated oncologic readiness and return to intended oncologic therapy (RIOT) after surgery for BM. Patients undergoing surgery for histologically confirmed BM were retrospectively identified. Oncologic readiness was defined as sufficient postoperative clinical and neurological recovery to allow the next indicated oncologic treatment. RIOT was defined as postoperative radiotherapy and/or systemic treatment within 30 d …

27.08.2026journal-article

Advanced Healthcare Materials

Injectable Modular Cellularized Blocks via Dual‐Photocrosslinking for Enhanced Cell Therapy

Jiajia Wang, Junyi Wang, Shuhan Duan, Huijing Ma, Wentao Jiang, Rongpu Liu, Huijiao Yan, Licheng Wan, Shaoyi Wang, Rong Yang, Wenjie Zhang

ABSTRACT Cell‐based regenerative medicine is limited by poor survival of transplanted cells and the lack of scalable, ready‐to‐use delivery platforms. Here, we developed an injectable dual‐photocrosslinking microsphere (DP‐MS) bioink composed of Ru/SPS, o‐nitrobenzyl‐modified hyaluronic acid (HANB), and gelatin methacryloyl (GelMA). Orthogonal green (525 nm) and UV (365 nm) light enable sequential crosslinking: first to generate cell‐laden microspheres, and the second step requires only 10 s to induce inter‐microsp …

27.08.2026journal-article

Psychopharmacology

Pilot study comparing the effects of high dose THC to high dose psilocybin and placebo in the set and setting of a classic psychedelic therapy session

Frederick S. Barrett, David Wolinsky, Zach Daily, Joseph Ciancio, Kristy Arthur, Ryan Vandrey

Abstract Rationale Delta-9-tetrahydrocannabinol (Δ9-THC) has been reported to evoke psychedelic-like experiences at high doses in some individuals. However, the doses of Δ9-THC that occasion such effects and the phenomenology of these experiences are poorly understood. Objectives This brief report presents preliminary findings from a pilot human laboratory study that directly compared the acute effects of Δ9-THC and psilocybin under set (expectancy) and setting (context) conditions of a typical psychedelic clinical …

27.08.2026journal-article

PM&R

Predicting functional outcomes following surgical intervention and inpatient rehabilitation stay in children with cerebral palsy

Amy Barbuto, Michelle L. Seymour, Sruthi P. Thomas, Katy Mitchell, Christian M. Niedzwecki

Abstract Background The ability to predict functional outcomes in children with cerebral palsy ( CP ) after surgical procedures and a subsequent inpatient rehabilitation unit ( IRU ) stay is limited based on current literature. Objective To determine if length of stay ( LOS ) and functional outcomes could be predicted in children with CP following a surgical procedure and IRU stay based on the surgical procedure performed, pattern of involvement, etiology, and Gross Motor Function Classification System level. Desig …

27.08.2026journal-article

Angewandte Chemie International Edition

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu

ABSTRACT Photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) have emerged as promising anticancer modalities due to their noninvasive nature, spatiotemporal precision, and high tumor suppression efficacy. Integrating platinum with these phototherapies addresses key limitations of conventional platinum chemotherapy, specifically systemic toxicity and pervasive drug resistance. Since cancer cell membrane proteins, including receptors and transporters, and subcellular organelles play a pivotal role as th …

27.08.2026journal-article

Journal on Audio, Speech, and Music Processing

Early-time sound field reconstruction from binaural room impulse responses and perceptual evaluation in auditory augmented reality

Amal Emthyas, Annika Neidhardt, Sebastià V. Amengual Garí, Enzo De Sena

Abstract Realistic, coherent auditory augmented reality (AAR) requires virtual auditory illusions to be spatialised and acoustically matched to the local environment. To realise AAR, the early part of the sound field with the direct sound and early reflections are reconstructed from a sparse set of binaural room impulse responses (BRIRs). A system-inversion-based BRIR reconstruction method is proposed, based on a sparse spatio-temporal representation of the sound field. Late reflections are taken from an available …

27.08.2026journal-article

Nephrology Dialysis Transplantation

Comparative Effectiveness of Combination Therapy in Patients with Chronic Kidney Disease and Diabetes mellitus Type 2 using Real World Data

Janis Casper, Julian Doricic, Zhejia Tian, Jonas Michael Willerding, Marit Glammeier, Anette Melk, Kai Schmidt-Ott, Bernhard M W Schmidt

Abstract Background and hypothesis Diabetes mellitus type 2 (T2DM) is the primary driver of chronic kidney disease (CKD). Renin-angiotensin-aldosterone system inhibitors (RAASi) represent basic therapy for CKD in T2DM. Recent studies demonstrated renal benefits of sodium glucose cotransporter 2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP1-RA), but data on direct comparisons and potential additive effects of their combination remain unclear. Methods Using data from the US Collaborative Ne …

27.08.2026journal-article

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

The Impact of Statin Use on the Outcomes of Platelet-Rich Plasma (PRP) Therapy in Patients with Early (I–II) Stage Knee Osteoarthritis

Mustafa Cem Özkan, Oğuzhan Erciyes, Taner Bertan, Umut Canbek, Ulaş Akgün, Fatih İlker Can, Emre Gültaç, Nevres Aydoğan

There are studies indicating that both statins and Platelet-Rich Plasma (PRP) have effects on inflammation and the arthritis process. The aim of our study was to investigate the effect of statin use on the clinical and functional outcomes of PRP treatment in patients with early-stage knee osteoarthritis. Between January 2018 and August 2020, the medical records of all patients who underwent PRP treatment for stage I–II knee osteoarthritis were retrospectively reviewed. Patients who did not use statins and received …

27.08.2026journal-article

npj Digital Medicine

Probabilistic calibration of a closed-loop cardiac electromechanical model with application to cardiac resynchronization therapy

Ester Bergantin, Federica Caforio, Francisco Sahli Costabal, Christoph M. Augustin, Simone Pezzuto

Abstract Cardiac conduction disorders such as left bundle branch block induce ventricular dyssynchrony and increase the risk of heart failure. Cardiac resynchronization therapy (CRT) improves cardiac function in approximately 70% of patients; however, identifying the optimal pacing strategy for a given patient remains challenging. We present a computational framework that integrates physics-based modeling with Bayesian personalization to simulate cardiac electromechanical function and response to CRT. Patient anato …

26.08.2026journal-article

ACTA MEDICA IRANICA

Immunogenicity of COVID-19 Vaccines in Patients Under Immunosuppressive Therapy: Insights Into Antibody Response and Gender Differences

Reza Farrokhseresht, Hanieh Roghanian, Hamidreza Samimagham, Mitra Kazemi Jahromi, Hoda Borooghani, Mohsen Arabi

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted millions worldwide. Patients with autoimmune rheumatic diseases (ARDs) may exhibit attenuated responses to vaccination secondary to immunosuppressive therapy, potentially resulting in reduced vaccine effectiveness. This study investigates the immunogenicity of COVID-19 vaccines in patients with ARDs and evaluates antibody responses and the factors associated with such responses. We …

26.08.2026journal-article

Radiation Sciences in Oncology

Associations of psoas muscle index and inflammatory markers with FDG PET/CT-derived metabolic response after total neoadjuvant therapy in locally advanced rectal cancer

Gizem Kavak, Mehmetcan Atak, Osman Sütçüoğlu, Semra Demirtaş Şenlik, Özlem Özmen, Ömür Berna Çakmak Öksüzoğlu, Yıldız Güney

Objective: Total neoadjuvant therapy (TNT) is increasingly used for locally advanced rectal cancer, but factors associated with metabolic tumor response remain unclear. This study aimed to explore correlations between fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT)-derived metabolic tumor response and patient-related factors, including body composition, systemic inflammatory markers, and imaging-based biomarkers, in patients receiving TNT. Materials and Methods: This retrospective s …

26.08.2026journal-article

Frontiers in Psychiatry

Comparative efficacy and cognitive safety of bifrontal versus bitemporal electroconvulsive therapy in adolescents with major depressive disorder: a retrospective cohort study

Xiaolu Chen, Ke Liu, Xiaoshan Shen, Yifan Yang, Hao Yu, Qibing Chen, Xiaoli Wang, Xiao Li

Background Electroconvulsive therapy (ECT) remains a rapid and highly effective treatment for severe, treatment-resistant depression in adolescents, particularly when immediate suicide risk is present. However, its clinical utilization in the pediatric population is still low, largely restricted by pervasive concerns regarding cognitive impairment. While randomized trials in adults suggest that bifrontal (BF) electrode placement offers a superior cognitive safety profile compared to the standard bitemporal (BT) pla …

26.08.2026journal-article

Diseases

Exercise-Based Rehabilitation Following Lower-Limb Revascularisation in Patients with Peripheral Arterial Disease: A Scoping Review

Shinichi Watanabe, Takayasu Koike, Kenji Tsujimoto, Ryoma Tahara, Tomohiko Kamo, Katsuyoshi Suzuki, Keisuke Suzuki

Objective: Exercise therapy is recommended for patients with peripheral arterial disease (PAD) to improve walking capacity and functional outcomes. However, rehabilitation programmes after lower-limb revascularisation remain poorly defined. We aimed to map the existing literature on exercise-based rehabilitation following lower-limb revascularisation in patients with PAD and summarise key intervention features and reported outcomes. Data Sources: PubMed/MEDLINE, Embase, the Physiotherapy Evidence Database (PEDro), …

26.08.2026journal-article

World Journal of Cardiology

Assessing residual cardiovascular risk and vulnerable plaques via non-traditional lipids: From biomarkers to novel targets for precision therapy

Zi-Yi Lu, Ya-Fei Li, Lei Bao, Xu-Tong Wang, Hui Wu, Yin-Fei Xu, Yi Wang, Yan Chen

Coronary artery disease is a leading cause of death and disability-adjusted life-years worldwide. Acute coronary syndrome, a major clinical manifestation of coronary artery disease, commonly results from disruption of vulnerable atherosclerotic plaques. Conventional lipid parameters, especially low-density lipoprotein cholesterol, play a central role in cardiovascular risk assessment and management. However, these traditional markers have important limitations in their ability to fully capture the complexity of ath …

26.08.2026journal-article

Journal of Occupational Health

Heat-mitigation effects of protective sheets in the construction industry for the prevention of heat stress disorders

Chikage Nagano, Kimiyo Mori, Yumi Nakao, Seichi Horie

Abstract Purpose This study experimentally investigated whether highly heat-shielding protective sheets used at construction sites could reduce heat stress. Methods A construction-site simulation apparatus was installed in an artificial climate chamber, and direct solar radiation was simulated using infrared heating. Tempered glass partitions allowed the installation of different sheet materials. Wet bulb globe temperature (WBGT), air temperature (Ta), globe temperature (Tg), and relative humidity (RH) were continu …

26.08.2026journal-article

Journal of Clinical Medicine

How Early Is Early? Defining Functional Rehabilitation After Acute Achilles Tendon Rupture: A Narrative Review

Masanori Hashimoto, Youichi Yasui, Tomoyuki Nakasa, Hirotaka Kawano, Wataru Miyamoto

Early functional rehabilitation after acute Achilles tendon rupture is increasingly used in nonoperative protocols, but the definition of “early” remains highly heterogeneous across the literature and no standardized timing threshold has been established. This narrative review clarifies the conceptual and operational definitions of early rehabilitation and examines the unresolved timing-threshold problem. Existing evidence supports early functional rehabilitation without a demonstrated increase in rerupture risk co …

27.08.2026journal-article

Annals of Work Exposures and Health

Examining the psychometric properties of the Occupational Stress Injury Resiliency Tool with comparison of concurrent, and predictive validity with other leading indicators of work-related psychological conditions

Peter Smith, Marta Pienkowski, Jackie Sam, Teresa D'Elia

Abstract Background This study assesses the psychometric properties of a measure of work-related exposures associated with psychological conditions—the Occupational Stress Injury Resiliency Tool (OSIRT). It also compares the associations between the OSIRT, and 2 other leading indicator measures, with 3 mental health outcomes, cross-sectionally and longitudinally. Methods Three surveys were completed between August 2024 and September 2025. In an initial sample of 895 respondents, the validity and reliability of OSIR …

26.08.2026journal-article

International Journal of Sports Science & Coaching

Concordance of large language models with a hamstring strain guideline: Implications for athlete rehabilitation and return-to-sport guidance

Ahmet Murat Çörekci, Sergen Devran, Sertaç Yakal, Abdullah Faruk Uyanık, Gökhan Metin

Hamstring strain injury is a common sports-related injury with substantial recurrence risk, and large language models are increasingly used as sources of health information by athletes, coaches, and clinicians. This study evaluated the concordance of three contemporary large language models with the 2022 hamstring strain injury clinical practice guideline. Fourteen guideline-derived clinical questions were submitted to ChatGPT-5.2, Gemini 3 Pro, and DeepSeek-3.2v using identical single-turn prompts on January 17, 2 …

26.08.2026journal-article

World Journal of Stem Cells

Mesenchymal stem cells therapy ameliorates esophageal dysmotility in gastroesophageal reflux disease by modulating smooth muscle contractility, alleviating senescence by targeting the DNMT3a-HIF1α axis

Yi Li, Wen-Ya Zhu, Bo Zhang, Ze-Rui Wang, Zhao-Yang Chen, Qian-Qian Chen, En-Qiang Linghu

BACKGROUND Gastroesophageal reflux disease (GERD) is associated with esophageal dysmotility, leading to impaired acid clearance and persistent symptoms. Mesenchymal stem cell (MSC) therapy holds promise for tissue regeneration and functional restoration. AIM To investigate the therapeutic efficacy and underlying molecular mechanisms of MSC treatment on esophageal dysmotility in a rat model of GERD and in human esophageal smooth muscle cells (HESMCs). METHODS A rat model of chronic GERD was established surgically. R …

26.08.2026journal-article

Drug Metabolism and Personalized Therapy

Safinamide dual molecular mechanisms: sodium channel and glutamate modulation as a translational rationale for neuropathic pain – A narrative review

Utpal Bhui, Radheshyam Pal, Amit Chakraborty, Sathvik Belagodu Sridhar, Uttam Prasad Panigrahy, Shubhrajit Mantry, Bimlesh Kumar

Abstract Introduction Neuropathic pain is a chronic and debilitating condition characterized by maladaptive changes in peripheral and central nervous system pathways. It is driven by abnormal neuronal excitability and excitatory neurotransmission. Among the key contributors are voltage-gated sodium channels (VGSCs) and glutamatergic mechanisms, both of which play pivotal roles in peripheral and central sensitization. Content This narrative review was conducted through a structured literature search of PubMed/MEDLIN …

26.08.2026journal-article

Exploring Science Academic Conference Series

Sensorimotor Closed-Loop Control in Post-Stroke Wrist-Hand Rehabilitation Robots: A Structured Narrative Review

Shengwei Chai

Post-stroke wrist-hand rehabilitation robots can increase training intensity, repetition, and measurement. Still, systems centered mainly on mechanical assistance may not fully address the sensorimotor impairments that constrain functional recovery. This structured narrative review examines how sensorimotor closed-loop control may reshape wrist-hand robotic rehabilitation by linking somatosensory feedback, voluntary motor effort recognition, and home-based translation. The review was informed by a PubMed-based lite …

26.08.2026journal-article

International Journal of Cognitive Sciences

A Systematic Review of Relationships Between Self-Directed Speech and Self-Processes

Cassidy Sterling, Alain Morin

Self-directed speech is a well-established aspect of human cognition, although its relationships with self-processes such as self-consciousness, self-rumination, mindfulness, self-concept clarity, and self-esteem remain poorly understood. The present study aimed to synthesize existing empirical findings to clarify how individual differences in self-directed speech relate to self-processes. Guided by PRISMA-informed systematic review procedures, this narrative review examined studies published between 2000 and 2025 …