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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Molecular Pharmaceutics

A Dual-Action CXCR4-Targeted Peptide−Drug Conjugate Engineered to Enhance Antitumor Efficacy and Mitigate Myelosuppression in Pancreatic Cancer

Ke Zhu, Xuanxin Liu, Dapeng Li, Tao Wang, Tao Wen, Xiaocui Fang, Yanlian Yang, Jian Liu, Jie Meng, Chen Wang, Haiyan Xu

Abstract Gemcitabine (GEM) is a first-line therapeutic option for pancreatic cancer; however, it has low efficacy due to rapidly developed drug resistance and severe dose-limiting myelosuppression. To enhance its therapeutic effect, this study developed a novel peptide−drug conjugate using a CXCR4 antagonistic peptide as the targeting head and gemcitabine as the drug payload, based on the characteristics of pancreatic tumor cells highly expressing CXCR4 that mediates immunosuppression and tumor progression through …

24.08.2026journal-article

Journal of Clinical Medicine

Clinical and Radiological Outcomes of Oral Bisphosphonate Therapy Combined with Conservative Treatment in Subchondral Bone Marrow Edema of the Knee: A Retrospective Cohort Study

Goker Yurdakul, Murat Korkmaz, Irfan Karadak, Abdullah Iyigun, Muhammed Kazez, Nezih Yayli, Mustafa Fatih Erkoc, Fatih Golgelioglu

Background/Objectives: Subchondral bone marrow edema (BME) of the knee often causes persistent pain despite conservative treatment, and evidence supporting oral bisphosphonates is limited. We compared conservative treatment alone with conservative treatment plus oral alendronate. Methods: This retrospective cohort study included 82 patients with MRI-confirmed subchondral BME of the knee treated between January 2020 and January 2025. Patients received conservative treatment alone (n = 44) or conservative treatment p …

24.08.2026journal-article

JEADV Clinical Practice

When Treatment Meets Natural History: Understanding Early Dermatitis‐Related Adverse Events in Systemic Atopic Dermatitis Trials

Diego Ruiz Dasilva, Alondra Soto‐Gonzalez, Haya Alkiswani, Graham H. Litchman, Harrison Nguyen, Gil Yosipovitch, Firas George Hougeir, Matthew Zirwas, David Cotter, Brad Glick, E. James Song, Christopher G. Bunick, Neal Bhatia, Adam Friedman, Leon Kircik, Mona Shahriari, Peter Lio, James Del Rosso

ABSTRACT Biologics and Janus kinase (JAK) inhibitors have transformed the management of atopic dermatitis (AD), yet some patients experience early worsening of disease activity during treatment initiation. In clinical trials, these events are typically recorded as treatment‐emergent adverse events (TEAEs), most commonly coded as “atopic dermatitis”. We conducted a structured narrative review of phase 3 randomized trials evaluating approved systemic therapies for AD used in combination with background topical therap …

24.08.2026journal-article

International Journal for Quality in Health Care

Assessment of Knowledge, Attitudes, and Practices around Cervical Cancer Screening in the Gulu District of Northern Uganda: A cross-sectional study

Tana Chongsuwat, Andre Nana, Aaliyah O Ibrahim, Ann E Evensen, James H Conway, Sumba O Pius, Ibrahim Sseddangira, Usman Iqbal, William Oloya

Abstract Background Cervical cancer is a global health issue, particularly Sub-Saharan Africa including Uganda, where it poses a severe burden. Despite the availability of screening methods, uptake remains low due to various barriers, such as limited resources and a lack of awareness. This study primarily aimed to assess the knowledge, attitudes, and practices related to cervical cancer screening among men and women in the Gulu District of Northern Uganda, with secondary objectives on understanding gender differenc …

24.08.2026journal-article

Current Oncology

Breast Cancer Patients’ Parenting Concerns User Personas: A Qualitative Analysis

Ying Zhang, Ming Liu, Xiaoning Fan, Hailing Tu, Yin Wang, Jingfang Hong

Breast cancer disproportionately affects young women raising minor children. Unresolved parenting concerns can impair patients mental health, reduce treatment adherence, and compromise long-term oncological outcomes. However, previous studies have paid limited attention to the heterogeneity of parenting concerns in this population and lack a theory-grounded classification framework for stratified supportive care. This descriptive qualitative study, framed by social role theory, recruited 17 Chinese breast cancer pa …

24.08.2026journal-article

World Journal of Clinical Oncology

Risk factors for surgical site infection after craniotomy for meningioma resection in a tertiary hospital in China

Hong Wang, Yu-Lu He, Yin Gao, Xing-Rong Gao, Li-Yuan Sun, Ji-Cheng Yan, Qun Lu, Kai-Wen Ni

BACKGROUND Meningioma is the most common intracranial neoplasm and carries a non-negligible surgical site infection (SSI) risk (reported incidence: 4%-6%) despite its clean-wound classification. Most existing studies enroll heterogeneous neurosurgical cohorts spanning vascular, traumatic, and biologically distinct tumor entities, even though meningioma itself is an independent SSI risk factor, which calls for disease-specific investigation. Preoperative host physiologic reserve indices have shown prognostic value a …

24.08.2026journal-article

Frontline Gastroenterology

The UK Clinical Guidelines for Alcohol Treatment (2025): an overview for gastroenterologists

Ewan Forrest, Steven Masson

In November 2025, the Department of Health and Social Care of the UK Government published the Clinical Guidelines for Alcohol Treatment with the aim to improve outcomes for people experiencing harmful alcohol use and alcohol dependence by supporting service planners, commissioners and providers to deliver high-quality care. The guidelines are comprehensive; however, their size means that identifying areas of particular relevance to gastroenterologists and hepatologists can be difficult. This article aims to highlig …

24.08.2026journal-article

International Journal of Dental Hygiene

Efficacy of Laser Therapy, Mechanical Scaling, and Scaling With Hand Instruments in Microbiological and Clinical Indices Alteration After Nonsurgical Periodontal Treatment: A Systematic Review and Network Meta‐Analysis

Zohreh Afshari, Javad Abbasi, Arefeh Esfandpour, Sima Kiani

ABSTRACT Introduction The major role of chronic periodontal diseases in impairing human oral health shows the importance of seeking the most efficient implement to address this prevalent issue. The objective of this study is to compare nonsurgical treatment tools, including Gracey's curette, sonic/ultrasonic, and laser instruments, considering their effect on subgingival microbial flora and clinical indices. Methods Following a search in six databases, clinical studies using Gracey's curette, sonic/ultrasonic, or l …

24.08.2026journal-article

Endocrine Oncology

Beyond mitotane: next-generation therapeutic landscapes in adrenocortical carcinoma.

Keya Kotecha, Katia Mariniello, Leonardo Guasti

Abstract The clinical management of adrenocortical carcinoma (ACC) has long been defined by its resistance to conventional therapies. Since the FIRM-ACT trial established the combination of etoposide, doxorubicin, and cisplatin plus mitotane (EDP-M) as the frontline standard, overall survival for metastatic patients has remained stubbornly low. This plateau in efficacy with cytotoxic regimes has necessitated a shift toward precision oncology and immunotherapy. However, translating the success of immune-checkpoint i …

24.08.2026journal-article

Current Cancer Drug Targets

PBMC‑secreted Sgp130FcH Inhibits Colorectal Cancer Cells and Cholangiocarcinoma: Proof‑of‑Concept Evidence

Khac Cuong Bui, Phuong Linh Thi Nham, Phuong Linh Tran, Dieu Linh Le, Anh Vu Nguyen, Thi Huyen La, Thu Hang Ngo, Przemyslaw Bozko, Hong Ngoc Tham, Quang Huy Nguyen, Linh Toan Nguyen, Mai Ly Thi Nguyen

Introduction/ Objective: IL-6 is associated with carcinogenesis, tumor burden, and poor prognosis in multiple malignancies, including Colorectal Cancer (CRC) and Cholangiocarcinoma (CCA). This study aimed to establish and evaluate the in vitro anti-cancer effect of Peripheral Blood Mononuclear Cell (PBMC)-derived soluble gp130Fc (PBMC Sgp130FcH) on CRC and CCA. Methods: Freshly isolated PBMCs and HCT116 cells were transfected with plasmids encoding Sgp130FcH and hyper-IL-6 (HIL6), respectively. mRNA expression was …

24.08.2026journal-article

Cancer Science

Association of Life's Essential 8 Score With Incident Pancreatic Cancer: A Prospective Cohort Study in Shanghai, China

Liping Yi, Xing Liu, Maryam Zaid, Kexin Zhang, Biying Wang, Yingqi Deng, Minhua Tang, Yonggen Jiang, Genming Zhao

ABSTRACT Life's Essential 8 (LE8) is a comprehensive metric of cardiovascular health (CVH). Higher LE8 scores have been associated with lower risks of chronic diseases, but evidence regarding pancreatic cancer (PC) in Chinese populations is scarce. We analyzed data from 60,556 cancer‐free adults in the Shanghai Suburban Adult Cohort and Biobank. LE8 includes four health behaviors (diet, physical activity, nicotine exposure, sleep) and four health factors (BMI, blood lipids, blood glucose, blood pressure), measured …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

A prospective, randomized, open label, comparative study of efficacy and tolerability of oral itraconazole versus combination therapy with oral itraconazole and oral terbinafine in treatment of dermatophytosis

Srinjoy Bhattacharya, Kumaraswamy Girish, Nandini Albur Shankaraiah

Background: Superficial dermatophytosis, caused by fungi like Trichophyton and Microsporum, affects skin, hair and nails, presenting as round, red, scaly patches with itching. Generally, topical antifungals are common preferred treatment, while extensive infections and immunocompromised patients often require systemic oral treatments due to frequent relapses and resistance to topical terbinafine. This study compares itraconazole monotherapy with combination therapy of itraconazole and terbinafine to optimize treatm …

24.08.2026journal-article

Holistic Integrative Oncology

The integrated application of music intervention in clinical practice for cancer patients

Fan Zhang, Xinyang Li, Junyan Wang, Minting Ma, Yu Xu, Lei Hong

Abstract Objective In recent years, the incidence of malignant tumors has continued to rise, making it the second leading cause of death and posing significant physical and psychological impacts on patients' health. Studies have shown that music intervention has a positive effect on alleviating emotions, improving symptoms, and enhancing the quality of life in cancer patients. The purpose of this review is to explore the application of music intervention in clinical practice for malignant tumor patients by summariz …

24.08.2026journal-article

International Journal of Analysis and Applications

A Tangent Similarity-Based Pentapartitioned Neutrosophic Soft Topological Framework for Cancer Diagnosis

Shoaib Arbab, Muhammad Idrees, Aqeedat Hussain, Walid Abdelfattah, Arif Mehmood, Cris L. Armada

This research paper introduces the concept of pentapartitioned neutrosophic soft topological spaces (PNSTS). In PNSTS, the indeterminacy is divided into three components: truth (ReT), hesitation (H), and falsehood (ReF). Fundamental topological concepts and tangent-based similarity measures have been discussed and applied to a cancer data set to ascertain the similarity between patients and potential treatments. To analyze results more effectively, we have employed Heatmaps, 3D surface plotting, PCA, t-SNE, and DBS …

24.08.2026journal-article

Blood Journal

Immunoglobulin constant domains as targets for T-cell receptor-based treatment of multiple myeloma

Miranda H Meeuwsen, Anne K. Wouters, Johannes C Wellershoff, Tassilo L.A. Wachsmann, Dennis F.G Remst, Renate S. Hagedoorn, Michel G.D. Kester, Dirk M. van der Steen, Arnoud H. de Ru, Els P. van Hees, Masashi Matsuda, Fumihiko Ishikawa, Peter A. van Veelen, J.H. Frederik Falkenburg, Mirjam H. M. Heemskerk

Despite major progress with chimeric antigen receptor (CAR) T-cell therapy, multiple myeloma (MM) remains largely incurable, and most patient relapse. To broaden therapeutic options and overcome antigen escape, we explored T-cell receptor (TCR)-based targeting of intracellular antigens derived from immunoglobulin (Ig) heavy chain constant domains. Using HLA class-I peptidomics, we identified nine IgG- or IgA- derived peptides presented by common HLA alleles (HLA-A*01:01, HLA-A*02:01, HLA-A*03:01, and HLA-B*07:02). …

24.08.2026journal-article

Updates in Surgery

Role of liquid biopsy in the multimodal assessment and treatment of esophageal cancer: a surgical perspective

Alberto Aiolfi, Davide Bona, Emanuele Rausa, Vladimira Tichà, Antonio Biondi, Juana Riitano, Luigi Bonavina

Abstract Esophageal cancer (EC) remains a highly lethal malignancy, characterized by late diagnosis, early systemic dissemination, and high recurrence rates. Conventional diagnostic and surveillance strategies have limited sensitivity for early disease detection and minimal residual disease. Liquid biopsy technologies have emerged as promising minimally invasive tools for diagnosis, prognostication, and longitudinal monitoring. This scoping review summarizes current evidence on the clinical utilization of liquid bi …

24.08.2026journal-article

Frontiers in Oncology

Arylsulfatase D promotes malignant phenotypes in glioblastoma cells and is linked to altered Hippo pathway phosphorylation

Xuzhao Li, Qifan Hou, Yanli Tang, Nianhua Wang, Chen Zhong, Lixin Xu, Jun Wang

Introduction Glioblastoma (GBM) is a highly aggressive malignant brain tumor with persistently poor clinical outcomes and few effective treatment options. Arylsulfatase D (ARSD), a lysosomal sulfatase implicated in several cancers, has not been fully characterized in GBM. Methods ARSD expression in GBM was evaluated using bioinformatic analyses and immunohistochemical validation. ARSD was overexpressed or knocked down in U87MG, U251MG, and A172 cells, and proliferation, three-dimensional spheroid growth, apoptosis, …

24.08.2026journal-article

Frontiers in Medicine

Venetoclax plus azacitidine in higher-risk myelodysplastic syndromes: a treatment-purpose framework for interpreting response depth

Xinfu Zou, Jinyang Bu, Aojiao Chu, Ling Shi, Zheng Zhang, Qin Zheng, Meihong Luo

Venetoclax plus azacitidine has demonstrated substantial clinical activity in treatment-naïve higher-risk myelodysplastic syndromes (HR-MDS), including high rates of complete remission, marrow complete remission, and overall response. However, recent phase 3 experience indicates that greater response depth does not necessarily translate into improved overall survival. We propose a treatment-purpose framework for interpreting the clinical value of venetoclax plus azacitidine in HR-MDS. This framework first distingui …

24.08.2026journal-article

PLOS One

Metagenomic analysis of gut microbiota and its correlation with thyroid hormones in papillary thyroid cancer before and after operation

Wenyi Qin, Jiajun Huo, Xiongsheng Xiao, Siyi Li, Haiqing Luo, Yongkang Wu, Weijie Chen, Zhuoting Chen, Changwei Zheng, Muge Liu, Baibei Li, Guiping Zhou, Zhibin Huang, Xuemeng Li, Jinquan Li, Zhi Zhang, Jian Ye

Background The changes of intestinal flora and thyroid hormone levels before and after operation for papillary thyroid cancer (PTC) and their relationship are not clear. It may interfere with the intestinal thyroid axis, change the systemic thyroid hormone regulation and exogenous treatment response. It is recognized that this microbial involvement is clinically related to long-term metabolic outcomes, and future strategies for microbial targeted adjuvant therapy are suggested. This study aims to provide direct evi …

24.08.2026journal-article

Theoretical and Natural Science

Breast Cancer Risk Prediction and IDC Tumor Classification in Different Stages Based on Machine Learning Models

Yunze Li, Nor Samsiah Sani

Based on the medical statistical analyses of relevant information, in recent years, breast cancer is one of the leading causes of cancer-related deaths in women worldwide. Hence, the early detection and accurate diagnosis of breast cancer patients is significant to improve their prognosis. In this study, we propose a multi-modal, data-driven intelligent framework especially designed to breast cancer analysis the Multi-Dimensional Feature Refinement Cancer Network (MDFR-Cancer-Net) that can be used to analyse breast …

24.08.2026journal-article

Frontiers in Oncology

Pretransplant albumin-to-globulin ratio and long-term outcomes after liver transplantation for hepatocellular carcinoma: a two-center cohort study

Xun Liu, Xiao-An Liu, Di Wang, Jing Wang, Han-Xuan Wang, Ren Lang, Anshi Wu

Background Prognosis after liver transplantation for hepatocellular carcinoma (HCC) is driven mainly by tumor burden, vascular invasion, and alpha-fetoprotein. Routine pretransplant nutritional indices may add information on recipient condition, but direct comparisons are scarce and recurrence is not always analyzed with competing mortality. Methods The development cohort included 254 adults undergoing first liver transplantation for pathologically confirmed HCC. Overall survival (OS) was the primary outcome; time …

24.08.2026journal-article

Journal of Nephrology

Comparison of bortezomib with dexamethasone and thalidomide with dexamethasone in the treatment of patients with monoclonal immunoglobulin deposition disease

Jianan Jiang, Wencui Chen, Xiaomei Wu, Jinzhou Guo, Weiwei Xu, Xianghua Huang

ABSTRACT Background There is currently no standardized treatment strategy for monoclonal immunoglobulin deposition disease, and anti-plasma cell therapy is considered an effective method for treating patients with this pathology. Methods This retrospective study included 72 patients with biopsy-confirmed monoclonal immunoglobulin deposition ­disease from 2005 to 2025, divided by first-line therapy into bortezomib/dexamethasone (BD, n = 37) and thalidomide/­dexamethasone (TD, n = 35) groups. The bortezomib/dexametha …

24.08.2026journal-article

Cancers

Can Contrast-Enhanced Ultrasound Reduce the False-Negative Rate of Metastatic Axillary Lymph Nodes After Neoadjuvant Therapy in Breast Cancer?

Sijia Zhao, Jia Luo, Manying Li, Jiaping Li, Jiaqian Zhong, Peiwei Chen, Xiaoyan Xie, Ying Lin, Yanling Zheng

Background: Accurate assessment of axillary lymph node (ALN) status after neoadjuvant therapy (NAT) remains essential for surgical planning in patients with initially node-positive breast cancer. This study evaluated the potential value of contrast-enhanced ultrasound (CEUS) in conjunction with sentinel lymph node biopsy (SLNB) for post-NAT axillary assessment and explored clinicopathologic factors associated with lymph node (LN) status. Methods: In this retrospective study, 179 patients with cytologically confirme …

24.08.2026journal-article

Operative Neurosurgery

Toward 3-Dimensional Tumor Analysis for Planning Optimal Resection in Intradural Extramedullary Tumors: A Single-Institution Feasibility Study

Adhith Palla, Hammad A. Khan, Blake A. Perdikis, Nicolas K. Goff, Eric A. Grin, Roshni Patel, Jonathan T. Yang, J. Ricardo McFaline-Figueroa, Darryl Lau, Anthony Frempong-Boadu, Ilya Laufer

BACKGROUND AND OBJECTIVES: Intradural extramedullary spinal tumors (IDEMs) are ideally managed with gross total resection (GTR) for optimal local disease control in the absence of established adjuvant regimens. In this retrospective cohort study, we investigated the utility of morphology-based analysis of optimal IDEM resection quality compared with current linear measurement benchmarks. METHODS: Tumors were manually segmented from preoperative contrast-enhanced MRI. Morphological features of sphericity, elongation …