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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

ACR Open Rheumatology

Reduction of CXCR3 + CCR6 + CD4 + T Cells and IL ‐17+ RORγt + CD4 + T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy

Addison Pacheco, Patricia Remalante‐Rayco, Nigil Haroon, Denis Poddubnyy, Robert D. Inman

Objective We recently reported an immune profile that stratifies patients with axial spondyloarthritis based on clinical response to secukinumab. We now undertake an exploratory study on the secukinumab nonresponder patients to determine if immunologic changes occur during their initial secukinumab treatment that could determine their next biologic response. Methods At the clinician's discretion, 18 patients who did not respond to secukinumab were either switched to a tumor necrosis factor inhibitor (TNFi; n = 8) o …

29.08.2026journal-article

EJNMMI Physics

Development of a multifunctional anthropomorphic phantom for performance evaluation in nuclear medicine imaging: preliminary PET/CT validation

Xuesong Su, Zuowei Zou, Yingmao Chen, Hao Hong, Zhiwen Chen, Xuejuan Wang, Jianhua Geng

Abstract Purpose To develop an anthropomorphic phantom that enables the simultaneous evaluation of key performance metrics for nuclear medicine imaging systems and to preliminarily validate its application in PET/CT. Methods The anthropomorphic phantom replicates thoracic and abdominal anatomy, simulating human skeletal structures, lung tissue, soft tissue, and tumors. The phantom is divided into five functional regions: a lung tumor detection region (right lung with spheres), an attenuation and scatter correction …

29.08.2026journal-article

Psychiatry and Clinical Neurosciences

Brain Network Convergence of Abnormal Gray Matter and Functional Activity of Pathological Dissociative Symptoms

Xuhan Cui, Leyi Zhang, Yangpan Ou, Yong Liu, Bing Lang, Wenbin Guo

Aim Pathological dissociation is a complex clinical symptom widely observed across various psychiatric disorders. Dissociative symptoms prolong the duration of hospitalization and are associated with a poor clinical prognosis. Although several pathological models (e.g., the frontal‐limbic overmodulation model and the defense cascade model) have been proposed to interpret dissociative symptoms, heterogeneous regional‐level imaging findings impede our comprehension of the neural changes underlying dissociative sympto …

29.08.2026journal-article

Journal of Feline Medicine and Surgery Open Reports

EXPRESS: Surgical management of bilateral atypical tibial fractures associated with long-term bisphosphonate therapy in a cat

Justin Koh Wei Wong, Stephanie Colthurst

An eight-year-old, indoor, male neutered Oriental mix cat was presented with acute bilateral pelvic limb lameness without preceding trauma. The cat had received oral alendronate for 4.5 years for the management of idiopathic hypercalcaemia. Radiographs revealed bilateral, closed, comminuted proximal tibial and fibular fractures with cortical sclerosis. Staged bilateral open reduction and internal fixation were performed using orthogonal locking compression plates. Alendronate therapy was discontinued, and the cat r …

29.08.2026journal-article

Indian Journal of Radiology and Imaging

Prenatal Diagnosis of Thanatophoric Dysplasia Type I Based on Classical Ultrasound Findings During Anomaly Scan: A Case Report

Rajat Garg, Rashmi Singh

Abstract Thanatophoric dysplasia (TD), the most common lethal skeletal dysplasia, results from FGFR3 mutations causing impaired endochondral ossification. Where molecular testing is unavailable, ultrasound evaluation is the diagnostic cornerstone. We report a 24-year-old primigravida undergoing a routine anomaly scan at 22 weeks. Ultrasonography showed severe micromelia with femoral bowing (telephone-receiver appearance), a markedly narrow thoracic cage (thoracic circumference of 11.79 cm, falling below the fifth p …

29.08.2026journal-article

Journal of Clinical Medicine

The “Namaste Sign”—A Novel Coronal MRI Marker for the Evaluation of Anterior Cruciate Ligament Integrity

Shashank Chapala, Rajesh Botchu, Hasaam Uldin, Meili Jade Temsin Leung Chew, Kapil Shirodkar, Sang Bum Lee, Anoop Venkatapura Bylaswamy, Avneesh Chhabra

Magnetic resonance imaging (MRI) is universally recognized as the gold standard for evaluating anterior cruciate ligament (ACL) injuries. However, differentiating partial tears from complete ruptures using the standard sagittal plane remains a diagnostic challenge. The oblique coronal orientation of the ACL often leads to volume averaging artifacts and inaccurate interpretations. While axial imaging offers a favorable alternative, distal tears near the tibial attachment are frequently missed. This review synthesize …

29.08.2026journal-article

Journal of Clinical Medicine

Prospective Assessment of Carboxyhemoglobin and Methemoglobin Levels in Operating Room Personnel During HIPEC/Peritonectomy Compared with Standard Colorectal Surgery

Emil Kinda, Petar Matosevic, Sanda Smud Orehovec, Ivan Romic, Rudolf Radojkovic, Branko Bogdanic

Background/Objectives: In the operating room, surgical staff are exposed to inhalation of smoke from the combustion of tissues when using electrocautery. By introducing HIPEC/peritonectomy in the treatment of malignant neoplasms of the peritoneum, exposure to smoke is significantly increased. To adequately perform this procedure, high-power monopolar cautery is used. The aim of this study was to assess carbon monoxide exposure associated with surgical smoke generated during peritonectomy procedures and to compare i …

29.08.2026journal-article

International Journal of Prognostics and Health Management

Multiscale Ordinal Complexity Analysis for Wind Turbine Bearing Fault Diagnosis

Paulo R. L. Almeida, Thyago L. V. Lima, Alisson V. Brito, Abel C. Lima Filho

Permutation-entropy methods for bearing fault diagnosis in wind turbines are typically validated on laboratory test rigs without enforcing specimen-level separation in cross-validation or quantifying axis-specific diagnostic contributions. This study addresses these limitations using the Fraunhofer LBF operational wind turbine bearing dataset, applying multiscale permutation entropy (MPE) to triaxial front-bearing accelerometer signals across 44 bearing specimens (18 healthy, 10 inner race, 4 outer race, 12 roller …

29.08.2026journal-article

Pharmaceuticals

Trimetazidine in Chronic Coronary Syndrome and Coronary Artery Disease: A Narrative Review of Clinical Efficacy, Safety, and Current Guideline Position

Daniel Miron Brie, Cristian Mornoș, Alexandru Tîrziu, Roxana Popescu, Alina Diduța Brie

Background: Chronic coronary syndrome (CCS) is a major source of morbidity and healthcare utilization, and a substantial proportion of patients continue to experience angina despite contemporary revascularization and guideline-directed medical therapy. Trimetazidine, a metabolic anti-ischemic agent that does not affect heart rate or blood pressure, has been used for decades as a non-hemodynamic add-on. Its position in international guidelines, however, has shifted. We aimed to synthesize current evidence on the cli …

29.08.2026journal-article

Obesity Surgery

Weighed Down by Paperwork: Identifying Barriers to Metabolic and Bariatric Surgery Evaluation in the United States

Rylee Barber, Stephen Moorhead, Kalina Siehl, Ronit Pathak, Mary K Bryant

Abstract Background Obesity affects over 42% of U.S. adults, yet access to metabolic and bariatric surgery (MBS) remains limited despite its proven efficacy. While use of GLP-1 receptor agonists has risen in the past three years, MBS volume has declined over 25% during the same period. Reported barriers to MBS include long wait times, societal sigma, fear of surgery, and insurance restrictions. This study investigated appointment accessibility and program requirements for patients seeking MBS. Methods We conducted …

29.08.2026journal-article

JAMA

LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial Infarction

Gilles Montalescot, Emile Ferrari, Géraud Souteyrand, Claire Bouleti, Grégoire Range, Laure Batias-Moreau, Marco Chioccioli, Andrea Picchi, Jean-Guillaume Dillinger, Giovanni Esposito, Giuseppe Patti, Flavien Vincent, Nassim Braik, Stéphane Ederhy, Pierre Coste, Sinda Hannachi, Nassim Redjimi, Michel Zeitouni, Benjamin Duband, Etienne Fourrier, Paul Guedeney, Niki Procopi, Pierre Sabouret, Abdourahmane Diallo, Karine Brochard, Amel Chamam, Nicolas Vignolles, Mathieu Kerneis, Johanne Silvain, J. Wouter Jukema, François Mach, Angel Cequier-Fillat, Holger Thiele, Stanislaw Bartus, Leonardo Bolognese, Eric Vicaut, AMUNDSEN Investigators of the ACTION Study Group, Denis Angoulvant, Anne Bellemain-Appaix, Farzin Beygui

Importance Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition is recommended as second- or third-line lipid-lowering therapy after myocardial infarction (MI), resulting in prolonged periods of inadequate low-density lipoprotein cholesterol (LDL-C) control. Whether in–catheterization laboratory decision of PCSK9 inhibition, started before mechanical reperfusion, could improve LDL-C control and clinical outcomes at 1 year is unknown. Objective To evaluate evolocumab as first-line therapy vs standard car …

29.08.2026journal-article

Farabi Tıp Dergisi

Awake Tracheal Intubation Practice and Clinical Decision-Making in Brief Airway Scenarios Among Anesthesiologists in Türkiye: A Cross-Sectional Survey

Engin Çetin, Ahmet Yuksek

Objective: Awake tracheal intubation (ATI) is recommended for an anticipated difficult airway, yet its use remains limited. This study evaluated anesthesiologists’ ATI practices and scenario-based decision-making and identified factors associated with its use.Material and Methods: This cross-sectional, convenience-sampled online survey was conducted in Türkiye (13 March–13 April 2026). Anesthesiology residents and specialists completed an anonymous questionnaire covering demographics, three brief clinical scenarios …

29.08.2026journal-article

Journal of the Royal Society of Medicine

Seven lessons for financial incentivisation schemes in healthcare: a qualitative study of NHS Resolution’s Maternity Incentive Scheme

Graham Paul Martin, Gizdem Akdur, Jane O’Hara, Mary Dixon-Woods

Objectives: Avoidable harm and variations in quality have remained persistent features of health systems, but the track record of financial incentives in driving improvement is mixed. Based on an evaluation of NHS Resolution’s Maternity Incentive Scheme (MIS), which focuses on safety of maternity care in English NHS trusts, we identify generalisable principles to inform design of financial incentive schemes in healthcare. Design: Qualitative process evaluation based on interviews with those involved in the design a …

29.08.2026journal-article

Advanced Materials

Switching Peroxymonosulfate Redox Routes by Manipulating Spinel Tetrahedral and Octahedral Site Activity for Multi‐Scenario Wastewater Treatment

Zhiyong Zhao, Yuanyuan Lv, Jiachen Zhang, Shuai Yue, Mengxue Yang, Yanxiao Li, Weitao Liu, Pengfei Wang, Sihui Zhan

ABSTRACT For diverse wastewater treatment scenarios, achieving controllable switching of reactive oxygen species within a unified catalytic system remains a major challenge. Here, an inert cation substitution strategy is proposed to regulate tetrahedral and octahedral Co activity in Co 3 O 4 , enabling controllable switching between radical and nonradical pathways. Octahedral‐Co‐enriched ZnCo 2 O 4 (ZCO) selectively directs peroxymonosulfate (PMS) activation toward the 1 O 2 pathway (95.8% contribution), whereas te …

29.08.2026journal-article

Journal of Trauma Anaesthesia, Resuscitation and Critical Care

Airway Management in a Patient with Extensive Maxillofacial Trauma: A Case Report

Abhishek Nagarajappa, Deepak Shanker S., Reshma Kalagara, Christopher Dass

Managing the airway in patients with severe maxillofacial trauma remains one of the most demanding challenges in trauma care. Facial fractures not only distort normal anatomy but can also lead to airway obstruction, bleeding, aspiration risk, and difficulty in ventilation and intubation. Effective airway management in these cases depends on rapid decision-making, readiness for alternative airway techniques, and close coordination between the anesthesiologist and surgeon. A well-planned, individualized approach is e …

29.08.2026journal-article

Translational Medicine

Translational medicine in abdominal military field surgery: from innovations to standards of care for abdominal gunshot wounds

V. A. Syusyura, R. I. Plishchuk, M. M. Magomedov, A. V. Pirogov, A. N. Kazantsev

The high mortality rate of abdominal gunshot wounds (15–60 %), rising antibiotic resistance, and the need for accelerated innovation necessitate a systematic analysis of current approaches to diagnostics, surgical tactics, and translational medicine in military field surgery. The objective of this review is to develop a comprehensive scientific and practical paradigm for abdominal military field surgery that integrates epistemological, translational, and prognostic aspects. The methodology included searching the Ru …

29.08.2026journal-article

Translational Medicine

Pathophysiological mechanisms of sepsis-associated acute kidney injury in children

Yu. V. Bykov

The aim of this review was to systematize current pathophysiological mechanisms of sepsis-associated acute kidney injury (SA-AKI) in children and their relevance for early recognition of renal dysfunction. A review of 44 literature sources, published predominantly between 2021 and 2026, was conducted. SA-AKI cannot be explained solely by arterial hypotension or reduced renal perfusion. Its pathogenesis involves systemic inflammation, endothelial dysfunction, endothelial glycocalyx damage, intrarenal microcirculator …

29.08.2026journal-article

Journal of Clinical Monitoring and Computing

Transition from mandatory to discretionary nurse-measured MEWS assessment in a continuously monitored surgical ward: Diagnostic performance of wearable-derived early warning scores

EE Jerry, MA Afonso, JC De Vries, A Akkermans, S Turco, AR Bouwman, SW Nienhuijs

Abstract Early detection of clinical deterioration on surgical wards is vital to prevent adverse outcomes. Conventional ward monitoring using the Modified Early Warning Score (MEWS) relies on intermittent nurse-measured vital signs, but its role may change when continuous wearable monitoring is already available. This study evaluated the transition from mandatory to discretionary nurse-measured MEWS assessment in a continuously monitored surgical ward and compared the diagnostic performance of two wearable-derived …

29.08.2026journal-article

Structural Health Monitoring

Semantic knowledge transfer framework for wind turbine gearbox compound fault diagnosis via zero-shot learning

Qi Deng, Weixiong Jiang, Jun Wu, Xuesong He, Yiwei Cheng

Compound fault diagnosis of wind turbine gearboxes (WTGs) has received extensive attention. Existing deep learning-based methods typically require sufficient compound fault samples for model training. However, collecting such samples is extremely difficult and often impractical in real-world industrial scenarios. Inspired by zero-shot learning, this paper proposes a semantic knowledge transfer framework to diagnose compound faults using only single-fault data for training. Within this framework, a semantic knowledg …

29.08.2026journal-article

Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer)

Enhancing Antimalarial Treatment Adherence: A Systematic Review of Multifaceted Intervention Strategies

Elisa Nugraha Haryadi Salakay, Grace Novylian Tandialo, Ricky Lazarus Rumboirusi, Grace Fitriana Primasari Hau Mahu

Background: Despite the availability of effective antimalarial medications, poor adherence remains a significant obstacle in malaria control, particularly in endemic areas. Numerous interventions have sought to enhance adherence; however, a clear understanding of their effectiveness is lacking. Objective: This systematic review aimed to evaluate the effectiveness of intervention strategies to improve adherence to antimalarial treatments and identify the contextual factors that influence them. Method: Following the …

29.08.2026journal-article

European Journal of Dentistry

The Role of Artificial Intelligence Models in Predicting Post-Prosthetic Facial Esthetics in Edentulous Patients: Clinical and Anthropometric Comparative Study

Rania Moussa, Mostafa I. Fayad, Omar M. Alaryani, Faisal Suliman Altamimi, Elaf Barri, Leen Ahmed Qarras, Marwa Kothayer

Abstract Artificial intelligence (AI) is increasingly used in esthetic dentistry; however, its accuracy in predicting post-prosthetic facial outcomes in edentulous patients remains unclear. This study aimed to evaluate the ability of AI models to simulate post-denture facial esthetics compared with actual clinical outcomes. A prospective within-subject observational study was conducted on 14 completely edentulous patients receiving new complete dentures. Standardized facial photographs were obtained pretreatment (T …

29.08.2026journal-article

Nanomaterials

Crystalline and Amorphous Cerium Phosphate Nanoparticles as Enzyme-Mimetic Nanomaterials for Regenerative Medicine

Ekaterina V. Silina, Artem S. Chizhov, Maria P. Kruglova, Alexey A. Kryukov, Svetlana A. Dodonova, Maksim A. Pugachevskii, Natalia E. Manturova, Victor A. Stupin

Wounds represent a persistent challenge in modern medicine, driving the search for novel nanomaterials capable of modulating oxidative stress and promoting tissue regeneration. While cerium oxide nanoparticles have been extensively studied for their enzyme-mimetic activity, hydrated cerium orthophosphates remain relatively unexplored despite their promising biocompatibility and redox properties. The aim of the study is the synthesis of cerium phosphate nanoparticles (CePO4 NPs) via controlled hydrolysis of a Ce(NO3 …

29.08.2026journal-article

Journal of Clinical Medicine

Novel Quantitative Metrics for Foveal Hypoplasia Derived from Optical Coherence Tomography Angiography Using AngioTool

Charlotte Egbring, Sarah Kleemann, Nicole Eter, Jens Julian Storp

Background/Objectives: This monocentric case–control study prospectively recruited patients with foveal hypoplasia (FH) and compared them with retrospectively selected age- and sex-matched healthy controls. It is the first study to employ AngioTool software to quantitatively assess retinal microvascular alterations in FH using Optical Coherence Tomography Angiography (OCT-A). Methods: In total, 19 patients with FH and 19 age- and sex-matched healthy controls were included at Münster University Hospital, Germany, an …

29.08.2026journal-article

Journal of Clinical Medicine

Agreement and Classification Performance of a Mobile Self-Triage Application Based on the Manchester Triage System in Hemodynamically Stable Adult Walk-In Emergency Department Patients: A Prospective Observational Study

Ahmet Buğra Önler, Suha Serin, Bahadir Caglar

Background/Objectives: Digital self-triage tools may support patient-flow management in crowded emergency departments (EDs), but their agreement with established professional triage systems requires prospective validation. We evaluated the agreement and classification performance of a locally developed mobile self-triage application, structured according to Manchester Triage System (MTS)-related urgency logic, compared with professional MTS assessment in adult ED patients. Methods: This prospective, observational, …