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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

The Turkish Journal of Pediatrics

The face of pediatric and adult brain abscesses, differences and clinical characteristics: a single center 10-year experience

Tamer Çelik, Merve Kılıç Çil, Ümit Çelik, Mehmet Can, Ali İhsan Ökten

Background. Brain abscesses (BA) are a medical emergency in all age groups and require early diagnosis and treatment. Childhood BA constitute 25% of all abscesses and may have a different clinical course than adults. This article aims to investigate patients followed up for adult and child BA over a 10-year period. Materials and Methods. A retrospective analysis was performed on adult and pediatric patients diagnosed with BA. Demographic, clinical, predisposing factors, imaging, treatment modalities, and prognosis …

29.08.2026journal-article

Current Anesthesiology Reports

The Impact of Intrathecal Hydrophilic Opioids on Postoperative Pain, Opioid Consumption and Adverse Events for Abdominal Surgery: A Systematic Review and Meta-analysis

Katrina Pirie, Andrea Yap, Maria A. Lopez-Olivo, Bernhard Riedel, Paul S. Myles

Abstract Purpose of Review Intrathecal morphine (ITM) is a promising analgesic option for major abdominal surgery, but its clinical efficacy, potential adverse events and optimal dosing require further investigation. Methods We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) for data from 1990 until July 2024 to identify studies comparing a preoperative intrathecal dose of hydrophilic opioid to alternative analgesia in adult patients undergoing abdominal surgery under general …

29.08.2026journal-article

BMC Gastroenterology

Predictive value of epithelial lesion heterogeneity in the etiological diagnosis of chronic inflammatory bowel disease

H. Abdoulaye Biyou, M. Zaryouhi, I. Fadlallah, H. Bourkhime, Sanae Moqran, S. El-Yaagoubi, M. El-youssfi, L. Tahiri Elousrouti, N. Hammas, Laila Chbani

Abstract Introduction Chronic inflammatory bowel diseases (IBD) are characterized by chronic, intermittent, and continuous inflammation of a part of the digestive tract, with an increased risk of dysplasia and colorectal cancer (CRC). They typically include Crohn’s disease (CD) and ulcerative colitis (UC). The diagnosis of IBD is multidisciplinary. Multiple systematic mucosal biopsies (at least two per colonic segment plus ileal sampling) are essential for establishing a diagnosis, monitoring treatment, and/or iden …

29.08.2026journal-article

Obesity Surgery

Baseline Mental Health Status and Early Psychiatric Outcomes after Metabolic-Bariatric Surgery: A Retrospective Cohort Study

Patricia M. Ortega, Luke Boyle, Dana Mahdi, Zahra Al-Essah, Ali Abdul Hussein, Mina Abdul Hussein, Aslesha Deshraju, Elena Brachimi, Prasidha Rai, Elsie Ampomah, Neha Hussain, Faizan Kiani, Mary Obigbesan, Lucy Tweedlie, Samantha Scholtz, Sanjay Purkayastha, Christos Tsironis, Sherif Hakky, Ravi Aggarwal, Ahmed R. Ahmed, Tricia Tan, Julia Kenkre, Kleopatra Alexiadou, Saira Hameed, Harvinder Chahal, Jonathan Cousins, Chioma Izzi-Engbeaya

Abstract Objective To evaluate whether documented preoperative mental health (MH) conditions were associated with early postoperative psychiatric events and metabolic outcomes after primary metabolic-bariatric surgery (MBS). Methods A retrospective cohort study of adults who underwent primary MBS at a tertiary UK bariatric centre between April 2021 and March 2024 was conducted. Preoperative MH conditions and postoperative outcomes were identified via review of electronic health records. Comparisons between groups w …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Association Between Antimicrobial Resistance and the Clinical Evolution of Patients with Infections in the Pediatric Intensive Care Unit of the National Institute of Pediatrics

Scott Macías, Alejandra Aquino, Agustín R de Colsa, Jocelin Merida, Virginia Diaz, Damaris Manzano, Isabel Medina

Abstract Background Sepsis is the most common cause of the over two million annual deaths from worldwide infections. The World Health Organization is focused on optimizing early diagnosis, treatment, and prevention. The rise of multidrug-resistant (MDR) bacteria limits conventional antibiotics. Healthcare-associated infections (HAIs) are frequent in pediatric and neonatal intensive care units, leading to higher mortality and costs. Essential strategies include strengthening surveillance, infection control, and deve …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Optimizing Empirical Antibiotic Therapy in Febrile Pediatric Oncology Patients through a Clinical Decision Pathway

Yamileth Arellano, Martha Avilés Robles, Fernando Ríosvelasco

Abstract Background Timely management of a child with cancer and fever (CCF) requires accurate evaluation and appropriate antibiotic selection to prevent infectious complications. Clinical decision tools, such as Clinical Decision Pathways (CDPs), are increasingly adopted in healthcare systems for their ability to standardize and optimize clinical practice. The aim of this study was to assess the effectiveness and utility of an adapted CDP for initial antibiotic selection in children with cancer and fever. Methods …

29.08.2026journal-article

Archiv Euromedica

GLP-1-BASED THERAPIES BEYOND DIABETES: EMERGING CLINICAL APPLICATIONS AND FUTURE PERSPECTIVES

Anna Szeszko, Małgorzata Lubowiecka, Weronika Czernek, Magdalena Cichorzewska, Martyna Płachta, Rafał Wojtan

Background Glucagon-like peptide-1 (GLP-1)-based therapies were initially developed for the treatment of type 2 diabetes mellitus, but their clinical use has expanded substantially because of their effects on body weight and obesity-related complications. GLP-1 receptor agonists, dual and triple receptor agonists, and GLP-1-containing combination therapies are now being evaluated across cardiovascular, hepatic, kidney, respiratory and musculoskeletal diseases, as well as other conditions with metabolic, neuroendocr …

29.08.2026journal-article

Medical Decision Making

Best–Worst Scaling as a Values Clarification Method within a Decision Aid for Kidney Treatment Decision Making

Semra Ozdemir, Juan Marcos Gonzalez, Eric Andrew Finkelstein

Background: Best–worst scaling (BWS) has been increasingly used as a values clarification method to help patients make value-concordant decisions. However, evidence on its use remains limited. Objective: To examine 1) the association between BWS-derived treatment preference scores and patients’ stated and real-world treatment choices and 2) whether BWS-identified best-match treatments were concordant with treatment choices among older adults with end-stage kidney disease (ESKD). Methods: We conducted a prospective …

29.08.2026journal-article

PKLI Journal of Health Sciences

Collaborating for Excellence, Strengthening Clinical Trials in Pakistan - Editorial Commentary

Sadia Hassan, Saeed Hamid, Zeba Aziz, Arishay Hussaini, Javed Akram, Irfan Ahmed

Pakistan, the world’s fifth most populous country, has immense clinical research potential given its diverse population and high disease burden, particularly in endocrinology, neurology and cardiology. Progress, however, is constrained by inconsistent ethical review, weak infrastructure, and limited resources. Strengthening clinical trials requires training, strong governance, incentives for faculty, industry partnerships, and patient and public involvement. In July 2025, Pakistan Kidney and Liver Institute and Res …

29.08.2026journal-article

Veterinary Medicine and Science

Blue‒Green Neutrophilic Inclusions in a Cat With Severe Hepatocellular Injury

Zynia R. Alvarez, Kimberly M. Demos‐Davies, Ian M. Hubbard, Davis M. Seelig, Angela D. Gwynn

ABSTRACT A 5‐year‐old female spayed domestic long‐haired cat presented with fever, lethargy and inappetence. Haematologic evaluation revealed mild neutrophilia with a regenerative left shift and moderate thrombocytopenia. A review of a peripheral blood smear identified a moderate number of blue‒green neutrophilic inclusions. Further characterisation revealed that these inclusions exhibited broad‐spectrum autofluorescence, were negative for Prussian blue staining, and were positive for Sudan Black staining. Biochemi …

29.08.2026journal-article

International Journal of Peptide Research and Therapeutics

Treatment with Alamandine Reduces Established Pulmonary Fibrosis: Preliminary Histological, Functional, and Biochemical Insights

Isabel Amaral Martins, Andresa Thomé Silveira, Juliane Flor, Aline Blanco, Giuliano Rizzotto Guimarães, Adriana Fernanda K. Vizuete, Katya Rigatto

Abstract Introduction Pulmonary fibrosis (PF) is a challenging interstitial lung disease with limited therapeutic options. This study explores the therapeutic effects of alamandine (ALA), a renin-angiotensin system peptide, in reversing established fibrotic progression in an experimental model. Methods Male Wistar rats were divided into four groups ( n = 5–6/group): control (CO), ALA-treated (ALA), bleomycin-induced fibrosis (BLM), and bleomycin plus ALA treatment (BA). Fibrosis was induced by intratracheal bleomyc …

29.08.2026journal-article

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Blunt versus penetrating trauma: differences in early physiology, coagulopathy, and outcomes in a Scandinavian trauma centre

Erik von Oelreich, Jesper Eriksson, Bjarni Arnason, Daniel Ohlén, Axel Hedin, Anders Gille, Malin Jonsson Fagerlund, Magnus Hedberg

Abstract Background Blunt and penetrating trauma differ in injury patterns, management, and outcomes, but data comparing early physiological and haemostatic responses within Scandinavian trauma systems remain limited. We aimed to investigate differences in clinical characteristics, early physiology, and outcomes between blunt and penetrating trauma patients at a major Swedish trauma centre. Methods This registry-based observational cohort study included adult trauma patients admitted to the Karolinska University Ho …

29.08.2026journal-article

African Journal of Pharmacy and Alternative Medicine

Knowledge and Attitudes Toward Cervical Cancer and Human Papilloma Virus Vaccination in Rafiki Area, Rongai Sub-County, Nakuru County, Kenya: A Cross-sectional Study

Mercy M. MICHIRA, Dinah L. SANGURA, Mercy K. JEPCHIRCHIR, Nahashon G. AKUNGA, Wairimu KARAIHIRA, James O. MEROKA, Jim AMISI

The human papillomavirus (HPV) has been proven to be a primary driver in the development of cervical cancer. Despite increasing awareness efforts, Human Papillomavirus (HPV) vaccine uptake remains low in many low-resource settings. This study assessed knowledge and attitudes towards cervical cancer and human papillomavirus vaccination, and predictors of HPV vaccine uptake among individuals aged 15-49 years in Rafiki area, Rongai sub-county, Nakuru County, Kenya. A cross-sectional survey was conducted with 328 parti …

29.08.2026journal-article

Journal of Robotic Surgery

Impact of robotic platform transition on short term outcomes in colorectal cancer surgeries

Rebeca Hara Nahime, Paulo Roberto Stevanato Filho, Tiago Santoro Bezerra, Tomás Mansur Duarte Miranda Marques, Renata Mayumi Takahashi, Bruna Elisa Catin Kupper, Wilson Toshihiko Nakagawa, Ademar Lopes, Samuel Aguiar

Abstract Robotic colorectal surgery is increasingly complex, expanding from pelvic to multiquadrant procedures. Reports on the impact of institutional robotic platform transition remain limited. This study evaluated the challenges and effects of transitioning from the da Vinci Si (dV Si) to the da Vinci X/Xi (dV X/Xi) platform. A prospective observational cohort with historical comparison describing an institutional experience that included consecutive elective robotic colorectal cancer resections performed in 2023 …

29.08.2026journal-article

BMC Surgery

Preoperative biliary stenting is associated with increased bacterial contamination and postoperative inflammation in pancreatic head resections

Sara Al-Madhi, Aristotelis Perrakis, Sara Acciuffi, Fuad Al-Qahom, Maximilian Dölling, Seong Jeong, Peter Lemmer, Maksym Boruta, Mohammad Othman Alhomsi, Mihailo Andric, Frank Meyer, Roland S. Croner, Mirhasan Rahimli

Abstract Background The role of preoperative biliary drainage (PBD) in patients with resectable pancreatic head cancer remains controversial. Although traditionally used to reduce hyperbilirubinemia, increasing evidence suggests an association with higher postoperative morbidity. This study evaluated the impact of preoperative biliary stenting on microbial contamination, postoperative inflammatory response, and clinical outcomes. Methods This retrospective single-center study included 102 patients with preoperative …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Beyond the Grain: Correlating Imaging Findings with Mycetoma Pathogens to Optimize Timely diagnosis and Therapy

Mohammed Fadul, Mustaphaa Bahar, Mohamaed Mustfa, Ahmed Fahal, Amel Omer

Abstract Background Mycetoma is a devastating, progressively destructive neglected tropical disease highly endemic in Sudan, which holds the highest documented global case count (prevalence of 14.5/100,000). Clinically, it presents as a painless subcutaneous mass with sinuses and grain discharge. Frequent delayed presentation leads to high morbidity, disability, and often necessitates amputation. Advanced cases present a diagnostic challenge as their radiological appearance mimics osteosarcoma and other severe bone …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Impact of obesity on clinical and angiographic characteristics in patients with ST-elevation myocardial infarction

Sinhasana Pattalegedara Tharushika Promodini, Saththiyanathan Akilan, Liudmila Kalatsei

Background: Obesity is a well-established cardiovascular risk factor and is strongly associated with metabolic dysregulation, systemic inflammation, and accelerated atherosclerosis. However, its influence on clinical presentation, laboratory parameters, and coronary angiographic characteristics in patients with ST-elevation myocardial infarction (STEMI) remains controversial. Methods: The study included 75 patients with STEMI who were admitted to the Grodno Regional Cardiological Center (Belarus) for treatment from …

29.08.2026journal-article

Egyptian Journal of Radiology and Nuclear Medicine

Apparent diffusion coefficient metrics for adult-type diffuse gliomas classified according to WHO 2021: a systematic review

Dragos Gabriel Margalin, Razvan Stanciulescu, Didina-Catalina Barbalata, Corneliu Toader

Abstract Purpose This study aimed to determine the associations of apparent diffusion coefficient (ADC) values with the molecular and histological subtypes of adult-type diffuse gliomas classified in accordance with the 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System, fifth edition (WHO CNS5). Methods PubMed, Scopus, Cochrane and Google Scholar were searched to identify relevant studies up to December 2025. The search and selection strategies followed the relevant items o …

29.08.2026journal-article

npj Genomic Medicine

aiDIVA – hybrid AI for rare disease diagnostics using evidence-based, machine learning and language models

Dominic Boceck, Lucia Laugwitz, Marc Sturm, Daniela Bezdan, Axel Gschwind, Tobias B. Haack, Stephan Ossowski

Abstract Genome sequencing enables accurate detection of genetic variants and is transforming rare disease diagnostics. While data generation is scalable, prioritization and clinical interpretation remain challenging, often requiring expert manual classification. AI-driven decision support systems are therefore needed to assist in causal variant identification or to fully automate large-scale re-analysis of unsolved cases. Existing tools often estimate variant impact on protein function, but few integrate genomic, …

29.08.2026journal-article

Translational Medicine

Data variability in rats depending on housing and breeding conditions. Acceptability criteria for biological test systems

A. E. Katelnikova, M. A. Akimova, M. N. Makarova, V. G. Makarov, M. A. Kovaleva, E. A. Shamray, A. Yu. Pereboeva, A. S. Ivkina, D. Yu. Ivkin

Background. The reliability and reproducibility of preclinical in vivo studies significantly depend on the quality of laboratory animals. Objective. To compare the variability of clinical laboratory and behavioral parameters, as well as the level of microbiological control, in rats obtained from four breeding facilities located in the Russian Federation. Materials and Methods. This paper presents coefficient of variation (CV %) values for complete blood count parameters, biochemical analysis parameters (alanine ami …

29.08.2026journal-article

Journal of Feline Medicine and Surgery Open Reports

EXPRESS: A Case of Portal Vein Thrombosis in a Cat with Partial Splenic Rotation and Intermittent Colonic Displacement

Hyuna Kim, YONGSUK JO, Joonghyun Song

Case Summary: A 4-year-old neutered male Turkish Angora cat presented with lethargy, mental dullness and lower urinary tract signs. Hematological and biochemical analyses confirmed hepatic dysfunction. Diagnostic imaging identified portal vein thrombosis (PVT), an extrahepatic portosystemic shunt and collateral vessels surrounding the PVT. Additionally, partial splenic rotation and intermittent colonic displacement were identified. Primary hepatic disease, a common cause of PVT, could not be excluded in this patien …

29.08.2026journal-article

Journal of Clinical Nursing

Cultural Complexities in Conducting Research With Patients With Cancer: A Qualitative Study From the Perspective of Nurse Researchers

Ruishuang Zheng, Hanfei Cui, Yanhui Wang, Qiaohong Guo, Jun Wang, Jieqiong Xia, Ping Zhu, Melissa J. Bloomer

ABSTRACT Aim To explore the cultural challenges and complexities faced by researchers conducting studies with cancer patients in the Chinese cultural context. Design A descriptive qualitative study. Methods Semi‐structured interviews were conducted with 22 nurse researchers from tertiary hospitals, medical universities, and secondary nursing colleges from all six regions in China between April 2023 and December 2024. Data were analysed using inductive thematic analysis as described by Braun and Clarke. Results From …

29.08.2026journal-article

Quality of Life Research

Deciding on thresholds for clinical relevance of PROMIS-upper extremity v2.0 in patients with upper extremity injury

Suus G. J. van Bruggen, Lore E. de Vreeze, Charlotte M. Lameijer, Frank W. Bloemers, Caroline B. Terwee

Abstract Purpose In this study we focused on gaining better interpretation of the PROMIS-Upper-Extremity v2.0 (PROMIS-UE v2.0) T-score scale for measuring upper extremity function in patients with upper extremity injuries (UEIs). This is fundamental in order to clearly understand the clinical relevance of these outcomes. The aim of this study was to identify interpretive thresholds for mild, moderate and severe upper extremity function problems for PROMIS-UE v2.0 T-scores, in patients with UEIs, by performing a vig …

29.08.2026journal-article

Journal of Wasit for Science and Medicine

<b>Assessment of SHANK3, UBE3A, Dopamine Levels, and <i>CACNA1H</i> Gene Expression in Autism Spectrum Disorder: A Case-Control Study</b>

Hayder Atta Abdul-Jabbar Hasan, Muthana Ibrahim Maleek, Noor Hameed Hussein Hamdan

This study investigated dopamine levels and changes in UBE3A, SHANK3, and CACNA1H gene expression in children with autism spectrum disorder (ASD) to enhance understanding of the biological changes associated with the disorder. The study was conducted at Al-Zahra Teaching Hospital in Al-Kut, Iraq, involving 50 children with ASD (40 males and 10 females), aged 3–12 years, and 25 healthy controls. Blood samples were collected from all participants. Dopamine, SHANK3, and UBE3A levels were measured using ELISA, while CA …