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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Journal of Child Neurology

Safety and Local Tolerability of Diazepam Nasal Spray for Children With Epilepsy Aged 2-5 Years: Final Results of a Phase 1/2a Trial

Eric B. Segal, James W. Wheless, Steven M. Wolf, Muhammad Zafar, J. Ben Renfroe, Miguel A. Lopez-Toledano, Leock Y. Ngo, Adrian L. Rabinowicz, Enrique Carrazana

Diazepam nasal spray is approved to treat seizure clusters in patients aged ≥2 years. A long-term safety study in patients aged 6-65 years found a safety profile similar to diazepam rectal gel. We conducted an open-label, phase 1/2a trial of diazepam nasal spray in children with epilepsy aged 2-5 years with motor seizures or seizures with clear alteration of awareness. After a pharmacokinetic period, caregivers were instructed to use diazepam nasal spray (0.5 mg/kg) as needed for frequent seizures or seizure cluste …

26.08.2026journal-article

International Health Sciences Review

Acute traumatic coagulopathy: new concepts in endotheliopathy and hemostatic resuscitation

Ana Clara Pessoa Pontes, João Francisco Ferreira Andriola, Gabriel Alves Groff, Carla Lúcia de Camargo, Elisângela da Silva Mendes Nunes, Paulo Rogério Vieira Lamarca Flores

Acute traumatic coagulopathy (ATC) is an early and complex manifestation of trauma-induced coagulopathy that develops through the interaction of hemorrhagic shock, tissue hypoperfusion, endothelial dysfunction, glycocalyx degradation, inflammation, and dysregulated fibrinolysis, contributing substantially to preventable trauma-related mortality. This narrative review aimed to summarize current evidence regarding the pathophysiological mechanisms underlying ATC, with emphasis on trauma-induced endotheliopathy, and t …

26.08.2026journal-article

Journal of Paediatrics and Child Health

Peripheral Blood Eosinophil Count as a Predictor of Corticosteroid Resistance in Paediatric Asthma: A Prospective Observational Study

Shravya S. Rao, Karthik Subrahmanya, Vishwas Kadambila

ABSTRACT Background Asthma is one of the most common chronic inflammatory disorders in children and remains a major cause of morbidity worldwide. Although inhaled corticosteroids (ICS) are the cornerstone of long‐term asthma management, a considerable proportion of paediatric patients exhibit reduced responsiveness to corticosteroid therapy, resulting in persistent symptoms, frequent exacerbations, impaired quality of life and increased healthcare utilization. Early identification of children at risk of corticoster …

26.08.2026journal-article

Frontiers in Oral Health

Labeled ingredient composition and literature-reported hazard signals in children's toothpastes available through selected UAE retail sources

Sally Manla, Manal Al Halabi, Abiola Senok, Rania Nassar, Anas Salami, Iyad Hussein, Mawlood Kowash

Background Young children frequently swallow toothpaste during brushing, making the composition of ingredients and the context of exposure relevant to pediatric oral care. Objective To conduct a descriptive survey of children's toothpastes available through selected UAE retail sources and to develop a structured evidence map of literature-reported biological effects associated with labeled ingredients, without performing product-level safety or risk assessment. Methods We surveyed children's toothpastes marketed in …

26.08.2026journal-article

N.N. Priorov Journal of Traumatology and Orthopedics

Rehabilitation potential for CNS pathology in patients with musculoskeletal dysfunction using the categories of the International Classification of Functioning, Disability and Health (ICF)

Boris B. Polyaev, Mikhail B. Tsykunov, Olga V. Fuchizhi, Mariya A. Bulatova, A. Y Suvorov

Introduction.Determining the rehabilitation potential (RP) is a key stage in planning medical rehabilitation (MR). The International Classification of Functioning, Disability and Health (ICF) provides a standardized method for assessing impairments, including from the perspective of a physical therapist (PT) as a leading member of the multidisciplinary rehabilitation team (MDRT). The assessment of the musculoskeletal system in patients with CNS pathology is particularly important, as it serves as the primary effect …

26.08.2026journal-article

Health Science Reports

Cardiovascular Diseases: Exploring Epidemiology, Pathophysiology, Risk Factors, and Medicinal Plant‐Based Therapies: A Narrative Review

Nawfal Hasan Siam, Umme Halima Mithila, Sadia Alam Tisha, Hridoy Saha, Ayesha Binte Mahbub, Farhan Nizam, Johirul Islam, Noushin Tabasumma, Md. Mazharul Islam Chowdhury

ABSTRACT Background and Aims Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing coronary artery disease, hypertension, heart failure, and cerebrovascular disorders. The global burden of CVD continues to rise, driven by complex interactions among endothelial dysfunction, oxidative stress, inflammation, genetic predisposition, and lifestyle‐related risk factors. This review aims to provide a comprehensive overview of the epidemiology, pathophysiology, risk factors, …

26.08.2026journal-article

The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences

Self-perceptions of aging and advance care planning: Longitudinal evidence from the Health and Retirement Study

Rita X Hu, Yifan Lou

Abstract Objectives Advance care planning (ACP) is increasingly conceptualized as a proactive, communication-centered process that supports person-centered care in later life. Although prior research has focused on demographic and clinical predictors, less is known about the psychological factors that shape how individuals engage in planning. Guided by Stereotype Embodiment Theory, this study examined whether self-perceptions of aging (SPA) prospectively predict patterns of ACP engagement. Methods Data were drawn f …

26.08.2026journal-article

Journal of Medical Internet Research

The Performance of Large Language Models in Extracting Intestinal Symptoms From Electronic Health Records: Retrospective Observational Study

Xinyue Zhang, Quanyu Wang, Beibei Liu, Xinyi Sang, Sheng Wei

Abstract Background Unstructured electronic health records (EHRs) hinder the monitoring of intestinal infections. Large language models (LLMs) enable automated symptom extraction. However, their clinical validation is limited by a lack of systematic multimodel comparisons, unclear prompting strategies, and the privacy risks of cloud-based models (eg, data leakage and cross-border data transfer). Objective This study aimed to systematically evaluate the performance of locally deployed open-source LLMs across 4 model …

26.08.2026journal-article

International Journal of Contemporary Pediatrics

3% saline versus mannitol in the treatment of cerebral edema in children: a randomized controlled trial

Misbah Sultana S., Rizwan U. Zama, Naushad Malagi

Background: Cerebral edema with raised intracranial pressure is a pediatric neurological emergency associated with coma, herniation and death. Mannitol and hypertonic saline are commonly used osmotic agents, but comparative pediatric data remain limited and heterogeneous. To compare the efficacy and safety of 3% hypertonic saline with 20% mannitol in children aged 3 months to 12 years with cerebral edema. Methods: This randomized controlled trial was conducted from 2023 to 2025 among 70 children with clinical or ra …

26.08.2026journal-article

International Journal of Contemporary Pediatrics

Sepsis in the newborn: urgency and uncertainty in neonatal sepsis

Abhay Kumar Yadav

Background: Neonatal sepsis is a syndrome characterized by systemic signs and symptoms of infection along with bacteremia in the first month of life. It remains a leading cause of neonatal morbidity and mortality worldwide, particularly in low- and middle-income countries. Early diagnosis is challenging because of non-specific clinical manifestations. Methods: A cross-sectional study was conducted from February 2026 to April 2026 at Rapti Academy of Health Sciences, Nepal. Medical records of 125 neonates aged 0-28 …

26.08.2026journal-article

Internal Medicine Journal

Stigmatising substance‐related language in the electronic health records of hospitalised patients after addiction consult service implementation

Ryder Cuppett, Justin Birge, Kristin Daniel, Alëna A. Balasanova

Abstract Objectives Stigmatising language about patients with substance use disorders (SUD) is common in healthcare settings and negatively impacts patient care. Addiction consult services are associated with improved clinician attitudes and less stigmatising views towards patients with SUD. We investigated whether implementation of an addiction consult service at a large urban medical centre was associated with changes in prevalence of stigmatising language in the electronic health record (EHR) of hospitalised pat …

26.08.2026journal-article

Journal of Adolescent and Young Adult Oncology

Delivery of Guideline Concordant Supportive Care for AYAs with Cancer in a Statewide Population-Based Cohort

Jacob N. Stein, Christopher D. Baggett, Emily R. Haines, Nicole Knape, Jennifer L. Lund, Hannah C. Winslow, KyungSu Kim, Jordan Lodato Hunt, Alison Manikowski, Catherine Habashy, Andrew B. Smitherman, Katherine E. Reeder-Hayes

Purpose: In the past two decades, there has been a growing recognition of the unique needs of adolescent and young adult (AYA) cancer patients. Alongside this recognition is the emergence of guidelines for high-quality AYA cancer care. Despite such tailored guidelines, preliminary studies suggest a gap between recommended versus received care among AYAs. We sought to examine patterns in receipt of guideline-concordant care among this population using a state-wide claims database. Methods: We conducted a retrospecti …

26.08.2026journal-article

Health Security

Establishing and Maintaining a Safety Training Program at Scientific Institutions

Segaran P. Pillai, Cristina M. Rodriguez, Marisa J. Newcomer

Employers have a legal and ethical responsibility to provide a safe working environment for their employees. Safety training demonstrates a commitment to fulfilling this responsibility, fostering a sense of trust and accountability. Safety training is important for maintaining a safe and healthy work environment, complying with regulations, and promoting overall wellbeing within organizations and communities. A good safety training program has numerous benefits including (1) employee satisfaction, (2) risk mitigati …

26.08.2026journal-article

Samsun Sağlık Bilimleri Dergisi

THE RELATIONSHIP BETWEEN HEALTH PROGRAM VIEWING MOTIVATION AND TRADITIONAL AND COMPLEMENTARY MEDICINE ATTITUDES AMONG OLDER ADULTS

Naciye Esra Koyuncu, Berna Bayır

Aim: This study was conducted to determine the relationship between the motivation of individuals aged 65 and over to follow health programmes and their attitudes towards conventional and complementary medicine. Method: This cross-sectional and exploratory study was conducted with 176 older adults registered at a family health centre in the province of Konya. Data were collected using the Personal Information Form, the Health Programme Adherence Motivation Scale, and the Attitudes towards Traditional and Complement …

26.08.2026journal-article

Editon Consortium Journal of Research in Medical and Health Sciences

Formulation and Characterisation of a Hibiscus–Baobab-Based Functional Drink with Enhanced Nutritional and Antioxidant Properties

Pius M. Mathi

The purpose of this article is to develop a functional plant-based beverage that harnesses the nutritional and bioactive properties of baobab powder and hibiscus flower extract. A completely randomised design was used in the study, with baobab levels of 1 per cent, 2 per cent, and 3 per cent and hibiscus extract concentrations of 6.25 per cent, 12.5 per cent, and 25 per cent. A total of nine variants were evaluated for sensory, physicochemical, phytochemical, antioxidant activity, and nutritional attributes. Sensor …

26.08.2026journal-article

Journal of Medical Internet Research

Patient-Oriented Digital Health Intervention for Chronic Kidney Disease: From Evidence to Everyday Care

Maoliosa Donald, Dwight Sparkes, Matthew Thomas James

Abstract Lightfoot and colleagues explored patient perspectives on the implementation and sustainability of My Kidneys & Me, a digital self-management intervention for chronic kidney disease, identifying key factors that may influence successful adoption into routine care. The study shows that generating evidence of effectiveness alone is insufficient for successful mobilization into practice, highlighting the importance of embedding implementation evaluation in concert with clinical trials to identify practical st …

26.08.2026journal-article

Mental Health and Social Inclusion

Loneliness, social support and self-esteem among Vietnamese young people

Nguyen Thi Anh Thu, Tran Viet Hoang, Bui Minh Duc, Le Thi Minh Loan, Nguyen Van Luot, Hoang Thi Thao

Purpose This study aims to examine how perceived social support from friends, family and significant others is associated with loneliness among Vietnamese young people and whether self-esteem explains these associations. Design/methodology/approach A cross-sectional survey was conducted with 996 Vietnamese young people aged 16–30 from Hanoi, Phu Tho, Da Nang and Ho Chi Minh City. Participants completed the UCLA loneliness scale (Version 3), the multidimensional scale of perceived social support and the Rosenberg se …

26.08.2026journal-article

PLOS Digital Health

A natural language processing approach to determine whether streamlined health technology assessment for multi-indication medicines is feasible

Isaiah Luc, Drew Carter, Erik Bergman, Gabriel Westman, Tracy Merlin

Conducting a health technology assessment (HTA) for each indication of a medicine contributes to increasing demand on HTA systems and results in delays in access. Streamlining assessments for subsequent indications has been proposed, but there is limited evidence on how this could be achieved. We aimed to quantify semantic similarity between HTA documents for different indications of the same medicine to explore whether concepts could be carried forward to subsequent assessments. Public Summary Documents (PSDs) fro …

26.08.2026journal-article

Revista da Associação Brasileira de Pesquisadores/as Negros/as (ABPN)

SAÚDE NA FLORESTA NEGRA: DESAFIOS INTERSECCIONAIS DA MULHER NEGRA NA AMAZÔNIA

Maura Nunes Pimentel de Carvalho, Denise Machado Duran Gutierrez

Este ensaio analisa as adversidades enfrentadas pelas mulheres negras na área da saúde na Amazônia, sublinhando a necessidade de adotar perspectivas interseccionais, conforme proposto por Patricia Hill Collins, para combater as desigualdades no acesso e cuidado. Examina como a interseção de raça, gênero, classe e espaço geográfico afeta adversamente tanto o acesso quanto a qualidade dos cuidados de saúde, destacando as barreiras geográficas, econômicas, culturais e institucionais enfrentadas. A pesquisa enfatiza a …

26.08.2026journal-article

International Journal of Contemporary Pediatrics

Efficacy and maternal experience with manual breast pump versus electric breast pump in mothers of preterm infants: a prospective observational study

Hillori B. Vithalani, Vatsal Bhadesia, Jatin Mistri, Harsh Pandya

Background: Mother's own milk is the optimal nutrition for preterm infants admitted in neonatal intensive care unit (NICU). Effective breast milk expression is essential to establish and maintain lactation. Although manual and electric breast pumps are widely used, evidence comparing their efficacy and maternal experience. Methods: This prospective observational study was conducted over six months at Setu Newborn Care Centre, Ahmedabad. 100 mothers of preterm infants (<34 weeks' gestation) were enrolled and allocat …

26.08.2026journal-article

International Journal of Contemporary Pediatrics

Hematological parameters as predictors of short-term outcomes in perinatal birth asphyxia in term neonates: a prospective case-control study

Mansi D. Patel, Twinkle D. Patel, Poonam H. Singh

Background: Perinatal asphyxia is a significant cause of neonatal morbidity and mortality globally. Haematological changes, particularly in nucleated red blood cell (nRBC) counts, may offer early diagnostic and prognostic insights. Objective: To estimate and compare haematological parameters in term neonates with and without birth asphyxia and to evaluate their association with short-term outcomes, including hypoxic ischemic encephalopathy (HIE) and meconium aspiration syndrome (MAS). Methods: A hospital-based pros …

26.08.2026journal-article

International Journal of Contemporary Pediatrics

Clinical insights on nutrition support in pediatric cancer care: a survey of pediatric oncologists

Sripriya Venkiteswaran, Sangeeta Mudaliar, Purvi Kadakia, Uma Seshadri, Purnota D. Bahl, Anju Morarka

Cuddles Foundation, an NGO in India providing comprehensive nutrition care to children with cancer, conducted a nationwide survey among pediatric oncology professionals to understand the perceived impact of nutrition intervention programs on clinical outcomes, treatment tolerance, and caregiver empowerment for pediatric oncology patients. Responses from 48 pediatric oncology doctors, including residents, consultants, and department heads, revealed overwhelmingly positive perceptions of nutrition in improving patien …

26.08.2026journal-article

International Journal of Contemporary Pediatrics

Evaluating the efficacy of the SICK score in predicting clinical outcomes among paediatric patients presenting to the emergency department of a tertiary care centre in Kerala

Akhil Joshy, Bincy Varghese, Jacob Abraham, Carol S. Cherian

Background: Early risk stratification in the paediatric emergency department (ED) is crucial for optimal resource use and prevention of avoidable mortality. The signs of inflammation in children that kill (SICK) score is a bedside tool based on observable physiological parameters. However, evidence regarding its role in guiding level-of-care decisions and its association with hospital stay is limited. This study evaluated its ability to predict pediatric intensive care unit (PICU) admission and its correlation with …

26.08.2026journal-article

Frontiers in Public Health

Clinical characteristics and prognostic factors in non-HIV patients with Pneumocystis jirovecii pneumonia and BALF cytomegalovirus co-detection: a retrospective cohort study

Chaomin Guo, Yajiao An, Jingyun Ye, Yanning Ma, Qiang Zhao, Lifeng Wang, Wei Ma, Mingze Zhang, Miaoyu Wang, Yang Wang, Jiyong Yang, Liyan Ye, Liuyang Yang

Background Pneumocystis jirovecii pneumonia (PJP) is a life-threatening opportunistic infection in immunocompromised patients. BALF cytomegalovirus (CMV) co-detection is frequently observed in PJP patients, but its clinical characteristics and prognostic impact in non-HIV populations remain unclear. Methods In this single-center retrospective cohort study, we enrolled 62 non-HIV patients with confirmed PJP between 2019 and 2023. BALF CMV co-detection was defined as detectable CMV DNA in bronchoalveolar lavage fluid …