Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Alter & Demenz · Seite 99

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
07.08.2026journal-article

Journal of Clinical Medicine

Implementation of KDIGO CKD Screening and Its Prognostic Implications in Community-Dwelling Adults Aged 75 Years or Older: A Population-Based Cohort Study

María Isabel Uriarte-Ayestarán, Alicia Gutiérrez-Misis, María Victoria Castell-Alcalá, José M. Mostaza, Carlos Lahoz, Paula Lorenzana-Honorato, Francisco Javier San Andrés-Rebollo, Juan Cárdenas-Valladolid, Pilar Vich-Pérez, Paula Regueiro-Toribio, Miguel Ángel Salinero-Fort

Background: Chronic kidney disease (CKD) is highly prevalent in older adults, yet distinguishing pathological CKD from age-related decline in kidney function remains challenging. KDIGO guidelines recommend combined assessment of estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (uACR), but implementation in primary care is uncertain. We evaluated CKD screening patterns, KDIGO risk categories, and the prognostic value of eGFR and albuminuria for all-cause mortality in adults aged ≥7 …

07.08.2026journal-article

Experimental & Molecular Medicine

Somatic mutations and genome mosaicism in aging and disease

Elizabeth Pan, Alexander Maslov, Jan Vijg

Abstract Age-related genome mosaicism is an inherent feature of multicellularity and genomic instability. It occurs because of DNA mutations, the accumulation of which leads to diverse genomic landscapes across different tissues. DNA mutations in the genome are consequences of DNA damage, changes in the chemical structure of DNA, such as strand breaks or loss of bases. DNA damage is very frequent and normally repaired quickly. However, errors intrinsic to DNA repair or replication can give rise to permanent changes …

07.08.2026journal-article

Frontiers in Aging Neuroscience

Integrating computational modeling, neuroimaging, and neuromodulation to decompose perceptual decision-making in healthy aging: a review of methods, findings, and gaps

Anna Udoratina, Vladimir Maksimenko, Susanna Gordleeva

Perceptual decision-making (PDM) — the transformation of sensory input into behavioral choice — declines with healthy aging, leading to slower responses, altered accuracy, and negative impacts on quality of life. Recent advances in model-based cognitive neuroscience, particularly drift-diffusion models (DDMs), allow decomposition of PDM into latent components (e.g., evidence accumulation, decision caution, non-decision time) and enable identification of neural circuits associated with each component. This decomposi …

07.08.2026journal-article

Frontiers in Public Health

Integrated arts engagement as preventive infrastructure for active and healthy aging: a conceptual and policy framework

Feng Li, Haoyu Suo, Sinuo Chen, Chengmeng Zhang

Population aging is changing the work of public health. Longer lives require not only medical treatment, but also support for functional ability, social connection, meaning, participation, and everyday wellbeing. Arts engagement is increasingly discussed in relation to health, yet arts activities often remain treated as cultural or recreational provision rather than as part of preventive public health systems. This conceptual article develops the idea of integrated community arts engagement as a framework for under …

07.08.2026journal-article

Proceedings of the Canadian Engineering Education Association (CEEA)

Engineers Solve Problems to Help People: An Un-Sustainable Identity Crisis

Libby Osgood

If engineering can be defined as “solving problems to help people,” the description could be praised for being human-centred instead of focusing on devices or processes. However, from a deep sustainability perspective, the anthropocentric definition is too preferential to humans and could result in environmental harm. Because engineering is intrinsically linked to humans, sustainable engineering educators have a challenge to convey non-anthropocentric content within an inherently human-focused discipline resulting …

07.08.2026journal-article

Oral Sciences Reports

The Interplay of Loneliness, Oral Health and Quality of Life: A Study of Thai Older Adults

Nantachit Chuengsamarn, Nattapat Khongsirisombat

Objectives: This study aimed to examine the association between oral health, oral health-related quality of life (OHRQoL) and loneliness among Thai older adults. Methods: A cross-sectional study was conducted among 421 adults aged 60 and older in Ang Thong Province, Thailand. Data were collected through structured interviews and oral examinations. Loneliness and OHRQoL were assessed using the Thai version of the 6-item Revised UCLA Loneliness Scale (RULS-6), and the Thai version of The Oral Health Impact Profile 14 …

07.08.2026journal-article

Journal of Medical Internet Research

Heterogeneous Associations Between Frequent Virtual Communication and Loneliness Among Older Adults: Observational Analysis

Daisuke Kato, Ichiro Kawachi, Katsunori Kondo, Atsushi Nakagomi, Koichiro Shiba

Background Loneliness is a long-standing and widely acknowledged public health problem among older adults, yet evidence remains mixed regarding how virtual communication is associated with loneliness. Less is known about whether this association varies across baseline profiles among older adults. Objective This study aimed to examine the association between frequent virtual communication with family, friends, or acquaintances and loneliness among older adults in Japan and explore whether this association varied acr …

07.08.2026journal-article

Frontiers in Endocrinology

Insulin delivery characteristics and glycemic control in older adults with type 1 diabetes using the Minimed™ 780G system: a real-world analysis

Špela Volčanšek, Petra Vidmar, Andrej Janež, Aleš Skvarča

Introduction Diabetes self-management in older adults with type 1 diabetes (T1D) presents a unique clinical challenge, since maintaining tight glycemic control must be carefully weighed against age-related vulnerabilities. This study aimed to analyze glycemic control through the effects of customized algorithm settings in a cohort of older adults with T1D using an automated insulin delivery (AID) system. Methods This retrospective real-world data analysis included users of the MiniMed™ 780G AID system, aged ≥60 yea …

07.08.2026journal-article

Annals of Clinical and Translational Neurology

Arterial Spin‐Labeling MRI at the Cortical‐ CSF Interface: A Novel Biomarker in Alzheimer Disease

Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael

ABSTRACT Background/Objective Arterial spin‐labeling ( ASL ) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF ‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐ CSF interface ( IF ) perfusion for comparison between Alzheimer disease ( AD ) and cognitively normal controls. Methods In this retrospective study, participants with AD and cognitively normal controls with ASL and 3D T1‐weighted MRI were included. Parenchymal cerebr …

07.08.2026journal-article

Science Advances

Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging

Irene Calvo-Asensio, Andreas Tarcevski, Fatima Dhalla, Anja Kusch, Thomas Barthlott, Saulius Zuklys, Georg A. Holländer, Michael D. Morgan

To date, the identity and maintenance of postnatal thymic epithelial progenitor cells (TEPCs) remain unclear, as does the persistence of bipotent TEPCs after birth or whether lineage-restricted progenitors independently maintain separate TEC compartments. Using an inducible lineage-tracing system based on expression of the thymoproteasomal protein β5t, which is expressed in embryonic and a subset of postnatal TEPCs, we explored the early dynamics of the relationships between thymic epithelial cell (TEC) progenitors …

07.08.2026journal-article

Journal of Neurology

Frontotemporal dementia with right temporal predominance: a clinical comparison with left-predominant FTD

Jennifer C. Thompson, Christopher Kobylecki, Matthew Jones, Jessica Haigh, Matthew Larbey, Tobias C. Langheinrich, Rachel Thomasson, Anna M. T. Richardson, Julie S. Snowden

Abstract Background The right-temporal variant of frontotemporal dementia (FTD) is well characterised. Whether it should be considered a distinct clinical entity, separate from other syndromes of FTD, remains an open question. The study addressed the issue through a retrospective comparison of clinical characteristics of patients with predominant atrophy in right or left anterior temporal lobe (R-ATL vs. L-ATL). Methods Patients were identified from a clinical database, diagnosed with FTD, and reported to show temp …

07.08.2026journal-article

Applied Sciences

Human-Centered AI Healthcare Interventions and Quality of Life in Older Adults Living Alone: A Systematic Review and Meta-Analysis

Mi-Ae Jeong, Sang-Dol Kim

The growth of single-person older adult households has heightened concerns about social isolation, chronic disease management, and diminished quality of life (QoL). A systematic review with meta-analysis was conducted to examine the efficacy of human-centered AI healthcare interventions on QoL among older adults living alone. Five electronic databases (PubMed, Web of Science, CINAHL, Embase, and Cochrane CENTRAL) were searched (January 2020–March 2026) following PRISMA 2020 guidelines. Only randomized controlled tr …

07.08.2026journal-article

British Journal of Radiology

Advanced neuroimaging of vascular cognitive impairment and dementia: biomarkers, guidelines, and clinical impact

Jose Federico Ojeda-Esparza, Daniele Botta, Aikaterini Fitsiori, Corrado Santarosa, Kevin Battistini, Alexandre Cusin, Ioana Hutuca, Marcella Pucci, Caterina Bernetti, Frederic Assal, Lukas Sveikata, Karl-Olof Lövblad, Felix T Kurz

Abstract Vascular cognitive impairment and dementia (VCID) is a leading modifiable contributor to dementia, accounting for an estimated 27–33% of attributable dementia cases. Neuroimaging is central to detection, phenotyping, and longitudinal monitoring. This neuroradiology-focused review integrates the STRIVE-2 imaging lexicon with the VasCog-2 clinical framework and reviews the advanced MRI techniques most pertinent to VCID, spanning clinically established to emerging research approaches: arterial spin labelling, …

07.08.2026journal-article

Life Medicine

Bile acids as a “new hormone” in aging-related liver disease

Buyu Deng, Xingjian Li, Yue Li, Longchuan Han, Zhihui Zou, Yingting Zhang, Jing Luo, Xinxin Tang, Hui Kong, Chenxi Shi, Ying Huang, Hanzhi Luo, Yinkun Fu, Ming He

Abstract Bile acids (BAs) have evolved from their classical definition as digestive surfactants to be recognized as potent endocrine signaling molecules that orchestrate systemic metabolism. Through activation of nuclear receptors such as farnesoid X receptor (FXR) and membrane receptors such as G protein-coupled BA receptor 1 (GPBAR1/TGR5), BAs regulate glucose, lipid, immune, and energy homeostasis. Aging reshapes BA synthesis, enterohepatic circulation, hydrophobicity, microbial biotransformation, and receptor r …

07.08.2026journal-article

FEBS Letters

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille

Age‐related decline in neurovascular integrity is an increasingly recognized contributor to cognitive impairment and neurodegenerative vulnerability. A central feature is blood–brain barrier (BBB) dysfunction arising from endothelial senescence, altered barrier regulation, and chronic low‐grade inflammation. In parallel, aging remodels the gut microbiota, with reduced diversity, loss of short‐chain fatty acid‐producing commensals, and expansion of pro‐inflammatory taxa. Converging evidence indicates that age‐relate …

07.08.2026journal-article

BMC Geriatrics

Clinical characterization in a population of latin-American older adults using the frontotemporal dementia assessment scale: an observational study

Laura Sofia Aguilera-Ariño, Maria Alejandra Piñeros-Rendon, Maria Paula Patiño-Rattiva, Sofía López-Rodríguez, Suhamny Navas-Peñaranda, Mateo Avilés-Gomez, Paula Natalia Acosta, Juan Andrés Ospina, Claudia Talero-Gutierrez

Abstract Background Aging is associated with gradual changes in cognitive, functional, and behavioral domains that may affect everyday functioning in older adults. In Latin America, these these functional and behavioral variations are frequently underrecognized in community settings due to limited access to standardized assessment tools. The Frontotemporal Dementia Rating Scale (FTD-FRS), validated in Spanish, allows allows the assessment of functional and behavioral changes related to daily activities and executiv …

07.08.2026journal-article

Frontiers in Aging Neuroscience

Multimodal integration of serum DAPK1 and gastric myoelectrical activity reveals stage-specific correlates in Parkinson’s disease

Zhining Li, Pei Lu, Can Li, Liangqun Rong, Zixuan Wu, Yumeng Liu, Yuyao Tian, Aiping Gong, Lishun Xiao, Chun-feng Liu

Objective Integrated biomarkers for cross-sectional multidimensional assessment of Parkinson’s disease (PD) remain limited. This study examined associations between serum DAPK1, a systemic molecular marker, and peripheral gastric myoelectrical activity assessed by electrogastrography (EGG) in PD. Methods In this cross-sectional study enrolling 203 participants, including 101 healthy controls (HC), 50 early-stage PD (EPD), and 52 mid-to-late-stage PD (LPD), we collected clinical data, serum DAPK1 levels, and EGG mea …

07.08.2026journal-article

Healthcare

A Mobile Application Intervention for Emotional Health in Older Adults: Designed for Dementia Prevention

Sang Ho Han, Se Hee Kong

Background/Objectives: With increasing aging in the global population, dementia prevalence continues to rise. Mobile health (mHealth)-based cognitive interventions have emerged as widely used non-pharmacological approaches for dementia prevention. In this study, we aimed to evaluate how the dementia-prevention application MELI affects depression, anxiety, and life satisfaction in older adults. Methods: Participants were community-dwelling older adults aged ≥ 60 years without a prior diagnosis of dementia. While the …

07.08.2026journal-article

EPRA International Journal of Economics Business and Management Studies

DOES SOCIAL MEDIA MARKETING REALLY CHANGE WHAT YOUNG PEOPLE BUY? AN EMPIRICAL STUDY AMONG COLLEGE STUDENTS IN KARNATAKA

Sharanabasava H M

This study examines how five dimensions of social media marketing (SMM) — paid advertisements, influencer content, peer recommendations, user-generated reviews, and brand engagement — shape the buying behaviour of college-going youth in Bagalkote district, Karnataka. Primary data were collected from 100 college students through a structured Likert-scale questionnaire. Percentage analysis, mean and standard deviation, Pearson correlation, and Chi-Square tests were employed for analysis. User-generated content emerge …

07.08.2026journal-article

Annals of Medicine & Surgery

Early-onset frontotemporal dementia misdiagnosed as psychosis: a case from rural Nepal

Priya Shrestha, Shiva Raj Pandey, Vivek Pandey, Milan Pangenee, Suraj Tiwari

Background: Early-onset behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder characterized by prominent behavioral and personality changes and is frequently misdiagnosed as a primary psychiatric illness, particularly in low-resource settings, leading to diagnostic delays and inappropriate treatment. Materials and methods: We report the case of a 36-year-old man from rural Nepal with an 18-month history of progressive behavioral changes. Clinical history, longitudinal symptom progressio …

07.08.2026journal-article

Dermato

Dermatologic Consequences of Ozempic-Induced Weight Loss: A Review of Facial Aging, Aesthetic Implications, and Treatment

Rehet Chugh, Kenneth Treasure, Alisha Suhail, Nesreen Shahrour, Ashley Christensen, Michaela Trivette, Mildred Min

Background/Objectives: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), originally developed for Type II Diabetes, has become popular for weight loss due to its ability to suppress appetite and promote fat loss. Although semaglutide’s metabolic benefits are well established, many patients have also reported unintended facial changes including facial fat atrophy, skin laxity, and an aged appearance, collectively known as “Ozempic face.” Methods: To better understand these dermatological effects, a …

07.08.2026journal-article

GeroScience

Aging is associated with altered estrogen receptor expression and alters redox protein balance in human female skeletal muscle

Andrea Tamariz-Ellemann, Line Boel Nørregaard, Mikkel Oxfeldt, Line Barner Dalgaard, Susana Novella, Mette Hansen, Ylva Hellsten, Lasse Gliemann

Abstract It has been hypothesized that age‑related declines in skeletal muscle and vascular function in females may be partly estrogen‑dependent. This study investigated skeletal muscle protein expression of estrogen receptor α (ERα), estrogen receptor β (ERβ), and G protein–coupled estrogen receptor 1 (GPER1), and their association with proteins involved in redox regulation and vascular function, in relation to age, menopausal status, and lifelong physical activity. Skeletal muscle biopsies were obtained from 107 …

07.08.2026journal-article

International Scientific Journal of Engineering and Management

Perspective of People Towards Financial Inclusion and Pradhan Mantri Jan Dhan Yojana: An Empirical Study

H. GLORY JAIVANTHY, K GEETHA RANI

Abstract Financial inclusion is an essential pillar of inclusive economic development because it ensures equitable access to banking and financial services for all sections of society. This study examines people's perspectives towards Financial Inclusion and the Pradhan Mantri Jan Dhan Yojana (PMJDY) by analysing awareness, accessibility, utilization of banking services, customer satisfaction, and perceived benefits. A descriptive research design was adopted using primary and secondary data collected from 100 respo …

07.08.2026journal-article

International Journal of Natural Sciences and Interdisciplinary Research

Extending Context–Mechanism–Outcome Theory for Digital Dementia RiskReduction Education: A Realist-Informed Conceptual Framework for Future Theory Development

Peter Carey

Background: Dementia prevention has emerged as a global public health priority, with growing evidence indicating that a substantial proportion of dementia cases may be delayed or prevented through modification of life-course risk factors. Despite this expanding epidemiological evidence base, translating knowledge into sustained behavioural change remains a persistent challenge. Digital dementia risk-reduction education offers unprecedented opportunities to increase public access to evidence-based prevention informa …