Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Therapie & Reha · Seite 99

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

Current Psychiatry Reports

Eating Disorder Focused Family Therapy with Autistic Children and Young People: A Narrative Review of Recent Developments

Amelia Austin, Rachel Loomes, Fiona Duffy

Abstract Purpose of review This review aims to report the recent advances for eating disorder focused family therapy (FT-ED) for Autistic children and young people, including outcomes, experiences, and suggested adaptations. Recent findings Quantitative studies suggest that Autistic children and young people (and those with high autistic traits) receiving outpatient FT-ED are more likely to require escalation to more intensive levels of care compared to non-autistic peers. Qualitative research shows that Autistic y …

14.08.2026journal-article

Advances in Translational Research

Novel biomarkers in breast cancer for precision therapy and adaptive treatment strategies

Dao-Fu Dai, Tamas Micsik

Abstract Breast cancer is a biologically heterogeneous disease in which clinical outcomes are strongly influenced by molecular characteristics that guide therapeutic decision-making. While the traditional framework based on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) has enabled major advances in patient stratification, it provides only a limited and static representation of tumor biology. Increasing evidence indicates that breast cancer evolves dynamicall …

14.08.2026journal-article

International Forum of Allergy & Rhinology

Clinical Improvement and Immune Signatures Following Platelet‐Rich Plasma Therapy for Post‐Viral Olfactory Dysfunction

Vivienne M. Li, Jennifer S. Lee, Arwa Kurabi, Thomas Zhou, Farhoud Faraji, Carol H. Yan

ABSTRACT Background Platelet‐rich plasma (PRP) has emerged as a promising therapy for post‐viral olfactory dysfunction (PVOD) though its biological mechanisms remain unclear. This study evaluated clinical outcomes and targeted proteomic changes following PRP for refractory PVOD. Methods Adults with PVOD ≥ 6 months refractory to standard therapies underwent a single bilateral PRP injection into the olfactory clefts. Demographics, subjective olfactory ratings, and psychophysical assessment using the University of Pen …

14.08.2026journal-article

Cerrahpaşa Medical Journal

Effect of Maintenance Anti-EGFR Therapy on Survival in RAS Wild-Type Metastatic Colorectal Cancer: Real-World Data

Simay Çokgezer, Selay Artan, Sevde Topuz, Muhammet Şenkal, Abdulmunir Azizy, Burak Şakar, Didem Taştekin, Senem Karabulut

Objective: This study aimed to evaluate the impact of anti-epidermal growth factor receptor (anti-EGFR)–based maintenance therapy administered after first-line chemotherapy combined with anti-EGFR treatment on progression-free survival (PFS) and overall survival (OS) in patients with RAS wild-type metastatic colorectal cancer (mCRC), using real-world data. Methods: Patients followed at a single center between 2015 and 2025 were retrospectively analyzed. A total of 37 RAS wild-type patients who achieved disease cont …

14.08.2026journal-article

Robotics

Advances in Pneumatic Upper-Limb Rehabilitation Robots: A Critical Review of Structural Design, Human–Robot Interaction, and Clinical Translation

Yonggen Zhao, Yeming Zhang, Maolin Cai, Feng Wei

Upper-limb motor dysfunction resulting from neurological disorders severely limits patients’ activities of daily living and social participation. Pneumatic upper-limb rehabilitation robots have emerged as a promising intervention owing to their inherent compliance, lightweight design, and high power-to-weight ratio, which facilitate safe, repetitive, and home-based training. Despite these advantages, extensive clinical translation remains hindered by challenges including actuator hysteresis, nonlinear dynamics, lim …

14.08.2026journal-article

Pharmaceutics

Bergapten as a Multifunctional Phytochemical in Cancer Therapy: Mechanistic Insights, Pharmacokinetics, and Possible Nanotechnology-Enabled Formulation Strategies

Victória Dogani Rodrigues, Maria Angélica Miglino, Claúdia Rucco Penteado Detregiachi, Sandra Maria Barbalho, Lucas Fornari Laurindo

Bergapten is a plant-derived linear furanocoumarin widely distributed in Rutaceae and Apiaceae species and increasingly recognized for its multifunctional anticancer potential. This review critically synthesizes current evidence on bergapten’s biosynthesis, physicochemical and pharmacokinetic properties, anti-inflammatory and antioxidant pharmacodynamics, and mechanistic antitumor activity, highlighting its translational relevance within pharmaceutical development. Preclinical studies across diverse malignancies de …

14.08.2026journal-article

CAMPO JURÍDICO

ANTIMICROBIAL RESISTANCE IN INTENSIVE CARE: CURRENT CHALLENGES AND FUTURE PERSPECTIVES ON COMBINATION ANTIMICROBIAL THERAPY

Dianah Dantas Pulvirenti, João Pedro Zanatto, Ana Carolina Fontana Bolsoni, José Gabriel Cavalcanti Garcia, Maria Júlia Daniel Peixoto, Edna Pereira da Silva, Arthur Menegucci Vicenconi, Bruna Gonçalves Manzoni, Lucileia Mazuqueli Marques, Mirella Cristina Mazuqueli Marques, Fabiana Campos Castro Carvalho, Rodolfo de Oliveira Medeiros

Antimicrobial resistance represents one of the greatest contemporary challenges in intensive care medicine, being associated with increased mortality, prolonged hospital stays, higher healthcare costs, and reduced therapeutic options. Critically ill patients are particularly susceptible to the development and dissemination of multidrug-resistant microorganisms due to disease severity, frequent exposure to invasive devices, prolonged antimicrobial use, and immune dysregulation associated with critical illness. In th …

14.08.2026journal-article

Gynecology and Minimally Invasive Therapy

Complication Spectrum of Hysterectomy: A Retrospective Cohort Study from a Tertiary Care Hospital

Arun Sanap, Neha Gangane, Medha Davile, Anusha Kamath, Shuchita Mundle, Anita Yadav

Abstract Objectives: The objective of this study was to investigate the complications of hysterectomy. Materials and Methods: This retrospective cohort study was conducted at Tertiary Care Hospital and Institute of National Importance in Central India, including 310 patients, to analyze the complications associated with the hysterectomy. Medical records were obtained, and the demographic details, associated co-morbidities, surgical details, including indication, timing, and route of hysterectomy, were noted. Intrao …

14.08.2026journal-article

Nutrients

Medical Nutrition Therapy with Meal Sequence and Divided Carbohydrate Intake: Associations with Ketonuria Resolution and Neonatal Outcomes in Gestational Diabetes Mellitus

Saeko Imai, Shizuo Kajiyama, Yuki Higuchi, Shintaro Kajiyama, Yoshitaka Hashimoto, Michiaki Fukui

Background/Objectives: Ketonuria is frequently observed in women with gestational diabetes mellitus (GDM), particularly when energy and carbohydrate intake is inadequate. This retrospective study evaluated nutritional status and neonatal outcomes following dietitian-led medical nutrition therapy (MNT) in 517 Japanese women with GDM with and without ketonuria. Methods: Dietary counseling emphasized a meal sequence in which vegetables were consumed before protein-rich foods and carbohydrates were consumed last, toget …

14.08.2026journal-article

RSV

Care Management for Neurological Sequelae in Brazil's Unified Health System: Strategies for Comprehensive Rehabilitation

Juliana Aparecida Pereira Ribeiro, Gabriela Eiras Ortoni, Mônica Rodrigues da Silva, Wenderson Gonçalves Andrade, Janayna de Oliveira Silva, Mônica Alessandra Dias Rocha, Regina Gabriela Caldas de Moraes, Oldair Donizete Galeni

Neurological sequelae resulting from stroke, traumatic brain injury, spinal cord injury, neurodegenerative disorders, and other neurological conditions have become a major challenge for healthcare systems due to their long-term impact on functionality, autonomy, and quality of life. In Brazil's Unified Health System (SUS), comprehensive rehabilitation requires coordinated care management capable of integrating different levels of healthcare while ensuring continuity, equity, and patient-centered interventions. This …

14.08.2026journal-article

Journal of Clinical Medicine

Hematological Toxicities in the Modern Era of Melanoma Therapy

Rodica Anghel, Ana-Maria Zamfirescu-Deryder, Vlad-Luca Moga, Antonia-Ruxandra Folea, Radu-Valeriu Toma, Andreea-Iren Șerban, Liviu Bîlteanu

Background/Objectives: The advent of immune checkpoint inhibitors (ICIs) and targeted therapies has revolutionized advanced melanoma treatment but introduced unique immune-related adverse events (irAEs). Hematological irAEs (Hem-irAEs) are rare but carry disproportionately high morbidity and mortality. This review systematically synthesizes current literature to comprehensively understand the incidence, pathophysiology, clinical presentation, and management of Hem-irAEs in modern melanoma therapy. Methods: A compre …

14.08.2026journal-article

Traumatology and Orthopedics of Russia

EFFICACY AND SAFETY OF VARIOUS ORAL ANTIBACTERIAL THERAPY REGIMENS FOR IMPLANT-ASSOCIATED INFECTION CAUSED BY LEADING GRAM-NEGATIVE PATHOGENS

Olga S. Tufanova, Svetlana A. Bozhkova, Ekaterina M. Gordina, Alexander P. Antipov

Background. The high level of antibacterial resistance of the leading gram-negative pathogens of orthopedic infection leads to difficulties in selecting antibacterial drugs at both in patient and out patient treatment stages. Does the antibiotic resistance of Gram(-) bacteria isolated from patients to oral antibiotics affect the effectiveness of treatment? Is it necessary to prescribe oral AB drugs to patients who have isolated a pathogen resistant to them? Are there differences in the efficacy and safety of using …

14.08.2026journal-article

Chronic Diseases and Translational Medicine

Rehabilitation After Stroke in a Transition From Hospital to Municipality—Impact of Amount of Rehabilitation

Gabriel Tafdrup Notkin, Dorthe Gaby Bove, Lisbet Lind, Michael Broksgaard Jensen, Stig Molsted

ABSTRACT Background Stroke is a leading cause of long‐term disability that impairs physical function and health‐related quality of life (HRQoL). Rehabilitation during and after hospitalization is essential for promoting neurological recovery and functional independence. This study aims to investigate (1) changes in physical function, balance, and HRQoL from hospital admission to completion of rehabilitation after stroke; (2) associations between rehabilitation amount and changes in physical function and balance; an …

14.08.2026journal-article

Pharmaceutics

Machine Learning for Valproic Acid Therapy: A Scoping Review of Pharmacokinetic-Prediction Models and Pharmacokinetic-Informed Clinical Outcome Models

Janthima Methaneethorn, Supavadee Aramvith, Wanaporn Charoenchokthavee, Sohaib Habiballah, Khanita Duangchaemkarn, Brad Reisfeld

Background/Objectives: Population pharmacokinetics (PopPK) has been used to aid valproic acid (VPA) dose individualization. However, this approach faces limitations owing to the complexity and high dimensionality of datasets. Machine learning (ML) can handle these challenges. However, the comparative evaluation of these ML algorithms and their practical application in optimizing VPA therapy have not yet been established. This review aims to summarize the current evidence, identify research gaps, and outline ML appl …

14.08.2026journal-article

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology

Quality of Life Outcomes in Patients with Pulmonary Hypertension Receiving Prostacyclin Therapy: Impact of Anxiety, Depression, Sociodemographic Characteristics, and Treatment-Related Factors

Fatma Yıldırım, Elif Ok, Vesile Ünver, Dilek Sezgin, Halil Ataş, Betül Şentürk Saraç

Objective: Despite advances in prostacyclin therapy, pulmonary hypertension (PH) continues to impair patients' quality of life (QoL). This study aimed to identify the clinical and psychological factors associated with QoL in patients receiving prostacyclin therapy. Method: This cross-sectional study was conducted between July 2023 and September 2024 and included 58 patients with PH receiving prostacyclin therapy. Data were collected using a structured questionnaire assessing sociodemographic and disease-related cha …

14.08.2026journal-article

Pilot and Feasibility Studies

Protocol for a feasibility study of a self-help resource based on the principles of cognitive behavioural therapy to reduce needle fear in young people aged 11- to 16 years

Fiona Sotir, David White, Gemma Wheeler, Helen Rodd, Zoe Marshman

Abstract Background Needle fear affects up to half of all young people, with the potential to impede their accessing and acceptance of healthcare interventions. There is presently a lack of accessible self-help resources available to support young people in managing needle-based procedures. This feasibility study aims to create a trial protocol for future definitive assessment of a self-help tool co-designed with young people, to manage their fear of needles. Methods This article presents the protocol for a study t …

14.08.2026journal-article

physioscience

Group therapy in physiotherapy

Marwin Weber, Lea Gorenflo, Lukas Horstmeier, Nicole Wimmesberger, Franziska Killinger, Julia Allekotte, Joerg J. Meerpohl, Sebastian Voigt-Radloff, Angelika Eisele-Metzger

Abstract Group therapy is rarely used in outpatient physiotherapy in Germany, although it is permitted according to the “Heilmittelrichtlinie” and would be preferable to individual therapy if equally suitable. Group therapy could help expand treatment capacities, reduce costs, and promote factors such as motivation and adherence. Whether it is similarly effective to individual therapy for diagnoses that are frequently prescribed, however, remains unclear. To provide an overview of the current evidence on group-base …

14.08.2026journal-article

Discover Artificial Intelligence

Wearable art therapy as a novel multisensory intervention for alleviating depressive symptoms

Jin Xue, Herdian

Abstract Depression is a main global cause of emotional disability, impacting cognitive function, social interactions, and quality of life. Traditional assessment methods depend on subjective, time-consuming self-reported surveys and clinical interviews, and challenging for continuous monitoring and intervention. To address these limitations, this research-proposed system integrates wearable sensing technologies, multisensory art therapy, and deep learning (DL) techniques to provide personalized and continuous ment …

14.08.2026journal-article

Gynecology and Minimally Invasive Therapy

Ovarian Cystectomy by Vaginal Natural Orifice Transluminal Endoscopic Surgery at 12 Weeks of Pregnancy: A Case Report

Kotone Suzuki, Mai Shimura, Ayaka Yukimori, Hana Ueda, Rena Maeda, Satomi Arakawa, Mari Ishizaka, Riho Sato, Asumi Mishina, Yoshiko Arata, Tatsuya Matsunaga, Yuka Oi

Abstract We report a rare case of bilateral ovarian tumor resection using vaginal natural orifice transluminal endoscopic surgery (vNOTES) at 12 weeks of gestation. A 33-year-old primigravida presented with two cystic ovarian masses, wherein bilateral mature teratomas were suggested based on magnetic resonance imaging. Given the risks associated with the masses during pregnancy, vNOTES was the preferred surgical approach. The tumors were extracorporeally resected after aspiration through the posterior vaginal forni …

14.08.2026journal-article

Frontiers in Medicine

Early dynamic immune-inflammatory and nutritional recovery signature is associated with durable benefit and early progression in advanced non-small cell lung cancer receiving first-line PD-1/PD-L1 inhibitor-based therapy: a real-world retrospective cohort study

Tingting Zhan, Hang Cao

Background Durable benefit from first-line PD-1/PD-L1 inhibitor-based therapy remains heterogeneous in advanced non-small cell lung cancer (NSCLC). Baseline biomarkers, including PD-L1 tumor proportion score, tumor mutational burden, and static inflammatory indices, only partly capture this heterogeneity and may not reflect host response. We evaluated whether a cycle 2 immune-inflammatory and nutritional recovery signature from blood markers was associated with durable clinical benefit (DCB), early progression, and …

14.08.2026journal-article

Medicina

Clinical Outcomes Following Transition from ICS/LABA to Single-Inhaler Triple Therapy in Patients with Uncontrolled Asthma: A Real-World Cohort Study

Melis Yağdıran, Kurtuluş Aksu

Background and Objectives: A considerable proportion of patients with asthma remain inadequately controlled despite treatment with inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) therapy. Single-inhaler triple therapy comprising an inhaled corticosteroid, a long-acting β2-agonist, and a long-acting muscarinic antagonist (ICS/LABA/LAMA) has emerged as an effective step-up treatment; however, real-world evidence remains limited. This study aimed to evaluate the effects of transitioning from high-dose ICS/LAB …

14.08.2026journal-article

Machine Learning and Knowledge Extraction

Persona-ASR: Bilingual Target-Speaker Speech Recognition for Kazakh–English Overlapping Speech

Rakhat Meiramov, Tomiris Rakhimzhanova, Adil Taibassarov, Zhanat Makhataeva, Huseyin Atakan Varol

Target-speaker automatic speech recognition (TS-ASR) enables transcription of a specific speaker in multi-talker environments, yet remains largely unexplored for multilingual, low-resource languages. Existing TS-ASR systems predominantly target monolingual English using diarization-based or speaker-embedding approaches, leaving a critical gap for languages such as Kazakh, where code-switching with Russian and English is commonplace. We propose Persona-ASR, a modular two-stage architecture. The first stage is an exp …

14.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Effects of plyometric training on explosive power and swimming performance in adolescent swimmers: a systematic review and meta-analysis with dose-response analysis

Rangxi Jin, Mitchell James Finlay, Francisco Cuenca-Fernández, Wei Huang

Abstract Adolescent swimmers depend heavily on lower-limb power during critical phases such as the block start, wall turn, and sprints, with the circa-peak height velocity (PHV) period representing a sensitive window for neuromuscular development. Plyometric training (PT), utilizing the stretch-shortening cycle, is a key component of long-term athletic development, yet evidence stratified by maturation stage is lacking. This systematic review and meta-analysis searched PubMed, Web of Science, Embase, EBSCO, Cochran …

14.08.2026journal-article

Endocrine Connections

Impact of GAD-65 Antibody Detection on Antihyperglycemic Therapy in T2D

Sharon Halliburton, Eric Herber, Kevin M. Pantalone, Marcie Parker, Amanda Soric

Abstract Guidelines recommend Latent Autoimmune Diabetes in Adults be managed similar to type 1 diabetes, emphasizing early insulin initiation, while other guidances suggest incorporating non-insulin antihyperglycemic therapies based on comorbidities and C-peptide levels. The study objective was to explore whether glutamic acid decarboxylase-65 autoantibody detection in individuals diagnosed with type 2 diabetes impacts antihyperglycemic treatment. This retrospective, observational cohort study at an academic integ …