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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
23.08.2026journal-article

Journal of Cosmetic Dermatology

Efficacy and Safety of Yellow Light Monotherapy Versus Yellow Light Combined With 20% Vitamin C for the Treatment of Melasma: A Single‐Center, Randomized, Double‐Blind, Placebo‐Controlled Clinical Study

Dan Du, Xu Liu, Yuwei Huang, Shuwei Wu, Xian Jiang

ABSTRACT Background Melasma treatment remains challenging due to limited effective and safe options. This study evaluated the efficacy and safety of yellow light phototherapy alone versus combined with 20% vitamin C in treating melasma. Methods Seventy‐one patients were randomly assigned to receive twice‐weekly yellow light phototherapy combined with either 20% vitamin C solution ( n = 35) or its corresponding vehicle ( n = 36). The primary outcome was the change from baseline in modified Melasma Area and Severity …

23.08.2026journal-article

Healthcare

Early Orthodontic Treatment in Children: A Qualitative Exploration of Orthodontists’ Perspectives and Practices in Saudi Arabia

Guna Shekhar Madiraju, Yousef Majed Almugla

Background and Objectives: The optimal timing of orthodontic intervention in children remains debated, particularly during the mixed dentition phase. Despite potential benefits, variability in clinical decision-making persists. This study explored orthodontists’ perceptions, clinical practices, and clinical decision-making regarding the timing of early orthodontic intervention in Saudi Arabia. Materials and Methods: An interpretive qualitative study was conducted using semi-structured interviews with nineteen licen …

23.08.2026journal-article

Interdisciplinary Medical Journal

Analysis of gene expression to explore the contribution of cancer-associated fibroblasts to breast cancer progression: a computational analysis

Nail Beşli, Nilufer Ercin, Bahar Sarikamis Johnson, Ulkan Celik

Objective: Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment that greatly influence breast cancer progression. In this study, we used in silico analysis to determine the potential pathways and genes that could affect breast cancer progression associated with CAFs.Method: Data from breast cancer patients, collected through microarray and next-generation sequencing (NGS), were retrieved using the Gene Expression Omnibus (GEO) platform. The differentially expressed genes (DEGs) …

23.08.2026journal-article

Bioengineering

Research Progress on the Pre-Treatment of Chicken Feathers for Biogas Production

Isa Beatriz Conceição Oliveira-Alves, Hortência E. P. Santana, Ingrid Vieira Fernandes, Meirielly Jesus, Joana Santos, Fernando Mata, Samia Tássia Andrade Maciel, Denise Santos Ruzene, Daniel Pereira Silva

Keratin is an abundant, recalcitrant structural protein that constitutes the primary component of several animal wastes, particularly chicken feathers. Because of their potential and availability, various technologies, such as anaerobic biodigestion, have been used to degrade keratin and transform feathers into biogas and other value-added products. However, due to their fibrous architecture and rigid structure, keratinous materials are elastic, water-insoluble, and enzymatically resistant, which makes natural degr …

23.08.2026journal-article

BJU International

Diet and risk of bladder cancer: a systematic review of epidemiological evidence

Keiichiro Miyajima, Marcin Miszczyk, Navid Roessler, Shota Inoue, Paweł Rajwa, Akihiro Matsukawa, Fumihiko Urabe, Keiichiro Mori, Takafumi Yanagisawa, Pierre I. Karakiewicz, Jeremy Yuen‐Chun Teoh, Alberto Briganti, Lin Yang, Eva Schernhammer, Takahiro Kimura, Shahrokh F. Shariat

Purpose Although tobacco use and occupational exposures are established risk factors for urothelial cancer (UC), the influence of dietary factors remains uncertain. We conducted a systematic review to synthesize evidence from prospective cohort studies examining associations between dietary exposures and UC incidence. Methods A comprehensive literature search of MEDLINE, Embase, and Web of Science (May 2025) was performed to identify prospective studies evaluating dietary factors with UC incidence. The risk of bias …

23.08.2026journal-article

International Journal of Cancer

Assessing the Consistency of Genitourinary Cancer Estimates: A Comparison of Data From the Global Cancer Observatory and the Global Burden of Disease Study

Xiaohan Li, Zhengju Ren, Yao Chen, Wei Fan, Guangping Zhao, Ying Huang, Qing Jiang

ABSTRACT The Global Cancer Observatory (GLOBOCAN) and the global burden of disease (GBD) are two key databases for cancer epidemiology. In this study, we aim to assess the consistency of genitourinary cancer incidence and mortality estimates from the same year across the two databases, analyze the association between observed discrepancies and levels of social development and available health resources, and explore the reasons underlying these differences. Age‐standardized incidence and mortality rates (ASIR and AS …

23.08.2026journal-article

Expert Systems

Systematic Literature Review of Deep Learning Techniques for Lung Cancer Segmentation

Muhammad Sufyan, Jun Qian, Jianqiang Li, Azhar Imran, Fahad Sabah

ABSTRACT Accurate lung nodule segmentation is essential for early lung cancer diagnosis and treatment planning. Although deep learning (DL) has significantly advanced automated segmentation, existing review studies often lack an integrated technical–clinical perspective and provide limited guidance for real‐world deployment. In this study, we conduct a systematic literature review following PRISMA 2020 guidelines, analysing 311 publications and synthesizing 113 high‐quality studies published between 2019 and 2026. …

23.08.2026journal-article

Cellular Physiology and Biochemistry

Effects of Mebendazole and Flutamide Combination in Prostate Cancer Cell Lines: a Comprehensive in Vitro Analysis

Mohammad Reza Fattahi Fattahi, Diana Taheri, Seyed Hassan Inanloo, Akram Mirzaei, Helia Azodian Ghajar, Leonardo Oliveira Reis, Seyed Mohammad Kazem Aghamir

Background/Aims: The aim of this research was to use Mebendazole as an anticancer candidate to reduce the dose of Flutamide and reduce its side effects. Method: In this in vitro study, we evaluated the effect of Mebendazole, Flutamide and Mebendazole-Flutamide combination therapy in LNCaP, DU145 and PC3 cell lines as representatives of human prostate cancer. The assessment includes scratch-wound assay, colony formation assay, flow cytometric analysis of apoptosis and DNA cell cycle, real-time PCR (BAX/BCL2, E-cadhe …

23.08.2026journal-article

Surgical Practice

Survival Analysis of Palliative Mastectomy for Patients With De Novo Stage IV Breast Cancer: A Single‐Centre Experience

Xiao Hong Su, Wai Fong Tsang, Ho Yan Yuen

ABSTRACT Objective To audit the impact of palliative mastectomy with axillary dissection (PMAD) on the prognosis of patients with de novo stage IV breast cancer in the Pok Oi Hospital (POH), Hong Kong. Methodology We retrospectively reviewed 5377 patients with breast cancer treated in POH between January 2010 and October 2025 and identified 68 patients with de novo stage IV disease who underwent PMAD after systemic therapy. Progression‐free survival (PFS) and overall survival (OS) were estimated by the Kaplan–Meier …

23.08.2026journal-article

iMetaMed

A Pan‐Cancer Single‐Cell Atlas of Bone Metastases Reveals Convergent Malignant Programs and Coordinated Immune Dysfunction

Yitong Pan, Zhou Yang, Junyuan Deng, Feng Liu, Guang Lei

ABSTRACT Bone metastases (BoMs) are a major clinical challenge across cancer types, yet mechanistic insights remain limited by small cohorts and insufficient profiling depth. Here, we present a single‐cell RNA sequencing atlas of 95 BoMs, 22 healthy bone marrows (hBMs) and 129 primary tumors (PTs) spanning 10 cancer types, comprising 895,475 high‐quality transcriptomes, to map cellular remodeling during bone metastatic colonization. Malignant cells in BoMs converged on chromosomal instability—high proliferative sta …

23.08.2026journal-article

Acta Anaesthesiologica Scandinavica

Anaesthetic Type and Survival in Metastatic Colorectal Cancer: A Nationwide Registry Study

Ahmed Tarfy, Anna Enlund, Erland Östberg, Hanna Vikman, Anders Berglund, Mats Enlund, Maziar Nikberg

ABSTRACT Background The impact of anaesthetic choice on survival following metastatic cancer surgery is uncertain. Inhalational anaesthetics, such as sevoflurane, may promote inflammation and tumour progression, while the intravenous agent propofol has been suggested to be anti‐inflammatory. This study aimed to evaluate the association between anaesthetic maintenance with inhalational anaesthesia versus propofol‐based total intravenous anaesthesia and overall survival in patients undergoing surgery for metastatic c …

23.08.2026journal-article

Cancers

Evaluating the Performance of Machine Learning Models for Predicting 5-Year Breast Cancer Survival: A Systematic Review and Meta-Analysis

Ashin Krishna Chalil, Bindu Therayangalath, Vikram Patil, Chaithra Nagaraju

Background: Breast cancer is the most common malignancy among women worldwide and a leading cause of cancer-related mortality. Despite advances in diagnosis and treatment, accurately predicting 5-year survival remains challenging because of disease heterogeneity. This study systematically evaluated the performance of machine learning (ML) models for predicting 5-year breast cancer survival and synthesised their overall discriminative performance. Methods: A systematic search of PubMed, Scopus, and Web of Science (2 …

23.08.2026journal-article

Biomedicines

Upfront Versus Deferred CDK4/6 Inhibitor Use in Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: A Real-World Study

Pınar Kubilay Tolunay, Bediz Kurt İnci, Berkan Karabuğa, Ali Topkaç, Şura Usta, Ergin Aydemir, Nejat Emre Öksüz, Enes Erul, İrem Küçükşahin, Hatime Arzu Yaşar, Hakan Akbulut, Ülkü Yalçıntaş Arslan, Öztürk Ateş

Background/Objectives: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) are commonly used as first-line treatment for hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer. However, the optimal timing of CDK4/6i initiation remains uncertain. This study compared overall survival (OS) between upfront first-line and deferred second-line CDK4/6i use in routine clinical practice. Methods: This retrospective, two-center cohort study included 403 patients with hormone …

23.08.2026journal-article

Journal of Composites Science

Mechanical Properties of AZ91D Magnesium Alloy with Short Carbon Fibers Under Heat Treatment and Equal-Channel Angular Pressing

Song-Jeng Huang, Jun Yi Lin, William Li, Chuan Li, Sathiyalingam Kannaiyan

AZ91D is a lightweight, representative commercial magnesium alloy known for its excellent castability and specific strength. However, the mechanical properties of as-cast AZ91D remain limited by inherent brittleness, relatively low strength, and microstructural inhomogeneity caused by enrichment of secondary phases at grain boundaries. In this study, AZ91D/Csf (short carbon fiber at 0, 2.5, and 5 wt.%) composites were prepared by gravity casting with mechanical stirring, followed by post-casting T4 heat treatment a …

23.08.2026journal-article

Symmetry

SDFR-Net: A Stage-Asymmetric Spectral Diffusion and Frequency–Spatial Refinement Network for Brain Tumor MRI Segmentation

Jingshi Lei, Hongwei Deng, Xicheng Fu, Yi Lei, Lei Xu, Qiangfei Wang

Accurate brain tumor segmentation from multi-modal magnetic resonance imaging (MRI) is essential for clinical diagnosis and treatment planning. However, effectively capturing long-range contextual information and fine lesion boundaries under limited computational budgets remains challenging. In this work, we propose SDFR-Net, a lightweight stage-asymmetric Spectral Diffusion and Frequency–Spatial Refinement Network for efficient 2.5D brain tumor MRI segmentation. Instead of applying identical processing across all …

23.08.2026journal-article

Surgeries

Simultaneous Carotid Endarterectomy and Ipsilateral Parotidectomy for Asymptomatic Carotid Artery Stenosis and Concurrent Warthin’s Tumor: A Multicenter Retrospective Case Series

Priscilla Nardi, Valerio Rinaldi, Greta D’Onofrio, Valeria Iacoucci, Sara Lembo, Lodovica Pepe, Marcella Vaglica, Roberta Zilli, Rocco Pasqua, Giulia Pizzardi, Massimo Ruggeri, Giampaolo Prezioso, Vito D’Andrea, Antonio Minni, Gianfrancesco Niccolini, Lorenzo Silvani, Marco De Vincentis, Giulio Illuminati

Background: Management of high-grade carotid artery stenosis with concomitant ipsilateral parotid gland tumor presents a rare and challenging surgical condition. Due to the rarity of this dual pathology, standardized guidelines are lacking. Material and Methods: A retrospective study was conducted between January 2020 and May 2025. Six asymptomatic patients with significant carotid stenosis and coexisting ipsilateral Warthin’s tumor underwent simultaneous eversion CEA (carotid endarterectomy) and partial superficia …

23.08.2026journal-article

International Journal of Molecular Sciences

Medical Cannabis and the Hallmarks of Cancer: A Critical Narrative Review

Diana Russo, Rute Fernandes, Valéria Tavares, Ana Agrelo, Rui Medeiros

Cancer remains a highly complex and heterogeneous disease, causing major morbidity and mortality worldwide despite advances in diagnosis and treatment. The hallmarks of cancer enlighten the biological mechanisms supporting tumourigenesis and malignant evolution, while helping to identify potential therapeutic targets. Medical cannabis has mostly been used in oncology for supportive care, but increasing preclinical evidence suggests interference with cancer-related signalling pathways. This narrative review summariz …

23.08.2026journal-article

Journal of Clinical Medicine

Safety and Efficacy of Brolucizumab in the Treatment of Patients with Diabetic Macular Edema and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

Sharifa N. Bourisly, Fatmah S. Semairan, Yousef Mesaed Al-Shammari, Noor Alali, Lulwa Abbas Alfoudari, Abdulaziz F. Abdulkareem, Abdullah M. Alharran

Background: Brolucizumab is an intravitreal anti-vascular endothelial growth factor (anti-VEGF) agent developed to improve retinal drying and treatment durability in diabetic eye disease. However, its overall efficacy and safety in diabetic macular edema (DME) and diabetic retinopathy remain uncertain because available trials differ in population, comparator, dosing schedule, and follow-up. Methods: We searched PubMed, Cochrane Library, Scopus, and Web of Science from inception to 25 April 2026. Randomized controll …

23.08.2026journal-article

Biomedicines

Integrated Molecular Profiling of Endometrial Cancer: NGS Findings, MSI/MMR Status, Histopathological Features, and TCGA-Inspired Molecular Classification

Merve Cirak-Balta, Suleyman Erdogdu, Busra Ekinci, Seda Orenay-Boyacioglu, Olcay Boyacioglu, Ibrahim Halil Erdogdu, Nil Culhaci

Background/Objectives: Endometrial cancer is a heterogeneous malignancy that displays distinct molecular features and clinical behaviors. The molecular profile of endometrial cancer and its relationship with menopausal status, histological subtype, tumor grade, mismatch repair (MMR)/microsatellite instability (MSI) status, co-mutation patterns, and TCGA molecular classification were investigated in the current study. Methods: A total of 81 histopathologically confirmed endometrial cancer cases were retrospectively …

23.08.2026journal-article

Journal of Child and Adolescent Psychopharmacology

Families’ Neighborhood Resources Predict Treatment Response for Regulating Together, a Group Therapy for Emotion Dysregulation in Autistic Youth

Walker S. McKinney, Lauren M. Schmitt, Jennifer R. Ruberg, Marika Coffman, Debra Reisinger, Rebecca C. Shaffer

Introduction: Autistic youth often face difficulties with emotion dysregulation (ED) and associated challenging behaviors. The Regulating Together (RT) group therapy was developed to treat ED in autistic youth ages 8–18 years and has been shown to be feasible, acceptable, and efficacious at reducing ED. Results from other clinical trials suggest the efficacy of behavioral therapies may vary based on family- or neighborhood-level social determinants of health (SDOH: “the conditions in the environments where people a …

23.08.2026journal-article

International Journal of Molecular Sciences

Blood Plasma Analysis in Ovarian Cancer Patients Using an AFM/MS Approach: Effect of Sample Dilution on Proteome Depth

Arina I. Gordeeva, Anastasia A. Konstantinova, Tatiana A. Materova, Elizaveta E. Rybakova, Maria O. Ershova, Nikita E. Vavilov, Victor G. Zgoda, Tatyana O. Pleshakova, Alexander I. Archakov

Early detection of ovarian cancer remains challenging because of the lack of sensitive and reproducible blood-based biomarkers. A major challenge in plasma proteomics is the extremely wide dynamic range of protein concentrations, which prevents simultaneous detection of both high- and low abundance proteins and limits the identification of disease-associated signals. In this study, we applied a combined atomic force microscopy and mass spectrometry (AFM/MS) approach to investigate how sample dilution affects plasma …

23.08.2026journal-article

Cancers

Association Between Body Mass Index and Treatment Toxicity in Patients with Metastatic Renal Cell Carcinoma Treated with Sunitinib or Pazopanib

Ahmet Kürşad Dişli, Ayşe Nuransoy Cengiz, Muhammet Cengiz, İrfan Buğday, Sinan Yıldırım, Rıdvan Gönül, Oktay Bozkurt, Mevlüde İnanç, Metin Özkan

Background/Objectives: Sunitinib and pazopanib are administered at fixed doses in patients with metastatic renal cell carcinoma (mRCC), without adjustment for body composition. This study aimed to investigate the association between body mass index (BMI) and treatment-related toxicity and treatment discontinuation in patients with mRCC receiving first-line sunitinib or pazopanib. Methods: A total of 136 patients with mRCC treated with sunitinib (n = 90) or pazopanib (n = 46) were retrospectively evaluated. BMI was …

23.08.2026journal-article

Smart Molecules

A photoimmune synergizing RNA interference technology for highly effective antitumor treatment

Xiang Xia, Bingbing Wu, Xueze Zhao, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng

Abstract Photoimmunotherapy and RNA interference (RNAi) hold great potential for tumor therapy but exhibit limited efficacy as monotherapies. In this work, we report a red‐light‐activated combinatorial therapy that integrates photodynamic immunotherapy (PIT) with RNAi via a rationally designed photosensitizer, FNBS, developed on the basis of our previously reported advanced photosensitizer platform, HNBS. Upon cellular uptake and following red light irradiation, FNBS induces pyroptosis through the activation of nuc …

23.08.2026journal-article

Histopathology

AI for tumour proportion scoring of programmed death‐ligand 1 immunohistochemistry in non‐small cell lung cancer: a review of commercial and non‐commercial tools

Joachim Webers, Sandrina Martens, Pascal Gervois, Inge Mertens, Yuri Tolkach, Yves Sucaet, Esther Wolfs, Dirk Valkenborg

Programmed death‐ligand 1 (PD‐L1) expression, commonly quantified as tumour proportion score (TPS), is a key biomarker guiding immunotherapy in non‐small cell lung cancer (NSCLC). Manual scoring of PD‐L1 immunohistochemistry (IHC) is time‐consuming and challenged by preanalytical variability and interpretive subjectivity, which can hinder consistent treatment selection. Artificial intelligence (AI) tools aim to support more standardized PD‐L1 scoring. We compare publicly available evidence on PD‐L1 AI tools and ide …