Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Therapie & Reha · Seite 102

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

British Journal of Clinical Pharmacology

Twenty years of inhaler therapy: A nationwide drug utilization study

Katrine Bitsch Johansen, Lars Christian Lund, Zandra Nymand Ennis, Andrew Scourfield, Anders Løkke, Sidsel Arnspang Pedersen

Aims This study aimed to map nationwide trends and prescribing patterns in inhaler use from 2004 to 2023. In light of evolving clinical guidelines and attention to the environmental impact of inhalers within recent years, we also examined variation in prescribing behaviour and patient‐level treatment choices. Methods Using nationwide health registries, we identified all individuals redeeming prescriptions for pressurized metered‐dose inhalers (pMDIs), dry powder inhalers (DPIs) and soft mist inhalers (SMIs) in Denm …

14.08.2026journal-article

Hygiene and sanitation

Myocardial and microvascular remodeling in dust-related lung pathology as a morphological substrate of occupational cardiomyopathy in miners

Oleg I. Bondarev, Egor S. Filimonov

Introduction. Heart diseases are the leading cause of death among miners (>60%). Between 2000 and 2016, 1,797 acute cardiovascular events occurred at the workplace, including 467 fatal cases. These are usually classified as ischemic heart disease, but this is not confirmed by microscopy and does not account for direct damage to the heart by coal-rock dust.Objective. To provide microscopic evidence for defining “dust cardiomyopathy” as a distinct occupational heart disease.Materials and methods. Heart tissue from …

14.08.2026journal-article

International Journal of Traditional and Complementary Medicine Research

One-Year Outcomes of Bioresonance Therapy for Smoking Cessation: A Prospective Primary Care Study

Gamze Dur, Nazlı Şensoy

Aim: Tobacco use remains a major global health concern. Despite pharmacological advances, many smokers seek non-invasive interventions due to side-effect concerns. This study evaluated the 1-year effectiveness of a standardized biophysical therapy, namely Bioresonance Therapy (BRT), for smoking cessation in a primary care setting.Material and Methods: In this prospective longitudinal study, 50 adult participants (mean age 44.3 ± 10.4) underwent a standardized BRT protocol. Nicotine dependence was assessed using the …

14.08.2026journal-article

Journal of Pharmaceuticals and Natural Sciences

Review: Drug Interactions Between Depression and Epilepsy Therapy

Erwin Samsul, Sandrina Nur Yulianda, Rahmawati Eka Sari, Dina Nurfauziah Rahmi, Rahma Nur Afifah, Risma Nur Ramadhani, Annisa Azhalia Syakina, Selvina Nirmaya Saputri, Listra Febrina Taruk

Background: Managing comorbid depression and epilepsy is challenging due to complex drug-drug interactions (DDIs). Objective: This systematic review evaluates clinically significant pharmacokinetic and pharmacodynamic interactions between antidepressants and antiepileptic drugs (AEDs). Methods: A systematic search was conducted across PubMed, ScienceDirect, and Google Scholar (2010–2025) following PRISMA guidelines. Results: Of 377 identified records, 24 studies met the inclusion criteria. Pharmacokinetic interacti …

14.08.2026journal-article

ACS Omega

Mining of Novel Human DPP-IV-Targeting Tripeptides through Multicomputational Screening and In Vitro Validation for Diabetes Therapy

James V. Lavilla, Francis Kirby B. Burnea, Hironobu Hojo, Changge Guan, Charlie A. Lavilla

Abstract Inhibition of human dipeptidyl peptidase IV (hDPP-IV) is considered an effective strategy in the management of type 2 diabetes (T2D). However, the lack of high-throughput screening approaches and the high cost of experimental evaluation have limited the discovery of peptide-based hDPP-IV inhibitors. Herein, an integrated multicomputational screening strategy was employed to successfully mine novel hDPP-IV inhibitory tripeptides. Among the screened candidates, FAW exhibited the highest inhibitory activity, …

14.08.2026journal-article

Russian Journal of Skin and Venereal Diseases

Comparative efficacy of photodynamic therapy, autologous platelet-rich plasma therapy, and their combination in the treatment of diffuse telogen effluvium

Farah Bedoui, Vladimir B. Pineguin, Viktoria M. Poglazova, Olga V. Cergeeva

Background. Diffuse telogen effluvium accounts for a significant proportion of visits to trichologists and reduces the quality of life of patients. However, comparative data on the effectiveness of various physiotherapeutic methods for this condition remain limited. Photodynamic therapy and PRP therapy are considered promising methods for stimulating hair growth by targeting various pathogenesis factors, but the feasibility of their combined use remains poorly understood. AIM:To evaluate the clinical efficacy of ph …

14.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Acute adaptations in dynamic torque and torque control to practicing with known and unknown sequences of concentric and eccentric muscle contractions in healthy young adults

Balázs Gáspár, Sarolta Tar, Ádám Fésüs, Patrik Ivusza, Mátyás Varga, Balázs Sebesi, Zsolt Murlasits, Anikó Kőnig-Péter, Tibor Hortobágyi, Márk Váczi

Abstract Background During human movement, the neuromuscular system continuously adapts to varying and differently predictable demands. Practicing with sequences of known and unknown types of muscle contractions could train force control of muscle. We compared the acute effects of practicing with eccentric and concentric quadriceps muscle contractions at different velocities with known and unknown sequences, on knee extension torque, torque steadiness, and joint position sense in healthy young adults. Methods Ninet …

14.08.2026journal-article

International Journal of Offender Therapy and Comparative Criminology

Exploring the Truths of Moral Reconation Therapy: A Dialogical Narrative Analysis of the Voices of Women on Probation and Facilitators

Vanessa Lynn, Addrain Conyers

This study examines Moral Reconation Therapy (MRT) as a mandated narrative intervention focusing on how women on probation and MRT facilitators make sense of its emphasis on responsibility, honesty, and trust. Drawing on interviews with eight women on probation and two MRT facilitators at a Women Reentry Project, we conduct a dialogical narrative analysis. This approach examines how multiple, sometimes competing, voices emerge within the clients’ accounts and those of the facilitators. Women frequently draw on inst …

14.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Development and validation of the arabic version of the Spine Functional Index (SFI-AR) in patients with spinal disorders

Marc Boutros, Guy Awad, Caren Hassan, Shaza Hammad, Tia-Maria Akoury, Zina Smadi, Rami Rachkidi

Background The Spine Functional Index (SFI) is a patient-reported outcome measure used to evaluate functional limitations in patients with spinal disorders. However, no validated Arabic version has been available, limiting standardized assessment in Arabic-speaking populations. Methods This prospective cross-sectional validation study translated and culturally adapted the SFI into Arabic (SFI-AR) following internationally accepted guidelines, including forward and back-translation, expert committee review, and pilo …

14.08.2026journal-article

Hygiene and sanitation

The impact of occupational experience on the development of circulatory system pathology in workers in the coal mining industry

Egor S. Filimonov, Olesya A. Rumpel, Oleg I. Bondarev

Introduction. Primary prevention of circulatory system diseases is extremely important due to the additional impact of harmful industrial factors on the body, which can accelerate the development of cardiovascular pathology in workers of industrial enterprises.The aim of the study was to investigate the incidence of atherosclerosis and premorbid heart failure in coal mining workers, depending on their occupation and the duration of exposure to harmful industrial factors.Material and methods. Four hundred ninety sev …

14.08.2026journal-article

International Journal of Educational Teaching and Research

Discussion on the Sports and Exercise Rehabilitation Majors in New Zealand Universities and their Relationships with Aging Society

Man Li, Xu Dai

With the increase in the number of older people around the world, problems in their health have attracted more attention from society. Sports and exercise rehabilitation play an essential role in improving the physical fitness, boosting the mental health and overall quality of life of older people, and thus have gradually become important ways to address the health problems of an aging society. As the main institutions for knowledge innovation and talent cultivation, universities in New Zealand have achieved good r …

14.08.2026journal-article

JCC Plus

Hepatitis E Infection in Patients With IBD Treated With Advanced Therapy: A Case Series

Jakub Jirsa, Kristyna Kubickova, Dana Duricova

ABSTRACT Background and Aims Hepatitis E virus is an RNA virus with 8 genotypes. Infection is usually acute and asymptomatic, but chronic infection may develop in immunocompromised individuals. Data on the course of hepatitis E virus infection in patients with inflammatory bowel disease receiving advanced therapy are limited. We aimed to describe the clinical course and outcomes of hepatitis E virus infection in this population. Methods We conducted a case series of consecutive patients with inflammatory bowel dise …

14.08.2026journal-article

ACS Applied Materials & Interfaces

Ingestible Hydrogel-Encapsulated Optogenetic Yeast Controlled by Wearable Electronics Enables Programmable IL-10 Delivery for Inflammatory Bowel Disease Therapy

Chao Zhang, Hongxiang Li, Yue Jiang, Lu Wang, Zhijie Feng, Yanyan Shi, Duo Liu, Hanjie Wang

Abstract Engineered yeast-living drugs offer significant potential for oral protein therapy but remain limited by poor intestinal retention and lack of precise spatiotemporal control over therapeutic delivery. Here, we developed an ingestible hydrogel-encapsulated optogenetic yeast system controlled by a wearable electronic device for programmable interleukin-10 (IL-10) delivery in inflammatory bowel disease (IBD). We engineered Pichia pastoris with an EL222-based blue-light-inducible circuit achieving rapid, strin …

14.08.2026journal-article

Frontiers in Pharmacology

Aztreonam–avibactam therapy following surgical source control for blaNDM-positive carbapenem-resistant Klebsiella pneumoniae intra-abdominal infection in an infant: a case report

Jie Liu, Xiaoli He, Wanlin Zhao, Lijia Du, Lina Qiao, Lu Qing

Treating carbapenem-resistant Klebsiella pneumoniae (CRKP) is challenging, particularly when resistance is mediated by New Delhi metallo-β-lactamase (NDM). Clinical experience with fixed-combination aztreonam–avibactam (ATM–AVI) in young infants remains extremely limited. Here, we report a case of a 2-month-old boy who underwent emergency laparotomy for intestinal obstruction owing to small bowel volvulus with segmental necrosis, followed by bowel resection and reanastomosis. His postoperative course was complicate …

14.08.2026journal-article

Journal of Humanities and Social Sciences Studies

The effectiveness of a counseling program based on play therapy in reducing shyness among fifth-grade students

Rizan Mohamad Taher Humdan, Saleh Salem Al Khwaldeh

The present study aimed to investigate the effectiveness of a counseling program based on play therapy in reducing shyness among fifth-grade students. To achieve the objectives of the study, the researcher adopted a quasi-experimental design with two groups: an experimental group and a control group. The study sample consisted of (30) fifth-grade female students from Amouriya Basic Second School affiliated with the Directorate of Education of Marka District in Amman. The participants were selected using purposive s …

14.08.2026journal-article

Current Pharmaceutical Research

Peptidomimetics Based Therapy Across Cancer, Diabetes, Infection, Neurological and Cardiovascular Disease

Ankita sharma Sharma, Happy, Kapil kumar verma, Saloni Bhardwaj

Peptidomimetics are synthetic compounds designed to mimic the structural and functional features of natural peptides while overcoming limitations such as poor stability, low bioavailability, and rapid degradation. These compounds maintain the ability to interact with biological targets, offering enhanced receptor selectivity, potency, and pharmacokinetic properties. Traditional classification divides peptidomimetics into structural, functional, and functional-structural types, while modern approaches categorize the …

14.08.2026journal-article

Canadian Journal of Respiratory Therapy

Comparison of the active cycle breathing technique with other self-administered breathing techniques for the management of mucociliary production in cystic fibrosis: A systematic review

Muhammad Najeeb Ullah Khan, Asma Osama

Background Cystic fibrosis (CF) is characterized by excessive airway mucus, recurrent infections, impaired ventilation, and progressive decline in lung function. Airway clearance techniques are central to management. Among them is the active cycle of breathing technique (ACBT), which incorporates breathing control, thoracic expansion exercises, and the forced expiratory technique (FET). Comparative evaluation with other self-administered exercises is needed to identify the most effective approach for clinical use. …

14.08.2026journal-article

International Journal of Language & Communication Disorders

Speech and Language Therapists’ Views Regarding Their Scope of Practice in Written Language

Carol Moxam, Claire d'Urban‐Jackson, Lauren Ackerman

ABSTRACT Background Spoken and written language are closely linked, and Speech and Language Therapists (SLTs) have expertise in the language skills that support both. However, unlike countries such as the US and Australia, UK SLTs lack clear guidance on their role in written language. This study explores the views of SLTs working with adults (aged 16+) and children to inform consideration of a UK position statement. Aims To examine UK SLTs’ views on their role and scope of practice in written language assessment an …

14.08.2026journal-article

Journal of Monolingual and Bilingual Speech

The Impact of AI Voice Tutors on Phonetic Acquisition Among Saudi EFL Learners: A Quasi-Experimental Study at Jouf University

Ahmad Mugableh, Mamdouh Alhuwaykim

Abstract This study investigates the impact of AI-powered voice tutors on the phonetic acquisition of Saudi EFL learners. Although digital technologies are increasingly integrated into language education, empirical research has yet to examine the extent to which AI-driven pronunciation feedback yields measurable phonetic gains in Arab EFL contexts. This quasi-experimental study evaluates whether personalized AI feedback enhances both segmental accuracy (e.g., /p/–/b/, /v/–/f/, /ɪ/–/iː/) and suprasegmental control ( …

14.08.2026journal-article

MRS Bulletin

Covalent organic frameworks: Smart nanoarchitectures for targeted cancer therapy and imaging

Pankaj Garg, Sharad S. Singhal

Abstract Cancer remains one of the leading causes of death worldwide and requires new and targeted approaches for early detection and treatment. Covalent organic frameworks (COFs) are emerging as promising nanostructured materials for cancer applications. With remarkable properties such as tunable pore size and high specific surface area, chemical stability, and good biocompatibility, COFs can effectively encapsulate and release drugs, reducing drug toxicity while targeting tumor tissues. In this article, we overvi …

14.08.2026journal-article

Medicine Advances

Decoding Molecular Mechanisms of Pongamia pinnata Phytochemicals in Cancer Therapy

Rajib Dhar, Vetriselvan Subramaniyan

ABSTRACT Pongamia pinnata (L.) Pierre (P. Pinnata) is commonly found in Southeast Asia and is recognized for its multiple bioactive phytochemicals with notable therapeutic potential. The phytochemicals constituents of P. pinnata showing antioxidant, anti‐inflammatory, and anti‐metastasis properties. In cancer therapy, the primary objective is to eliminate malignant cells effectively, with minimal damage on healthy cells. Although conventional treatment chemotherapy, radiotherapy, and immunotherapy effectively targe …

14.08.2026journal-article

Medicine

Effect of dual antiplatelet therapy on prognosis of patients with myocardial infarction with nonobstructive coronary artery disease

Yao Qin, Huan Zhao, Shu-Lei Fu, Wei-Li Cheng, Jun Zhang, Yu-Qing Zhang, Xiao-Qing Lian

Background: The diverse pathogenic mechanisms of myocardial infarction with nonobstructive coronary artery disease (MINOCA) result in therapeutic difficulties. The purpose of this meta-analysis was to assess the impact of dual antiplatelet therapy (DAPT) on prognosis of patients with MINOCA. Methods: Relevant studies published prior to May 2025 were identified through a search of the PubMed, Embase and Web of Science databases. We evaluated the data using hazard ratios (HRs) and 95% confidence interval (CI). Hetero …

14.08.2026journal-article

Journal of Speech, Language, and Hearing Research

False Belief Understanding in Deaf and Hard of Hearing Children: Systematic Review With Meta-Analysis

Vaia Thomaidou, Konstantinos I. Bougioukas, Panagiota Peleka, Panagiota Metallidou

Purpose: This meta-analysis aimed to compare the performance of deaf and hard of hearing (DHH) children who use cochlear implants (CIs) or hearing aids (HAs) with their typically hearing (TH) peers on false belief (FB) understanding tasks. Method: Data were synthesized from 13 studies comprising 292 participants 1.92–14.03 years of age. A multilevel random-effects meta-analysis was conducted, followed by metaregression to examine the effects of age, mean age at onset, type of hearing amplifier, type of FB task, and …

14.08.2026journal-article

Frontiers in Immunology

The LVI Component Hypothesis: the lymphatic-to-vascular invasion ratio as an enrichment biomarker for therapy with PD-L1×VEGF-A bispecific antibodies

Kenneth A. Kern

Lymphovascular invasion (LVI) describes intravasated tumor cells within intratumoral lymphatic or blood vessels. LVI is reported routinely on pathologic examination because it is prognostic for reduced disease-free and overall survival across many solid tumors. In contrast, it is not considered a predictive biomarker because its presence cannot discriminate which patients benefit from a given therapy. To become predictive, a biomarker must reflect the aberrant, specific biology a drug targets. Bispecific antibodies …