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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

BMC Medical Education

Application effect of flipped classroom combined with SNAPPS teaching model in emergency medicine interns

Ying Lan, Wang Li

Abstract Objective To explore the application value of flipped classroom (FC) combined with SNAPPS teaching framework in emergency department clinical teaching for medical interns. Methods In this randomized controlled trial, a total of 104 fifth-year undergraduate medical interns who were undertaking their clinical rotation in the Emergency Department from 2023 to 2025 were randomly assigned to the reform group ( n = 51, FC combined SNAPPS teaching) and the control group ( n = 53, lecture-based teaching). All part …

28.08.2026journal-article

Frontiers in Medicine

Pulmonary cryptococcosis with or without immunocompromise: a retrospective comparative study of clinical and CT features and influential factors for lesion absorption

Juan Liao, Wenzhao Zhang, Liqing Peng, Ying Liu, Dianying Liao, Jianqun Yu

Background Pulmonary cryptococcosis (PC) is an invasive fungal infection with rising incidence in immunocompetent populations. The differential clinical and imaging characteristics between immunocompromised (ICP) and non-immunocompromised (NICP) patients remain incompletely characterized, limiting precision in diagnosis and management. Method A retrospective study was conducted on 117 patients with confirmed PC from a single tertiary center. Patients were stratified into ICP and NICP groups based on refined criteri …

28.08.2026journal-article

Frontiers in Public Health

Lineage structure and penicillin-binding protein variability in clinical Streptococcus pneumoniae isolates from Southwest China exhibiting reduced susceptibility to penicillin

Chenglin Miao, Ziyi Yan, Li Liu, Xin Huang, Yingying Li, Linghan Kuang, Xingxin Liu, Jiaji Ling, Jingjing Luo, Huilian Chen, Xiaocui Huang, Xinghua Zhu, Yali Cui, Yi Xie, Yongmei Jiang

Background Reduced susceptibility to penicillin in Streptococcus pneumoniae is mediated primarily by alterations in penicillin-binding proteins (PBPs) and often coexists with multidrug resistance within successful lineages. The region-specific genomic characterization of clinically relevant pneumococci with reduced penicillin susceptibility in Southwest China remains limited. Methods We performed whole-genome sequencing of 204 clinical S. pneumoniae isolates collected from five institutions in Southwest China (2018 …

28.08.2026journal-article

Frontiers in Digital Health

Managing vulnerability: cross-sector reflections on the ethics and equity implications of AI use among young adults with chronic conditions

MacKenzie Isaac, Sneha Dave, Terry Adirim

Generation Patient, a global advocacy organization led by young adults with chronic and rare medical conditions, convened a Roundtable in December 2025 to explore the potential and realized impacts of increased AI use in patient care. Across two hours, fifteen participants with a blend of lived, scholarly, and professional expertise engaged in a semi-structured focus group on the benefits and drawbacks of using AI to meet their healthcare needs within and beyond the clinic. Reflexive thematic analysis of the Roundt …

28.08.2026journal-article

Andrology

Male Sexual and Reproductive Health in Diabetes and Obesity Pharmacotherapy: A Source‐Triangulated Counseling Map

Marek Broul, Michal Dubský, Aneta Hujová, Michaela Liegertová

ABSTRACT Background Drugs used for diabetes and obesity increasingly shape male sexual and reproductive counseling, but clinical studies, trial registrations, regulatory labels, and patents answer different questions. Objectives The objective is to map these sources and define what each can support when counseling men receiving metabolic drugs. Materials and Methods We reviewed human studies, ClinicalTrials.gov records, FDA/EMA labels, and selected patent or pipeline documents using source‐specific eligibility crit …

28.08.2026journal-article

Health Information Management Journal

Health information technology use in clinical practice and implications for implementation: Examples from Canberra Health Services, Australia

Chelsea Liu, Rosemary Wyber, Uday N. Yadav, Rohan Essex, Paul Dugdale

Background: Health information technology (HIT) has advanced rapidly over the past two decades, yet digital transformation in healthcare remains difficult and lags behind many other sectors. Existing literature suggests that implementation outcomes are context-dependent and may vary across settings, limiting the feasibility of universal standardisation. Objective: Building on this broader literature, this study examines three contrasting HIT implementations at Canberra Health Services (CHS), Australia, to address t …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

LYVE-1 expression in skin in necrotizing necrobiosis lipoidica

N.N. Svechnikova, S.V. Michurina, V.I. Konenkov, I.Yu. Ishchenko, S.A. Arkhipov, V.V. Arkhipova

Background. The mechanisms underlying skin structural changes in necrobiosis lipoidica (NL), which has a torpid course, remain unclear. The role of the lymphatic system and the significance of the LYVE-1 receptor in the etiology and pathogenesis of NL have not been studied. Objective. To evaluate LYVE-1 expression in skin with necrotizing NL. Materials and methods. Clinical observation, detection of the LYVE-1 marker in histological skin sections using immunohistochemistry were used. Results. A decrease in the expr …

28.08.2026journal-article

Bleeding, Thrombosis and Vascular Biology

Clinical characteristics, prescription patterns and clinical outcomes of patients with extended therapy with direct oral anticoagulants for unprovoked venous thromboembolism.

Alicia Lorenzo, Carmine Siniscalchi, Silvia Natalia Morales, Teresa Sancho, Reina Valle, Aida Gil-Diaz, Parham Sadeghipour, Patricia Sigüenza, Manuel Monreal, The RIETE Investigators

Background: Extended therapy with direct oral anticoagulants (DOACs) is common for managing unprovoked venous thromboembolism (VTE), but real-world data on dosing decisions and their association with outcomes are limited. Methods: From April 2013 to September 2023, we identified patients with unprovoked VTE in the RIETE registry who survived the first 6 months without recurrent VTE or major bleeding. We examined predictors of reduced- vs. full-dose DOACs (rivaroxaban or apixaban), and the association between dosing …

28.08.2026journal-article

JUCS - Journal of Universal Computer Science

A Proactive Fault Tolerance Approach for Saga Transactions in Microservices Using a Health Prediction Model

Jiangke Wu, Xiaojun Chen, Rongxing Shi

The Saga pattern guarantees eventual consistency in microservices but depends on passive post-failure compensation, resulting in resource inefficiency and possible data discrepancies. This study introduces the ”Proactive Saga Failure Avoidance (PSFA)” system, which incorporates deep learning-based health evaluation into the Saga orchestrator. The platform employs an LSTM model to monitor real-time service metrics, enabling the prediction of imminent failures prior to transaction execution. Upon detectio …

28.08.2026journal-article

Advances in Mental Health and Intellectual Disabilities

Amplifying user voices: reporting real-world experiences of a wearable device and digital application marketed for individuals with intellectual disabilities and their carers

Kendra Thomson, Amanda Marcinkiewicz, Carly Magnaaca, Sarah Ludmilla Bernier, Tiziana Volpe, Yani Hamdani, Johanna Lake, Yona Lunsky

Purpose People with intellectual disabilities may have difficulties communicating, especially when experiencing heightened arousal. This study aimed to assess user experiences with wearable technology paired with an application promoted in the community as an early detection system for signaling distressing experiences like anxiety in those with limited communication. Design/methodology/approach With little known about the user experience in this population, the authors conducted a qualitative study involving inter …

28.08.2026journal-article

npj Women's Health

Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality

Zehra Esra Ilhan, Andrea Marchetto, Georgia Lorentzen, Paweł Łaniewski, Leslie V. Farland, Melissa M. Herbst-Kralovetz

Abstract Paraben esters are endocrine disruptors linked to breast cancer, yet their role in other estrogen-mediated cancers remains limited. Preclinical evidence suggests that parabens accumulate in tissues and may promote carcinogenesis, while clinical data indicate widespread exposure. Our re-analysis of cervicovaginal metabolomes revealed elevated paraben metabolites in endometrial and cervical cancer patients compared with controls. Overall, longitudinal studies considering intrinsic and environmental factors a …

28.08.2026journal-article

Frontiers in Public Health

More is not always better: longitudinal associations and nonlinear dose–response relationships between physical activity, psychological capital, and positive body image among Chinese university students

Yi Li, Xi Chen

Objective This study examined the longitudinal associations between physical activity (PA), psychological capital (PsyCap), and positive body image, operationalized as body appreciation, among Chinese university students. We further evaluated the mediating role of PsyCap and explored potential nonlinear dose–response relationships between different dimensions of PA and body appreciation. Methods A two-wave longitudinal survey with a three-month interval was conducted among 669 university students from four universi …

28.08.2026journal-article

International journal of health sciences

Barriers and supporters of home care implementation for the elderly in developing countries: A scoping review

Sulardi Sulardi, Nila Alfa Fauziah, Novalia Efrianty

Home care is an approach that has the potential to support aging in place, but its implementation faces various barriers at the individual, family, health worker, community, organizational, financing, and policy levels. This scoping review aims to map evidence on barriers and supporting factors for the implementation of home care for older adults in developing countries in the literature over the past ten years. The scoping review uses the Joanna Briggs Institute (JBI) framework and the PRISMA-ScR reporting princip …

28.08.2026journal-article

Discover Artificial Intelligence

An explainable hybrid of classical and quantum support vector machine models for maternal mental health risk prediction using multicountry data

Shallon Ahimbisibwe, Emmanuel Ahishakiye, Samuel Maling, Simon Kawuma, Richard Ntwari, Boaz Twinamasiko, Fred Kaggwa

Abstract Maternal mental health disorders remain a major public health problem, particularly in low- and middle-income countries, where limited mental health resources and inadequate screening systems lead to late diagnosis and intervention. Recent advances in artificial intelligence have demonstrated great potential in improving the prediction of early maternal mental health risks. However, most current methods are limited to traditional machine learning models and lack interpretability. This study introduces the …

28.08.2026journal-article

Bioengineering & Translational Medicine

Engineered exosomes with RNA ‐motif short hairpin RNA loading and Rab4‐boosted production enable controlled ferroptosis in endometrial carcinoma

Jiarui Zhang, Yuwei Yao, Wan Shu, Shuangshuang Cheng, Guanglei Zhong, Jia Yu, Jinhua Chen, Kejun Dong, Yingying Peng, Jun Zhang, Hongbo Wang

Abstract Therapeutic challenges in endometrial carcinoma (EC) arise from the limited efficacy and toxicity of current treatments. Although exosome‐based RNA interference shows promise, its clinical translation is hindered by inefficient cargo loading, low yields, and poor tumor targeting. We have engineered an exosome platform (cRGD‐ExoM) that integrates the following innovations: Firstly, RNA motifs enable the enrichment of shRNA loading by over 80‐fold for targeting of ferroptosis regulators (glutathione peroxida …

28.08.2026journal-article

Clinical and Translational Medicine

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies

Jinlin Zhang, Jile Liu, Mohan Zhao, Xiaoyu Zhang, Linlin Liu, Mengnan Li, Changze Cao, Rui Zhang, Mingfeng Zhao

Abstract To date, the treatment of acute myeloid leukaemia (AML) remains a major challenge in hematologic malignancies, particularly among elderly patients who are unfit for intensive chemotherapy. Venetoclax, a BCL‐2 inhibitor, in combination with azacitidine, has significantly improved the prognosis and survival of this patient population. However, approximately 30% of patients do not respond to venetoclax‐based combination regimens, and most initial responders eventually experience relapse. Therefore, resistance …

28.08.2026journal-article

International Journal of Public Health and Medical Research

Sorting Out Australia's New E-cigarette Regulation Policies and Existing Research Gaps

Yundong Yang

With the spread of electronic cigarettes around the world, many countries have implemented various regulations, and Australia has one of the stricter systems globally. Systematically review the new regulations on electronic cigarettes in Australia and focus on the transition to a strict prescription-only system and a wide-ranging ban on non-therapeutic and disposable vaping products. Based on the changes in legislation, the government aims to prevent new smokers among young people at the same time as enabling older …

28.08.2026journal-article

International Journal of Public Health and Medical Research

Exploration on the Influence of Oxidative Stress on the Progression of Age-related Degenerative Lesions

Yiwen Wang

Research on how oxidative stress affects the development of age-related degenerative diseases. Rather than considering oxidative stress as an increase in free radicals, this paper now refers to it as a fluctuating disorder in redox homeostasis that involves reactive oxygen species, antioxidant defence, mitochondrial function, inflammatory amplification and damaged cell repair. Based on the classic theories of ageing and later review literature, this paper examines how oxidative stress contributes to the accumulatio …

28.08.2026journal-article

International Diabetes Nursing

Nurses’ perceptions of continuous glucose monitoring in pediatric high-dependency care: a single-center survey of workflow and safety during management of an infant with hyperinsulinemic hypoglycemia

Soo Ting Joyce Lim, Yuen Ching Angela Hui, Nazimah Binte Mohamed Sani, Daniel Chan

Background: Dysglycemia is associated with increased morbidity and mortality in critically ill pediatric patients. Continuous glucose monitoring (CGM) offers real-time glucose trend data, addressing limitations of point-of-care (POC) testing, such as intermittent readings and high workload. However, successful implementation of CGM in high-dependency (HD) pediatric care depends significantly on nurses’ perceptions and acceptance, which could better manage nursing workload. Objective: This study explores nurses’ per …

28.08.2026journal-article

Health Research Journal of Indonesia

Hubungan Waktu Tunggu Pelayanan Rawat Jalan dengan Kepuasan Pasien Berdasarkan Standar Pelayanan Minimal (SPM) di RSUD Ratu Zalecha Martapura

Gusti Muhammad Nizar, H. Raziansyah, Any Zahrotul Widniah

Latar Belakang: Waktu tunggu pelayanan merupakan salah satu indikator mutu pelayanan rumah sakit yang ditetapkan dalam Standar Pelayanan Minimal (SPM). Waktu tunggu yang melebihi standar dapat menurunkan kualitas pelayanan dan berdampak terhadap kepuasan pasien. RSUD Ratu Zalecha Martapura masih menghadapi permasalahan waktu tunggu pelayanan rawat jalan yang belum sepenuhnya memenuhi standar ≤60 menit. Tujuan: Menganalisis hubungan waktu tunggu pelayanan rawat jalan dengan kepuasan pasien berdasarkan Standar Pelaya …

28.08.2026journal-article

Belitung Nursing Journal

Self-management-based health coaching for sustainable behavior change in chronic disease care: A concept analysis using Walker and Avant’s framework

Rian Adi Pamungkas, Kathlen Potempa, Kanittha Chamroonsawasdi, Andi Mayasari Usman, Samoraphop Banharak

Background: Self-management-based health coaching is increasingly applied in chronic disease management; however, conceptual ambiguity persists regarding its defining characteristics and theoretical boundaries. A clear and consistent conceptualization is essential to strengthen its application in nursing research and practice. Objective: This study aimed to clarify the concept of self-management–based health coaching in chronic disease care. Method: A concept analysis was conducted using Walker and Avant’s framewor …

28.08.2026journal-article

Frontiers in Psychiatry

Real-world anti-amyloid therapy beyond traditional symptomatic populations: a longitudinal case series

Jayoung Han, Yuan Fang, Darlingtina Esiaka, Olufunmilola Abraham

Introduction Anti-amyloid monoclonal antibodies are approved as disease-modifying therapies for early Alzheimer’s disease (AD), but real-world evidence remains limited, particularly among individuals treated during preclinical or minimally symptomatic stages. This study characterized clinical and biomarker trajectories among anti-amyloid therapy recipients across disease stages. Method We conducted a longitudinal retrospective case series of three biomarker-positive individuals from the Alzheimer’s Disease Neuroima …