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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

P1.086. Impact of Surgery Versus Non-Surgery on the Prognosis of Esophageal Cancer Patients With Clinically Identified Metastatic Supraclavicular Lymph Nodes

Yiheng Huang, Yuqin Cao, Hecheng Li

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The clinical significance of supraclavicular lymph node (SCLN) involvement in esophageal cancer remains controversial. The role of surgery in managing patients with SCLN metastases remains uncertain. This study evaluates the prognostic outcomes of patients with SCLN-positive esophageal cancer who received either surgical or nonsurgical treatment, aiming to develop evidence-based management strategies for this subgroup. Methods A retros …

22.08.2026journal-article

Diseases of the Esophagus

OA08.5. Incidence of Lymph Node Metastases in pT1 Chemo- and Radiotherapy Naïve Esophageal and Gastric Cancer in the Nordic Countries

David Edholm, Joonas H Kauppila, Michael P Achiam, Oliver Nørholm Kempf, Tobias Hauge, Mats Lindblad, Tom Mala

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background Although endoscopic resection is reported to be safe for early stage esophagogastric cancer, uncertainty remains regarding oncological efficacy, particularly for submucosal lesions. The aim of this study was to assess the frequency of lymph node metastasis (LNM) and survival in patients operated for chemo- and radiotherapy naïve pT1 esophagogastric cancer. Methods Patients who underwent surgical resectio …

22.08.2026journal-article

Cell Biochemistry and Biophysics

Host-Derived Proteomic Profiling of Human and Canine Mammary Tumor Xenografts Identifies Enrichment of Lipid Metabolism-Related Pathways

Elisa Díaz-Grijuela, Saioa Goñi, Alejandro Urdiciain, Miguel Barajas, Ileana B. Gonzalez-Valdes, Maider Espinal, Claudia Caballero-Mínguez, Enrique Santamaria, Agustín Hernández, Egoitz Astigarraga, Gabriel Barreda-Gómez, Raquel Urtasun, Joaquín Fernandez-Irigoyen

Abstract Breast cancer is the most frequently diagnosed cancer in women worldwide and one of the most common malignancies in dogs. Notable clinical, hormonal and molecular similarities between both species suggest that dogs may serve as a valuable comparative oncology model. Alterations in lipid homeostasis and metabolism are closely associated with the acquisition of cancer hallmarks. In this study, a comparative proteomic analysis of murine host-derived proteins was performed in cell line-derived xenograft (CDX) …

22.08.2026journal-article

Current Oncology Reports

Percutaneous Management of Desmoid Tumors

Gina P. Landinez, Shakthi Kumaran Ramasamy, Xiao Wu, Kiyon Naser-Tavakolian, Abin Sajan, Areeb Siddiqui, John Moody, Kirema Garcia-Reyes, Junaid Raja, Venkatesh P. Krishnasamy

Abstract Purpose of Review To provide a comprehensive review of percutaneous image-guided techniques in the management of desmoid tumors including evolving thermal and non-thermal ablation options, as well as trans-arterial catheter options. Beyond each treatment modality, we aim to highlight considerations related to patient selection, technical components, and the growing interplay between percutaneous therapies and emerging systemic therapies. Recent Findings Percutaneous ablation, particularly cryoablation, has …

22.08.2026journal-article

Effective Pharmacotherapy

Justification for the Redundancy of Wide Axillary Llymphodissection in Patients with Early Breast Cancer who Developed Ttransformation from Iinitial cN1 to Complete Clinical Response after Neoadjuvant Chemotherapy

S.P. Botkin Moscow Multidisciplinary Scientific and Clinical Center, D.A. Karseladze, K.S. Titov, I.N. Lebedinsky, I.N. Kutz, D.D. Dolidze, S.S. Lebedev, A.A. Tatarova, E.Yu. Neretin, RUDN University, Moscow, Russian Medical Academy of Continuous Professional Education, Moscow

The aim of the study was to determine the feasibility of de-escalation of the volume of lymphodissection by performing selective target biopsy of the sentinel lymph node in patients with initial stage cN1 disease who progressed to cN0 after NACT and demonstrate that this approach does not result in worsening oncological outcomes or local recurrences. For this purpose, 345 patients with primary operable breast cancer were studied. In the first stage, the patients received NACT followed by radical surgery in the peri …

22.08.2026journal-article

BMC Microbiology

Effects of cephalexin treatment on DNA replication dynamics in Escherichia coli

Iren Grigoryan, Dominika Krawiel, Emma L. Dunbar, Stelinda Peros, Ronan R. McCarthy, Christian J. Rudolph

Abstract Background In bacteria, DNA replication and chromosome segregation are tightly coordinated with cell division. The replication run-out method, which combines inhibition of transcription initiation by rifampicin with inhibition of cell division by cephalexin, is widely used to analyse replication dynamics by allowing ongoing replication forks to complete in the absence of new initiations. While this approach is generally robust, the physiological consequences of the individual components of the method, part …

22.08.2026journal-article

Diseases of the Esophagus

P1.108. Molecular Determinants of Tumor Morphology in Esophageal Adenocarcinoma

Gavin Wilson, Jin-Soo Park, Frances Allison, Yvonne Bach, Jonathan Allen, Premalatha Shathasivam, Dahanny Aguilar, Razan Almohamedi, Sheng-Ben Liang, Elliot Wakeam, Gail Darling, Elena Elimova, Sangeetha Kalimuthu, Jonathan Yeung

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Esophageal adenocarcinoma (EAC) is histologically graded as well, moderately, or poorly differentiated. Poorly differentiated tumours are associated with worse prognosis compared to well and moderately differentiated tumours. However, the molecular mechanisms driving these differences are poorly understood and their delineation may lead to improved biologically-informed patient stratification and therapeutic development. Methods We primarily a …

22.08.2026journal-article

Diseases of the Esophagus

P1.075. Treatment Efficacy and Strategy in Immune Checkpoint Inhibitors Treatment for Stage IV Advanced Esophageal Cancer

Kosuke Narumiya, Yasuhiro Okumura, Shunsuke Yamagishi, Nao Yoshida, Hayato Abe, Yusuke Mitsuka, Ryo Muraishi, Yukiyasu Okamura

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The results of two trials, KeyNote590 and CheckMate648, have made it possible to use immune checkpoint inhibitors (ICIs) as first-line treatment for Stage IV esophageal cancer, and unprecedented therapeutic effects can now be expected, including multimodality therapy such as conversion surgery (CS) and chemo-radiation therapy. Treatment strategies have only just begun therefore the indications of using ICI to aim for a cure for it have …

22.08.2026journal-article

Diseases of the Esophagus

P1.042. Utility of a Fenestrated Surgical Drain for the Prevention and Treatment of Esophageal Leak

Nathan Yat Shun Mak, Michelle Lau, Edward Cheong, Jie qi Lim, Dulcena Yen, Koy Min Chue, Nan Guang Tan, Wai Keong Wong, Ya-Lyn Annalisa Ng, Daryl Chia, Jeremy Tian Hui Tan

Abstract Topic Benign Disease: Iatrogenic Esophageal Disease, Perforation and Postsurgical Complications Background Esophageal transmural defects are associated with high morbidity and mortality. Sponge-based endoscopic vacuum therapy (EVT) is effective but costly and requires frequent exchanges under general anesthesia. We describe a modified, cost-effective EVT approach using a fenestrated, spongeless radio-opaque silicone drain for both prevention and treatment of esophageal leaks. Methods A retrospective case s …

22.08.2026journal-article

Diseases of the Esophagus

PD06.09. Second-Line Treatment Efficacy in Functional Heartburn Based on HRM and MII-pH Evaluation

Hiromi Arakawa, Tomoaki Matsumura, Tomomi Ozaki, Miyuki Iwasaki, Michiko Sonoda, Jun Kato

Abstract Topic Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia Background Functional heartburn (FH) accounts for approximately half of patients with proton pump inhibitor (PPI)- or vonoprazan-refractory non-erosive reflux symptoms. However, the clinical characteristics of FH and the efficacy of second-line therapies remain incompletely understood. We evaluated patient characteristics and treatment outcomes following physiological evaluation. Methods Between September 2013 and December 2025, we retrospect …

22.08.2026journal-article

Diseases of the Esophagus

P1.197. Linking Collagenase Activity and Anastomotic Leakage After Esophagectomy for Cancer

Ward Seurs, Hans Van Veer, Tim Vanuytsel, Stijn Vanstraelen, Jan Tack, Philippe Nafteux, Raf Bisschops, Lieven Depypere, Marie Joossens

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background The etiopathogenesis of anastomotic leakage (AL) after esophagectomy is inadequately understood. In colorectal surgery, AL has been linked with phenotypic switching of commensal bacteria to pathogenic collagenase-producing bacteria. We aimed to explore for the first time if collagenase activity might also play a role in AL after esophagectomy for cancer. Methods Samples were endoscopically collect …

22.08.2026journal-article

Diagnostics

The Stalk Sign in Bladder Cancer: CEUS Versus MRI

Fabrizio Urraro, Nicoletta Giordano, Vittorio Patanè, Maria Chiara Brunese, Giuseppe Ambrosio, Anna Russo, Roberto Calbi, Antonio Cioffi, Alfonso Reginelli

Background: The fibrovascular stalk is characteristic of papillary bladder tumors and may be visualized on MRI as the inchworm sign. Contrast-enhanced ultrasound (CEUS) may depict the same structure dynamically by demonstrating pedicle perfusion before tumor enhancement. We hypothesized that CEUS would be more sensitive than the MRI inchworm sign for detecting a histologically confirmed fibrovascular stalk and that stalk presence would be associated with non-muscle-invasive bladder cancer without completely excludi …

22.08.2026journal-article

Insights into Imaging

Super-resolution MRI and 2.5D deep learning for intratumoral-peritumoral radiomics in preoperative prediction of rectal cancer perineural invasion

Yuhang Wang, Dandan Dong, Shengming Shi, Yupeng Wu, Apekshya Singh, Jiayi Xie, Qiuyang Chen, Jianwei Zhu, Xiaofu Li

Abstract Objectives Preoperative prediction of perineural invasion (PNI) in rectal cancer (RC) is challenging due to limited MRI resolution and the neglect of extramural microenvironmental features. We developed a noninvasive framework integrating super-resolution MRI, 2.5D deep learning (DL), and intratumoral-peritumoral radiomics for preoperative PNI prediction. Materials and methods A dual-center cohort of 312 RC patients with pathologically confirmed PNI status was analyzed. Preoperative MRI underwent 4× super- …

22.08.2026journal-article

Cells

Exploring the Utility of ALDH1 as a Marker for the Cancer Stem Cell Population in OCCC Cell Lines

Blane Gebreyes, Bart Kolendowski, Yudith Ramos-Valdes, Trevor G. Shepherd, Gabriel E. DiMattia

Metastasis, chemoresistance, and tumour recurrence are facilitated by cancer stem cells (CSCs), a small subpopulation of cells capable of regenerating a primary tumour while maintaining the tumour’s genetic and phenotypic features. CSCs can be identified by the expression of specific markers; however, the CSC population in ovarian clear cell carcinoma (OCCC), a rare histotype of ovarian cancer, remains poorly defined. Given the well-established role that CSCs play in cancer progression and metastasis, it is critica …

22.08.2026journal-article

International Journal of Molecular Sciences

Whole-Exome Sequencing Identifies Candidate Genomic Features Associated with Response to Platinum-Based Chemotherapy and Ixabepilone-Based Treatment in Ovarian Cancer

Tobias M. P. Hartwich, Stefania Bellone, Orazio De Tommasi, Sarah Ottum, Victoria Ettorre, Michelle Greenman, Namrata Sethi, Cem Demirkiran, Kevin Y. Yang, Ammal Abbasi, Ludmil B. Alexandrov, Alessandro D. Santin

Carboplatin/paclitaxel (CP) chemotherapy is the cornerstone of therapy for advanced stage ovarian cancer (OC). However, despite initial sensitivity, this regimen cannot avoid the emergence of resistance. Ixabepilone ± bevacizumab (IB) is a combination recently added to NCCN guidelines for the treatment of platinum-resistant OC. It would be desirable to identify biomarkers able to differentiate patients who are resistant to CP and IB, and biomarkers that identify which patients may benefit from IB treatment. We anal …

22.08.2026journal-article

Diseases of the Esophagus

P04.5. Repurposing Cholesterol-Lowering Statins to Overcome Esophageal Cancer Therapy Resistance, From Bench to Bedside

Luis Castro, Sanjima Pal, Megan Sperry, Yi Fei Yan, Shuyuan Wang, Mingyang Kong, Ruo Y Ma, Qian Qiu, Nicholas Bertos, Mehrnoush Dehghani, Andrew Meng, Carmen Mueller, Jonathan Cools-Lartigue, Mathieu Rousseau, Sara Najmeh, Jonathan Spicer, Donald Ingber, Lorenzo Ferri

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Esophageal cancer is the seventh cause of cancer mortality worldwide. Despite recent advances in the perioperative management of esophageal adenocarcinoma with systemic and immunotherapy, significant therapy resistance persists. New approaches are in demand, and repurposing approved drugs for other indications is an attractive and low-cost approach to address this issue. Interfering with the adaptive metabolism of cancer cells holds pr …

22.08.2026journal-article

Cell Death & Disease

NEK2-AURKA axis drives ubiquitin-dependent IFT88 degradation to suppress ciliogenesis and promote basal-type bladder cancer

E Du, Wei Wang, Qiang Su, Wei Huang, Yuanjiong Qi, Weijie Tang, Zhihong Zhang, Changwen Zhang, Jingxian Li

Abstract Loss of primary cilia is common in cancer, but its relevance to molecular subtypes of muscle-invasive bladder cancer (MIBC) is unclear. Here, we combined transcriptomic and co-expression analyses with experiments in bladder cancer cell lines, human tumor specimens, and xenografts to investigate the basis of cilia loss in basal MIBC. Primary cilia were less frequent in basal than in luminal MIBC. Depletion of IFT88 reduced ciliogenesis and increased cell proliferation and migration. Conversely, IFT88 overex …

22.08.2026journal-article

Journal of the American Chemical Society

In Situ Construction of a Reticulated Peptide Scaffold via Responsive Self-Assembly and Proximal Covalent Labeling for Enhanced Tumor Imaging and Therapy

Ruxin Feng, Yunfeng Qiu, Yang Zhao, Rixin Wang, Weilu Xu, Jinhui Ning, Yumin Li, Juyue Zhou, Dingqing Feng, Suying Xu, Leyu Wang

Abstract Precise imaging and specific retention of therapeutic agents at solid tumors were particularly desirable yet hindered by limited specificity and fast diffusion. Herein, we established a dual-trigger-mediated synergistic strategy to form a reticulated peptide network in situ by functional peptide (CL-YPFG) through responsive self-assembly and covalent labeling for prolonged imaging and boosted accumulation of drugs. Specifically, the CL-YPFG underwent morphology transformation from nanoparticles to nanofibe …

22.08.2026journal-article

The Indian Journal of Medical Research

Stage-specific lipidomic signatures as biomarkers in progression of cervical cancer

Akshata Kishore Karekar, Sandhya Kaustubh Kamat, Padmaja Yashwant Samant, Sucheta Prakash Dandekar, Dinesh Amrith Uchil, Mayuri Nalinkumar Gandhi, Jayanti Mania-Pramanik, Shilpa Chandrakant Kerkar

Background and objectives Lipidomics has advanced cancer research by uncovering biomarkers that reveal key mechanisms of tumourigenesis. By analysing endpoint lipid metabolites influenced by genetic and environmental factors, the lipidome closely reflects a cell’s functional state. Mass spectrometry, strengthened by modern bioinformatics and biostatistics, now enables precise detection of cancer-related lipid changes, motivating us to adopt this approach. Methods We have applied advanced mass spectrometry and machi …

22.08.2026journal-article

Diseases of the Esophagus

PD09.02. Nutritional Vulnerability Predicts Treatment Delivery and Survival in Locally Advanced Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Immunochemotherapy

Maohui Chen, Yizhou Huang, Taidui Zeng, Chun Chen, Bin Zheng

Abstract Topic Esophageal Cancer: Other Background Malnutrition is highly prevalent in esophageal squamous cell carcinoma (ESCC) and may critically modulate host resilience to intensive multimodal therapy. In the era of neoadjuvant immunochemotherapy (nICT), the prognostic utility of structured nutritional assessment remains incompletely defined. This study aimed to establish clinically relevant Patient-Generated Subjective Global Assessment (PG-SGA) thresholds and to determine their associations with treatment fea …

22.08.2026journal-article

Diseases of the Esophagus

P1.169. Magnetic and ICG High Risk Lymph Node Mapping in Upper GI Cancer: A Safety, Feasibility and Diagnostic Performance Clinical Study

Markus Trochsler, David Liu, David Watson, Tim Bright, Shalvin Prasad, Andrew Dwyer, Susan Gan, Andrew Ruszkiewicz, Cuong Duong, Conrad stranz, Brendan DESMOND, John Spillane, David Williams, Lauren Kennedy, Louise Jackett, David Moffat, Essa El-Aklouk, Anil Shetty, Aidan Cousins, Emma Bradshaw, Sweet Ping, Harsh Kanhere

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Accurate localisation of high-risk lymph node (HRLN) stations in upper gastrointestinal cancer could enable tailored resection and focused ultra-staging while avoiding unnecessary lymphadenectomy. Clinically practical tracers and workflows remain limited. Preliminary results are provided at submission, with planned update to the final dataset before abstract publication. Methods This multi-centre observational comparator study enro …

22.08.2026journal-article

Diseases of the Esophagus

P1.193. Neoadjuvant Therapies vs Upfront Surgery for cT2N0 Oesophageal Cancer – a Systematic Review and Meta-Analysis

Dr Eiran Gannon, Dr Matt Davey, Dr Jessie Elliott, Dr John Reynolds, Dr Noel Donlon, Dr Carmen Mueller, Dr Lorenzo Ferri

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background In March 2026, the International Society for Diseases of the Esophagus (ISDE) made ‘conditional’ recommendations in support of neoadjuvant therapy (NAT) over primary surgical resection (PSR) for patients diagnosed with cT2N0 oesophageal cancer. Notwithstanding this, controversial exists due to potential overtreatment. Our aim was to perform a systematic review and meta-analysis to evaluate oncological and survival outcomes in patie …

22.08.2026journal-article

Diseases of the Esophagus

P1.067. Multinational Comparison of Surgical Approaches and Postoperative Outcomes in Esophageal Cancer: An International Multicenter Cohort Study

Simiao Lu, Yi Zhu, Yongtao Han, Qiuling Shi, Xuefeng Leng

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Esophagectomy for esophageal cancer carries substantial morbidity, yet the extent to which institutional surgical strategy—encompassing operative approach, lymphadenectomy extent, and neoadjuvant treatment protocol—determines postoperative complication profiles remains poorly characterized across different geographic practice environments. Methods We performed a retrospective analysis of a prospectively maintained international mul …

22.08.2026journal-article

Diseases of the Esophagus

V-06. Surgical Treatment of Gastroesophageal Reflux Disease in a Patient With Situs Inversus Totalis and Kartagener Syndrome

Sergio Szachnowicz, Evelyn Moura de Assis, Rodrigo de Andrade Lima Vieira de Melo, Camila Maria de Câmara, Rubens antonio Aissar Sallum, Ulysses Jr Ribeiro, Paulo Herman

Abstract Topic Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia Background Situs inversus totalis is a rare genetic condition characterized by a complete mirror-image transposition of thoracic and abdominal organs. This anatomical anomaly poses technical challenges for surgeons, often requiring adaptations in surgical techniques. Kartagener syndrome, a subset of primary ciliary dyskinesia, includes situs inversus totalis, chronic sinusitis, and bronchiectasis. Patients with this syndrome may develop gastr …