Therapie & Reha: neue Gesundheitspublikationen – Seite 114

13.08.2026journal-article

Advanced Electromagnetics

Study on the Mechanism of Music Therapy in Improving Sleep Quality of Patients with Chronic Insomnia Based on EEG Signal Analysis

Y. Zhang

Chronic insomnia is a common sleep disorder that can severely compromise physical and mental health, cognitive function and occupational safety. As a non-pharmacological intervention, music therapy has demonstrated unique advantages in improving sleep quality. By collecting electroencephalogram (EEG) signals of patients with chronic insomnia before and after music therapy, this study explores the regulatory effect of music therapy on cerebral neural activity. The results show that music therapy can significantly al …

13.08.2026journal-article

HIV Infection and Immunosuppressive Disorders

Аntiretroviral therapy for young adults perinatally infected with HIV: the treatment experience from childhood through adulthood

A. V. Samarina, E. Zh. Sereda, N. V. Sizova, I. A. Abramova, N. S. Dyldina, E. K. Fertikh, O. L. Mozaleva

From 2018 to 2024, the Russian Federation witnessed an increase in the number of young people with perinatally acquired HIV (PHIV) who reached the age of 18 years and transitioned to adult care. It is known that young individuals with PHIV have a duration of HIV infection equal to their age (more than 18 years), with delayed or late initiation of antiretroviral therapy (ART), often in the setting of advanced disease stages. In addition to the direct damaging effect of HIV and the associated chronic inflammation, th …

13.08.2026journal-article

Inorganic Chemistry

Dinuclear Ir(III)/Ru(II)/Os(II) Bis-terpyridine Complexes Tethered by Tetrathienyl-Substituted Diketopyrrolopyrrole: Synthesis, Photophysics, and Antimicrobial Photodynamic Therapy

Xinyang Sun, Md Razzak, Giulia Kassab, Guorong Sun, Kalara D. Gamage, Maharajan Sivasubramanian, Habiba Afrin, Kuo-Hao Chen, Svetlana Kilina, Juan Chen, Gang Zheng, Leu-Wei Lo, Wenfang Sun

Abstract Three dinuclear bis-terpyridine Ir(III)/Ru(II)/Os(II) complexes DPP-M (M = Ir, Ru, Os) tethered by tetrathienyl-substituted diketopyrrolopyrrole were synthesized and characterized as near-IR photosensitizers. Photophysical studies, including UV–vis absorption, emission, and transient absorption, were conducted to investigate the singlet and triplet excited states of the complexes and to understand how different metals influence their photophysical properties. All complexes demonstrated panchromatic absorpt …

13.08.2026journal-article

Renal Replacement Therapy

Elevated serum ferritin levels and infection-related mortality in maintenance hemodialysis patients: 10-year outcomes of the Q-Cohort study

Yutaro Hirashima, Hiroto Hiyamuta, Shunsuke Yamada, Hiromasa Kitamura, Masatomo Taniguchi, Kazuhiko Tsuruya, Tetsuro Ago, Toshiaki Nakano

Abstract Background Serum ferritin guides iron therapy in hemodialysis patients but also reflects inflammation and systemic illness. We examined the association between baseline serum ferritin and infection-related mortality in maintenance hemodialysis patients. Methods We analyzed 3529 participants in the Japanese Q-Cohort Study. The primary analysis categorized serum ferritin into quartiles. Clinically motivated supplementary analyses used clinical categories, a 300 ng/mL cutoff, and log-transformed ferritin. Inf …

13.08.2026journal-article

Clinical and Preventive Medicine

USE OF MODULAR PHYSICAL MODELS AND DYNAMIC SIMULATIONS IN THE TRAINING OF SPECIALISTS IN THERAPY AND REHABILITATION

Nataliia V. Stuchynska, Halyna V. Khrapiichuk, Oksana M. Melnyk

Introduction. Russia’s military aggression has sharply intensified the problem of training specialists in therapy and rehabilitation. During the years of the full-scale invasion, the number of wounded requiring prosthetics and orthotics has increased substantially. Overcoming the crises and challenges of wartime requires prompt responses and integration of innovative teaching methods that enhance professional training by combining theoretical knowledge with practical experience.Aim. To investigate the effectiveness …

13.08.2026journal-article

Antibiotics

Efficacy and Safety of Adjusting Antimicrobial Therapy in Episodes of Fever and Neutropenia Catalogued as Fever of Unknown Origin in Children with Cancer: A Randomized Clinical Trial

Carolina Ibáñez, Romina Valenzuela, Marlon Barraza, Ana M. Álvarez, Ernesto Paya, Verónica Contardo, Valentina Gutiérrez, Karen Ducasse, Juan P. Torres, Paulina Coria, Verónica de la Maza, Daniela Martínez, Tamara Inostroza, María E. Santolaya

Background/Objectives: The objective of this study is to evaluate the efficacy and safety of maintaining antimicrobial (AM) therapy or adjusting AM therapy during episodes of febrile neutropenia (FN) catalogued as a fever of unknown origin (FUO) in children with cancer. Methods: This is a prospective, multicenter, noninferiority, randomized study, approved by ethics committee, in children with episodes of FN in eight hospitals in Chile. Microbiological and molecular samples were drawn at admission. Patients with FU …

13.08.2026journal-article

Journal of Endovascular Therapy

Updated Systematic Review of Long-Term Outcomes of Endovascular Popliteal Artery Aneurysm Repair: Evidence From 2014 to 2025

Paula Dias, Miguel Castro e Silva, Luís Orelhas, Jorge Costa, Beatriz Tavares, Ricardo Vale Pereira, Manuel Fonseca

Introduction: Endovascular repair has increasingly been adopted as a less-invasive alternative to open surgery for popliteal artery aneurysms, yet its long-term durability remains debated. Since the last comprehensive review in 2015, substantial new data with extended follow-up have emerged. This systematic review aimed to evaluate long-term outcomes after endovascular popliteal artery aneurysm repair (EPAR) and summarise contemporary evidence published between 2014 and 2025. Methods: In accordance with Preferred R …

13.08.2026journal-article

Advanced Healthcare Materials

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Yong Qu, Tao Peng, Yating Zhang, Juanmei Cao, Birong Wang, Chuxing Chai, Zhiyuan Gao, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Xu Liu, Tianqi Zhao, Yufan Chen, Weimin Lv, Di Lu, Changzheng Huang, Dan Ding, Jinxiang Zhang, Min Li

ABSTRACT Photodynamic therapy (PDT) has been shown to improve survival and quality of life in patients with unresectable extrahepatic cholangiocarcinoma. However, its therapeutic efficacy is frequently limited by the survival of residual tumor cells that can re‐enter the proliferative cycle. Our previous studies showed that residual cholangiocarcinoma cells can re‐enter the proliferative cycle following PDT accompanied by hypoxia‐induced activation of the HIF‐1α survival pathway and intracellular antioxidant progra …

13.08.2026journal-article

Obstetrics & Gynecology

Cost-Effectiveness Analysis of Menopausal Hormone Therapy

Elizabeth Gill, Wu Zeng, Katerina Shvartsman, Jill Brown

OBJECTIVE: To evaluate the cost effectiveness of menopausal hormone therapy (MHT) based on the risk–benefit profiles of current MHT formulations. METHODS: We used a Markov model to examine the cost effectiveness of MHT for hypothetical 50-year-old women with vasomotor symptoms compared with transdermal estradiol (E2) alone for patients without a uterus and transdermal E2 in combination with micronized progesterone for patients with a uterus, assuming 5 years of use. Using a health system perspective, we expressed t …

13.08.2026journal-article

Diseases of Aquatic Organisms

Blood analytes in California sea lion Zalophus californianus pups: reference intervals and malnutrition effects, from admission to rehabilitation

Faye E. Giebink, Alissa C. Deming, Justin R. Perrault, Malena Berndt, Sharon R. Melin, Nicole I. Stacy

Blood analyte data are limited for California sea lion Zalophus californianus pups despite frequent admission to rehabilitation facilities. The objectives of this study were to establish blood analyte reference intervals for rehabilitated California sea lion pups (n = 58) deemed clinically normal for release and for free-ranging California sea lion pups (n = 37) during routine health assessment on San Miguel Island, California, USA; to compare manual white blood cell (WBC) differentials to an in-house hematology an …

13.08.2026journal-article

Current Oncology

Durable Hematologic Response in Therapy-Related Myelodysplastic Syndrome During Nivolumab Treatment for Metastatic Melanoma: A Case Report

Fathima Nashfa M. Hamza, Fatima Eltayeb, Mohammed Al Katari, Mohammed F. K. Ibrahim

Immunotherapy is the standard first-line palliative treatment for metastatic melanoma; however, its role in myelodysplastic syndrome (MDS) remains uncertain. We report a case in which nivolumab, administered for metastatic melanoma, was associated with a marked improvement in concurrent treatment-related MDS. A 67-year-old man with a history of oligosecretory multiple myeloma developed transfusion-dependent MDS following autologous stem cell transplantation, requiring twice-weekly blood transfusions. He subsequentl …

13.08.2026journal-article

HIV Infection and Immunosuppressive Disorders

Features of the course of HIV infection and the structure of comorbid diseases in women of childbearing age during antiretroviral therapy

E. B. Yastrebova, V. Ya. Rosenberg, I. E. Nebozhin, Ya. V. Romanova

The aim : to analyze the characteristics of HIV infection and the structure of comorbid diseases in women of childbearing age. Materials and methods . A total of 100 women of childbearing age were studied at the Republican Clinical Infectious Diseases Hospital. The average age was 42.5±0.6 years (range: 35 to 52 years). The duration of HIV infection was 15.6±1.2 years (range: 2 to 26 years). Transmission routes: sexual (63%) and parenteral (37%), HCV infection (42%) (90% treated). Marital status: married (62%), coh …

13.08.2026journal-article

Signal Transduction and Targeted Therapy

Translational insights and clinical challenges of targeting cancer stem cells

Mehreen Ahmed, Amr Al-Haidari, Shruti Agarwal, Jianmin Sun, Emma U. Hammarlund, Lars Rönnstrand, Kenneth J. Pienta, Özge Tatli, Julhash U. Kazi

Abstract Cancer stem cells (CSCs) are tumor cell subsets with self-renewal, multilineage differentiation, and tumor-initiating capacity that sustain cancer initiation, progression, metastasis, and relapse. Targeting CSCs therefore represents a promising route to improve the durability of cancer treatment. However, translation of this approach into routine care has been slow because of the biological complexity and clinical constraints. This review discusses current concepts of CSC origin and plasticity, the criteri …

13.08.2026journal-article

PLOS One

L-Phenylalanine restriction enhances L-boronophenylalanine uptake and improves boron neutron capture therapy efficacy in tumor cell lines

Yuki Tamari, Rie Saba, Takushi Takata, Hiroyuki Kimura, Mao Takita, Kenta Yashiro, Minoru Suzuki, Hideya Yamazaki, Kei Yamada

Boron neutron capture therapy (BNCT) relies on the selective uptake of boron-10 compounds by tumor cells. L-boronophenylalanine (BPA) serves as a key carrier, and enhancing its accumulation is critical for improving BNCT efficacy. In this study, we examined how L-phenylalanine (Phe) restriction affects BPA uptake and related cellular responses in the tumor cell lines SAS, U87-MG, PANC-1, and A375, as well as in the immortalized keratinocyte line HaCaT. Quantitative analysis using inductively coupled plasma atomic e …

13.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Contemporary Phase I Cardiac Rehabilitation

Lena Cook, Bijay Mukesh Jeswani, Dale M. Needham, Paul Ricard, Stephanie L. Hiser

Patients in cardiac intensive care units (ICUs) often require mechanical circulatory support (MCS) devices. Phase I cardiac rehabilitation for patients requiring a single MCS device appears safe and feasible. However, the simultaneous use of multiple MCS devices is relatively new and rehabilitation practices have had less evaluation in these circumstances. This case report describes phase I cardiac rehabilitation delivery in a 73-year-old man with cardiogenic shock supported with simultaneous femoral-femoral, veno- …

13.08.2026journal-article

Biophotonics Discovery

Extracorporeal near-infrared–activated antimicrobial photodynamic therapy for pneumonia using an ICG–polymer formulation

Isabelle Almeida de Lima, Michelle Barreto Requena, Vadila Giovana Guerra, Cristina Kurachi, Natalia Mayumi Inada

SignificancePneumonia remains a global health challenge, exacerbated by antimicrobial resistance, which limits the effectiveness of conventional treatments. Antimicrobial photodynamic therapy (aPDT) has emerged as a promising alternative for lower respiratory infections; however, its in vivo performance is hindered by lung surfactant, which traps photosensitizers and reduces their ability to reach bacterial targets.AimTo address this limitation, recent studies demonstrated that combining indocyanine green (ICG) wit …

13.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

The influence of the physical work environment on presenteeism: A theoretical exploration

Christian Bassaw, Mehdi Ghiai, Debajyoti Pati

Background Presenteeism, defined as attending work despite reduced functional capacity, has been widely studied in occupational health and organizational research. However, the role of the physical work environment remains underexplored and inconsistently integrated into dominant conceptual models. Objective This integrative review examines the role of the physical work environment in presenteeism in knowledge-intensive workplaces, while considering organizational structures and health-related resources, and synthe …

13.08.2026journal-article

Advanced Electromagnetics

Positive Effects of Solution-Focused Short-Term Therapy Combined with Routine Nursing Care on the Psychological State and Quality of Life of Patients with Geriatric Syndromes

W. J. Ye, Q. Li, Q. Wang, Z. L. Liu

Patients with geriatric syndromes often show limited improvement in psychological state and quality of life after routine care alone. This study applies a structured solution-focused brief therapy intervention combined with routine nursing care, guiding patients to focus on personal strengths and achievable goals through six standardized sessions. The intervention is implemented by uniformly trained nursing staff according to an operating manual, ensuring procedural consistency and scalability. At the 4-week follow …

13.08.2026journal-article

Annali Italiani di Chirurgia

Effect of PDCA Cycle-Based Orthopedic Rehabilitation Nursing on Perioperative Pain and Functional Recovery in Patients With Femoral Fractures

Zhiyong Cui, Xin Song, Huipeng Zhou, Peng Zhao, Yanda Li, Yanyang Guo

AIM: To investigate the effects of orthopedic rehabilitation nursing based on the Plan–Do–Check–Act (PDCA) cycle model on perioperative pain and postoperative functional recovery in patients undergoing surgical treatment for femoral fractures.METHODS: This retrospective single-center study included 120 patients who underwent surgical treatment for femoral fractures at The 964th Hospital of Chinese People’s Liberation Army Joint Logistics Support Force between May 2023 and May 2025. Based on the nursing intervention …

13.08.2026journal-article

International Journal of Surgery Case Reports

Controlled hypotension therapy with isosorbide dinitrate for postoperative bleeding of transurethral resection of the prostate

Zihao Li, Hongliang Li, Zhenzhuo Chen, Li Wang, Tie Chong, Dong Zhang

Introduction: Postoperative bleeding is a well-known complication of transurethral resection of the prostate (TURP). This study aims to evaluate the efficacy and safety of controlled hypotension using isosorbide dinitrate (ISDN) as a treatment for refractory postoperative bleeding after TURP when conventional non-surgical treatments have failed. Methods: A retrospective analysis was conducted of eight patients who experienced postoperative bleeding following TURP and did not respond to standard non-surgical interve …

13.08.2026journal-article

OTJR: Occupational Therapy Journal of Research

Structural Relationships Among Positive Occupations, Psychological Distress, Life Functioning, and Well-Being in Community Mental Health

Takuya Noguchi, Makoto Kyougoku

This cross-sectional study examined associations among positive occupations, psychological distress, life functioning, subjective well-being, and perceived interpersonal difficulties among 276 adults with mental illness receiving community-based mental health services, including psychiatric day hospitals, in Japan. Positive occupations were defined as occupational experiences characterized by personally meaningful engagement, a sense of involvement, opportunities for achievement, and supportive social interaction. …

13.08.2026journal-article

MedScien

Research on Conservative Rehabilitation and Prevention Strategies for Patellar Dislocation Among College Students

Linglang Chen

In recent years, with the extensive popularization of campus sports activities, the number of reported knee injuries such as patellar dislocation has kept rising among college students. Although most such injuries can reset spontaneously, insufficient attention has resulted in a persistently high recurrence rate after the first dislocation, and female students face a notably higher onset risk than male students. A review of existing domestic and overseas literature shows that current research mainly focuses on surg …

13.08.2026journal-article

Advanced Electromagnetics

Learning Behavioral Characteristics and Teaching Intervention Strategies of Midwifery Students in Higher Vocational Colleges Using K-means Clustering Algorithm

Y. Sun, N. Han, C. Liu, Y. Q. Bi, L. C. Meng, G. H. Gao

To address the difficulty of integrating multi-source heterogeneous learning behavior data and the broadness of conventional teaching intervention strategies, this paper proposes a data-driven analysis framework based on K-means clustering for higher vocational midwifery education. The study collects multidimensional behavioral data from online learning logs, smart classroom interaction records, and practical training assessments, and constructs a 12-dimensional feature system covering cognitive input, behavioral a …

13.08.2026journal-article

Philology. Theory & Practice

Changes in the morphological structure of Walter White’s speech as a marker of the film character’s transformation in the television series “Breaking Bad”

Tatiana Igorevna Utkina, Elizaveta Sergeevna Kuznetsova

The study aims to identify the correlation between changes in the morphological structure of speech and the stages of Walter White’s identity transformation in the television series “Breaking Bad”. Using a corpus of the character’s utterances (50,290 tokens divided into three periods – the emergence, ascendancy, and dominance and downfall of Heisenberg), the study analyzes the frequency of personal pronouns (“I”, “you”, “we”, “me”, “us”) and proto-agentive / emotive verb constructions. The scientific novelty of the …

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Aktuelle Forschung nach Fachgebiet

Study on the Mechanism of Music Therapy in Improving Sleep Quality of Patients with Chronic Insomnia Based on EEG Signal Analysis

Аntiretroviral therapy for young adults perinatally infected with HIV: the treatment experience from childhood through adulthood

Dinuclear Ir(III)/Ru(II)/Os(II) Bis-terpyridine Complexes Tethered by Tetrathienyl-Substituted Diketopyrrolopyrrole: Synthesis, Photophysics, and Antimicrobial Photodynamic Therapy

Elevated serum ferritin levels and infection-related mortality in maintenance hemodialysis patients: 10-year outcomes of the Q-Cohort study

USE OF MODULAR PHYSICAL MODELS AND DYNAMIC SIMULATIONS IN THE TRAINING OF SPECIALISTS IN THERAPY AND REHABILITATION

Efficacy and Safety of Adjusting Antimicrobial Therapy in Episodes of Fever and Neutropenia Catalogued as Fever of Unknown Origin in Children with Cancer: A Randomized Clinical Trial

Updated Systematic Review of Long-Term Outcomes of Endovascular Popliteal Artery Aneurysm Repair: Evidence From 2014 to 2025

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Cost-Effectiveness Analysis of Menopausal Hormone Therapy

Blood analytes in California sea lion Zalophus californianus pups: reference intervals and malnutrition effects, from admission to rehabilitation

Durable Hematologic Response in Therapy-Related Myelodysplastic Syndrome During Nivolumab Treatment for Metastatic Melanoma: A Case Report

Features of the course of HIV infection and the structure of comorbid diseases in women of childbearing age during antiretroviral therapy

Translational insights and clinical challenges of targeting cancer stem cells

L-Phenylalanine restriction enhances L-boronophenylalanine uptake and improves boron neutron capture therapy efficacy in tumor cell lines

Contemporary Phase I Cardiac Rehabilitation

Extracorporeal near-infrared–activated antimicrobial photodynamic therapy for pneumonia using an ICG–polymer formulation

The influence of the physical work environment on presenteeism: A theoretical exploration

Positive Effects of Solution-Focused Short-Term Therapy Combined with Routine Nursing Care on the Psychological State and Quality of Life of Patients with Geriatric Syndromes

Effect of PDCA Cycle-Based Orthopedic Rehabilitation Nursing on Perioperative Pain and Functional Recovery in Patients With Femoral Fractures

Controlled hypotension therapy with isosorbide dinitrate for postoperative bleeding of transurethral resection of the prostate

Structural Relationships Among Positive Occupations, Psychological Distress, Life Functioning, and Well-Being in Community Mental Health

Research on Conservative Rehabilitation and Prevention Strategies for Patellar Dislocation Among College Students

Learning Behavioral Characteristics and Teaching Intervention Strategies of Midwifery Students in Higher Vocational Colleges Using K-means Clustering Algorithm

Changes in the morphological structure of Walter White’s speech as a marker of the film character’s transformation in the television series “Breaking Bad”