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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

Judi Clinical Journal

Vertebral Mass Mimicking Thoracic Outlet Syndrome: A Case Report with Literature Review

Fahmi H. Kakamad, Shakew S. Mohammed, Razan Babarasul Jalal, Azad S. Hattam, Saywan K. Asaad, Abdullah K. Ghafour, Lawand A. Sharif, Huzaifa Hamid Ahmed, Hadeel A. Yasseen, Miran I. Hassan, Hiwa S. Namiq, Harun Amanj Ahmed

Abstract Introduction: Neurogenic thoracic outlet syndrome is the most common subtype of thoracic outlet syndrome and can be readily mimicked and misdiagnosed. This report presents a rare cervical vertebral lesion mimicking neurogenic thoracic outlet syndrome, highlighting an important diagnostic pitfall. Case presentation: Presenting with two years of left shoulder pain and immobility following heavy labor, a 17-year-old male underwent provocative testing and nerve conduction studies suggesting left neurogenic tho …

30.08.2026journal-article

Journal of Clinical Medicine

Effects of Exercise Interventions on Peripheral Brain-Derived Neurotrophic Factor: An Umbrella Meta-Analysis Across Clinical and Healthy Populations

Mesut Süleymanoğulları, Cemre Didem Eyipınar, Raul Ioan Muntean, Halil İbrahim Ceylan

Background and Objectives: Brain-derived neurotrophic factor (BDNF) supports neuronal function and plasticity, but exercise meta-analyses may reuse primary studies and combine distinct outcomes. We evaluated review-level evidence while preventing direct reuse of the same primary-study evidence within pooled syntheses in this umbrella review and meta-analysis. Methods: Thirty-nine systematic reviews with quantitative syntheses of peripheral BDNF were assessed. Review–primary-study links were normalized, methodologic …

30.08.2026journal-article

Journal of Clinical Medicine

Gender Differences in Diabetes Technology: Adherence and Outcomes—A Systematic Review

Sandro La Vignera, Aldo E. Calogero, Rossella Cannarella, Andrea Crafa, Federica Barbagallo, Giuseppe Papa, Vincenzo Provenzano, Francesca Provenzano, Rosita A. Condorelli

Background/Objectives: Diabetes management technologies—including continuous glucose monitors (CGM), insulin pumps (CSII), advanced hybrid closed-loop (AHCL) systems, and mobile health applications—have transformed diabetes care, yet gender-specific differences in ad-herence, clinical outcomes, and patient-reported outcomes remain inadequately char-acterised. Methods: We conducted a systematic literature review following PRISMA 2020 guide-lines, searching SciSpace, Google Scholar, and PubMed databases. From 852 ide …

30.08.2026journal-article

Journal of Translational Medicine

Inflammation as a central mechanism: interactions among epithelial, immune, and neural units in dry eye disease and their therapeutic implications

Han Yu, Xinru Wang, Suxia Li

Abstract Dry eye disease (DED) is a prevalent multifactorial ocular surface disorder. Early research primarily attributed its pathogenesis to insufficient tear secretion or excessive tear evaporation. Advances in mechanistic research have shifted the academic understanding from a narrow tear film-centric perspective toward an integrated framework of disrupted overall ocular surface homeostasis. Cumulative evidence has validated inflammation as the core mechanism driving DED onset and its persistent, refractory prog …

30.08.2026journal-article

CNS Neuroscience & Therapeutics

PPARγ ‐Dependent Pioglitazone Treatment Suppresses Neuroinflammation and Improves Cognition in Sepsis‐Associated Encephalopathy in Mice

Jing Zhang, Peng Wang, Nan Li, Yan Gao

ABSTRACT Objective To assess whether pioglitazone (Pio) protects against sepsis‐associated encephalopathy (SAE) and to probe underlying mechanisms. Methods Sepsis was induced in male C57BL/6 mice by caecal ligation and puncture (CLP). At 24 h post‐CLP, mice received Pio and/or the PPAR‐γ antagonist GW9662 and were followed for 14‐day survival. Cognitive and affective behaviors were evaluated using a behavioral battery. Blood–brain barrier (BBB) permeability was assessed by Evans blue extravasation, and hippocampal …

30.08.2026journal-article

Annals of Clinical and Translational Neurology

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio

ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging. Methods We analysed baseline ALSFRS‐R item responses from 866 PRO‐ACT participants. Ordinal SuStaIn inferred subtype‐specific sequences of functional deterioration and assigned each participant to a subtype and a SuStaIn‐derived functional stage. Longitu …

30.08.2026journal-article

Clinical and Translational Medicine

CDO1 as a prognostic biomarker and therapeutic target in gastric cancer: Mechanistic insights into the PI3K/AKT‐THBS1 axis and epigenetic reactivation by decitabine

Fazhi Wang, Runkai Zhou, Jinfeng Cai, Jiazhe Wen, Abudushalamu Yalikun, Yang Yu, Yugang Wen

Abstract Background As a pivotal metabolic enzyme, cysteine dioxygenase type 1 (CDO1) exerts tumour‐suppressive effects across diverse tumour types, and its expression is strongly correlated with clinical prognosis. However, the molecular mechanisms underlying CDO1‐mediated tumour suppression in gastric cancer (GC), its relationship with the tumour‐associated immune microenvironment, and pharmacological strategies to restore its expression remain poorly understood. Methods CDO1 expression and prognosis were evaluat …

30.08.2026journal-article

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218

PERFIL EPIDEMIOLÓGICO, CLÍNICO E VARIAÇÃO DA ACUIDADE VISUAL EM PACIENTES COM RETINOSE PIGMENTAR: ESTUDO LONGITUDINAL RETROSPECTIVO EM UM HOSPITAL OFTALMOLÓGICO DO SUL DO BRASIL

Lilian Zaki, Licia Deon Weirich, Cassio Tokuji Tsujiguchi, Clodomir Salgueiro Cordeiro de Carvalho, Marcos Solano Vale, Camila Marinelli Martins

A retinose pigmentar é a distrofia hereditária da retina mais prevalente, caracterizada pela degeneração progressiva dos fotorreceptores e comprometimento visual de evolução variável. Este estudo teve como objetivo descrever o perfil epidemiológico, clínico e oftalmológico e avaliar a variação da acuidade visual de pacientes com retinose pigmentar acompanhados em um hospital oftalmológico do Sul do Brasil. Foi realizado um estudo observacional longitudinal retrospectivo, baseado em prontuários eletrônicos de pacien …

30.08.2026journal-article

Revista ft

Hipertensão arterial e doença renal crônica em idosos: revisão das evidências sobre evolução clínica e tratamento

Beatriz Aguiar Medeiros, Julia Gauer Gomides Tavares, Nicolly Cristine Nobre Bredun, Michel Hosananh Vasconcelos

Systemic arterial hypertension (SAH) and chronic kidney disease (CKD) are among the most prevalent chronic conditions in the elderly, frequently coexisting and mutually exacerbating their outcomes. This interaction compromises quality of life and increases the risk of cardiovascular and renal complications, making its management a significant challenge. This study analyzed the influence of hypertension on the progression of kidney disease in the elderly and evaluated the effectiveness of available therapeutic strat …

30.08.2026journal-article

Clinical Case Reports

A Rare Finding of Retroperitoneal Sepsis Following Robot‐Assisted Transanal Minimally Invasive Surgery ( TAMIS ): A Case Report and Review of the Literature

Jonathan Tiong, Khang Duy Ricky Le, Annie Jiao Wang, Jean Flanagan, Dilshan Udayasiri

ABSTRACT Robot‐assisted transanal minimally invasive surgery (TAMIS) is a safe and effective platform for the local excision of early rectal lesions. While postoperative complications such as bleeding or contained perforation are recognized, rapidly progressive retroperitoneal sepsis remains an exceedingly rare occurrence. A 56‐year‐old male underwent robot‐assisted TAMIS for a pT1 grade 1 rectal neuroendocrine tumor (NET). Despite successful circumferential excision and defect closure with sutures, the patient dev …

30.08.2026journal-article

Veterinary and Comparative Orthopaedics and Traumatology

Race Performance Following Arthroscopic Surgery for Femoropatellar and Tarsocrural Osteochondrosis in Juvenile Thoroughbreds

Federico Pepe, Francesca Beccati, Francesca Bonaspetti, Marco Pepe, Maria Chiara Pressanto

Abstract The objective of this study is to evaluate racing performance of Thoroughbred yearlings following arthroscopic surgery for osteochondrosis (OC) of the femoropatellar (FP) and tarsocrural (TC) joints. This is a retrospective study of Thoroughbreds < 2 years old undergoing arthroscopic surgery for OC in the FP or TC joint (2010–2022). For each case, two age- and sex-matched controls from the same stud farm were selected. Lesions were graded on preoperative radiographs and described. Racing outcomes (number o …

30.08.2026journal-article

Exercise Medicine

High-Intensity Exercise Induced Changes in Oxidative Stress and Skeletal Muscle Damage in Male Endurance and Resistance Trained Athletes: A Comparative Study

Debdatta Saha, Tamalica Hore, Debajyoti Mukherjee, Ananda Kisor Pal, Santiranjan Dasgupta, Rubia Mondal, Amit Bandyopadhyay

Objectives: High-intensity exercise (HIE) can induce skeletal muscle damage and oxidative stress not only in sedentary individuals but also in trained athletes. This study aimed to evaluate and compare oxidative stress levels and muscle damage markers following high-intensity exercise among male resistance-trained athletes (RA, n = 18), endurance-trained athletes (EA, n = 18), and sedentary controls (SC, n = 30) aged 20–30 years.Methods: A familiarization trial was performed for each participant to determine the tr …

30.08.2026journal-article

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY

Reducing Potentially Harmful Drug‐Related Problems in Outpatient Prescribing: A Quasi‐Experimental Evaluation of a Multifaceted Clinical Pharmacist Intervention in Vietnam

Thanh‐Tam Le, Thang Nguyen, Minh‐Thy Tran‐Doan, Huong‐Thao Nguyen

ABSTRACT Background Drug‐related problems (DRPs) are common in ambulatory prescribing and can cause preventable harm, yet evidence that pharmacist‐led interventions reduce clinically meaningful DRPs in Vietnam remains limited. This study evaluated a multifaceted clinical pharmacist intervention to reduce the prevalence and potential clinical harm of DRPs in adult outpatient prescriptions. Methods We conducted a quasi‐experimental pre‐post study of electronic adult outpatient prescription records at a tertiary hospi …

30.08.2026journal-article

Journal of Internal Medicine

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede

Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine and metabolic disorder with prominent reproductive, psychological, dermatological, and cardiometabolic consequences. Once considered primarily a reproductive disorder …

30.08.2026journal-article

Veterinary Record Case Reports

Treatment of separation anxiety and fear of noises, confinement and unfamiliar people in a dog using escitalopram and clonidine

Erica Grier

Abstract A 3‐year‐old, 8.9 kg, neutered male dachshund was presented for fear and anxiety that significantly affected his daily quality of life. Distressing situations included being separated from his owner, confined in crates, exposed to noises and introduced to unfamiliar people. Clinical signs frequently included trembling, barking, hypersalivation, urination and attempts to escape or hide, with a recovery time of 20–40 minutes. Previous treatment with fluoxetine, a cannabidiol supplement and trazodone, alongsi …

30.08.2026journal-article

International Journal of Dental Hygiene

Evaluation of Dyclonine Hydrochloride Mucilage for Pain Control in Plaque Control‐Oriented Periodontal Therapy: A Double‐Blind Randomised Clinical Trial

Zeng Yi, Zhou Hangfan, Huang Rongli, Wu Zixiang, Chu Xiangyuan, Yang Jiantang, Yang Kun, Yan Fuhua, Ge Song

ABSTRACT Objective To evaluate the effectiveness of dyclonine hydrochloride mucilage (DYC) in controlling pain during guided biofilm therapy (GBT) and its potential to improve patient comfort and adherence to regular supportive periodontal treatment. Methods Patients aged 18–65 years undergoing GBT were enrolled in this randomised, double‐blind, split‐mouth placebo‐controlled study. The left and right sides of the mouth were randomly assigned to the control or experimental group using a coin toss. The Modified Dent …

30.08.2026journal-article

Tomography

Anatomy-Weighted CTDIvol from Routine CT Metadata: A Patient-Specific, Multi-Vendor Study Using Deep-Learning Segmentation

Shuji Yamamoto

Background/Objectives: The volume computed tomography (CT) dose index (CTDIvol) is a scanner output, not an organ dose, and cannot express how tube-current modulation varies along a patient. An organ-specific weighted CTDIvol addressing this has been reported before, in single-institution cohorts and often from inputs routine archives do not retain. New here is not the quantity but what an open, multi-vendor operationalisation reveals: whether its inputs survive archive curation and what the fallback costs when the …

30.08.2026journal-article

Wilderness & Environmental Medicine

Read It and Weep: An Evaluation of People Involved in Avalanches and Their Forecast Reading Habits

Sarah Petelinsek, Rowan Kelner, Jamal Jones, Nikki Champion, Michael Morgan, Patrick G. Hughes

Introduction The aim of this investigation is to gain insight into how humans interact with the avalanche forecast and better understand the role that the avalanche forecast plays in prevention of human-triggered avalanche incidents. Methods Using a 5-y cross-sectional study of self-reported survey data of participants involved in avalanches, we performed a secondary analysis to identify trends and patterns in avalanche forecast reading habits. The study assessed avalanche forecast reading habits, perceptions, and …

30.08.2026journal-article

Scientific Reports

Regional disparities in osteosarcoma and soft tissue sarcoma treatment across Northwest China: a cross-sectional multicenter survey

Wenpeng Yang, Junshen Wu, Maierdanjiang Maihemuti, Suzhi Ji, Renbing Jiang

Abstract Osteosarcoma and soft tissue sarcoma are rare but aggressive malignancies requiring multidisciplinary care. Despite consensus guidelines, real-world treatment patterns across Northwest China remain poorly characterized. We conducted a cross-sectional, questionnaire-based multicenter survey of 67 hospitals treating osteosarcoma and 60 treating soft tissue sarcoma across three regional clusters in Northwest China (Xinjiang-Qinghai, Gansu-Ningxia, Shaanxi-Shanxi). The survey instrument, developed through lite …

30.08.2026journal-article

International Journal of Sexual Science

Treatment Options in Erectile Dysfunction

Arda Tongal, Hakan Türk

Erectile dysfunction is a common and important health problem that affects the quality of life of individuals and their partners. Although its etiology includes various factors, the majority of cases have organic causes. In cases of organic ED, lifestyle modification remains the main approach, and oral phosphodiesterase type 5 (PDE5) inhibitors make up the main part of non-invasive management. Additionally, intraurethral suppositories, extracorporeal shock wave therapy (ESWT), and vacuum erection devices are also e …

29.08.2026journal-article

Translational Medicine

Assessment of fertility and reproductive potential in the arctic regions of the Russian Federation from 2014 to 2023

E. D. Mayskaya, T. M. Duryagina, A. N. Smolinets, M. D. Sukharev, A. L. Sannikov, A. G. Kalinin

Background. Assessment of the reproductive potential of the subarctic territories of Russia is of high significance due to the specific climatic, geographical, socio-economic and ethno-demographic conditions that affect fertility. Despite national demographic trends, regional variability in fertility rates, infertility, reproductive behaviour and accessibility of assisted reproductive technologies remains insufficiently studied, which limits the development of targeted management decisions. Aim. To conduct a compre …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Time to Antibiotics and Clinical Outcomes in Pediatric Cancer Patients with Fever: Evaluating the "Golden Hour" Concept

Medalit Luna Vilchez, Grisell Leonor Portilla Uribe, Mitsi Lorraine Santiago Abal, Victoria Angélica Godoy Vila, Alicia Janeth Mafaldo Rengifo, Gloria Francia Oscanoa

Abstract Background In low- andmiddle-income countries, infections remain the leading cause of treatment-related mortality in pediatric patients with cancer. The "Golden Hour" concept advocates antibiotic administration within 60 minutes of emergency department (ED) triage to reduce sepsis and ICU admission. We evaluated whether time to antibiotic administration (TTA) &gt;60 min versus ≤60 min impacts adverse clinical outcomes in children with cancer and fever. Methods We conducted a prospective longitudinal at the …

29.08.2026journal-article

Bioelectronic Medicine

Teaching through technology: comparing student experiences of VR and computer simulations in orthoptics education

Michael Batterley, Georg Meyer, Jignasa Mehta, Simon Campion, Ryan Ward

Abstract Background Virtual Reality (VR) has previously been found to provide both an effective and enjoyable learning environment for users to develop a wide range of skills. However, despite uptake in fields such as medicine and veterinary medicine, there is little research into the use of VR for diagnostics training with Orthoptists. Methods This study compared students’ experiences of a collaborative VR learning environment with the Strabismus desktop computer simulation for practicing the diagnosis of ocular d …

29.08.2026journal-article

International Journal of Medical Science and Pharmaceutical Research

Benefits of Using Hydroxychloroquine/Chloroquine in the Treatment of Immunomediated Rheumatic Diseases

Jozelio Freire de Carvalho, Mariana Fernandes Carneiro

Antimalarial drugs, particularly hydroxychloroquine (HCQ) and chloroquine (CQ), have been used for decades as cornerstone therapies in the management of immune‑mediated rheumatic diseases (IMRDs). Beyond their classical role in disease activity control, these agents exert pleiotropic effects encompassing immunomodulation, anti‑inflammatory signaling, antithrombotic activity, and metabolic and cardiovascular protection. Robust clinical evidence supports their ability to reduce disease flares, limit cumulative organ …