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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
04.08.2026journal-article

JNCI: Journal of the National Cancer Institute

The joint association of clonal hematopoiesis of indeterminate potential and biological aging with cancer risk among 332,911 individuals

Li Wang, Kaili Sun, Siqi Lu, Yuyang Zheng, Xueqing Jia, Yanjie Zhao, Lujia Shen, Jingyun Zhang, Jing Shao, Xiao Tan, Jie Sun, Zuyun Liu

Abstract Background Clonal hematopoiesis of indeterminate potential (CHIP) and biological aging have been individually associated with increased cancer risks. However, their joint effect on cancer risks remains unknown. Methods We analyzed data from 332,911 participants at baseline in the UK Biobank. We defined CHIP as a pathogenic variant with variant allele fractions ≥2%. Biological aging was assessed by the phenotypic age acceleration (PhenoAgeAccel) and categorized as biologically younger and older. Association …

04.08.2026journal-article

F1000Research

Comparative Effectiveness of Progressive Muscle Relaxation, Autogenic Training, and Combined Therapy on Blood Pressure Among Older Adults with Hypertension: A Quasi-Experimental Study

Puji Setya Rini, Santhna Letchmi Panduragan, Fatimah Yahya, Hafizah Che Hassan, Yulius Tiranda

Background Hypertension is a major chronic cardiovascular condition among older adults that contributes substantially to global morbidity and mortality rates. Mind–body therapies, such as progressive muscle relaxation (PMR) and autogenic training (AT), may help regulate blood pressure; however, evidence regarding their comparative and combined effects on institutionalized older adults is limited. This study evaluated the effects of PMR, AT, and combined PMR + AT interventions on blood pressure in older adults with …

04.08.2026journal-article

Moscow State University of Technology and Management named after K.G. Razumovsky (First Cossack University). Social Sciences Series

ТРАДИЦИОННЫЕ ЦЕННОСТИ РУССКОГО МИРА И ИСТОРИОСОФСКАЯ СУЩНОСТЬ РУССКОЙ ИДЕИ КАК ГЛАВНЫЕ ПРИНЦИПЫ ФОРМИРОВАНИЯ НАЦИОНАЛЬНОЙ ИДЕНТИЧНОСТИ РУССКОГО НАРОДА В СОВРЕМЕННОСТИ. МАСС-МЕДИЙНЫЙ АСПЕКТ

Ю.В. Кот

Проведен культурологический анализ понятия «Русский мир» и историософской сущности русской идеи в контексте массового сознания, национальной идентичности с опорой на традицию русской философской мысли. Феномен русской идеи рассматривается как актуальное явление духовной жизни современной России. Для государственных и патриотически направленных частных масс-медиа, включая электронные, контекст понятия «Русский мир» и суть русской идеи являются приоритетными для трансляции широким массам населения России и союзническ …

04.08.2026journal-article

Frontiers in Public Health

Wuli-Shili-Renli methodology as a service quality management tool among private older adults care institutions in Taizhou, China: an empirical study

Lili Huang, Jing-Jing Fu, Dan Xu

Background Population aging, a global crisis, has made private integrated medical - nursing facilities the primary providers for older adults care. However, the operational flaws of these facilities can potentially be addressed by the China - originated Wuli-Shili-Renli (WSR) methodology, which integrates physical resources, systematic management, and human factors. Methods A retrospective empirical before-after study was conducted to evaluate the implementation effect of the WSR framework on service quality manage …

04.08.2026journal-article

SocietàMutamentoPolitica

«Two Heads Are Better Than One but They Must Be Good Ones»: Ethical and Methodological Challenges of Social Work With «people Living on the Street»

Andrea Gollini

This paper presents a case study analysis focused on an accompaniment process with a person living on the street, developed in a city in Northern Italy. Through the story of Arnold – a migrant man facing housing, employment, and relational precarity – the article examines key ethical and methodological challenges of social work with people who live on the street: managing relational timeframes, negotiating the boundaries between support and control, holding together protection and freedom, and the effort to sustain …

04.08.2026journal-article

Prosthetics & Orthotics International

Observational study of people with complete hand amputation using a multigrip myoelectric prosthesis after using a standard myoelectric prosthesis

Marc Marty, Nathalie de Hesselle, Mireille Grenier, Anthony Palacio, Michèle Timsit, Amelie Touillet, Frédéric Charlate, Stephane Vigier, Emilie Leblong, Yoann Ronzi, Léo Borrini, Emilie Braley, Patrice Schumacker, Simona Audemar, Thierry Jacob-Chia, Estelle Elie, Juliette Milcamps, Renaud Urbinelli, Isabelle Loiret

Background: Clinical evidence substantiating the advantages multi-grip myoelectric hand prosthesis over conventional myoelectric hand prosthesis in daily life remains inconclusive. Objectives: The study aimed to assess the efficacy of using a multi-grip myoelectric hand prosthesis after utilizing a conventional myoelectric hand prosthesis. Study Design: A before-and-after, multi-center, observational study included adults with complete hand amputation using a standard myoelectric hand prosthesis for more than 4 wee …

14.08.2026journal-article

Journal of Antimicrobial Chemotherapy

Do current oral ciprofloxacin regimens achieve pharmacokinetic/pharmacodynamic targets within safe exposure limits in older adults with Pseudomonas aeruginosa infection? A population pharmacokinetic analysis

Mehdi El Hassani, Daniel J G Thirion, Aysenur Yaliniz, Katherine Desforges, Josée Verdon, Emily G McDonald, Amélie Marsot

Abstract Background Ciprofloxacin is one of the few orally available antibiotics with activity against Pseudomonas aeruginosa. This study developed a population pharmacokinetic (popPK) model for oral ciprofloxacin in older adults and evaluated whether standard regimens achieve the pharmacokinetic/pharmacodynamic (PK/PD) target of 24 h area under the concentration–time curve over minimal inhibitory concentration (AUC0-24/MIC) ≥ 125. Methods This was a prospective pilot study in patients ≥75 years taking oral ciprofl …

14.08.2026journal-article

Journal of Antimicrobial Chemotherapy

Factors associated with virological failure in people with HIV treated with bictegravir/emtricitabine/tenofovir alafenamide. Impact of pre-existing mutations and risk of resistance emergence. ANRS-CO3-AquiVIH-NA cohort

Pantxika Bellecave, Alaric Peyrouny-Mazeau, Olivier Leleux, Mojgan Hessamfar, Gwenaël Le Moal, Didier Neau, Laure Alleman, Charles Cazanave, Estibaliz Lazaro, Pierre Duffau, Marie-Anne Vandenhende, Bernard Castan, Camille Tumiotto, Fabrice Bonnet

Abstract Objectives We investigated, in a real-world setting, virological factors associated with virological failure (VF) after bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) initiation in people with HIV (PWH) with and without pre-existing drug resistance mutation (PRM) and the emergence of new resistance mutations at virological failure. Methods Treatment-experienced PWH from ANRS-CO3-AquiVIH-NA cohort starting B/F/TAF between 2018 and 2021 were stratified depending on their baseline viral load (VL): …

04.08.2026journal-article

Journal of Physiological Anthropology

Daytime skin temperature and nocturia in the subsequent night among community-dwelling older adults in the cold season in the HEIJO-KYO study

Daisuke Tamaru, Kenji Obayashi, Yoshiaki Tai, Yuki Yamagami, Kazuki Okumura, Hiromitsu Negoro, Keigo Saeki

Abstract Background Both Nocturia and cold exposure are associated with higher mortality and other health problems. The previous studies already indicated the significant association between nocturia and air temperature. Skin temperature might be superior to air temperature in that it can show the individualized impact of cold exposure. The current study aimed to investigate the association between distal–proximal skin temperature gradient (DPG) and nocturia among older adults in the living environment. Methods The …

04.08.2026journal-article

Prosthetics & Orthotics International

The role of walking speed and leg proprioception in foot clearance for older transtibial prosthesis users

Anna C. Pogharian, Kiley L. Armstrong, Jenny A. Kent, Rebecca L. Stine, Matthew J. Major

Background: Falling is a concern for both older persons and transtibial prosthesis users (TTPUs), with older TTPUs potentially facing compounded risk. Older adults and TTPUs display foot clearance (FC) behavior that may contribute to increased tripping risk. Further, a person’s knowledge of their leg orientation in space (ie proprioception) plays a role in managing FC and is affected by age and prosthesis use. Objective: To examine the effect of walking speed on FC of older TTPUs and the relationship between FC and …

04.08.2026journal-article

Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences

The social well-being of the older generation: dynamics over ten years (based on the materials of the Komi Republic)

L. Popova, E Zorina

The acceleration of demographic aging in Russia significantly raises the urgency of issues of quality of life and social well-being of the third age population, which is a powerful electoral resource capable of having a noticeable impact on the political situation and social development. The purpose of the article is to study the change in the social well-being of elderly people of the Komi Republic under conditions of the economic crisis, reform of the pension system, post-Covid situation, the beginning of the Spe …

04.08.2026journal-article

People and Nature

The impact of zoo education programmes on connection to nature considering programme type, participants' demographics and their initial connection

Viktoria Feucht, Paul Wilhelm Dierkes, Martin Bratteler, Anna Bresser, Sandra Buchberger, Jule Hadler, Andreas Haeser‐Kalthoff, Elia Heule, Axel Kästner, Constanze Mager, João Neves, Kathrin Rapp Schürmann, Kathrin Monika Röper, Rebecca D. Schulte‐Iserlohe, Lisa Schwarz, Tanja Spengler, Marcel Stawinoga, Ina Steinert, Franziska Waked, Stephan Worm, Matthias Winfried Kleespies

Abstract Participants in environmental education programmes can have different preexisting attitudes and experiences that could influence the educational outcomes. The present study focuses on zoo education and its goal of connecting people to nature. It analyses the effect of educational programmes on participants' connection to nature, considering their preexisting (initial) connection to nature. Twenty zoos collected data from programme participants using questionnaires before and after their programmes. Using t …

04.08.2026journal-article

Circulation

Strategies for Optimizing Heart Failure Care in the Older Adult: A Scientific Statement From the American Heart Association

Sabra C. Lewsey, Trejeeve Martyn, Vanessa Blumer, Nicholas K. Brownell, Quin E. Denfeld, Shannon M. Dunlay, Parag Goyal, Shannon Halloway, Daniel Matlock, Orly Vardeny, Harriette G.C. Van Spall, on behalf of the American Heart Association Cardiovascular Disease in Older Populations Committee of the Council on Clinical Cardiology and Council on Cardiovascular and Stroke Nursing, Council on Basic Cardiovascular Sciences, Council on Lifelong Congenital Heart Disease and Heart Health in the Young, Heart Failure and Transplantation Committee of the Council on Clinical Cardiology

Heart failure prevalence is increasing and has a disproportionate burden on older adults. Older adults, however, may encounter unique challenges in accessing and navigating comprehensive disease-modifying, guideline-directed therapies, thus limiting use among those at highest risk of cardiovascular death or worsening heart failure. Care of the older adult with heart failure requires tailored treatment plans to overcome barriers to effective therapies in this population. This scientific statement reviews the literat …

04.08.2026journal-article

Frontiers in Psychiatry

Cross-species conversations: the development of the AURAL-Pet coding system to capture how people talk to pets in daily life

Dara S. Jonkoski, Nicole M. Lorig, Molly C. Delzio, Alyssa Klensin, Abigail Marsters, Huashi Li, Amanda M. Bernal, Matthias R. Mehl, Kerri E. Rodriguez, Emily E. Bray

While pets are a well-established fixture in many households, how owners perceive their pets’ roles can range from distant housemates to casual companions to trusted confidantes. At the same time, findings relating to the impact pets have on human health and wellbeing are mixed. A potential explanation for these disparate effects is the naturally occurring variation in daily human-pet interactions and relationship quality. However, there is a lack of methodological approaches that can accurately quantify naturalist …

04.08.2026journal-article

Aging Clinical and Experimental Research

Radiofrequency Echographic Multi-Spectrometry for bone health assessment in prostate cancer patients receiving Androgen deprivation therapy: A prospective comparative observational study

Manuela Montatore, Riccardo Guglielmi, Amanda Isaac, Maria Grazia Capasso, Antonio Corvasce, Federica Masino, Giuseppe Guglielmi

Abstract Background Androgen deprivation therapy (ADT), used in selected patients with prostate cancer (PCa), is associated with accelerated bone loss and increased fragility fracture risk. Radiofrequency Echographic Multi-Spectrometry (REMS) is a non-ionizing ultrasound-based technique for axial bone mineral density (BMD) assessment. Aim To evaluate REMS-derived BMD at the lumbar spine and femoral neck in men with PCa receiving ADT and in age- and body mass index-matched healthy controls. Methods In this cross-sec …

04.08.2026journal-article

Journal of Enterprising Communities: People and Places in the Global Economy

Nurturing start-up seeds: exploring the fertile ground of entrepreneurial curriculum in Nigerian universities

Joy Eghonghon Akahome, Obi Fidelis Nnadi

Purpose This study aims to examine how entrepreneurial curricula in Nigerian universities develop human capital for sustainable start-up creation among youth. It explores how knowledge, skills and entrepreneurial mindsets are formed through university-based entrepreneurship education and how these translate (or fail to translate) into start-up readiness within a resource-constrained environment. Design/methodology/approach A qualitative case study design was adopted within an interpretivist paradigm. Data were coll …

04.08.2026journal-article

SocietàMutamentoPolitica

Legal Aid at the Margins: Realizing Rights for People Experiencing Homelessness in Italy

Maria Chiara Pedroni

Legal aid is widely recognised as a key mechanism for enabling access to justice, however its inherent ambivalences and structural limitations have been highlighted in the literature. This paper explores how access to rights is enacted in everyday practice through a qualitative study of a volunteer-based organisation of “street lawyers” operating in Italy, which provides free legal aid to people experiencing homelessness. Drawing on volunteers’ accounts of their everyday practices, role interpretations, and encount …

04.08.2026journal-article

Frontiers in Psychiatry

Social isolation, loneliness, disability progression, and mortality among older adults with cardiac disease: a longitudinal NHATS study

Xiaoyu He, Yuxiao Sun, Chang Zhou, Yue Yu, Shangwei Huang, Tianwen Wei, Jieyun You, Qi Zhang

Background Cardiac disease is the leading cause of morbidity and mortality among older adults, yet the psychosocial pathways through which it accelerates functional decline remain poorly characterized. Social isolation and loneliness are plausible mediators, but their longitudinal roles in the cardiac disease–disability–mortality cascade have not been examined in an integrated framework. Methods We analyzed 5,654 US Medicare beneficiaries aged ≥65 from the National Health and Aging Trends Study (NHATS) followed acr …

04.08.2026journal-article

Genes & Nutrition

Epigenetic changes reveal that vitamin B12 intake is associated with lower insulin resistance in older adults

Chao-Qiang Lai, Laurence D. Parnell, Yu-Chi Lee, Bruce S. Kristal, Oladimeji J. Akinlawon, Margaret P. Winderman, Tamara K. Reed, Liam Fouhy, Kelsey M. Mangano, Josiemer Mattei, Katherine L. Tucker, José M. Ordovás

Abstract Background Dietary choices influence both risk and development of type 2 diabetes (T2D), but the precise mechanisms remain incompletely described. Dietary intake and lifestyle behaviors can alter epigenetic states with subsequent modulations on gene expression which then can change the risk of T2D. Methods An epigenome-wide association study was conducted to identify any epigenetic links to diabetes risk by investigating epigenetic changes during a 6-year follow-up in 374 participants who were free of T2D …

04.08.2026journal-article

Frontiers in Public Health

Caregiving experiences and support challenges of older caregivers from the perspective of the digital divide: a qualitative study

Qi Liu, Lisha Xia, Chun Wu, Weina Dang, Juelian Li, Yali Liu, Chao Shang, Yu Deng, Jinxia Zhang

Purpose This study aims to explore the caregiving experiences and support challenges faced by older caregivers when using digital health technologies. By examining these experiences through the lens of the digital divide, this research seeks to provide empirical evidence to support the development of inclusive and age-friendly digital health services. Methods This study employed a qualitative descriptive design. Using purposive sampling, 16 older caregivers of hospitalized older patients were recruited from the car …

04.08.2026journal-article

Therapeutic Recreation Journal

The Empowering Language Framework: A Model for Recreational Therapy to Foster Autonomy in Older Adults

Shelly Bates, Carmen Bowman

With the increasing number of older adults living in nursing and assisted living homes, Certified Therapeutic Recreation Specialists (CTRSs) proactively address issues that impact well-being, such as decreased autonomy. CTRSs serving older adults in the United States utilize a skill set that is uniquely positioned to promote autonomy through therapeutic relationship development and a person-centered care ideology. This conceptual paper proposes the Empowering Language Framework (ELF), an applied practice model that …

04.08.2026journal-article

Frontiers in Built Environment

Summer indoor thermal-humidity environment and thermal comfort of older adults in renovated nursing homes: a case study in Changsha, China

Fupeng Zhang, Lei Shi, Ying Zhang, Simian Liu, Meizhen Long, Wenqian Jiang

With the increasing demand for urban building stock renewal and elderly care facilities, nursing homes renovated from existing buildings have become increasingly common in hot-summer and cold-winter regions. However, whether their indoor thermal-humidity environments can meet the comfort and health needs of older adults remains insufficiently investigated. This study selected three typical renovated nursing homes in Changsha, China, as case buildings. Field measurements, subjective questionnaire surveys, and therma …

04.08.2026journal-article

Healthcare

Weak-Supervision Expectation–Maximization Framework for Identifying Decisional Vulnerability in Older Emergency Department Patients

Devin Sandlin, Steve Arze, Jacob Lane, Ayan Bhakta, Jennifer A. Walker, Anirudh Rayanki, Jenna R. Williamson, Nathan Hoot, Hao Wang

Background and Objectives: Decision-making capacity is essential for informed consent, yet its assessment in emergency departments (EDs) is often subjective and inconsistently documented. Older adults are particularly vulnerable to impaired capacity during acute illness. We aimed to develop a scalable, electronic health record (EHR)-based approach to support early identification of older ED patients at risk of decisional vulnerability using the Medical Information Mart for Intensive Care (MIMIC)-IV database. Method …

04.08.2026journal-article

BMC Geriatrics

Accelerometry-derived physical activity patterns and clinical correlates in Swiss geriatric inpatients: a cross-sectional study

Caroline Yvonne Tanner, Frank Stoller, Miriam Gaehwiler, Livia Vinzens, Dzuza Papik, Jessica Scherz, Patrick Eggenberger, Martina Betschart

Abstract Background Physical activity among hospitalized geriatric patients is very low, contributing to functional decline and delayed recovery. However, posture-sensitive thigh-worn accelerometry has not yet been used to assess physical activity and its clinical correlates in Swiss acute geriatric inpatients. This multicenter cross-sectional study aimed to (a) quantify physical activity patterns and (b) examine associations with demographic and clinical characteristics. Methods Inpatients from two acute geriatric …