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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
13.08.2026journal-article

Turkish Journal of Medical Sciences

Repurposing diclofenac for combination therapy: targeting the Warburg effect to enhance breast cancer treatment ​

GONCA TUNA, ELİF ERTÜRK, AYŞEN SAĞNAK, FERDA ARI

Background/aim: Diclofenac (Diclo), a widely used nonsteroidal antiinflammatory drug, has emerged as a potential candidate for drug repurposing in oncology, with reported anticancer effects extending beyond cyclooxygenase (COX) inhibition, including modulation of tumor metabolism. This study investigated the antiproliferative and glycolysis-associated effects of Diclo in MCF-7 breast cancer cells, alone and in combination with docetaxel (Doc) or 5-fluorouracil (5-FU). Materials and methods: Cell viability was asses …

13.08.2026journal-article

International Journal of Nursing and Midwifery Science (IJNMS)

CADRE SATISFACTION IN USING THE SI CETING APPLICATION AS AN INFORMATION AND EDUCATION MEDIA FOR STUNTING PREVENTION IN LEMINGGIR VILLAGE, MOJOSARI DISTRICT, MOJOKERTO REGENCY

Elies Meilinawati S. Budihartini

Cadres play an important role in delivering health education to prevent stunting. The use of digital educational media is expected to improve access to accurate information and support cadres in carrying out health promotion activities. This study aimed to determine cadres' satisfaction with the use of the SI CETING application as an information and education media for stunting prevention. This study employed a descriptive quantitative design. The research was conducted among cadres in a rural area. A total of 31 r …

13.08.2026journal-article

Trials

Remote STrOke Rehabilitation (ReSTORe): study protocol for a randomised controlled trial

Stuart Ennis, Lucy Eggleston, Nicole De Valliere, Harbinder Sandhu, Julie Bruce, Ranjit Lall, Anower Hossain, Mariam Ratna, Jason Madan, Mandana Zanganeh, Yufei Jiang, Jo Parsons, Yin-Ling Lin, Frances Ford, Marcus Davies, Rebecca Palmer, Ali Ali, Gordon McGregor

Abstract Background At least one third of long-term stroke survivors living at home experience ongoing (≥6 months) mild to moderate disability including fatigue, low functional capacity, muscle weakness, anxiety, and depression. Health-related quality of life (HRQoL) and societal participation are affected, particularly after routine contact with health professionals ends. Outpatient centre-based exercise rehabilitation programmes can improve physical and mental health, but these services are rarely provided in the …

13.08.2026journal-article

Frontiers in Medicine

Biomarker-driven immunotherapy and adoptive cell therapy in recurrent pancreatic ductal adenocarcinoma

Tao He, Guoan Li, Fuzhen Qi

Recurrent pancreatic ductal adenocarcinoma (PDAC) includes circulating tumor DNA (ctDNA)-defined molecular residual disease (MRD), isolated or oligometastatic relapse, disseminated measurable recurrence, and heavily pretreated refractory disease. These states differ in tumor burden, treatment urgency, tissue accessibility, and immune competence and should not be treated as one population. Immune checkpoint blockade has minimal activity in unselected PDAC, and randomized trials have not shown consistent benefit from …

13.08.2026journal-article

Journal of Endovascular Therapy

Transradial Access Versus Transfemoral Access in Angioplasty and Stenting for Peripheral Arterial Diseases: A Meta-Analysis of Comparative Studies and Systematic Review

Wenxin Yang, Zhaoxi Peng, Hongji Pu, Yan Fu, Yijun Liu, Peng Qiu, Xinwu Lu, Kaichuang Ye

Purpose: To compare the efficacy and safety of transradial (TR) versus transfemoral (TF) access in peripheral arterial angioplasty and stenting, providing evidence to guide clinical decision-making in endovascular interventions. Methods: A systematic review and meta-analysis were conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Randomized controlled trials (RCTs) and cohort studies comparing TR and TF approaches in patients with peripheral artery disease (P …

13.08.2026journal-article

Designs

Design of a New 3-UPU/S Parallel Ankle Rehabilitation Mechanism

Assia Abdi, Ridha Kelaiaia, Brahmia Allaoua, Adlen Kerboua, Ameur Latreche

Ankle injuries may lead to severe complications, including chronic instability and reduced mobility. Rehabilitation therefore plays a critical role in restoring normal ankle function and preventing long-term impairment. However, conventional manual physiotherapy presents several limitations, such as limited availability of therapists, variability in treatment, and reduced accessibility for home-based rehabilitation. Consequently, significant research efforts have been devoted to the development of robotic and mecha …

13.08.2026journal-article

RESEARCH JOURNAL OF PURE SCIENCE AND TECHNOLOGY

Spatial–Temporal Assessment of Indoor Air Quality and Occupational Risk-Control Practices in an Oil and Gas Facility in Delta State, Nigeria

Yusuf Saibu

This study evaluated the space- and time-varying Indoor Air Quality (IAQ) and Occupational Risk control Practices (ORCP) in Administrative Workspaces (AW) of an operating Oil and Gas Facility (OGF) in Delta State, Nigeria. A workplace-based observational cross-sectional design was used, with morning and evening measurements conducted in the reception area and three administrative offices, yielding 8 workspace-period observations. PM₂.₅, PM₁₀, CO₂, CO, SO₂, NO₂, TVOC, and relative humidity and temperature were measu …

13.08.2026journal-article

Anatomical Sciences Education

Re‐humanizing anatomy? Learning through human body donors in physiotherapy education

Robert Parish, Chris Carter, John Stephens, Debs Patten

Abstract Anatomical knowledge underpins clinical skills and professional identity in physiotherapy. However, dedicated teaching has declined in recent years. Body donor‐based learning, though common in medical education, is rarely used in physiotherapy. Its integration may enhance learning through embodied, haptic experiences, and greater physical and emotional engagement with anatomical structures. A qualitative methodology grounded in phenomenology and hermeneutics was employed, using Interpretative Phenomenologi …

13.08.2026journal-article

Advanced Electromagnetics

Application of Conformer Architecture in Clinical Speech Input and Intelligent Medical Record Generation

X. K. Zou, L. Wang, J. Sun, S. Y. Guo, N. Li

Accurate clinical speech recognition remains challenging because rapid pronunciation, domain-specific terminology, and background noise often degrade automatic speech recognition and subsequent medical record generation. This study proposes a multi-stage intelligent documentation framework that integrates a 12-layer Conformer architecture, BERT-BiLSTM-CRF semantic modeling, and BART-based structured text generation. The Conformer encoder captures both local acoustic characteristics and long-range contextual depende …

13.08.2026journal-article

Frontiers in Psychiatry

Clay field therapy for complex PTSD: a single-case study with HRV measurement

Magali Démurger, Valentino Pomini

Introduction Complex post-traumatic stress disorder (CPTSD) is associated with dysregulation of the autonomic nervous system, measurable through heart rate variability (HRV); however, the impact of sensorimotor approaches on these markers remains poorly documented. This single-case study examines variations in HRV indices across a ten-session weekly protocol of Clay Field Therapy (CFT) in a 58-year-old woman with CPTSD (DSM-5, TEC, TADS-I) and multiple developmental traumas. The CFT process aligns with sensorimotor …

13.08.2026journal-article

BMC Public Health

Real-world outcomes of a multidisciplinary rehabilitation programme for adults with long COVID: a retrospective cohort study

Lanre Peter Daodu, Kim Nottingham, Yogini Raste, Judith E. Allgrove, Francesca I. F. Arrigoni, Reem Kayyali

Abstract Background Long COVID imposes a substantial and ongoing burden, with persistent symptoms affecting daily functioning and quality of life. Multidisciplinary rehabilitation has been widely implemented in clinical practice; however, evidence describing real-world patient outcomes and service delivery remains limited. This study aimed to describe clinical and patient-reported outcomes among adults participating in a structured multidisciplinary rehabilitation programme for Long COVID, and to explore the associ …

13.08.2026journal-article

PLOS One

Prevalence and determinants of soil transmitted helminth infections among children on Highly Active Antiretroviral Therapy (HAART) in Mulobezi and Sesheke Districts, Zambia: A cross – sectional study

Benjamin Mbonshi, Evans Mwape Kabemba, Collins Bowa

Background Soil-transmitted helminth (STH) infections are a major public health challenge in regions where they overlap with HIV/AIDS. Children with HIV may be especially vulnerable to STHs due to immunosuppression, yet the burden and drivers of this co-infection among those on antiretroviral therapy (ART) in Zambia are not well documented. This study aimed to determine the prevalence and identify the key determinants of STH infections among ART-treated children in Western (Mulobezi and Sesheke districts) Zambia. M …

13.08.2026journal-article

Indonesian Journal of Innovation Multidisipliner Research

Molecular Basis for the Adjuvant Potential of Nigella sativa–Derived Bioactive Constituents in Overcoming Resistance to Cancer Therapy

Nasywa Zahirah Yustin, Ghani Phalosa, Feby Anastasya Sirait

Resistance to cancer therapy remains a major cause of treatment failure, tumor recurrence, and disease progression because malignant cells can adapt through interconnected mechanisms involving prosurvival signaling, apoptosis suppression, drug efflux, epithelial–mesenchymal plasticity, cancer stemness, and the tumor microenvironment. This narrative review evaluates the molecular basis and adjuvant potential of Nigella sativa–derived bioactive constituents in overcoming resistance to conventional cancer therapies. R …

13.08.2026journal-article

BMC Health Services Research

Organizational determinants of psychological safety and occupational stress in healthcare: a phenomenological study in a tertiary health system

Ibrahim Alghamdi, Shadi Ashour

Abstract Background Modern healthcare ecosystems are shaped by rising service demands, structural workforce shortages, and heightened organizational complexity. While individual-level burnout has been widely evaluated, the underlying organizational determinants that systematically influence psychological safety and occupational stress require deeper investigation. This study explores how healthcare structures, leadership execution, and workload governance shape these dynamics within a transforming tertiary health s …

13.08.2026journal-article

Cell and Gene Therapy Insights

Reflecting on the evolution of gene therapy from good idea to mundane miracle

Paula Cannon

“Five years from now, when we have treated and cured many people with sickle cell disease, it will begin to feel mundane.” Abi Pinchbeck, Editor, Cell and Gene Therapy Insights, speaks with Paula Cannon, Distinguished Professor of Molecular Microbiology and Immunology, Keck School of Medicine of USC, about the evolution of gene therapy from a bold engineering challenge to an increasingly routine clinical reality. They discuss the financial and regulatory barriers to patient access, the field’s perceived image probl …

13.08.2026journal-article

Case Reports in Ophthalmology

Acute Orbital Inflammation Following Neridronate Therapy: A Case Report

Sofia Ginelli, Jennifer Cattaneo, Anna Bruno, Francesca Mojana, Simona Caprani, Stefano Ranno

Introduction Bisphosphonates are known to occasionally induce ocular and orbital inflammation. While most reported cases involve agents such as zoledronate or alendronate, reports associated with neridronate remain exceedingly rare. Early recognition is vital as this condition can be vision-threatening but typically responds well to treatment. Case Presentation We describe a 69-year-old man who developed fever and myalgia, followed by the abrupt onset of severe unilateral orbital inflammation 72 hours after receivi …

13.08.2026journal-article

Frontiers in Endocrinology

Central and peripheral areal BMD, bone microarchitecture, and strength after initiation of androgen deprivation therapy in men with prostate cancer: a two-year follow-up study

Marsha M. van Oostwaard, Melissa S.A.M. Bevers, Johanna H.M. Driessen, Caroline E. Wyers, Joop P. van den Bergh

Introduction Androgen Deprivation Therapy (ADT) in prostate cancer (PCa) is associated with bone loss and increased fracture risk. Previous studies on the effects of ADT on bone have focused on areal bone mineral density (aBMD) from dual-energy X-ray absorptiometry (DXA) at the central skeleton, while the effects on peripheral aBMD, bone microarchitecture, and bone strength are less well studied. Methods In this two-year observational study, we examined the changes in aBMD and volumetric BMD, bone area, microarchit …

13.08.2026journal-article

International Journal of Web of Multidisciplinary Studies

Healing effect of ultrasonic sound wave therapy in case of femoral osteochondritis disecans. A narrative review

Dr.Ashish Yadav, Dr.Sudhansu Bhusan Mangaraj

ABSTRACT Background: Osteochondritis dissecans is a condition in which a segment of articular cartilage with its underlying subchondral bone gradually separates from the surrounding bone. Aim: The study's objective is to assess the therapeutic benefits of conservative physiotherapy. In order to determine the persuasiveness of ultrasonic wave treatment's fundamental therapeutic effects, practice-based conservative physical therapy is ultimately required. This assessment demonstrates both the repair of cartilage and …

13.08.2026journal-article

Advanced Electromagnetics

Analysis on the Effect of Chinese Herbs Decoction Combined with Warm Acupuncture and Auricular Point Sticking Therapy on Insomnia Caused by Deficiency of Both Qi and Yin

L. Zhang, W. G. Xue, Y. Wang, H. X. Zhang, Y. Ma

Objective: This study investigates the therapeutic effect of Chinese herb decoction combined with warm acupuncture and auricular point sticking therapy on insomnia caused by deficiency of both Qi and Yin. Methods: A total of 104 patients with Qi-Yin deficiency-type insomnia admitted to the hospital from November 2023 to November 2024 are selected and randomly divided into Group A and Group B, with 52 cases in each group, using the random number table method. Group B receives routine Western medical treatment, while …

13.08.2026journal-article

Advanced Science

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu

ABSTRACT Cisplatin‐induced acute kidney injury (CI‐AKI) is a frequent, dose‐dependent complication in patients receiving cisplatin chemotherapy, and effective targeted treatments remain unavailable. The development of targeted therapies for CI‐AKI may improve the efficacy of chemotherapy while mitigating renal toxicity. Given that ferroptosis is a key pathological mechanism in CI‐AKI, targeted drug delivery systems against this process represent a promising therapeutic strategy. Dipeptidase 1 (DPEP1) is highly expr …

13.08.2026journal-article

Electronics

AS-Split Conformer: A Stage-Wise Convolution–Attention Framework with Mamba Decoder for End-to-End Speech Recognition

Lulu Qin, Xuan Fu, Mingchen Sun, Dadong Wang

Automatic speech recognition (ASR) systems based on Conformer architectures achieve strong performance by jointly modeling local acoustic patterns and global contextual dependencies. However, their interleaved convolution–attention design leads to progressive entanglement of fine-grained acoustic features and global semantic representations, which weakens monotonic alignment in speech recognition and degrades performance in long utterances. To address this limitation, we propose an AS-Split Conformer–Mamba framewor …

13.08.2026journal-article

Evidence-Based Dentistry

Chemically modified curcumin in periodontal therapy: a scoping review

Vishala Bhargavi Chilukuri, Rupali Agnihotri, Deepa G. Kamath

Abstract Aims/Objectives Periodontitis, a multifactorial chronic inflammatory disease that destroys the supporting structures of the teeth, is conventionally managed with treatments focusing on biofilm removal; however, these therapies do not fully address the dysregulated host response central to disease progression. To address this, chemically modified curcumin (CMC) analogues have been developed by modifying curcumin, a derivative of Curcuma longa , a host-modulating agent with potent anti-inflammatory and antio …

13.08.2026journal-article

Neurological Research and Practice

Guideline of the German Society of Neurology (DGN): "diagnosis and therapy of HIV-1-associated neurological disorders”

Katrin Hahn, Gabriele Arendt, Christian Eggers, Cristina Granziera, Matthias Maschke

Abstract Epidemiology and treatment of HIV changed substantially within the last three decades. However, HIV-associated neurological disorders such as mild forms of HIV-associated neurocognitive disorder (HAND) as well as HIV-associated distal symmetrical sensory polyneuropathy are amongst the most frequent complications in patients with longstanding HIV infection. Opportunistic infections occur less frequently compared to former years, but especially in patients with late presentation of HIV progressive multifocal …

13.08.2026journal-article

Frontiers in Neurology

Robot-assisted integrated cognitive-motor rehabilitation in patients with chronic stroke: a randomized controlled trial

Seungwoo Cha, Jiyeon Lee, Hyojin Jeon, Min Ho Chun

Background Cognitive and motor impairments are major determinants of functional independence after stroke. While robot-assisted training is effective for motor recovery, its impact on cognitive function through integrated cognitive–motor training remains less explored. This study evaluated the effects of an end-effector robot-assisted integrated cognitive–motor rehabilitation program on global cognitive function and upper limb motor outcomes in patients with chronic stroke. Methods In this single-center, randomized …