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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
04.08.2026journal-article

Journal of the Peripheral Nervous System

Burden and Treatment Preference of Probable Neuropathic Pain in 13 592 people: A Cross‐Sectional and Discrete Choice Experiment in the General Population in Malaysia

Wee‐Kiat Tan, Maznah Dahlui, Azhari Rosman, Hiang Leng Tan, Noraidah Guntalib, Siew Pheng Chan, Shalini Sree Dharan, Pei Chiek Teh, Daniel Yi Jie Wong, Kenny Tan, Solomon Tesfaye, Lee‐Ling Lim

ABSTRACT Background and Aim Neuropathic pain (NeuP) is widely underdiagnosed, and treatment‐related adverse events often drive nonadherence. We investigated the probable NeuP prevalence, symptoms recognition, and treatment preferences among the general population in Malaysia. Methods We utilized a digital ID‐Pain questionnaire across nine tertiary hospitals to screen for probable NeuP. We also designed a discrete choice experiment (DCE) to assess participants' ability to differentiate NeuP from nociceptive symptoms …

04.08.2026journal-article

Journal of the American Heart Association

Association of Accelerometer‐Derived Physical Activity with Incident Cardiovascular Diseases and Mortality in People With Severe Mental Illness

Jing Du, Xingya Lei, Qiang Wang, Hongliang Feng, Zezhi Li, Ruizhi Zhang, Yaping Liu, Jihui Zhang, Yujing Zhou, Yannis Yan Liang

Background Cardiovascular vascular disease (CVD) is a leading cause of increased mortality in people with severe mental illness (SMI). This study aims to examine the dose–response and intensity‐specific associations between physical activity (PA) and CVD risk and mortality in people with SMI. Methods This prospective cohort study was conducted on 6313 participants with SMI with accelerometry data from UK Biobank from February 2013 to November 2021. Moderate‐to‐vigorous PA (MVPA) was categorized into 2 groups (<150 …

04.08.2026journal-article

Journal of the American Geriatrics Society

Cognitive Potentially Inappropriate Medications, Quality of Life, and Healthcare Use in Older Adults With Cognitive Disorders

Haowen Hsu, Collin M. Clark, Steven Feuerstein, Robert G. Wahler, Ranjit Singh, David M. Jacobs

ABSTRACT Background Older adults with cognitive disorders, including dementia and mild cognitive impairment, are particularly vulnerable to adverse effects from centrally acting medications. Cognitive potentially inappropriate medications (CogPIMs), including anticholinergics, antipsychotics, benzodiazepines (BZDs), and non‐benzodiazepine hypnotics (Z‐drugs), may worsen well‐being and increase healthcare utilization in this population. This study evaluates CogPIMs exposure and its association with health‐related qu …

04.08.2026journal-article

Journal of Consumer Behaviour

Feeling Younger, Choosing Complexity: How Subjective Age Influences Older Consumers' Preference for Visual Complexity

Xintao Yu, Qing Gu, Xiaochen Liu, Yuangeng Guo, Ou Li

ABSTRACT As population aging accelerates worldwide, older consumers are emerging as an increasingly important consumer segment. However, age stereotypes suggest that, as people grow older, they become increasingly conservative and prefer simplicity. This study challenges this view by examining whether and how feeling younger shapes older consumers' preferences for visual complexity. Building on self‐concept consistency theory, this research develops a theoretical framework and tests it across four experiments invol …

04.08.2026journal-article

Genes

Integrated Single-Cell and Bulk RNA-Sequencing Analysis Identifies an Aging-Related Gene Signature for Prognosis in Breast Cancer

Pengcheng Chen, Yindan Lin, Jingjia Li, Yiwei Gu, Xueyun Zhang

Background: Cellular senescence exerts a complex influence on BRCA progression and TME remodeling. However, the specific roles of ASIGs in regulating the TME and determining patient outcomes remain unclear. Methods: Using TCGA (training), METABRIC (validation), and single-cell RNA-seq datasets, we systematically characterized ASIGs in BRCA. Prognostic ASIGs were identified to define molecular subtypes and construct a 17-gene LASSO-Cox risk model, which was integrated with clinical factors to develop a prognostic no …

21.08.2026journal-article

Journal of Antimicrobial Chemotherapy

Effectiveness of dolutegravir/lamivudine versus bictegravir/emtricitabine/tenofovir alafenamide in people with HIV with very high viral load (≥500 000 copies/mL)

Juan Martin-Torres, Roser Navarro-Soler, Judit Iglesias-Franco, María Lagarde-Sebastián, Otilia Bisbal-Pardo, David Rial-Crestelo, Adriana Pinto-Martínez, Maria Belén Sánchez-López, Mireia Santacreu, Laura Bermejo, Asunción Hernando, Rafael Rubio, Federico Pulido

Abstract Objectives To compare the effectiveness of dolutegravir/lamivudine (DTG/3TC) versus bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) at Week 48 in treatment-naive adults with high baseline viral loads (≥500 000 copies/mL) and CD4+ cell count ≥200/mm3 and to assess immune recovery and safety. Methods We conducted a single-centre retrospective cohort study including all ART-naive people with HIV-1 (PWH) and HIV-RNA ≥500 000 copies/mL and CD4+ ≥200 cells/mm3 who initiated DTG/3TC or BIC/FTC/TAF d …

04.08.2026journal-article

Frontiers in Aging

Ulcerative colitis (UC) in the elderly: diagnostic and therapeutic considerations

Łucja Wróbel, Ewa Małecka-Wojciesko

Ulcerative colitis (UC) demonstrates a bimodal incidence distribution, with a significant second peak and the highest prevalence observed in individuals aged ≥60 years. The pathogenesis of elderly UC involves immunosenescence—manifested by Th17/Treg imbalance and the accumulation of cells with a pro-inflammatory senescence-associated secretory phenotype (SASP)—alongside age-related dysbiosis, increased intestinal permeability, and mitochondrial dysfunction that impairs mucosal regeneration. Clinically, older patien …

04.08.2026journal-article

Journal of the Association of Nurses in AIDS Care

Effective Handling of Health Care Transition for Young People Living With HIV: A Consensus of Experts in Thailand Using Modified Delphi Method

Linda Aurpibul, Pope Kosalaraksa, Pradthana Ounchanum, Kulkanya Chokephaibulkit, Wipaporn Natalie Songtaweesin, Ratchaneekorn Khampan, Nichkamol Lertamornkitti, Thanyawee Puthanakit, on behalf of the Thai PAPAYA Study Team

Abstract The aim of our study was to develop consensus from experts and advocates on the health care transition for young people living with HIV from pediatrics to adult care in Thailand using a modified Delphi method. Participants included physicians (58%), nurses (20%), clinic coordinators (11%), and outreach workers (11%). Survey items were distributed to gather responses. Consensus was achieved after two rounds of surveys (response rates: 86% and 94.5%, respectively). Key priorities identified included (1) pedi …

04.08.2026journal-article

Annals of Indian Academy of Neurology

Ultrasound-Guided Greater Occipital Nerve Pulsed Radiofrequency for Chronic Headache in Adults Aged 65 Years and Older: A Retrospective Cohort Study

Sukriye Dadali, Gulcin Babaoglu, Ulku Sabuncu, Ali Costu, Ibrahim Asoglu, Erkan Yavuz Akcaboy

Abstract Background and Objectives: Managing chronic headache in older adults is complicated by multimorbidity and polypharmacy. This study evaluated 6-month clinical outcomes, tolerability, and response predictors following ultrasound-guided greater occipital nerve pulsed radiofrequency (GONPRF) in patients aged ≥65 years. Methods: This retrospective cohort study analyzed 152 patients undergoing ultrasound-guided GONPRF following a positive diagnostic block (≥50% relief). Pain intensity (numeric rating scale, NRS) …

04.08.2026journal-article

Translational Exercise Biomedicine

Enhancing functional longevity: sports medicine facing the challenges of an aging society

Fabio Pigozzi, Alessandro Scotto di Palumbo, Federica Fagnani, Giuseppe Massazza, Ugo Riba, Maurizio Casasco

Abstract Modern medicine has successfully extended human life expectancy, yet these additional years are frequently accompanied by chronic disease, functional decline, and loss of independence. This editorial introduces functional longevity as a clinically and socially meaningful framework for healthy aging, defined as the preservation of physical, cognitive, and psychosocial capacity across the lifespan. Moving beyond survival as the primary outcome of healthcare, functional longevity aligns with the World Health …

04.08.2026journal-article

Nutrients

Protein-Containing Breakfasts Are Associated with Reduced Postprandial Glycaemic Excursions in Children and Young People with Type 1 Diabetes: A Pragmatic Study

Julie Johnson, Victoria Franklin, Ashley Shepherd, Sonja Allen, Debbie Blissitt, Kate Keen, Kirsty Maclean, Anne-Marie McKillup, Elizabeth Procter, Susan Roach, Adele Swart, Stuart D. R. Galloway

Background/Objectives: This study examined whether adding 10 g of protein to a high glycaemic index (GI) breakfast could attenuate postprandial glycaemic responses in children and young people (CYP) with type 1 diabetes (T1D). Postprandial glucose responses following this modified breakfast were compared with those after a high GI breakfast alone, a low GI breakfast, and participants’ usual breakfast. Methods: A pragmatic randomised crossover study was conducted in n = 25 CYP aged 5–17 years. Participants consumed …

04.08.2026journal-article

PLOS Digital Health

Acceptance and impact of Technology-Enabled Care (TEC) among community-dwelling older adults: A rapid review

Abraham Sahilemichael Kebede, Ann-Marie Morrissey, Kevin Moore, Katie Crowley

Technology-Enabled Care (TEC) represents a broad approach to supporting older adults’ quality of life, ageing in place, and independent living using digital, assistive, monitoring and communication technologies. This review aimed to synthesise existing evidence on factors influencing TEC acceptability and impact among community-dwelling older adults. We employed a rapid review methodology guided by the PCC framework (Population: community-dwelling older adults 55 years and above and carers; Concept: TEC acceptabili …

04.08.2026journal-article

F1000Research

Effectiveness and Cost-effectiveness of Home-Based Occupational Therapy with Activity Monitoring for Daily Functioning of People Post-Stroke: Protocol for a Partially Randomised Usual Care Stepped-Wedge Trial

Sanne Pellegrom, Margriet Pol, Ton Satink, Margo van Hartingsveldt, Johanna Maria van Dongen, Gerben ter Riet, Bianca Buurman, Maud Graff

Background Transitioning from a geriatric rehabilitation centre or hospital to home is challenging for persons post-stroke, as they must increase their ability to perform daily activities and self-manage their lives. Moreover, persons post-stroke exhibit more sedentary behaviour at home than during rehabilitation, which is detrimental to their health. The Occupational Therapy at Home E-Rehabilitation (OTHER) intervention aims to increase daily activities and self-management in persons post-stroke. OTHER involves in …

04.08.2026journal-article

Frontiers in Endocrinology

Machine learning versus traditional regression models for predicting diabetic retinopathy screening adherence among community-dwelling older adults with diabetes

Yawen Wang, Lanting Xia, Guiling Geng, Chunxing Ge, Haiyan Shen, Xiangyun Qian

Background Diabetic retinopathy (DR) is a leading cause of preventable vision loss among patients with diabetes, yet screening adherence remains suboptimal. Existing studies have mainly focused on clinical or sociodemographic determinants, with limited evidence integrating psychological mechanisms. The application of Protection Motivation Theory (PMT)-based constructs combined with machine learning for predicting DR screening adherence remains underexplored in community populations. Objective This study compared ma …

04.08.2026journal-article

Journal of Addiction Medicine

The HPTN 094 Peer Navigation Model: Integration of Substance Use Treatment and HIV Prevention and Care for People Who Inject Drugs

Nabila El-Bassel, Steven Shoptaw, Brett Hanscom, Timothy Skalland, Albert Hasson, Cecile Denis, David Goodman-Meza, Irene Kuo, Jordan E. Lake, Rashaunna Redd, Amy M. Richards, Rahul Paul Choudhury, Melissa Cummings, Jayla Harris-Wisecarver, Jessica Fogel, Paul Richardson, Redonna Chandler, Laramie R. Smith, David Metzger, Philip Andrew, for the HPTN 094 Study Team

Objectives: To describe HPTN 094 study’s peer navigation (PN) intervention, implemented in 5 urban US cities among people who inject drugs (PWID) at risk for or living with HIV, including guiding theories, core components, navigator training, available services, implementation challenges, and implications for future PN intervention research dissemination. Methods: This 2-arm, randomized, open-label study assessed outcomes for PWID receiving integrated care services delivered in a mobile health unit that provided me …

04.08.2026journal-article

Journal of the American Geriatrics Society

Why Do Residents Pursue Fellowship Training in Geriatric Medicine?

Paula E. Lester, William Gold, Shahidul Islam

ABSTRACT Background Despite the important role of Geriatricians in our society, there is a shortage of Geriatric Medicine specialists. This study surveyed fellows enrolled in ACGME approved Geriatric Medicine fellowships in the United States for insight into why they joined a Geriatric Medicine fellowship. Methods Survey links were sent to all Geriatric Medicine Program Directors from July–Sept in 2019 and 2020 and we asked them to share the surveys with their fellows. Survey responses were summarized using descrip …

04.08.2026journal-article

Frontiers in Sports and Active Living

Perceptions and experiences of engagement and participation in physical activity among older adults aging with long-term spinal cord injury

Kristina Fagher, Jan Lexell, Sophie Jörgensen

Background Older adults aging with long-term spinal cord injury (SCI) are insufficiently physically active to reach health benefits. However, little is known about their perceptions of physical activity (PA) and barriers and facilitators to their PA engagement. Objectives To explore perceptions and experiences of engagement and participation in PA among older adults aging with long-term SCI. Methods We interviewed 74 men and women (56–88 years) from the Swedish Aging with Spinal Cord Injury Study (SASCIS) using a s …

04.08.2026journal-article

International Law Journal

Субъект права на самоопределение: понятие «народа» в международном праве

М.А. Мирова

статья посвящена одному из наиболее дискуссионных вопросов права народов на самоопределение – определению субъекта этого права, то есть содержанию понятия «народ» в международном праве. Цель исследования – выявить юридически значимые критерии, позволяющие отграничить «народ» как носителя права на самоопределение от смежных правовых категорий: населения существующего государства, коренных народов и национальных меньшинств. Задачи исследования включают анализ подготовительных материалов (travaux préparatoires) Междун …

04.08.2026journal-article

The Gerontologist

Beyond digital access: domains and breadths of everyday digital technology engagement and associations with cognition among older adults

Kun Wang, Zhuoru Ma, Mina Lee, Joonhyeog Park, Charles Johnson, Danan Gu

Abstract Background and Objectives This study identified latent domains and usage-breadth patterns of everyday digital technology (EDT) engagement among older adults and examined their concurrent and prospective associations with cognition. Research Design and Methods The analytic sample comprised 2,910 adults aged ≥65 who completed the 2020 Leave-Behind Questionnaire of the Health and Retirement Study. Exploratory and confirmatory factor analyses identified latent domains across 31 digital activities, and latent c …

04.08.2026journal-article

PLOS One

Influence of the timing of brief, high-intensity cycling exercise on memory for novel words presented during an initial Portuguese lesson among older adolescents with ADHD: An exploratory study

M. David Diggs, Daniel Ferreira da Silva, Robert Moser, Melissa J. McGranahan, Patrick J. O’Connor

This exploratory study examined whether brief high-intensity cycling exercise, performed either before or after a single online Portuguese language lesson, improved language acquisition or retention in older adolescents with ADHD, compared to a resting control condition. Participants (n = 29; mean age 19.2; no prior Portuguese knowledge) were randomly assigned to one of the three conditions: control, exercise before, and exercise after. The 29-minute Portuguese lesson introduced vocabulary, grammar, and syntax. Imm …

04.08.2026journal-article

Journal of the American Heart Association

Risk Factors for Coronary Heart Disease and Stroke Among Older Adults With Metabolic Dysfunction–Associated Steatotic Liver Disease: A Nationwide Cohort Study

Sangwook Cheon, Seohui Jang, Eun Seok Kang, Jihun Song, Jaewon Khil, Seokjin Kong, Yihyun Kim, Jin Hyun Park, Minjeong Kang, Jeongin Lee, Taeho Kwak, Hye Jun Kim, Jinhyeok Choi, Hwamin Lee, Seogsong Jeong

Background Older adults with metabolic dysfunction–associated steatotic liver disease have elevated cardiovascular disease (CVD) risk, yet conventional models, such as the Framingham Risk Score, rely on linear assumptions and were developed for younger populations. Nonlinear machine learning approaches may improve risk prediction in this high‐risk group. Methods Using Korean National Health Insurance Service data, this population‐based cohort study followed up 67 575 adults, aged ≥65 years, with metabolic dysfuncti …

04.08.2026journal-article

Psicologia e Saúde em debate

RESTRIÇÃO DOMICILIAR E VULNERABILIDADE SOCIOFUNCIONAL DE IDOSO COM LIMITAÇÃO FÍSICA: Estudo de caso na Atenção Primária

Maynara Ribeiro Mengatto, Mirian Dombrowski Dreher, Samira Fuck Yussuf, Maria Solange Ferreira Alves, Fabrício Cardoso

O envelhecimento populacional impõe desafios à Atenção Primária à Saúde, sobretudo quando limitações funcionais coexistem com vulnerabilidades sociais. Objetivo: Analisar as vulnerabilidades sociofuncionais identificadas em um idoso acompanhado pela Atenção Primária à Saúde, considerando a interação entre limitação funcional, barreiras ambientais e rede de apoio. Método: Estudo qualitativo, de natureza descritivo-exploratória, delineado como estudo de caso único e realizado em uma Unidade Básica de Saúde de Joinvil …

04.08.2026journal-article

Journal of Clinical Medicine

Motor-Sparing Regional Analgesia in Frail and Sarcopenic Older Adults Undergoing Total Knee Arthroplasty: From Anatomy to Clinical Decision-Making—A Narrative Review

Paweł Pietraszek, Tomasz Reysner, Anna Kluzik, Anna Perek, Justyna Marszałek-Buko, Alicja Bartkowska-Śniatkowska, Katarzyna Wieczorowska-Tobis, Malgorzata Reysner

Total knee arthroplasty (TKA) is increasingly performed in older adults, a population with a growing prevalence of frailty and sarcopenia. Analgesic strategies focused mainly on pain reduction may overlook mobility, functional independence, fall prevention, and delirium risk, making motor preservation a central goal of perioperative care. This narrative review examines the anatomical basis, clinical evidence, and practical application of motor-sparing regional analgesia for older adults undergoing TKA, with emphasi …