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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Exploring Science Academic Conference Series

Sensorimotor Closed-Loop Control in Post-Stroke Wrist-Hand Rehabilitation Robots: A Structured Narrative Review

Shengwei Chai

Post-stroke wrist-hand rehabilitation robots can increase training intensity, repetition, and measurement. Still, systems centered mainly on mechanical assistance may not fully address the sensorimotor impairments that constrain functional recovery. This structured narrative review examines how sensorimotor closed-loop control may reshape wrist-hand robotic rehabilitation by linking somatosensory feedback, voluntary motor effort recognition, and home-based translation. The review was informed by a PubMed-based lite …

26.08.2026journal-article

International Journal of Cognitive Sciences

A Systematic Review of Relationships Between Self-Directed Speech and Self-Processes

Cassidy Sterling, Alain Morin

Self-directed speech is a well-established aspect of human cognition, although its relationships with self-processes such as self-consciousness, self-rumination, mindfulness, self-concept clarity, and self-esteem remain poorly understood. The present study aimed to synthesize existing empirical findings to clarify how individual differences in self-directed speech relate to self-processes. Guided by PRISMA-informed systematic review procedures, this narrative review examined studies published between 2000 and 2025 …

26.08.2026journal-article

Frontiers in Rehabilitation Sciences

Factors of family-centered care associated with state anxiety in parents of children and adolescents with disabilities

Yasuaki Kusumoto, Nobuaki Himuro, Yuta Sasaki, Eri Takahashi, Dai Iwase, Yukie Metoki, Kounosuke Tomori

Objective This study compared the family situations, specifically parents' perceptions of receiving family-centered care and their children's behavioral difficulties, among four parental groups classified by their combinations of state and trait anxiety levels, and investigated factors associated with state anxiety in parents of children and adolescents with disabilities. Methods Cross-sectional data of 95 parents of children and adolescents admitted as outpatients were analyzed. Responses were collected to the Sta …

26.08.2026journal-article

International Journal of Contemporary Pediatrics

Balanced crystalloids versus normal saline for fluid therapy in pediatrics diabetic ketoacidosis: a systematic review

Danny Alsalloum, Prabhakar Patil

Fluid therapy is a cornerstone of management in paediatric diabetic ketoacidosis (DKA). Although normal saline has traditionally been the preferred resuscitation fluid, concerns regarding hyperchloremic metabolic acidosis have led to increasing interest in balanced crystalloids such as Ringer’s lactate and Plasma-lyte. However, evidence regarding their efficacy and safety in children with DKA remains limited and has not been comprehensively synthesized. A systematic review of the literature was conducted to evaluat …

26.08.2026journal-article

Nature Communications

Human iPSC-cardiomyocyte-aggregate cell therapy in non-human primates and correlation of heart recovery with contractile and electrophysiological cardiomyocyte properties

Ina Gruh, Andreas Martens, Serghei Cebotari, Annette Schrod, Alexandra Haase, Caroline Halloin, Wiebke Triebert, Nils Kriedemann, Tobias Goecke, Morsi Arar, Klaus Hoeffler, Paul Frank, Karen Lampe, Amir Moussavi, Anna Kuleshova, Vojtech Hradil, Veronika Fricke, Monika Szepes, Kerstin Mätz-Rensing, Jörg Eiringhaus, Anna-Lena de Vries, Stephan Hohmann, Merlin Witte, Tim Kohrn, Jana Teske, Kevin Cyrys, Sara Szadocka, Annika Franke, Christopher Werlein, Karlo Komorowski, Mark Kühnel, Danny Jonigk, Susann Boretius, Christian Veltmann, David Duncker, Jonathan Jung, Nissim Benvenisty, Jeanne de la Roche, Martin Fischer, Axel Haverich

Abstract This study demonstrates the successful production and injection of human induced pluripotent stem cell cardiomyocyte aggregates into infarcted cynomolgus monkey hearts, resulting in substantial, structured human grafts three months after cell transplantation. Transient graft-induced arrhythmias decreased over time. Both the arrhythmogenicity and the substantial heart function recovery in vivo notably seemed to correlate with induced pluripotent stem cell clone-dependent contractile and electrophysiological …

26.08.2026journal-article

JMIR Serious Games

Effects of Virtual Reality–Based Intervention Combined With Conventional Therapy on Upper-Limb Function in Children With Hemiplegic Cerebral Palsy: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Chengqian Feng, Yang Li, Letian Cheng, Baizhen Xiong, Zhicheng Lin, Caihua Huang

Background Hemiplegic cerebral palsy (CP) commonly affects upper-limb function in children and may limit functional use of the affected arm and hand. Virtual reality (VR)–based rehabilitation can provide interactive, feedback-based, and task-oriented practice, but whether adding VR-based intervention to conventional therapy provides additional benefits remains uncertain. Previous reviews have often included broader CP populations, mixed comparators, or broad upper-limb outcome labels, limiting domain-specific inter …

26.08.2026journal-article

Modern Therapy in Psychiatry and Neurology Journal

On the issue of verification of post-traumatic stress disorder and readaptation of patients

Nadezhda Kravchenko, Oksana Suetina

The article discusses different points of view on some clinical aspects of post-traumatic stress disorder, the difficulties of its unambiguous verification, as well as the psychological problems of participants in armed conflicts that arise when they return to civilian life.

26.08.2026journal-article

Cancer Medicine

Diagnostic BMI and Induction Therapy Weight Change Associated With Hepatotoxicity in Pediatric Patients With Acute Lymphoblastic Leukemia

Emily J. Mason, John P. Woodhouse, Jeremy M. Schraw, Joanna S. Yi, Karen R. Rabin, M. Monica Gramatges, Mark C. Zobeck, Baojiang Chen, Melissa B. Harrell, Olga A. Taylor, Michael E. Scheurer, Philip J. Lupo, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin Brown

ABSTRACT Background Hepatotoxicity is a common treatment‐related complication in pediatric acute lymphoblastic leukemia (ALL). Excess adiposity at diagnosis has been identified as a risk factor, but the impact of weight change during therapy has not been examined. Methods We included patients aged 2–20 years newly diagnosed with ALL between 2005 and 2021. Hepatotoxicity was defined as: (1) transaminitis (ALT/AST > 10× the upper limit of normal), or (2) conjugated hyperbilirubinemia (cbili; > 3.0 mg/dL during induct …

26.08.2026journal-article

Frontiers in Oncology

Construction and internal validation of a risk prediction model for rapid bone loss during aromatase inhibitor therapy

Renda Jiang, Luning Wu, Liangying Zhao, Jiang Wang, Dalei Chen, Lingqiao Hu, Shiyu Wu, Chaoqun Chen, Guinv Hu

Purpose To establish and validate a risk prediction model for identifying hormone receptor-positive breast cancer patients at high risk of aromatase inhibitor-associated rapid bone loss. Methods This single-center retrospective study enrolled 247 patients receiving aromatase inhibitor (AI) therapy between 2016 and 2025. Rapid bone loss, defined as an annual bone mineral density (BMD) loss rate greater than 4% at either the lumbar spine or total hip, was the primary outcome. Predictor selection was conducted using t …

26.08.2026journal-article

Frontiers in Psychiatry

A pilot randomized controlled study of a digital art therapy paradigm for children with ASD: integrating pivotal response treatment into video animation and physical model design

Huili She, Xinyi Dai, Ting Deng, Ruhao Liu, Wenting Jiang, Xufeng Ma

Background The integration of digital technology into art therapy for children with autism spectrum disorder (ASD) represents an emerging trend, yet systematic design frameworks that translate evidence-based interventions into digital media remain underdeveloped. This study developed and evaluated a digital art therapy paradigm that structurally integrates pivotal response treatment (PRT) into video animation design while maintaining cross-media consistency with physical generalization tools. Methods Based on the b …

26.08.2026journal-article

Journal of Clinical Medicine

Cardiac Rehabilitation in Heart Failure: Evidence, Coverage, and Implementation

Pushan Aggarwal, Aishwarya Yannamani, Jyoti Jain, Ilija Klipa, Andrew Oehler, Hayah Kassis-George

Cardiac rehabilitation (CR) is a multicomponent secondary prevention intervention that improves functional capacity and quality of life across cardiac diagnoses, yet remains markedly underused in heart failure (HF). Existing reviews treat efficacy, coverage, delivery, and equity separately; this narrative review integrates them to clarify why uptake in HF remains low despite an established evidence base. We searched PubMed/MEDLINE and the Cochrane Library from January 2009 through December 2025, prioritizing clinic …

26.08.2026journal-article

Health Affairs Scholar

Cost and Utilization Outcomes of Pharmacist-Led Medication Therapy Optimization in a Medicare ACO Population

Hazem F Elewa, Joseph F Levy, Chintan Pandya, Steven E Goldberg, Travis A Morgan

Abstract Introduction Medication-related problems are a persistent source of avoidable spending among Medicare beneficiaries, presenting an important opportunity to improve the quality of care for seniors and reduce financial burden on the Medicare program. Methods We evaluated a pharmacist-led medication therapy optimization (MTO) program implemented in a Medicare accountable care organization population using a regression-adjusted difference-in-differences design with propensity score matching. The analysis inclu …

26.08.2026journal-article

Thoracic Cancer

Validity and Feasibility of the Constant‐Load Cycle Endurance Test in Lung Cancer Patients Undergoing Radiation Therapy

Junghwa Do, Sungeun Park, Sei Won Lee, A. Hyun Kim, Sang Ah Kim, Seung Hak Lee, Hwayeong Cheon, Jae Yong Jeon

ABSTRACT Purpose This study evaluated the validity of the constant‐load cycle endurance test (CET), performed at 75% of maximal power output, in patients with lung cancer undergoing radiation therapy. Its feasibility, responsiveness to pulmonary rehabilitation (PR), and clinical applicability were also examined. Methods Thirty‐three patients participated in a 4‐week PR program during radiation therapy. CET time was compared with the 6‐min walk test (6MWT) to assess concurrent validity. Patients were stratified by 6 …

26.08.2026journal-article

European Journal of Heart Failure

The C-MIC II Follow-Up Study: Safety and Efficacy Results 12 months After Deactivation of Cardiac Microcurrent Therapy

Jesus E Rame, Dragana N Kosevic, Tamara Kovacevic-Preradovic, Sasko Jovev, Marija Zdravkovic, Nermir Granov, Tanja Popov, Igor Rudez, Petar Vukovic, Velibor Ristic, Annette Holtdirk, Tim Friede, Muhammad Shahzeb Khan, Miodrag Peric, Faouzi Kallel, Marat Fudim, Stefan D Anker

Abstract Background The C-MIC II trial demonstrated benefits of 6 months of cardiac microcurrent (C-MIC) therapy in patients with non-ischemic heart failure with reduced ejection fraction (HFrEF). The prospective C-MIC II Follow-Up Study evaluates safety and efficacy outcomes post-device deactivation. Methods Primary safety-related endpoints included all-cause, cardiovascular and device-related mortality and hospitalizations and adverse events (AEs). Secondary efficacy-related endpoints included changes in left ven …

26.08.2026journal-article

Equine Veterinary Journal

Spatial and temporal radiation exposure during equine bone scintigraphy: Implications for occupational safety and post‐scintigraphy isolation

Mahmoud Mageed, Shahlaa Dyab, Maciej Przewoźny

Abstract Background Bone scintigraphy is a valuable diagnostic modality in equine orthopaedics, but it is associated with occupational radiation exposure and regulatory requirements for post‐procedural isolation. Objectives To quantify radiation dose rates emitted from horses undergoing bone scintigraphy, to evaluate the effects of distance (spatial) and time (temporal) on radiation exposure, and to derive evidence‐based recommendations for post‐scintigraphy isolation periods. Study Design Prospective, cross‐sectio …

26.08.2026journal-article

Frontiers in Oncology

Comparative evaluation of TACE-RFA versus monotherapies on a background of systemic therapy for recurrent hepatocellular carcinoma: a propensity score-matched analysis

Wendi Zhang, Zuhao Ye, Jinfa Wang, Xia Ren, Liping Ying, Yifeng Wu, Zongyang Wu, Chang Xin, Jiye Feng

Background The optimal locoregional treatment for recurrent hepatocellular carcinoma (rHCC) in the era of potent systemic therapy remains undefined. This study aimed to compare the efficacy, safety, and resource consumption of transarterial chemoembolization combined with radiofrequency ablation (TACE-RFA) versus TACE or RFA monotherapy, specifically when administered on a uniform background of systemic therapy (Lenvatinib plus PD-1 inhibitors). Methods We retrospectively reviewed 243 patients with rHCC who met str …

26.08.2026journal-article

Haemophilia

Effects of Manual Therapy and Structured Exercises on Postural Balance and Walking Capacity in Adults With Haemophilia

Ayşe Merve Tat, Necati Muhammed Tat, Pervin Yeşiloğlu Kılıçlar, Ali Doğan

ABSTRACT Introduction Haemophilic arthropathy (HA) impairs joint health, walking capacity, and postural balance in adults with haemophilia (AwH). Evidence regarding the combined effects of manual therapy and structured exercise on postural balance remains limited. Aim To investigate the effects of manual therapy combined with structured exercise on joint health, activity‐related pain, walking capacity, and static and dynamic balance in AwH. Methods This randomized controlled trial included 35 AwH (control group [CG …

26.08.2026journal-article

Journal of Endovascular Therapy

The Role of Intravascular Ultrasound in Aortoiliac Endovascular Interventions: International Expert-Based Delphi Consensus

Pietro Dioni, Luca Bertoglio, Filippo D’Amico, Eric A. Secemsky, Mohamad A. Hussain, Marc L. Schermerhorn, Michele Antonello, Yamume Tshomba, Stefano Gennai, Giovanni Pratesi, Mark Farber, Vincent Jongkind, Jörg Tessarek, Andrew Holden, Christopher Delaney, Kevin Mani, Erin C. Saricilar, Enrico Gallitto, Manar Khashram, Glenn Wei Leong Tan, Nuno V. Dias, Barend Mees, Ross Milner, Michele Piazza, Thomas Maldonado, Gustavo S. Oderich, Tilo Kölbel, Giovanni Tinelli, Adam W. Beck, Thodur Vasudevan, Alexander Oberhuber, Stefano Bonardelli, Sandro Lepidi, Mario D’Oria

Introduction: Intravascular ultrasound (IVUS) provides cross-sectional information on the intraluminal features of blood vessels, aiding procedural planning and postprocedural assessment of results. Although the use of IVUS in aortic procedures is increasing worldwide, consensus on best practices in aortoiliac interventions is still lacking. This study aims to obtain experts’ consensus and define recommendations regarding applications of intravascular ultrasound in aortoiliac endovascular interventions Methods: Del …

26.08.2026journal-article

Modern Therapy in Psychiatry and Neurology Journal

The mosaic of older mental disorders

Nataliya Petrova

The review provides statistical data on the prevalence of psychiatric disorders of various etiologies in elderly patients. The variants of clinical comorbidity are described and recommendations for safe pharmacotherapy are given. Special attention is paid to the original antipsychotic tiaprid (Tiapridal®, Sotex), which is used to correct behavioral disorders in mental disorders and organic lesions of the central nervous system. Clinical targets for tiaprid are aggression, irritability, and psychomotor agitation. Th …

26.08.2026journal-article

Medical Sciences

Extracellular Vesicles at the Interface of Cancer Therapy and Regenerative Medicine: Biology, Bidirectional Roles, and Engineered Therapeutics

Jun-Hyeog Jang

Extracellular vesicles (EVs), including exosomes and microvesicles, are nanoscale membrane-enclosed particles that transfer proteins, lipids, mRNAs, and microRNAs between cells. The same communication system is now being developed in two apparently opposing settings: mesenchymal stem/stromal cell (MSC)-derived EVs are explored as cell-free regenerative therapeutics, whereas tumor-derived EVs can promote metastasis, immune evasion, and treatment resistance while also serving as liquid-biopsy biomarkers. Rather than …

26.08.2026journal-article

DEN Open

Apparent Endoscopic Decrease in the Size of a Large Ulcerated Gastric Schwannoma After Helicobacter pylori Eradication Therapy: A Case Report

Takahito Awatsu, Daisuke Asaoka, Hirofumi Fukushima, Daishi Kabemura, Yusuke Nomoto, Osamu Nomura, Kazunori Kajino, Mariko Hojo, Akihito Nagahara

ABSTRACT Gastric subepithelial lesions (SELs) comprise a heterogeneous group of tumors, among which gastric schwannomas are rare and generally benign. We report a case of a large gastric schwannoma with ulceration and symptomatic anemia that showed an apparent endoscopic decrease in size following Helicobacter pylori eradication. An 85‐year‐old man presented with iron deficiency anemia. Esophagogastroduodenoscopy revealed a large ulcerated SEL in the lower body of the stomach, along with multiple gastric ulcers. En …

26.08.2026journal-article

Applied Sciences

Biomechanical Responses to a Six-Week Sport-Specific Physiotherapy Programme in Elite Male Flatwater Kayakers: A Prospective Controlled Cohort Study

Zoltán Bejek, Eszter Kővári, Mónika Horváth, Ágnes Mayer, Erzsébet Tóth-Jova, Bernadett Kertész

Background: Biomechanical evidence concerning sport-specific physiotherapy in elite kayaking remains limited. Objective: This study aimed to evaluate joint range of motion (ROM), muscle activation, and bilateral footrest force before and after a six-week physiotherapy programme. Methods: Twenty-two elite male kayakers participated in a non-randomised prospective controlled cohort study (study group, n = 11; control group, n = 11). Three-dimensional motion analysis, surface electromyography, and footrest-force measu …

26.08.2026journal-article

European Journal of Endocrinology

Sustained shrinkage of bilateral adrenal adenomas during long-term osilodrostat therapy

Erika Messina, Martina Romanisio, Antonio Gigante, Cinzia Parola, Lorenzo Cantore, Soraya Puglisi, Federica Solitro, Maurizio Balbi, Andrea Veltri, Massimo Terzolo, Giuseppe Reimondo

Abstract Introduction Surgery remains the first-line therapy for all forms of Cushing syndrome; medical therapy may be appropriate when surgery is not feasible or as adjunctive therapy in severe hypercortisolism. Case presentation A 70-year-old woman was hospitalized for hemorrhagic shock due to massive abdominal bleeding. Abdominal CT scan detected bilateral adrenal masses. Hormonal evaluation revealed ACTH-independent hypercortisolism. Given her frail condition, medical treatment was started while surgery was def …