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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

PD03.05. Comparison of Laparoscopic and Robotic Heller Myotomy With Fundoplication for Achalasia Treatment: A Randomized Clinical Trial - Preliminary Results

Arthur Youssif Mota Arabi, Sergio Szachnowicz, Edno Tales Bianchi, Ary Nasi, Camila Maria de Camara, Ricardo Zugaib Abdalla, Rubens Antonio Aissar Sallum, Ulysses Jr Ribeiro, Paulo Herman

Abstract Topic Benign Disease: Esophageal Surgery Background Achalasia is an esophageal motor disorder characterized by impaired lower esophageal sphincter relaxation and aperistalsis, often associated with Chagas disease in Brazil. Heller myotomy with fundoplication is the gold standard treatment. However, randomized trials comparing laparoscopic and robotic approaches regarding the main postoperative aspects remain scarce in the literature. Methods This open-label randomized controlled trial is conducted at a Bra …

22.08.2026journal-article

Diseases of the Esophagus

P1.236. Surgical Decision Model for Elderly Patients With Esophageal Cancer: Development and Validation of a Geriatric Stage (gStage) System

Yasue Kimura, Naomichi Koga, Rena Yokomizo, Munehide Terashi, Ayako Iwanaga, Masahiko Sugiyama, Masaru Morita

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The increasing age of patients with esophageal cancer poses significant challenges in surgical decision-making. Elderly individuals frequently present with multimorbidity, impaired physiological reserve, and nutritional vulnerability, all of which increase postoperative risk. Chronological age and performance status alone are insufficient to determine surgical eligibility. A structured approach incorporating mu …

22.08.2026journal-article

Diseases of the Esophagus

OA03-RF01.01. Patterns and Predictors of Recurrence in Patients With Esophageal Cancer Who Achieve Pathological Complete Response to Multimodal Therapy

Yuxin Yang, Zhigang Li

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Neoadjuvant chemoradiotherapy (nCRT) and chemoimmunotherapy (nICT) are increasingly used for locally advanced esophageal squamous cell carcinoma. Although pathological complete response (pCR) is associated with favorable survival, nearly one third of pCR patients still experience recurrence. This study aimed to identify risk factors and recurrence patterns in this population. Methods We retrospectively reviewed 392 patients who achieve …

22.08.2026journal-article

Effective Pharmacotherapy

Triple-Negative Breast Cancer: a Historical Retrospective of the Treatment Issue (Literature Review)

Kursk State Medical University, O.G. Frolova, V.V. Khvostovoy, O.I. Karaban, G.E. Ostroverkhov Oncological Research and Clinical Center, Kursk, D.V. Petrochenko

Breast cancer (BC) ranks first among malignant diseases in women worldwide, remaining a significant medical and socio-economic challenge. Triple-negative breast cancer (TNBC) is an aggressive and biologically heterogeneous subtype of BC characterized by the absence of estrogen, progesterone, and HER2 receptor expression. Despite considerable progress in the diagnosis and treatment of TNBC, there is currently an upward trend in morbidity and mortality rates, which is associated with the aggressiveness and heterogene …

22.08.2026journal-article

Scientific Reports

Tumor-specific co-expression of ACTB and miR-138-5p in colorectal adenocarcinoma

Nina Jankowska, Zuzanna Dąbrowska, Alicja Petniak, Tomasz Skoczylas, Aleksander Ciechański, Janusz Kocki, Paulina Gil-Kulik

Abstract Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancer-related mortality worldwide. The ACTB gene, traditionally considered a reference gene, exhibits transcriptional instability in colorectal cancer tissues. The primary aim of this study was to confirm ACTB instability in different tissue compartments (tumor, peritumoral region, and controls). A secondary research aim was to investigate cross-sectional associations between ACTB expression and variabl …

22.08.2026journal-article

International Journal of Cancer

Urinary and Faecal Amino‐Acids as Biomarkers for Colorectal Neoplasia in Lynch Syndrome—A Prospective Longitudinal Study

Roza C. M. Opperman, Elsa L. S. A. van Liere, Animesh Acharjee, Sudip Mondal, Eduard A. Struys, Andreas Antoniadis, Jasmijn E. B. de Boer, Shivra R. Siriram, Abdellatif Bakkali, Sofie Bosch, Maarten A. J. M. Jacobs, Jan Jacob Koornstra, Johan P. Kuijvenhoven, Monique E. van Leerdam, Manon C. W. Spaander, Tim G. J. de Meij, Evelien Dekker, Dewkoemar Ramsoekh, Nanne K. H. de Boer

ABSTRACT In Lynch syndrome, colonoscopy surveillance for colorectal cancer (CRC) is burdensome and post‐colonoscopy CRCs still occur. Unlike the faecal immunochemical test (FIT), gut metabolomic alterations including amino‐acids have shown potential as non‐invasive biomarkers for detecting both advanced and non‐advanced sporadic colorectal neoplasia. We aimed to evaluate the potential of faecal and urinary amino‐acids to refine colonoscopy surveillance in Lynch syndrome. Individuals with Lynch syndrome collected fa …

22.08.2026journal-article

Diseases of the Esophagus

P1.158. Clinical Performance of a Liquid Fiducial Marker for Preoperative Marking of the Optimal Resection Line in Gastroesophageal Cancer Surgery

Andreas Weise Mucha, Trygve Ulvund Solstad, August Adelsten Olsen-Nedergaard, Mette Kjølhede Nedergaard, Rajendra Singh Garbyal, Hanne Grossjohann, Michael Patrick Achiam

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Esophageal and gastroesophageal junction cancers have a poor prognosis despite improvements in curative treatment. Achieving microscopically cancer-free resection margins is essential for long-term outcomes, yet a substantial risk of microscopic positive margins remains. Neoadjuvant therapy can render tumors macroscopically undetectable, potentially increasing this risk. This study aimed to evaluate the performance and safety of a …

22.08.2026journal-article

Diseases of the Esophagus

P1.005. Preliminary Pilot Study Cohort Results - Cost-Effective Surveillance Strategies and Prediction of Cancer Recurrence After Endoscopic Therapy for Barrett’s Esophagus (Endeavor)

Martin Wyckmans, Rene Thieme, Rui Neves, Jennifer Kluczny, Henrik Maltzman, Fredrik Klevebro, Nikolas Stoecklein, Federica Ungaro, Alberto Barchi, Jacintha O'Sullivan, Dermot O'Toole, Jessie Elliott, Guillaume Piessen, Julien Branche, Veerle Coupé, Marjolein Greuter, Piotr Twardowski, Thomas Botelberge, Guido Van Hal, Costanza Di Patrizi, Nastaran Riahi Dehkordi, Dominiek De Wulf, Stefan Van Dongen, Ann Driessen, Elisabeth Macken, Souad Bouhadan, Pieter Dewint, Sanne Hoefnagel, Michael Achiam, Laser Bazancir, David Tate, Magnus Nilsson, Sheila Krishnadath

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dysplasia to early and invasive adenocarcinoma [2]. Endoscopic treatment is the mainstay for early mucosal cancer (T1a/b) but requires intense post-treatment surveillance [3]. This results in overtreatment in most, and undertreatment in only a su …

22.08.2026journal-article

Diseases of the Esophagus

P1.168. Lymph Node Metastatic Patterns and Therapeutic Value Index in Esophagogastric Junction Cancer: Esophageal Invasion Length and Neoadjuvant Chemotherapy

Koki Fujiwara, Satoru Matsuda, Kensuke Takebe, Yosuke Morimoto, Kazuaki Matsui, Masashi Takeuchi, Hirofumi Kawakubo, Yuko Kitagawa

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background The surgical approach and extent of lymph node (LN) dissection for esophagogastric junction (EGJ) carcinoma are stratified by the length of esophageal invasion (EIS); however, inter-institutional variation remains. We investigated LN metastasis patterns, the therapeutic value index (TI), and the impact of neoadjuvant chemotherapy (NAC) to optimize mediastinal LN dissection at our institution. Methods We retrospectively reviewed 111 …

22.08.2026journal-article

Diseases of the Esophagus

PD05.04. Clinical Value of Tumor and Host Metabolic Dynamics on Serial 18F-FDG PET in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma

Kuan-Yin Ko, Ta-Chen Huang, Chien-Huai Chuang, Chih-Hung Hsu, Jhe-Cyuan Guo, Hung-Yang Kuo, Chia-Chi Lin, Tsung-Che Wu, Jason C Cheng, Feng-Ming Hsu, Pei-Ming Huang, Jang-Ming Lee

Abstract Topic Esophageal Cancer: New Diagnostic Modalities (Including PET, PET-CT, New Tracers) Background We evaluated whether serial 18F-FDG PET–derived metabolic changes in tumor and host response are associated with pathologic complete response (pCR) and survival in patients with locally advanced resectable esophageal squamous cell carcinoma (ESCC), addressing the limited ability of baseline-to-preoperative PET response to detect substantial residual disease and to differentiate viable tumor from post-treatmen …

22.08.2026journal-article

Diseases of the Esophagus

P1.088. Reduced-Dose Cisplatin-Based Preoperative Chemotherapy vs. Surgery Alone for Cisplatin-Unfit Esophageal Cancer: A Multicenter Retrospective Study in Japan

Shota Fukuoka, Taisuke Hosokai, Motoo Nomura, Toru Kadono, Akitoshi Hakoda, Shun Yamamoto, Shigenori Kadowaki, Takeshi Yamashita, Kunihiro Fushiki, Kazuhiro Shiraishi, Yuta Sato, Kohei Kanamori, Yohei Ozawa, Atsushi Takeno, Masaaki Iwatsuki, Yuta Ibuki, Yusuke Amanuma, Kazuma Sato, Ryoma Haneda, Hisahiro Matsubara, Takeo Bamba, Hiroo Hiratsuka, Hisashi Fujiwara, Takashi Ogata, Yoshito Komatsu, Hiroshi Ichikawa, Takashi Ohta, Hiroaki Nagano, Satoru Matsuda, Hiroya Takeuchi, Ken Kato

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Based on the results of the JCOG1109 trial, preoperative chemotherapy with docetaxel, cisplatin, and fluorouracil followed by radical resection is the standard of care for resectable esophageal squamous cell carcinoma (ESCC). However, a standard strategy has not been established for patients excluded from JCOG1109, such as those aged 76 or older or those with organ dysfunction. This study aimed to compare the efficacy and safety of pre …

22.08.2026journal-article

Current Oncology

Treatment Patterns and Prognostic Nomograms for Overall Survival and Hepatic Progression-Free Survival in Unresectable Colorectal Liver Metastases Treated with Drug-Eluting Bead Chemoembolization: A Single-Center Study

Ketong Wu, Haiyang Chen, Dan Li, Yuan Wan, Weiyao Li, Bo Zhang

(1) Background: Drug-eluting bead transarterial chemoembolization (DEB-TACE) is increasingly used for unresectable colorectal liver metastases (CRLM), yet individualized prognostic tools are lacking. We developed and internally validated nomograms predicting overall survival (OS) and hepatic progression-free survival (hPFS). (2) Methods: In this single-center retrospective cohort, reported per the TRIPOD guideline, OS and hPFS were estimated by Kaplan–Meier methods, and independent predictors from multivariable Cox …

22.08.2026journal-article

Diseases of the Esophagus

P1.098. Significance of COX2 Expression in Esophageal Cancer

Naoki Hashimoto

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background The focus of studies on cyclooxygenase-2 (COX2) have been on its ability to mediate the biological behavior of human tumors including tumorigenesis, tumor progression, apoptosis and differentiation. The aim of the current study was to elucidate a further finding on the clinicopathologic significance of immunohistochemical expression of COX2 in esophageal squamous cell carcinoma. Methods The immunohistochemical expression of COX2 was examined f …

22.08.2026journal-article

Diseases of the Esophagus

P1.133. Strengthening the Host Before Surgery: Role of Immunonutrition in Esophagectomy for Esophageal Cancer

Shivangi Sharma, Cherring Tandup, Lasya Reddy, lileswar Kaman, Satish subbiah Nagaraj, Jayanta Samanto, Shibojit Talukdar, Swapnesh kumar Sahu

Abstract Topic Esophageal Cancer: Other Background Esophageal cancer commonly presents with dysphagia and malnutrition. Esophagectomy following neoadjuvant chemoradiation is the standard treatment for locally advanced disease but is associated with significant postoperative morbidity. Immunonutrition may improve immune response and reduce postoperative complications. Methods This prospective comparative study included 36 patients with squamous cell carcinoma of the esophagus who underwent neoadjuvant chemoradiation …

22.08.2026journal-article

Diseases of the Esophagus

V-25. Lateral Decubitus Position Vats Esophagectomy With Demonstration of Supracarinal Node Dissection for Cancer Esophagus

Abhishek Jain

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Video Description This video demonstrates a extensive and aggressive supracarinal mediastinal lymph node dissection in a case of Lateral decubitus position VATS Esophagectomy for cancer esophagus. VATS Esophagectomy in Lateral position is less commonly performed in Indian Subcontinent but we have experience of over 300 such cases so far. Hence this video demonstrates the quality of bilateral recurrent Nerve nodes dissection being …

22.08.2026journal-article

Diseases of the Esophagus

OA04.2. Single Cell Transcriptomic and T-Cell Receptor Diversity Analysis of Peripheral Blood Lymphocytes Comparing Proton Versus Photon-Based Chemoradiation in Esophageal Cancer

Steven Lin, Chen Braun, Ye Lin Son, Min Wang, Clemens Grassberger, Jacob Smith, Patrick Reeves, Ada Argueta, Ryan Park, Harald Paganetti, Theodore Hong, Mark Poznansky, Radhe Mohan

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Radiation-induced lymphopenia (RIL) is a common toxicity during and after chemoradiation (CRT) but can be significantly mitigated with proton therapy (PT). The objective of this study is to determine if quantitative sparing of lymphocytes could also result in qualitative improvements in lymphocytes after CRT with PT compared to photons in esophageal cancer patients. Methods Patients were prospectively enrolled for longitudinal blood collection …

22.08.2026journal-article

European Radiology

Quantitative dynamic contrast-enhanced magnetic resonance imaging for early assessment of treatment response in pancreatic ductal adenocarcinoma

Martin D. Holland, Ezinwanne E. Onuoha, Darryl Outlaw, Mehmet Akce, Midhun Malla, Salila Hashmi, Sushanth Reddy, J. Bart Rose, Desiree E. Morgan, Grant R. Williams, Moh’d Khushman, Dana B. Cardin, Katherine Frederick-Dyer, Xiaoyu Jiang, Zarine K. Shah, Bassel El-Rayes, Junzhong Xu, Harrison Kim

Abstract Objectives To prospectively evaluate whether quantitative DCE-MRI can predict early chemotherapy response in pancreatic ductal adenocarcinoma (PDAC), and to assess the added value of a point-of-care portable perfusion phantom (P4) for correcting scanner-dependent errors. Materials and methods Fifty-four patients with biopsy-confirmed PDAC were prospectively enrolled at two institutions; 42 completed MRI scans at baseline (1 ± 1 weeks before chemotherapy) and 7 ± 2 weeks after treatment initiation. P4s were …

22.08.2026journal-article

Diseases of the Esophagus

P1.234. Analysis of Prognostic Factors in Elderly Patients Following Minimally Invasive Esophagectomy for Esophageal Cancer

Jun Takahashi, Yohei Ozawa, Yusuke Taniyama, Chiaki Sato, Hiroshi Okamoto, Hirotaka Ihida, Naoto Ujiie, Takashi Kamei

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background With the aging of the global population, an increasing number of elderly patients undergo esophagectomy for esophageal cancer. Elderly populations exhibit considerable heterogeneity in overall health status due to differences in comorbidities. However, the factors influencing long-term outcomes after minimally invasive esophagectomy in this population have not been fully elucidated. This study aimed to identify …

22.08.2026journal-article

Diseases of the Esophagus

P1.183. Salvage Surgery and Conversion Surgery for Esophageal Cancer in Patients Aged 80 Years or Older

Hiroshi Sato, Yutaka Miyawaki, Yusuke Suzuki, Yutaka Kishimoto, Shinichi Sakuramoto

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background With the rapid aging of the population, esophageal cancer in individuals aged 80 and older continues to increase. Conversely, with recent advances in multidisciplinary treatment, including novel chemotherapies and immune checkpoint inhibitors, “salvage surgery” and “conversion surgery” are increasingly being performed. These procedures often involve more invasive techniques than standard approaches, and their applicability in the e …

22.08.2026journal-article

International Journal of Research Publications

Prognostic Value of Pretreatment Monocyte-to-Lymphocyte Ratio in Prostate Cancer: A Focused Systematic Review and Corrected Meta-analysis

Luqmanul Hakim, Ginanda Putra Siregar, Syah Mirsya Warli

Background : The monocyte-to-lymphocyte ratio (MLR) is an inexpensive systemic inflammatory marker, but its prognostic value in prostate cancer remains uncertain. This focused review evaluated whether pretreatment MLR is associated with overall survival (OS). Methods : A broader systematic search of Semantic Scholar, Scopus, PubMed/MEDLINE, Crossref, the Cochrane Library, and Web of Science identified studies of blood-cell ratios in prostate cancer. For this focused analysis, reports were rechecked for direct MLR m …

22.08.2026journal-article

Diseases of the Esophagus

P1.208. Long-Term Health Related Quality of Life Following Curative Treatment for Esophageal Cancer: A Systematic Review and Meta-Analysis

Josipa Petric, Ravi Vissapragada, David Watson, Norma Bulamu

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Treatment for esophageal cancer has a significant impact on health-related quality of life (HRQoL). Advances in treatment have resulted in improved survival rates, and the need to improve patient quality of life. This review summarizes the evidence on the impact of various treatments on long-term quality of life in order to inform practice. Methods A systematic literature search of MEDLINE (OVID), PubMed, CINAH …

22.08.2026journal-article

Diseases of the Esophagus

P1.123. Deep Learning and Machine Learning Radiomics-Based Models Predicting Esophagogastric Cancer Recurrence: A Systematic Review

Angeline Praveena Enton Raj, Morgan McLaughlin, Magnus Nilsson, Fredrik Klevebro, Gustav Strijkers, Bram Coolen, Mariska Leeflang, Antonios Tzortzakakis

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Esophageal and gastric cancers are associated with recurrence rates approaching 50% despite curative-intent treatment. Non-invasive imaging modalities including computed tomography (CT), positron emission tomography (PET/CT), and magnetic resonance imaging (MRI) are routinely used for staging and surveillance. Radiomics combined with machine learning (ML) and deep learning (DL) enables extraction of high-dimensional imaging features that may pr …

22.08.2026journal-article

Diseases of the Esophagus

P1.117. Photodynamic Therapy for Esophageal Cancer: A Single-Center Experience With Clinical Outcomes

YOUNGGI JUNG, JAEHO CHUNG, EUNJUE YI, HYOJUNG KIM, SUNGHO LEE, Jieon Kim

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Photodynamic therapy (PDT) is a minimally invasive local treatment that selectively destroys malignant cells with minimal systemic toxicity. It has emerged as an alternative therapeutic option for superficial esophageal lesions such as carcinoma in situ or high-grade dysplasia, and as a palliative or salvage modality in inoperable cases. This study aimed to evaluate the clinical outcomes and safety of PDT in patients with esoph …

22.08.2026journal-article

Diseases of the Esophagus

P1.231. Patients With Anastomotic Stricture After McKeown Operation for Esophageal Cancer Is Associated With Lower Rate of Recurrence: Retrospective Cohort Study

Yutaka Miyawaki, Tetsuro Toriumi, Yusuke Suzuki, Yutaka Kishimoto, Masatoshi Yoshizawa, Shinichi Sakuramoto, Hiroshi Sato

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background This was a single institutional retrospective study. Patients with esophageal squamous cell carcinoma who underwent esophagectomy with radical lymph node dissection reconstructed by gastric tube with cervical anastomosis were included in this study. Univariable and multivariable analysis were performed to reveal the effect of anastomotic stricture on long–term outcomes. Methods This was a single institutional r …