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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.08.2026journal-article

Scientific Data

AMYPAD-PNHS: A Pan-European, Multi-Site & Multimodal MRI Dataset of Older Adults Without Dementia

Leonard Pieperhoff, Mario Tranfa, Prithvi Arunachalam, Carole H. Sudre, Mathijs B. J. Dijsselhof, Beatriz Esteves Padrela, Federico Masserini, Stefano Caneva, Giuseppe Pontillo, David M. Cash, Emma S. Luckett, Craig Ritchie, Mercè Boada, Marta Marquié, Wiesje M. van der Flier, Rik Vandenberghe, Lisa Quenon, Bernard J. Hanseeuw, Pablo Martinez-Lage, Pierre Payoux, Anouk den Braber, Pieter Jelle Visser, Michael Schöll, Giovanni B. Frisoni, Andrew W. Stephens, Frank Jessen, Juan Domingo Gispert, Henk-Jan M. M. Mutsaerts, Alle Meije Wink, Lyduine E. Collij, Luigi Lorenzini, Frederik Barkhof

Abstract The Amyloid Imaging to Prevent Alzheimer’s Disease Prognostic and Natural History Study (AMYPAD-PNHS) multimodal magnetic resonance imaging (MRI) dataset provides open-access longitudinal MRI data of 2759 cognitively normal or mild cognitive impairment individuals, encompassing (micro-)structural, physiological, and functional MRI sequences from 10 European parent cohorts. Processed and raw images, and image-derived (endo-)phenotypes, are organized in Brain Imaging Data Structure (BIDS) standards and acces …

03.08.2026journal-article

Western Journal of Nursing Research

Family Caregivers of Patients with Dementia in Primary Care: Assessment of the Psychosomatic Dimensions of Caregiver Burden

Ioanna Dimitriadou, Charoula Mesira, Aikaterini Toska, Evangelos C. Fradelos, Theodosios Paralikas, Foteini Malli, Pavlos Sarafis, Maria Saridi

Background: Dementia represents a growing global public health challenge, with increasing reliance on informal family caregivers to support individuals living with the condition. Caregiving responsibilities may affect caregivers’ psychological well-being, resilience, and overall quality of life (QoL). Purpose: This study aimed to examine caregiver burden, resilience, and QoL among family caregivers of people with dementia in primary care settings and to explore the association of these outcomes with key sociodemogr …

03.08.2026journal-article

Journal of Clinical and Basic Psychosomatics

Effects of multisensory environmental stimulation interventions using virtual reality therapy in patients with dementia and comorbid conditions

Ziwei Zhou, Zhuqing Wang, Xinying Zhou, Qingfeng Xie, Yun Chen, Pei Li

As the incidence of dementia rises annually, the demand for cognitive intervention in dementia patients with comorbid underlying diseases has become increasingly urgent. However, most existing studies focus on single-modal interventions, and there remains a gap in exploring the composite intervention model of virtual reality (VR) technology combined with multisensory stimulation and its core effect mechanism. This study aims to investigate the effects of a multisensory environmental stimulation intervention using V …

03.08.2026journal-article

Journal of Imaging

Small-Data Deep Learning for Alzheimer-Spectrum Classification from Structural MRI: A Feasibility Study Using OASIS

Ian D. Li, Choong-Yong Ung, Cristina Correia

Accurate estimation of Alzheimer’s disease (AD) severity from structural magnetic resonance imaging (MRI) remains difficult, as disease-associated anatomical alterations are often subtle and publicly available datasets are typically too small to support robust deep learning model training. This feasibility study sought to determine how much Alzheimer’s disease spectrum-related information could be extracted from a small structural MRI cohort using a deliberately lightweight two-dimensional convolutional neural netw …

03.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

TELEATENDIMENTO NA ATENÇÃO PRIMÁRIA À SAÚDE NO CUIDADO ÀS PESSOAS COM DOENÇAS CRÔNICAS NÃO TRANSMISSÍVEIS: RELATO DE EXPERIÊNCIA

Amanda Nichele, Henrique Resin, Isadora Petry, EduardaEduarda Pufal, Laura Bosi Gil, Franciele Rissi dos Reis, Jéssica Damian, Joyce Premoli Soares, Patrícia Cilene Freitas Sant’ Anna, Márcia Rejane Strapasson

Objetivo: Relatar a experiência de teleatendimento em saúde de demandas relacionadas a doenças crônicas em adultos e idosos na rede de atenção à saúde do município de São Leopoldo/RS. Método: Trata-se de um relato de experiência em teleatendimento a pacientes com doenças crônicas, na perspectiva interdisciplinar em saúde. Resultados: A experiência relatada permitiu dar visibilidade ao programa de telessaúde, por meio do teleatendimento a usuários com demandas de doenças crônicas no município em estudo, que teve ori …

03.08.2026journal-article

Hydrology

Serendipity in Settings and Hydrologic Processes Helped People Survive Extreme Environments of the Sahara Desert

Franklin Schwartz, Ganming Liu

This paper explores the intricate relationship between novel paleo-hydrological settings and the sustainability of ancient human societies in the Sahara Desert, focusing on the sandstone massifs of Tassili n’Ajjer, Tadrart Acacus, and Messak Settafet. While this region is currently hyper-arid, archeological evidence reveals a history of significant human settlement facilitated by the African Humid Period (AHP). The core of the research is the idea that the natural geological and hydrogeological settings worked to m …

03.08.2026journal-article

ARACÊ

ENVELHECIMENTO POPULACIONAL E DOENÇAS CRÔNICAS: A NECESSIDADE DE UM NOVO MODELO DE ATENÇÃO QUE VALORIZE A ATENÇÃO PRIMÁRIA COMO COORDENADORA DO CUIDADO E O AUTOCUIDADO SUPERVISIONADO

Linda Inês Nascimento Nunes, Fernanda Jardim Molina, Renato Boy De Oliveira, André Lucas Nogueira Dantas, Luana Gama Belém, Glaucia Ribeiro Gonçalves De Rezende, Hugo Hermínio Abdon Gonçalves, Larissa Leão Batista Caxito

O Brasil vivencia um acelerado processo de envelhecimento populacional, acompanhado de uma transição epidemiológica na qual as doenças crônicas não transmissíveis assumem posição predominante. Esse duplo movimento impõe ao sistema de saúde a necessidade de repensar seu modelo de atenção, historicamente organizado em torno de eventos agudos e da lógica hospitalar. Este artigo tem por objetivo analisar a necessidade de um novo modelo de atenção à saúde da pessoa idosa com doenças crônicas, que valorize a atenção prim …

03.08.2026journal-article

International Journal of Older People Nursing

Comparative Efficacy of Non‐Pharmacological Multicomponent Interventions in Community‐Dwelling Older Adults With Frailty or Prefrailty: A Systematic Review and Network Meta‐Analysis

Huanyu Gao, Xuan Li, Minmin Leng, Zhen Wang

ABSTRACT Aim The purpose of this study was to compare the efficacy of different non‐pharmacological multicomponent interventions in community‐dwelling older adults with frailty or prefrailty and to determine the most effective non‐pharmacological multicomponent interventions. Background Frailty or prefrailty is highly prevalent among community‐dwelling older adults and contributes to significant distress among older adults and increases the caregiver burden. Non‐pharmacological multicomponent interventions are reco …

03.08.2026journal-article

Frontiers in Aging Neuroscience

Development and validation of a multimodal nomogram predicting anxiety and depression in Parkinson’s disease: integrating plasma biomarkers and clinical phenotypes

Guidong Liu, Yanqin Geng, Hanwen Zhang, Ping Ding, Yiping Zhou, Yiqing Ren, Wenshi Wei

Introduction Anxiety and depression are prevalent, disabling, yet frequently underdiagnosed non-motor symptoms in Parkinson’s disease (PD). This study aimed to develop and validate a non-invasive model predicting these affective disorders by integrating peripheral blood biomarkers with standardized clinical scales to facilitate early screening. Methods We retrospectively analyzed data from 290 patients with PD, who were randomly allocated into a training cohort ( n = 203) and a validation cohort ( n = 87). Baseline …

03.08.2026journal-article

Journal of Rehabilitation Medicine

Psychometric properties of loaded and unloaded timed stair tests in assessing people with knee osteoarthritis

Shamay S.M. Ng, Siyue Li, Peiming Chen, Eve Li, Carey K.L. Li, Hoi-Ying Lo, Mimi M.Y. Tse, Cynthia Y.Y. Lai

Objective: To compare timed stair test performance between individuals with knee osteoarthritis and healthy older adults, examine reliability under loaded and unloaded conditions, explore correlations with functional measures, and identify optimal cut-off times. Design: Cross-sectional study. Subjects/Patients: Sixty individuals with knee osteoarthritis and 30 healthy older adults. Methods: Participants completed unloaded and loaded timed stair test trials 7 days apart. Knee strength, balance, mobility, and self-re …

03.08.2026journal-article

Drug and Alcohol Review

Long‐Acting Injectable Buprenorphine in Prison: Insights From a Short‐Answer Survey of People in the Criminal Justice System Commencing Long‐Acting Injectable Buprenorphine During a Non‐Randomised Clinical Trial

Amelia Woods, Catherine Foley, Adrian Dunlop, Bethany White, Elizabeth McEntyre, Nicholas Lintzeris, Paul S. Haber, Jillian Roberts, Michael Doyle

ABSTRACT Introduction Long‐acting injectable buprenorphine (LAIB) is increasingly used in the Criminal Justice System (CJS) for treating people with opioid use disorder; however, little is known about these patients' experiences. We aimed to understand the perspectives of participants commenced on LAIB in prison as a part of the Understanding NSW Long‐Active Opioids in Custody‐Treatment (UNLOC‐T) study. Methods Results of an open‐ended survey administered by UNLOC‐T researchers underwent analysis. Participants were …

03.08.2026journal-article

Journal of Manufacturing and Materials Processing

Dynamic and Post-Deformation Static Aging as an Integrated Approach to Thermomechanical Processing of TiNi Shape Memory Alloys

Victor Komarov, Vladimir Cherkasov, Roman Karelin, Weisi Cai, Irina Khmelevskaya, Vladimir Andreev, Ulrich Prahl, Vladimir Yusupov, Chao Yang, Sergey Prokoshkin

The effect of thermomechanical processing (TMP) parameters on the structural-phase evolution and properties of Ni-enriched Ti–50.8 at.% Ni shape memory alloy was investigated. Compression deformation was performed at T = 300–500 °C, accompanied by the development of dynamic aging (DA) processes, to true strains of e = 0.5–1.3, followed by post-deformation static aging (SA) at 430 °C for 1 and 10 h. The structural-phase state and properties were characterized using optical and transmission electron microscopy, X-ray …

03.08.2026journal-article

Formosa Journal of Science and Technology

The Meaning of Moral Advice for the Bride in the Wotik Ritual of Wawi Waten in the Kloangpopot Indigenous People

Aurelius Fredimento, Edwardus Dionisius Goa, Felix Welu

This study aims to examine in depth the meaning of moral warnings conveyed to the bride in the Wotik Wawi Waten rite in the Kloangpopot indigenous people. This rite is an important part of the traditional marriage series that is full of cultural values and life norms that have been passed down from generation to generation. The approach used in this study is qualitative descriptive, with data collection techniques through participatory observation, in-depth interviews with traditional leaders and cultural actors, a …

03.08.2026journal-article

Life

Moving Beyond Outcome-Based Exercise Studies in Cognitive Aging: A Mechanism-Informed Narrative Review of Cerebrovascular Anchors and Supportive Biological Endpoints

Zhigang Zhao, Dong Wang, Wei Gao, Chun-Hsien Su

Exercise training is frequently examined in relation to cognitive and brain health in aging populations. Yet many exercise–cognition studies remain difficult to interpret mechanistically because cognitive outcomes are often assessed without sufficient alignment with exercise dose, biological endpoints, or participant vulnerability. This mechanism-informed narrative review argues that future research in cognitive aging should move beyond outcome-based interpretation alone and more explicitly connect the exercise sti …

03.08.2026journal-article

Journal of the American Geriatrics Society

Medication Adherence Interventions for Older Adults: A National Mixed‐Methods Study of Implementation Across Italian Healthcare Settings

Sara Mucherino, Luca Pasina, Manuela Casula, Monia Donati, Carlotta Lunghi, Elena Olmastroni, Valentina Orlando, Emanuel Raschi, Stefano Scotti, Marco Salluzzo, Elisabetta Poluzzi, Alessandro Nobili, Enrica Menditto

ABSTRACT Background Medication non‐adherence is common among older adults and represents a major challenge for healthcare systems. Effective interventions are needed to support adherence and inform quality‐improvement efforts. Objective To assess how medication‐adherence interventions for older adults are currently implemented in Italy and to identify care‐delivery priorities improving quality and feasibility across healthcare settings. Methods We conducted a mixed‐methods study within the Eldercare project. We adm …

03.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

CUIDADO MULTIPROFISSIONAL À PESSOA COM HIPERTENSÃO ARTERIAL NO SUS: DESAFIOS E POTENCIALIDADES

Luís Domingos Ramos Costa, Alissonmendes Fernandes, Giulia Magno Rocha de Oliveira, Nayane Regina Silva Araújo, Christiany Christiny Freitas Andrade, Helena Baptista Alves de Oliveira, Fabrício Silva Mendes, Luma Melo Barreto, Maria Eduarda Caetano Dias, Renata Santos Nogueira, Laisa Diógenes Medeiros Maciel, Lilia da Silva Melo, Jennfer Caroline Alves Fernandes

Objetivo: analisar criticamente as evidências científicas sobre o cuidado multiprofissional à pessoa com hipertensão arterial sistêmica no Sistema Único de Saúde (SUS), com ênfase nos desafios enfrentados pelos serviços e nas potencialidades das práticas colaborativas para o controle pressórico, a adesão ao tratamento e a qualidade de vida. Método: revisão integrativa da literatura conduzida segundo as seis etapas propostas por Whittemore e Knafl, com relato orientado pelo PRISMA 2020 e classificação do nível de ev …

03.08.2026journal-article

Journal of Health Politics, Policy and Law

Administrative and Financial Barriers to Using ABLE Accounts for People with Disabilities

Michael Levere, Guglielmo Briscese, Patricia van Hissenhoven, Harold Pollack

Abstract Context: This paper investigates barriers that people with disabilities face in using Achieving a Better Life Experience (ABLE) accounts. These accounts might be particularly beneficial for Supplemental Security Income recipients, who face a stringent $2,000 asset cap, but can save up to $100,000 in an ABLE account without jeopardizing benefits. Prior research indicates that few eligible persons use or know about ABLE accounts. Methods: We conduct qualitative interviews with caregivers who have opened (or …

03.08.2026journal-article

Revista de Geopolítica

RESPONSABILIDADE CIVIL POR ABANDONO DIGITAL DE IDOSOS: OS NOVOS CONTORNOS DO DEVER DE CUIDADO DIANTE DO ENVELHECIMENTO POPULACIONAL E DA EXCLUSÃO DIGITAL

Paulo Rodrigues Cotrim, Gustavo Davanço Nardi, Benedita Neida da Silva Flexa, Luiza Mércia Freire Corrêa, Vandeilson Araújo Dias, Marcos Alexandre Santos, Priscila Franco Avalos Lopes Planelis

O acelerado envelhecimento da população brasileira coincide com a consolidação de uma sociedade profundamente digitalizada, na qual serviços essenciais — bancários, de saúde, de comunicação e de cidadania — migram para plataformas eletrônicas. Nesse cenário, a exclusão digital das pessoas idosas assume feição de nova vulnerabilidade, e a omissão dos familiares em incluí-las e ampará-las no ambiente digital desponta como possível hipótese de responsabilização. Este artigo, de natureza teórica e apoiado em pesquisa b …

03.08.2026journal-article

Frontiers in Aging

Comparison of anesthesia induction with ciprofol, propofol, and etomidate in elderly patients undergoing gastrointestinal endoscopy: a single center, prospective, double blind randomized controlled trial

Yingchao Guan, Gang Zhou, Conghui Wang, Yusong Lin, Minghong Ju, Wen He, Xiaodong Wang

Background We compared benefits and adverse effects of anesthesia induction with ciprofol, propofol, and etomidate in elderly patients undergoing gastrointestinal endoscopy anesthesia. Methods A total of 391 patients who underwent painless gastrointestinal endoscopy; age ≥ 60 years; ASA I-III were involved between April 30 and 30 December 2025. The primary outcome was hypoxemia or apnea during anesthesia. Secondary outcomes included systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure …

03.08.2026journal-article

Asian Health, Science and Technology Reports

Effect of Nine-Square Counting Dance on Physical and Cognitive Function in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial

Donlaya Phisitsettakorn, Janne Mia Schmidt, Chartnakrop Laksanakunlabutr, Natthaporn Muangsuk, Sithanan Promsri, Ampha Pumpho, Titi Phanjaroen, Theerasak Boonwang

The cognitive impairment was increasingly prevalent with advancing age and was associated with an elevated risk of falls, injury, functional decline, and cognitive impairment. This study aimed to investigate the impact of a four-week integrated intervention involving a nine-square dance and a counting program on physical function by the Timed Up and Go Test (TUGT), the five-times sit-to-stand test (FTSST), 10-meter walk test (10MWT), 6-minute walk test (6MWT), and cognitive functioning by the Mini-Mental State Exam …

03.08.2026journal-article

European Journal of Medical Research

Association between sleep disorders and diabetic kidney disease among U.S. adults aged 45 and older: findings from the 2007–2014 NHANES

Lingjiang Liu, Shibei Zhang, Junlin Wu, Jie Gao, Chunyou Li, Shuhan He, Yaxin Hu, Huaiyi Zhu, Guoping Huang

Abstract Background Diabetic kidney disease (DKD) is a frequent microvascular manifestation of diabetes. However, the associations between sleep disorders, sleep duration time (SDT), and DKD remain inadequately understood. This study seeks to examine the associations of sleep-related factors with the prevalence of DKD among Americans aged 45 and older. Method A cross-sectional analysis was carried out utilizing the 2007–2014 National Health and Nutrition Examination Survey (NHANES) data. Four sleep-related variable …

03.08.2026journal-article

Journal of the American Geriatrics Society

How Does Receipt of Dementia Screening Impact Depressive Symptoms Among Patients and Their Family Members?

Yifan Lou, Joan K. Monin, Nicole R. Fowler

ABSTRACT Background The impact of dementia screening on the mental health of older adults and their family members remains insufficiently understood, particularly in light of the bidirectional dynamics within the older adult‐family dyad. This study aims to examine how dementia screening affects older adults and their family members over time, and whether these effects occur independently or simultaneously within the dyad. Participants and Setting One thousand eight hundred five older adults (≥ 65 years old) and the …

03.08.2026journal-article

Family Relations

How Chinese Youth Use Silver‐Haired Influencers as a Parasocial Surrogate for Older Family Members

Wenrui Liang, Rosya Izyanie Shamshudeen, Md Azalanshah Md Syed

ABSTRACT Objective This study examines how one‐way parasocial engagement with silver‐haired influencers videos satisfies the emotional needs of youth followers. It also explores the symbolic deconstruction of age stereotypes and the translation of digital empathy into intergenerational communication. Background In contemporary China, intergenerational family ties remain important, yet geographic mobility, demanding study and work schedules, and platform‐mediated communication are reshaping the conditions of youth‐g …

03.08.2026journal-article

Current Alzheimer Research

Descriptive Analysis of Genetic Variants in Individuals Without a Clinical Diagnosis of Alzheimer’s Disease in a Population from Southwestern Colombia

Liliana Doza Martinez, Helen Johana Ortiz Rojas, Jorge Hernán Izquierdo Loaiza, Daniela Arturo Terranova, Felipe García, José María Satizabal

Introduction: Alzheimer's Disease (AD) is the most common cause of dementia worldwide and a chronic neurodegenerative disorder with well-established pathophysiological mechanisms. In Colombia, its prevalence is increasing, but in the southwestern region, information on its clinical course is scarce, limiting adequate care and public health strategies. This study aimed to describe the frequency and characteristics of genetic variants in AD candidate genes in a population in southwestern Colombia without a clinical d …