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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

Journal of Clinical Medicine

Artificial Intelligence in Oral and Maxillofacial Surgery—A Narrative Review

Dominika Zawadka-Modras, Jacek Rożko, Aldona Chloupek, Dariusz Jurkiewicz

Background/Objectives: Artificial intelligence (AI) is rapidly transitioning from a theoretical concept to an active clinical tool in dentistry and medicine. These are fields in which the current market-driven shift towards automation is observed. The aim of this study was to describe the possible applications of artificial intelligence particularly in oral surgery and maxillofacial surgery, fields that are deeply rooted in manual work with patients. Methods: A review of current literature was conducted using PubMe …

30.08.2026journal-article

Pharmaceuticals

Contemporary Landscape of Active Clinical Trials in Pancreatic Ductal Adenocarcinoma: A ClinicalTrials.gov–Based Narrative Review with a Scoping Approach

Laura Radoš, Sara Matulić Čubranić, Marin Golčić, Iva Skočilić, Ivana Mikolašević, Andrej Belančić

Background: Pancreatic adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited survival gains despite advances in systemic therapy. However, rapid expansion of biomarker-directed therapies, immunotherapy, and novel treatment modalities has created an increasingly complex clinical trial landscape. We aimed to characterize contemporary PDAC clinical development and identify emerging therapeutic trends. Methods: We performed a narrative review with a scoping approach of active PDAC clinical tri …

30.08.2026journal-article

Clinical Case Reports

Aggressive Periodontitis and Palmoplantar Keratoderma: Papillon–Lefèvre Syndrome in an 11‐Year‐Old Nepalese Girl

Jenisha Bhattarai, Sanish Pokhrel, Yogendra Poudel, Ujjwal Rimal

ABSTRACT Papillon–Lefèvre syndrome is a rare autosomal recessive disorder characterized by palmoplantar keratoderma and aggressive periodontitis. We report an 11‐year‐old Nepalese girl presenting with severe periodontal destruction and characteristic cutaneous manifestations. Clinical and radiographic findings established the diagnosis. Early multidisciplinary management is essential to preserve function and improve quality of life.

30.08.2026journal-article

Clinical Obesity

Comparative Efficacy of Tirzepatide Versus Semaglutide for Weight Loss in Adults With Overweight or Obesity: A Systematic Review and Meta‐Analysis of Head‐to‐Head Studies

Giovanna Pagani Paccola, Roberta Fernandes de Oliveira, Matheus Menão Mochetti, Fernanda Pataro Marsola Razera, Rafael Vecchi, Renan Canale Peres Montanher

ABSTRACT This systematic review and meta‐analysis aimed to compare the efficacy and safety of tirzepatide versus semaglutide for weight reduction in adults with overweight or obesity. We included randomised controlled trials and observational studies comparing tirzepatide and semaglutide with ≥ 24 weeks of follow‐up. The primary outcome was percentage weight change from baseline. Secondary outcomes included absolute weight change, weight‐loss thresholds, HbA1c and safety outcomes. Ten studies including 41 381 parti …

30.08.2026journal-article

The International Journal of Cardiovascular Imaging

Improving image quality by reducing breathing artifacts in CT of patients early after coronary artery bypass graft surgery

Elizabet Nikolova, Tristan T. Demmert, Lukas Jacob Moser, Daniel Zedler, Luca Koechlin, Stak Dushaj, Héctor Rodriguez Cetina Biefer, Omer Dzemali, Victor Mergen, Matthias Eberhard, Hatem Alkadhi

Abstract The purpose of this study was to evaluate whether a misalignment correction algorithm reduces artifacts from breathing in patients undergoing computed tomography angiography (CTA) early after coronary artery bypass graft (CABG) surgery. In this retrospective study, consecutive patients undergoing CTA early after CABG surgery between November 2023 and March 2025 were screened. Patients exhibiting relevant breathing artifacts on standard reconstructions were included for the evaluation. CTA was acquired in t …

30.08.2026journal-article

Eskisehir Medical Journal, Eskisehir City Hospital

EFFECT OF PHACOEMULSIFICATION SURGERY ON MACULAR EDEMA IN PATIENTS WITH DIABETES MELLITUS

Irem Akoz Ozturk, Dicle Oncel Hazirolan, Nurten Unlu, Ferhat Saribas

Introduction: Aim of this study is to evaluate macular edema after cataract surgery in diabetic patients using Optical Coherence Tomography (OCT). Methods: Fifty eyes of 50 diabetic patients who underwent cataract surgery at the Ophthalmology Clinic of Ankara Training and Research Hospital between October 2008 and May 2011 were included in the study. The non-operated eyes were accepted as the control group. All patients included in the study had Type II Diabetes Mellitus (DM). Patients were analyzed retrospectively …

30.08.2026journal-article

HAND

Clinical Outcomes and Complications of Intramedullary Proximal Phalanx Fixation

Emma Roccaforte, Justin Choy, Winston Scambler, Matthew Kannenberg, William F. Pientka

Background: Proximal phalanx fractures are common hand injuries that can result in significant functional impairment if inadequately treated. While multiple fixation strategies exist, the optimal approach remains debated. Intramedullary headless screw fixation has gained interest due to its minimally invasive nature and ability to allow early mobilization. This study evaluates clinical, radiographic, and functional outcomes following fixation with a single intramedullary device. Methods: A retrospective review was …

30.08.2026journal-article

Clinical and Experimental Dental Research

Machine Learning Prediction of Anterior Open‐Bite Development After Stabilization Splint Treatment in Temporomandibular Disorder

Jae Joon Hwang, Hye‐Mi Jeon, Hye‐Min Ju, Sung‐Hee Jeong, Yong‐Woo Ahn, Soo‐Min Ok

ABSTRACT Objectives To develop interpretable machine learning (ML) models for risk stratification of clinically meaningful anterior overbite decrease after stabilization splint therapy in temporomandibular disorder (TMD) patients, and to compare ML performance with conventional logistic regression. Materials and Methods This retrospective cohort included 87 TMD patients treated with stabilization splints, physical therapy, and pharmacologic therapy. Thirty‐five pre‐treatment cephalometric and demographic features w …

30.08.2026journal-article

Applied AI Letters

A Multimodal Deep Learning Based Framework for Early and Accurate Diagnosis of Depression Using Electroencephalography and Event‐Related Potential Signals

Atefeh Abedzadeh Attar, Mohammad Hossein Moattar, Yahya Forghani

ABSTRACT Major depressive disorder significantly impacts both physical and mental health, leading to decreased emotional and cognitive functioning. The limitations of traditional methods for diagnosing depression—such as reliance on patient cooperation, subjective bias, and low accuracy—have prompted researchers to explore alternative diagnostic tools. This study presents a multimodal approach aimed at enhancing the accuracy of depression diagnosis by utilizing Electroencephalography (EEG) and Event‐Related Potenti …

30.08.2026journal-article

Farabi Tıp Dergisi

Evaluation of Helicobacter pylori Stool Antigen Test Results According to Demographic and Clinical Characteristics of Patients

Mustafa Erdem Sarp, Serranur Altun Sarp, Mediha Uğur, Özkan Bahadir

Objective: This study aimed to evaluate Helicobacter pylori (H. pylori) antigen test results in stool samples in relation to the epidemiological features of patients.Material and Methods: This retrospective study included patients who underwent H. pylori antigen testing between 2022 and 2024. Analyses were performed using the H. pylori antigen test kit produced by RDS Laboratory Systems (Ankara, Türkiye). Demographic and clinical data were obtained from the hospital information system. Positivity rates were evaluat …

30.08.2026journal-article

Archiv Euromedica

THE ROLE OF DIET AND LIFESTYLE IN THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER: A NARRATIVE REVIEW

Aleksandra Katarzyna Kłosowicz, Aleksandra Olga Pakulska, Natalia Rządzińska, Aleksandra Maria Błoch, Maria Anna Miller, Kornelia Julia Fimiarz, Aleksandra Jolanta Kamińska

Background Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by impaired concentration, impulsivity, and excessive motor activity. Although conventional therapy is effective in many patients, it may be associated with high costs, adverse effects, and incomplete symptom control. Therefore, complementary methods, such as dietary modifications and lifestyle factors, are gaining increasing importance in the management of ADHD. Aims The aim of this narrative review was to cri …

30.08.2026journal-article

Laryngoscope Investigative Otolaryngology

Airway Anatomy as a Predictor of Tracheostomy in Critically Ill Patients: A Multicampus Analysis of Airway Grade, Admission Diagnosis, and Clinical Trajectory

Michael Sramek, Dana Eitan, Darby Keirns, Bryant Noss, Hannah Gibbs, Austin R. Swisher, India Casaday, Payam Entezami

ABSTRACT Objective Determine whether the Cormack–Lehane airway grade at intubation predicts subsequent tracheostomy in critically ill adults and whether this association persists after controlling for admission diagnosis. Methods Retrospective multicenter cohort study of 10,234 ICU patients requiring ventilation across three campuses from April 2018 to June 2024. The primary predictor was Cormack–Lehane grade (1–4) during intubation; the primary outcome was tracheostomy. Principal problem documentation classified p …

30.08.2026journal-article

International Journal of Human and Health Sciences (IJHHS)

Assessment of Serum Vitamin D Levels among Patients Attending Institute of Nuclear Medicine and Allied Sciences (INMAS), Sylhet, Bangladesh

Kamrun Nahar, Muhammad Sirazul Munir

Deficiency of vitamin D is a major health problem globally and is associated with different chronic diseases. The aim of this study was to assess serum vitamin D levels according to age and gender at the Institute of Nuclear Medicine and Allied Sciences (INMAS), Sylhet, Bangladesh. A total 173 patients attending INMAS, Sylhet, for serum vitamin D levels evaluation from July 2022 to June 2023 were included in the study. Patients with vitamin D replacement therapy were excluded from this study. Serum viamin D was det …

30.08.2026journal-article

International Journal of Computer Science and Mobile Computing

Risk-Oriented Analysis and Classification of Network Attacks Affecting Hospital Information Systems: Evidence from a Patient-Monitoring Testbed

Crimary C. Mahinay, John Augustus P. Diesto, Jerald B. Babor, Ray Marlou T. Georpe, Welquim B. Panogaling, Serafin C. Palmares, Kristine T. Soberano

Hospital Information Systems increasingly rely on connected patient-monitoring devices that transmit biometric data through hospital networks. This study analyzed the WUSTL-EHMS-2020 testbed and assessed the potential risk of its recorded attacks to HIS. A quantitative descriptive secondary analysis retained all 16,318 verified records. Record-level summaries described Normal, Spoofing, and Data Alteration traffic; the primary comparison aggregated ordered records into 169 contiguous binary-label blocks (85 Normal …

30.08.2026journal-article

Journal of Clinical Medicine

Innovative Clinical Pathways for Pregnant Women with Obesity: The Padua Project (Northeastern Italy)

Maria Grazia Dalfrà, Giovanni Sartore, Eugenio Ragazzi, Silvia Burlina, Silvia Visentin, Silvia Pastrolin, Marco Tosi, Erich Cosmi, Annunziata Lapolla

Background/Objectives: Maternal obesity is associated with an increased risk of adverse maternal and neonatal outcomes. This study evaluated whether participation in a multidisciplinary antenatal care pathway improved pregnancy outcomes compared with routine clinical practice in women with pre-pregnancy obesity. Methods: 711 women of reproductive age with preconception body mass index (BMI) ≥ 30 kg/m2 were identified from medical records collected between 2010 and 2023: 233 women were managed according to the multi …

30.08.2026journal-article

Journal of Clinical Medicine

Association of PI-RADS Score with Clinically Significant Prostate Cancer and Histopathological Upgrading in Patients Undergoing Radical Prostatectomy: A Retrospective Single-Centre Study

Hubert Andrzej Krzepkowski, Tomasz Ząbkowski, Andrzej Wieczorek, Maciej Walędziak, Tomasz Waldemar Kamiński, Hubert Dąbrowski, Tomasz Syryło

Background and Objectives: Multiparametric magnetic resonance imaging (mpMRI) is widely used in prostate cancer diagnosis, but biopsy findings may still underestimate tumor aggressiveness. This study evaluated the association of Prostate Imaging Reporting and Data System (PI-RADS) assessment with clinically significant prostate cancer (csPCa) and histopathological upgrading after radical prostatectomy. Methods: The retrospective analysis comprised 564 patients who underwent mpMRI–transrectal ultrasound fusion-guide …

30.08.2026journal-article

International Journal of Stroke

Clinical Outcomes among Patients with Active Cancer and Acute Ischemic Stroke Treated with Antiplatelet versus Anticoagulant Therapy.

Gianluca Costamagna, Andreas Hottinger, Francoise Livio, Babak Benjamin Navi, Davide Strambo, Patrik Michel

Background: Patients with acute ischemic stroke (AIS) and active cancer (AC) face high risks of recurrent stroke and death. Evidence guiding antithrombotic selection remains limited. Aims: To investigate post-AIS prescribing patterns of antiplatelet versus anticoagulant therapy in AIS patients with AC and their associated clinical characteristics and outcomes. Methods: We retrospectively analyzed 2003–2024 data from the Acute-Stroke-Registry-and-Analysis-of-Lausanne (ASTRAL). We included patients with AC discharged …

30.08.2026journal-article

Sensors

Development and Clinical Evaluation of a Wearable 12-Lead Electrocardiographic Platform with Automated ECG Analysis for Telemedicine Applications

Zhadyra Alimbayeva, Chingiz Alimbayev, Kassymbek Ozhikenov, Kairat Karibayev, Aiman Ozhikenova, Kymbat Khaidarova, Madiyar Daniyalov, Ussen Shylmyrza, Yerbolat Igembay, Akzhol Nurdanali

Wearable electrocardiographic technologies have become increasingly important for continuous cardiac monitoring; however, most existing portable systems are limited by the number of recorded leads or provide only basic signal acquisition without advanced automated analysis. This study presents a third-generation wearable twelve-lead electrocardiographic platform developed for multilead ECG acquisition and automated spatial ECG analysis. Compared with the previous generation, the hardware modification primarily cons …

30.08.2026journal-article

Caucasian Medical Journal

Development and Internal Validation of a Clinical–Infectious Prediction Model Incorporating the Serum Pepsinogen I/II Ratio to Identify Histologically Confirmed Gastric Atrophy

Nursultan Kerimkulov, Bayan Nurgaliyeva

Background: Histologically confirmed gastric atrophy is a key precursor lesion in the intestinal pathway of gastric carcinogenesis. Serum pepsinogen I/II ratio (PGR) is a biologically plausible non-invasive marker of oxyntic gland loss, but its diagnostic performance varies across populations, assays, and clinical settings. Contemporary risk stratification increasingly favors multivariable prediction models over isolated biomarkers.Objective: To evaluate the association between serum PGR and histologically confirme …

30.08.2026journal-article

Frontiers on Healthcare Research

The Relationship Between the Jakarta Cardiovascular Score and Physical Activity: Screening of Cardiovascular Risk Factors in Older Adults

Department of Cardiology and Vascular Medicine, Dr. M. Djamil General Hospital, Padang, Indonesia, Citra Kiki Krevani Citra, Restu Restu Restu, Wahyudi Firmana Wahyudi, Rusdy Kamal Rusdy, Fikri Satria Fikri, Jolatuvel Bahana Jolatuvel, Najmi Ilal Hayati Najmi Ilal, Hajar Nurfa Jirin Hajar Nurfa

<p style="font-weight: 400;"><strong>Background:</strong> Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide, including in Indonesia, where low physical activity is a major modifiable risk factor. The Jakarta Cardiovascular Score (JAKVAS) was developed as a local modification of the Framingham Risk Score to better represent Indonesian populations by including physical activity as a variable. However, the quantitative relationship between physical activity level and JAKVAS has …

30.08.2026journal-article

International Journal of Pharmaceutical Sciences and Medicine

Quality by Design: Development of the Quality Target Product Profile (QTPP), Critical Quality Attributes (CQAs), Critical Material Attributes (CMAs) and Critical Process Parameters (CPPs) for Transdermal Drug Delivery Systems

C. Pandian, Praveen Kumar D, Gowtham A, Pooja B, Gunaseelan M, Keerthana M

The quality by design (QbD) paradigm has been the accepted model for building quality into pharmaceutical products rather than testing it in retrospectively. The systematic application of QbD to transdermal pharmaceutical delivery systems (TDDS) is relatively underdeveloped in the literature despite the growing commercial and clinical relevance of the dosage form, although QbD has been widely articulated for oral solid dosage forms and more recently for semisolid topical products. Transdermal patches present a diff …

30.08.2026journal-article

Psychoactives

Psilocybin-Assisted Therapy for Alcohol Use Disorder: A Systematic Review of Clinical Evidence

Laura Schäffert, Human-Friedrich Unterrainer

Background: Alcohol use disorder (AUD) remains a leading contributor to global morbidity, yet conventional treatments often yield suboptimal outcomes and high relapse rates. Psilocybin-assisted therapy has re-emerged as a potential intervention for substance use disorders, but its effectiveness and safety in AUD specifically remain to be comprehensively evaluated. Objective: To review and synthesize available evidence on the efficacy and safety of psilocybin-assisted therapy in adults with AUD. Methods: A systemati …

30.08.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

Federated Self-Supervised Learning for Privacy-Preserving Clinical Diagnostics in Distributed Healthcare Systems

Abinaya V., S. Swathi, G. Sharmila, S. Karpaga Iswarya, P. Priyadharsini, Harini A.

The increasing adoption of distributed digital healthcare systems has enabled collaborative artificial intelligence (AI)-based clinical diagnostics across hospitals and medical institutions. However, conventional centralized learning requires sensitive patient information to be transferred to a common server, introducing substantial concerns regarding data privacy, security, institutional governance, and regulatory compliance. Furthermore, obtaining sufficiently large and accurately annotated clinical datasets rema …

30.08.2026journal-article

Psychiatry and Clinical Neurosciences

Blood Neurofilament Light Chain as a Biomarker of Central Network Dysregulation in Methamphetamine Use Disorder: A Multi‐Modal Investigation with Clinical Implications

Shyh‐Yuh Wei, Yu‐Li Liu, Huai‐Hsuan Tseng, Po See Chen, Yen Kuang Yang, Yihong Yang, Tzu‐Yun Wang

Aim There is a critical need for objective biomarkers that can link peripheral assays to central neural network dysfunction. We investigated blood neurofilament light chain (NfL), a marker of axonal injury, and C‐reactive protein (CRP), a marker of systemic inflammation, in relation to the brain network topology and microstructural integrity in methamphetamine use disorder (MUD), a paradigm of acquired neurotoxicity. Methods Forty‐two male MUD patients and 44 male controls received diffusion and resting‐state funct …