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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

P1.109. Overexpression of RFC3 Relates to Tumor Development and Poor Outcome of Esophageal Squamous Cell Carcinoma

Hiroyuki Kanazawa, Shuhei Komatsu, Jun Kiuchi, Mahito Miyamae, Shoji Hirajima, Takuma Ohashi, Taisuke Imamura, Keiji Nishibeppu, Ryo Ishida, Satoshi Hamada, Masateru Yamauchi, Kenji Nanishi, Hiroki Shimizu, Tomohiro Arita, Toshiyuki Kosuga, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Hitoshi Fujiwara, Atsushi Shiozaki

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Replication factor C (activator 1) 3 (RFC3), located on 13q13.2, is reported to be necessary for the elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon. In this study, we tested whether RFC3 acts as a cancer-promoting factor by being overexpressed in esophageal squamous cell carcinoma (ESCC). Methods We analyzed 14 ESCC cell lines and 58 primary tumor samples of ESCC, which were curatively resected in our hos …

22.08.2026journal-article

Diseases of the Esophagus

PD09.08. Preoperative Nutritional–Inflammatory Composite Scores Derived via Principal Component Analysis for Survival Prediction in Esophageal Cancer: Multicenter Evidence

Ruichen Cui, Xiang Li, Shenglu Lian, Yushang Yang, Longqi Chen

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Multiple preoperative nutritional and inflammatory indices have been shown to be associated with cancer prognosis, but they are often used individually, resulting in fragmented information. In esophageal cancer, no effective approach has been established to integrate these indices into composite prognostic tools. Methods This multicenter, prospectively maintained, retrospective cohort study included 7,569 patie …

22.08.2026journal-article

Cells

Cancer Immune Responsiveness and MHC Class I Antigen Presentation: Mechanisms of Immune Escape and Immunotherapy Resistance in Gastrointestinal Cancers

Fabio Grizzi, Maurizio Chiriva-Internati, Mohamed A. A. A. Hegazi, Federica Rubbino, Fabio Pasqualini, Marco Spadaccini, Marta Andreozzi, Miriana Mercurio, Federico Cassano, Maria Terrin, Cesare Hassan, Robert S. Bresalier, Alessandro Repici, Silvia Carrara

The Antigen Processing and Presentation Machinery (APM) is essential for immune surveillance by enabling the presentation of antigenic peptides to T lymphocytes and facilitating the elimination of infected or transformed cells. In cancer, the integrity of this process influences cancer immune responsiveness (CIR), defined as a tumour’s capacity to be recognised by the immune system and respond to immunotherapy. Tumours with intact antigen presentation pathways are more likely to generate effective antitumour respon …

22.08.2026journal-article

Achievements of Science and Technology in Agro-Industrial Complex

Study of heat transfer coefficients during refrigeration treatment of biological objects

S. V. Belukov, N. V. Pribytkovsky, A. G. Donetskikh

Storing food products at low temperatures is one of the most effective and affordable preservation methods, extending their shelf life by slowing down the biochemical and microbiological processes occurring within the product. Optimizing refrigeration processes requires reliable data on the heat transfer coefficients of cooling media. The heat transfer coefficient depends on the thermophysical properties of the cooling medium and the product being cooled, the geometric shape and size of the object, the speed of the …

22.08.2026journal-article

Diseases of the Esophagus

OA02.7. CT-Based Segmentation AI and 3D Computer Graphics for Esophageal Cancer Surgery

Daisuke Kurita, Yasuyuki Seto, Ryota Kakuta, Ryoko Nozaki, Shota Igaue, Eigo Akimoto, Daichi Utsunomiya, Koshiro Ishiyama, Hiroyuki Daiko

Abstract Topic Esophageal Cancer: New Diagnostic Modalities (Including PET, PET-CT, New Tracers) Background Accurate understanding of complex mediastinal anatomy is essential for safe esophageal cancer surgery. However, CT-based segmentation and 3D reconstruction of the esophagus and mediastinal lymph nodes remain difficult because of low contrast and unclear anatomical boundaries. Methods This study included 180 esophageal cancer patients. One-millimeter contrast-enhanced CT images were manually annotated to train …

22.08.2026journal-article

Diseases of the Esophagus

P1.153. Dietitian-Led Integration of CT Body Composition Analysis in Oesophagogastric Cancer Care

Carmel Zoanetti, Lisa Murnane, Andrea Bramley, Paul Burton, Wendy Brown

Abstract Topic Esophageal Cancer: Other Background Malnutrition and poor muscle health are prevalent in patients with oesophagogastric cancer and are associated with poor outcomes. However, body composition assessment is not routinely implemented in clinical practice. This project aimed to assess the feasibility of incorporating body composition analysis for patients undergoing curative-intent oesophagogastric cancer surgery. Methods A prospective quality improvement project was conducted. All adult patients who un …

22.08.2026journal-article

Diseases of the Esophagus

P1.065. Lymph Node Yield as a Prerequisite for Prognostic Superiority of Ratio-Based Nodal Staging in Esophageal Cancer: A Multi-Institutional Validation Study

Simiao Lu, Xuefeng Leng

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) have been proposed as yield-independent alternatives to pN staging for esophageal cancer. However, their prognostic superiority over pN has not been validated across institutions with varying lymph node (LN) yields. We hypothesized that the discriminative advantage of ratio-based metrics is conditional on adequate lymphadenectomy. Methods A total of 2,490 patients …

22.08.2026journal-article

Urology Herald

Organ-sparing treatment in synchronous bilateral upper tract urothelial carcinoma and bladder cancer

I. Ya. Skvortsov, E. M. Nikolaeva, V. B. Matveev, E. R. Virshke, Zh. T. Fatiyan, N. A. Arzhanukhina

Introduction. Upper tract urothelial carcinoma (UTUC) is a rare but aggressive malignancy associated with high rates of recurrence, diagnostic and staging challenges, and a substantial risk of implantation metastasis. In patients with bilateral or multifocal disease, standard radical nephroureterectomy results in loss of renal function, thereby limiting options for systemic therapy and adversely affecting quality of life. Current clinical guidelines increasingly support organ-preserving endoscopic approaches in car …

22.08.2026journal-article

FACE

Successful Treatment of Long COVID Migraine With Supraorbital, Supratrochlear, and Greater Occipital Nerve Release

Robin N. Bai, Adam G. Evans, Anjani Patibandla, Yifan Guo

Long COVID headache is one of the most common yet poorly understood symptoms following SARS-CoV-2 infection, persisting for at least 3 months after the initial infection. Prior meta-analyses report the prevalence of persistent post-COVID headache to range from 6% to 18% beyond 6 months. Management remains challenging because of the unclear etiology and heterogeneous clinical presentation. Patients may experience either an exacerbation of pre-existing headache disorders or the development of new intermittent or dail …

22.08.2026journal-article

INDONESIAN JOURNAL OF URBAN AND ENVIRONMENTAL TECHNOLOGY

Sustainability Determinants of Local Domestic Wastewater Treatment Systems: A Technical Evaluation and Socioeconomic Constraints Analysis in Aceh Jaya District

Eldina Fatimah, Rismaliza Rismaliza, Ziana Ziana, Mohamad Hidayat bin Jamal, Qurratul 'Aini Benti Nasaiy

Access to adequate sanitation remains a major challenge in rural Indonesia. Aim: This study evaluated the physical condition, functionality, technical compliance, and community maintenance capacity of Local Domestic Wastewater Treatment Systems (SPALD-S) in Aceh Jaya District. Methodology and results: A quantitative descriptive survey assessed 95 randomly selected units through field inspections and household questionnaires. Septic tanks were classified as good (22%), lightly damaged (57%), heavily damaged (12%), o …

22.08.2026journal-article

Diseases of the Esophagus

P1.198. Systematic Screening for Anastomotic Leakage After Esophagectomy for Cancer: Lessons Learned From a Retrospective Analysis

Ward Seurs, Isabela Camargo De Sousa, Willem De Coninck, Johnny Moons, Stijn Vanstraelen, Hans Van Veer, Philippe Nafteux, Lieven Depypere

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Anastomotic leakage (AL) after esophagectomy for cancer is associated with negative outcomes that could be mitigated by screening and early treatment of the complication. We aimed to assess whether patients with AL diagnosed through systematic radiological screening did already exhibit signs of possible leakage which would have prompted diagnostic testing. Methods Patients undergoing esophagectomy …

22.08.2026journal-article

npj Precision Oncology

Outcomes of early-onset vs average-onset colorectal cancer patients on phase I matched and non-matched therapies

Daniel A. Fox, Deepak Bhamidipati, Heather Y. Lin, Louis E. Hinkle, Caitlynn Truc-Anh Pham, Jordi R. Ahnert, Stephane Champiat, Ecaterina E. Dumbrava, Siqing Fu, Lei Kang, Hung Le, Funda Meric-Bernstam, Aung Naing, Sarina A. Piha-Paul, Paula R. Pohlmann, Tin-Yun Tang, Apostolia M. Tsimberidou, Timothy A. Yap, Ryan W. Huey, David S. Hong

Abstract Early-onset colorectal cancer (EOCRC) is an increasingly prevalent disease with no age-specific therapies despite evidence suggesting biologic differences between EOCRC and average-onset CRC (AOCRC). In this single-institution analysis of patients treated on Phase I trials, we demonstrate that EOCRC patients have significantly higher response rates to molecularly matched therapies compared with AOCRC patients, while progression-free survival remains similar between groups suggesting that EOCRC may be parti …

22.08.2026journal-article

Journal of the Egyptian National Cancer Institute

Head and neck cancer: a comprehensive review of epidemiology, global burden and advances in radiotherapy

Karunya A S, Sudeep Kumara K, Avin Kumar, Kamalaksh Shenoy

Abstract Head and neck cancer (HNC), a heterogeneous group of malignancies that arising from the mucosal surfaces of the Upper Aerodigestive Tract (UADT), is a major health concern worldwide. By 2050, the number of cancer cases worldwide is expected to reach 35 million, with nearly half of all new cases and deaths occurring in Asia. In India, HNC is particularly prevalent accounting for about 30% of the global burden, with lip and oral cavity cancers (OCC) make up 10.17% of all cases, highlighting a serious public …

22.08.2026journal-article

Journal of Clinical Medicine

Saliency-Curated Deep Learning for Predicting Receptor Status in Breast Cancer Brain Metastases

Rafail C. Christodoulou, Giorgos Christofi, Constantinos Theofylaktou, Rafael Pitsillos, Iliana Aristokleous, Elena E. Solomou, Evros Vassiliou, Michalis F. Georgiou

Background: Breast cancer brain metastases (BCBMs) exhibit notable receptor discordance between primary tumors and metastases, yet obtaining intracranial biopsies is rarely practical. We created an interpretable deep learning radiogenomic model to predict estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status from MRI scans in BCBM cases. Methods: A total of 241 post-contrast T1-weighted MRIs from 142 patients were analyzed. We developed a mask-free 3D Residua …

22.08.2026journal-article

Cell Death Discovery

Targeting glucosylceramide generation induces cancer cell death through lysosomal dysfunction independent of ceramide accumulation

Alexandra J. Straus, Sachin K. Kempelingaiah, Stacey Nguyen, Sherina Premanandh, Can E. Senkal

Abstract The bioactive lipid ceramide is usually implicated in mediating anti-proliferative signaling. Therefore, preventing its conversion to complex sphingolipids was proposed as a valid target to induce cancer cell death. Higher expression of the sphingolipid metabolic enzyme glucosylceramide synthase (GCS), which converts ceramide to glucosylceramide (GlcCer), correlates with poor prognosis in cancers. Pre-clinical and cellular models targeting GCS to treat cancer achieves increases in ceramide levels with subs …

22.08.2026journal-article

Middle East Fertility Society Journal

Medical treatment of ectopic pregnancy with methotrexate: outcomes across the 5000 IU/L β-hCG threshold

Sevki Goksun Gokulu, Hatice Banu Atay, Murside Cevikoglu Kıllı, Huseyin Durukan

Abstract Purpose To evaluate the clinical significance of establishing a 5000 IU/L β-hCG threshold in the selection of patients for medical treatment of ectopic pregnancy. Materials and methods Between January 2019 and August 2025, a total of 182 patients diagnosed with ectopic pregnancy were treated at Mersin University Faculty of Medicine. Of these, 50% ( n = 91) underwent medical management with single-dose methotrexate, 42.9% ( n = 78) received surgical intervention, and 7.1% ( n = 13) were managed through clin …

22.08.2026journal-article

Diseases of the Esophagus

P1.004. Cryoablation of Barrett´s Esophagus in Patients not Suitable for Treatment With Radiofrequency Ablation

Peter Elbe, Stephan Haas, Fredrik Klevebro, Mats Lindblad

Abstract Topic Benign Disease: Barrett’s Esophagus: Pathology and Pathophysiology; Non-invasive Neoplasia Background Radiofrequency ablation (RFA) is the gold standard for ablation of the esophagus. However, there are occasions when RFA is not suitable, for example if the patient has suffered side effects from RFA, responded poorly to the ablation, or if it for various reasons is difficult to use existing RFA catheters. Cryoablation is a ablation method in which liquid nitrogen is sprayed into a balloon-catheter. T …

22.08.2026journal-article

Diseases of the Esophagus

P1.148. Risk of Institutional Financial Deficit in Esophageal Cancer Surgery: An Analysis Focusing on DPC Margin and Length of Stay

Tomoyuki Okumura, Yoshihisa Numata, Takeshi Miwa, Tatsuhiro Araki, Naoya Takeda, Masakazu Nagamori, Isaya Hashimoto, Tsutomu Fujii

Abstract Topic Esophageal Cancer: Other Background Esophagectomy is a highly invasive procedure requiring prolonged general anesthesia, intensive postoperative care, multidisciplinary management, and substantial healthcare resources. Under Japan’s Diagnosis Procedure Combination (DPC) bundled payment system, concerns have been raised regarding institutional financial vulnerability, particularly in cases with postoperative complications. Identifying factors associated with DPC-related financial deficit is essential …

22.08.2026journal-article

Georgian Medical Journal

Chronic stress as a factor in the progression of prostate cancer under war conditions

Andrii Tymoshenko, Nataliia Lukianova, Taras Zadvornyi, Yurii Vitruk, Vasyl Chekhun

Aim: To investigate the influence of stress factors on the development and progression of prostate cancer (PCa) with bone involvement in the pre-war period of 2011–2013 and during the period of the full-scale invasion of Russia from February 2022 to February 2025. Material and methods: A retrospective study of 549 patients with metastatic prostate cancer treated in outpatient and inpatient settings at the National Cancer Institute was performed. Patients were divided into two groups: Group 1 included 133 patients t …

22.08.2026journal-article

Diseases of the Esophagus

OA02.1. Radiation-Induced Lymphopenia During Neoadjuvant Chemoradiotherapy as Predictive Biomarker for Nivolumab Benefit in Esophageal Cancer

Pim Damen, Gulsah Ozden, Maaike Berbée, Jacco de Haan, Sarah Derks, Nadia Haj Mohammad, Erik Korevaar, Hanneke van Laarhoven, Marlinde de Leede, Radhe Mohan, Bianca Mostert, Stella Mook, Remi Nout, Barbara Stam, Famke Schneiders, Mathijs Tomassen, Joost Verhoeff, Rob Verhoeven, Fabienne Warmerdam, Christina Muijs, Steven Lin, Peter van Rossum

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Radiation-induced lymphopenia (RIL) is an established prognostic factor associated with poorer pathologic response, disease-free survival (DFS), and overall survival (OS) in locally advanced esophageal cancer patients undergoing concurrent chemoradiotherapy (CRT). In resectable patients, standard treatment can consist of neoadjuvant CRT followed by surgery, with adjuvant nivolumab indicated (since 2022) for incomplete pathologic respon …

22.08.2026journal-article

Diseases of the Esophagus

PD03.03. Clinical Characteristics and Selected Treatment in Patients With Transient Esophageal Motility Abnormalities Detected During Esophagogastroduodenoscopy

Hiroko Hosaka, Shiko Kuribayashi, Nozomi Furuichi, Yu Maruyama, Keiichi Oshima, Yuki Itoi, Keigo Sato, Hirohito Tanaka, Yoji Takeuchi, Toshio Uraoka

Abstract Topic Benign Disease: Esophageal Function and Motility Background Major esophageal motility disorders such as achalasia often present with characteristic abnormalities on esophagogastroduodenoscopy (EGD). However, transient abnormal esophageal contractions or mucosal color changes are occasionally observed during EGD and their meaning are not well understood, and the pathological significance of these findings remains unclear. This study aimed to elucidate symptom profiles, barium esophagography findings, …

22.08.2026journal-article

Diseases of the Esophagus

P1.244. Robotic-Assisted Versus Conventional Minimally Invasive Oesophagectomy for Oesophageal Cancer: A Comparative Meta-Analysis of Perioperative and Oncological Outcomes

Theo Reback, James Butterworth, Guillaume Lafaurie, William Butterworth, Yassar Qureshi, Borzoueh Mohammadi, Khaled Dawas

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Background Robotic-assisted minimally invasive oesophagectomy (RAMIE) is increasingly adopted to improve surgical precision, mediastinal dissection, and surgeon ergonomics. However, its clinical and oncological advantages over conventional minimally invasive oesophagectomy (cMIE) remain uncertain. This study presents the largest contemporary comparative meta-analysis between RAMIE and cMIE focusing on peri-operative and oncologica …

22.08.2026journal-article

Diseases of the Esophagus

OA01.1. Invited Lecture: Organ-Preserving Therapy for Higher Stage Esophageal Cancer Using Endoscopic Submucosal Dissection (ESD): Endoscopic Outcomes From OPERA-RADIO Phase 1 Clinical Trial

Professor Biniam Kidane, Dr Julian Kim, Dr Vivian Lu, Dr Stephen Gowing, Jasvir Dhaliwal, Dr Shantanu Banerji

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Esophagectomy is the mainstay of curative for esophageal cancer but comes with high risk for complications, especially in comorbid and frail patients. The OPERA RADIO trial aimed to assess the feasibility and safety of organ-preserving therapy with combining endoscopic submucosal dissection (ESD) and chemoradiotherapy. We report here the endoscopic/surgical outcomes of this trial. Methods OPERA-RADIO (NCT05667298) is a phase I …

22.08.2026journal-article

Diseases of the Esophagus

P1.010. Personalized Approach to Surgical Treatment of Epiphrenal Diverticula of the Esophagus

Oleg Vasnev, Roman Izrailov, Kirill Shishin, Mikhail Koshkin, Konstantin Lesko, Elen Valitova, Eduard Bulgakov

Abstract Topic Benign Disease: Esophageal Surgery Background Epiphrenal diverticula of the esophagus are a rare pathology, pathogenetically associated with disorders of esophageal motility. Despite the evolution of treatment methods towards minimally invasiveness, the incidence of postoperative complications (suture failure) remains high (up to 45%), which necessitates the search for new approaches to surgical tactics. Methods The prospective study included 7 patients with symptomatic epiphrenal diverticula who wer …