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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
12.08.2026journal-article

REMUNOM

Reabilitação de Maxila Severamente Atrófica Após Falha de Reabilitação All-on-4, Utilizando Quatro Implantes Zigomáticos em Configuração Cruzada Bilateral: Relato de Caso

Donizete Heliano Oliveira Borges, Lucas Pires da Silva, Nathalia Silva Béda

Introdução: A reabilitação de maxilas severamente atróficas permanece um desafio na Implantodontia, especialmente após a falha de tratamentos implantossuportados e a perda do osso residual. Nessas situações, a instalação de implantes convencionais pode ser limitada ou impossível, e os implantes zigomáticos podem proporcionar ancoragem no osso zigomático, evitando procedimentos extensos de enxertia óssea. Objetivo: Relatar a reabilitação de uma maxila severamente atrófica após a falha de uma reabilitação All-on-4, u …

12.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Explanatory Sequential Mixed-Methods Study of the Effectiveness of the Childhood Dysphagia Management Scale (CDMS): Part 2 of a CDMS Hybrid Effectiveness–Implementation Study

Jennifer Maybee, Emily DeBoer, Emily Cooper, John T. Brinton, Juliana G. Barnard, Jeremy Prager, Arwen Jackson

Purpose: As Part 2 of a Type 1 hybrid effectiveness–implementation study, we evaluated the effectiveness of the Childhood Dysphagia Management Scale (CDMS), a validated pediatric dysphagia outcomes assessment completed by therapists following instrumental swallow assessments. Method: Guided by the Reach, Effectiveness, Adoption, Implementation, and Maintenance and Consolidated Framework for Implementation Research implementation science frameworks, mixed methods were used to evaluate CDMS effectiveness in a tertiar …

12.08.2026journal-article

Language and Speech

Gradience in Sonority Sequencing: Evidence From German and Russian

Rowena Garcia, Ludger Paschen, Natalie Boll-Avetisyan

This research empirically tests the claim that the sonority sequencing principle (SSP), which dictates that syllables rise in sonority from the edges towards the nucleus, is gradient. This was tested on two languages that vary in their adherence to the SSP, that is, German, which does not allow SSP violations outside of sibilant-initial clusters, and Russian, a language that has more SSP violations. We performed corpus-based lexical statistics to test whether the type frequency (Study 1) and probability of attested …

12.08.2026journal-article

Frontiers in Immunology

Targeting macrophage polarization: mechanisms and potential of mesenchymal stromal/stem cells therapy in acne treatment— a narrative review

Yibing Yang, Nianlv Luo, Linyan Li, Yufen Zhao, Xiaoliang Xu, Hanxiao Wei, Ying Yang, Wen Yan, Tao Zhang

Acne vulgaris(AV) is a clinically common skin disease. Globally, about one in ten individuals is affected by it. Current research on acne primarily focuses on the following four areas: first, the inflammatory response; second, sebum metabolism disorders; third, the colonization of Cutibacterium acnes (C. acnes); and fourth, abnormal keratinization of the pilosebaceous duct. Although the exact pathogenesis of this condition has not yet been fully elucidated, the dual polarization of macrophages play a crucial role i …

12.08.2026journal-article

Journal of Surgical Oncology

The Financial Burden of Pancreatic Enzyme Replacement Therapy for Patients With Resected Pancreatic Cancer

Patricia G. Lu, Yu‐Hui H. Chang, Chee‐Chee Stucky, Alexandra Potter, George C. Linderman, Chi‐Fu Jeffrey Yang, Rahul Pannala, Nabil Wasif, Michelle A. Anderson, Zhi Ven Fong

ABSTRACT Background Post‐pancreatectomy exocrine insufficiency is common after resection for pancreatic cancer and requires pancreatic enzyme replacement therapy (PERT). We sought to determine the out‐of‐pocket cost of PERT and the association between PERT and survival. Methods The SEER‐linked Medicare database was queried for patients with pancreatic cancer who underwent pancreaticoduodenectomy (PD) or distal pancreatectomy (DP) from 2010 to 2019. Cumulative out‐of‐pocket costs were calculated and stratified by pr …

12.08.2026journal-article

Frontiers in Cardiovascular Medicine

Prognostic value of the systemic immune-inflammation index in acute limb ischemia undergoing endovascular therapy

Shuji Morikawa, Nao Takahashi, Ryo Ohinata, Takashi Mishina, Hikaru Hayakawa, Yuki Kumihashi, Naoya Inoue, Yohei Takayama, Toyoaki Murohara

Background Acute limb ischemia (ALI) is a vascular emergency associated with major amputation and mortality, highlighting the need for early risk stratification. The systemic immune-inflammation index (SII), calculated from platelet, neutrophil, and lymphocyte counts, is a composite biomarker reflecting systemic inflammation and immune status. Although SII has demonstrated prognostic value in various cardiovascular diseases, its role in patients with ALI undergoing endovascular therapy remains unclear. Objective To …

12.08.2026journal-article

Journal of Marital and Family Therapy

Artificial Intelligence as Companionship: A Systemic and Relational Examination Using Empirical Data From Psyhelp

Afarin Rajaei

ABSTRACT Artificial intelligence (AI) is increasingly used as a source of emotional support, reflection, and perceived companionship. Despite growing public and clinical interest in AI companionship, little research has examined how individuals construct these experiences within broader relational systems. Drawing on systemic, attachment, and social constructionist perspectives, this study examines AI companionship using anonymized data from Psyhelp, an AI‐assisted mental health platform. A qualitative‐dominant mix …

12.08.2026journal-article

Journal of Nephrology

Early exercise therapy for acute nephrotic syndrome: a randomised clinical trial

Yuma Hirano, Tomoyuki Fujikura, Tomoya Yamaguchi, Masaaki Nagashima, Makoto Hasui, Shunji Takashima, Yi Deng, Katsuya Yamauchi

Abstract Background In adults with acute nephrotic syndrome (NS), physical function often declines; however, limited evidence on the efficacy and safety of exercise therapy leads to its avoidance due to fears of exacerbated proteinuria and renal deterioration. This study aimed to assess whether early exercise therapy enhances physical function without elevating risks of non-remission or worsening kidney function. Methods This single-centre randomised controlled trial enrolled hospitalised adults receiving glucocort …

12.08.2026journal-article

Cancers

Construction Strategies, Microenvironmental Modelling and Precision-Therapy Applications of Glioma Organoid Models

Songming Chen, Wei Zhang, Luohuan Dai, Yubin Kuang, Haodi Yang, Jia Gu, Kang Peng, Nian Jiang, Hongwei Liu, Xuejun Li

Gliomas, and glioblastoma in particular, remain difficult to model because molecular heterogeneity, diffuse invasion, blood–brain and blood–tumour barrier effects, immune suppression and repeated therapeutic escape converge in the same disease. Two-dimensional cultures, glioma stem cell (GSC) systems, acute tumour slices and animal models remain indispensable for mechanistic research, pharmacology and in vivo validation. Glioma organoids are complementary research platforms, not components of routine diagnostic or …

12.08.2026journal-article

Journal of Human Lactation

Occupational Stress and Coping During a Public Health Emergency: A Mixed-Methods Approach to Understand the Experiences of Lactation Professionals in Clinical Settings

Mya Michele Carter, Linda Bennington, Michele Kekeh, Hadiza Galadima

Background: Breastfeeding remains the recommended feeding method during public health emergencies; however, pandemic-related restrictions created new challenges for mothers and their healthcare teams, including lactation professionals (LPs). The COVID-19 pandemic may have heightened LPs’ occupational stress and limited their ability to provide lactation support. Research Aims: This study examined occupational stress among LPs, identified stressors and coping strategies, and explored how pandemic-related workplace p …

12.08.2026journal-article

Journal of Entrepreneurial and Business Diversity

The Influence of Leadership Style, Communication and Occupational Safety and Health on Employee Job Satisfaction at Pt. Vibro Nusantara Indonesia

Nyoto Nyoto, Agung Suranto, Nicholas Renaldo, Achmad Tavip Junaedi, Suhardjo Suhardjo, Rebecca La Volla Nyoto

Purpose:This research aims to determine the influence of leadership style, communication, occupational safety and health on job satisfaction at PT. Vibro Nusantara Indonesia.Methodology:This research uses primary and secondary data originating from employees of PT. Vibro Nusantara Indonesia is included in the sample. The sampling technique in this research used the convenience sampling method. The number of samples obtained was 100 employees. This research analysis method uses descriptive analysis and several types …

12.08.2026journal-article

Journal of Ayurveda and Integrated Medical Sciences

Ayurvedic Management of Oligoasthenoteratospermia (Shukra Kshaya) with Rasayana Therapy: A Case Report

Chinmayi M.K, Ajay Kumar Sahu, Rashmi Mutha, Manish Paliwal

One of the most common reasons of male infertility is oligoasthenospermia (OAT syndrome), which is often associated with endocrine or idiopathic factors. This illness is known as Shukra Kshaya in Ayurveda, and the primary treatments for it are Rasayana and Vajikarana formulations that aid in spermatogenesis. This case involves a 31-year-old man who has been experiencing mild burning micturition and primary infertility for the past four years. Semen analysis at baseline (July 2025) revealed a total sperm count of 5 …

12.08.2026journal-article

Healthcare

Translating Patient–Professional Divergence into Care-Improvement Priorities in Pelvic Floor Rehabilitation: A Delphi-Dialogue Study

Lourdes Gil-Fraguas, Soraya Hijazi-Vega, Michelle Catta-Preta, Alex Trejo-Omeñaca, Jan Ferrer-Picó, Isabel Montes-Posada, Jesús Vara-Paniagua, Carolina de Miguel-Benadiba, Josep Maria Monguet-Fierro, Helena Bascuñana-Ambrós

Background/Objectives: Pelvic floor dysfunctions (PFDs) are highly prevalent chronic conditions associated with substantial functional and psychosocial burden. Although multidisciplinary pelvic floor rehabilitation is recommended as first-line management, its effectiveness depends not only on intervention efficacy but also on care delivery, communication, patient engagement, and long-term adherence. This study applied the Delphi-Dialogue Patients–Professionals (DDPP) framework to quantify patient–professional align …

12.08.2026journal-article

Journal of Immunotherapy

Local Therapy for Isolated Residual Metastatic Melanoma and Renal Cell Carcinoma Following Immune Checkpoint Inhibition Leading to Long-Term Remission

Olivia Wilkins, Alex Marki, Kellie A. Gardner, Geoffrey T. Gibney, Michael B. Atkins

Immune checkpoint inhibitors (ICI) have revolutionized the treatment of melanoma and renal cell carcinoma (RCC). Immune therapy response outcomes are based on radiographic measurements of cancer sites alone, without considering whether these sites contain a viable tumor that has metastatic potential. We hypothesized that ICI may lead to residual radiographic abnormalities that either contain nonviable tumor or tumor without metastatic potential that could be controlled with local therapy. In this retrospective coho …

12.08.2026journal-article

Russian Journal of Pediatric Hematology and Oncology

Assessment of quality of life in patients who underwent antineoplastic therapy for central nervous system malignancies in childhood

Yu. V. Dinikina, N. V. Muliarova, V. V. Chernikov, I. L. Nikitina, O. G. Zheludkova, I. A. Kelmanson, A. Yu. Smirnova, N. G. Goikalov, I. V. Vinyarskaya

Background . According to international statistics tumors of the central nervous system take a leading position in the structure of childhood cancer morbidity. The use of a multimodal strategy of anticancer therapy today allows achieving a high level of long-term survival, but often with severe variants of long-term toxicity. The study of the health status of cured patients and assessment of their quality of life (QOL) in the aspects of searching for controllable factors to reduce treatment toxicity is a pressing p …

12.08.2026journal-article

Global Journal of Basic Education

Methodology for the Formation of Speech Competence of Primary School Students Based on An Integrative Approach

Mamatraimova Dilshoda Chorshanbiyevna, Mukhtarova L.A

This article presents an in-depth analysis of the foundations of the methodology of developing speech competence in elementary school students through an integrative approach. The integrative teaching approach combines different areas of study, creating a holistic learning environment that enhances students' linguistic, communicative, and cognitive abilities. By connecting language learning with subjects such as reading literacy, environmental studies, visual arts, and technology, an integrative approach strengthen …

12.08.2026journal-article

Journal of Cardiovascular Development and Disease

Cardiotoxicity of Immune Checkpoint Inhibitors and Chimeric Antigen Receptor T-Cell Therapy

Ahmad Naser, Ahmed Ashraf Morgan, Lili Zhang

Over the last decade, immunotherapy has transformed oncology, with an ever-expanding list of indications. As with any therapeutic class, these agents are accompanied by adverse events that are increasingly recognized and pose new challenges for patient care expanding the scope of cardio-oncology. Using the PubMed database, this narrative review summarizes the cardiovascular adverse events associated with the most commonly used immunotherapies, immune checkpoint inhibitors (ICIs), with a focus on the mechanisms, epi …

12.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Word Category–Specific Semantic Deficits in Mild Cognitive Impairment: A BERT Embedding Analysis of Picture Description Narratives

Qiu-tong Chen, Xiao-tong Shang, Zhen-long Wang, Lu-xin Qing

Purpose: Mild cognitive impairment (MCI), a transitional state between normal aging and dementia, is associated with subtle but systematic disruptions in semantic memory, yet the representational mechanisms underlying these changes remain poorly understood. Grounded in neuropsychological evidence that semantic vulnerability in early neurodegeneration is selective across lexical categories, this study investigates whether MCI is associated with the category-specific contraction of semantic representational space. We …

12.08.2026journal-article

Healthcare

Changes in Emotional Regulation, Well-Being, and Pain Perception Following Music Therapy in People with Sensory Processing Sensitivity: A Non-Controlled Exploratory Study

Alicia Francisca Ponce-Valencia, Diana Jiménez Rodríguez, Leonor Alberola Amores, Alba Álvarez Pujante, Manuela Pérez-Chacón, Antonio Chacón, Paloma Echevarría Pérez

Background/Objectives: Highly sensitive persons (HSPs) are characterized by increased emotional and sensory responsiveness, which may predispose them to anxiety, emotional dysregulation, and sensory overload. Music therapy based on gong sound sessions has emerged as a complementary intervention aimed at promoting emotional well-being. This study analyzed immediate pre- and post-intervention variations in an adult population with sensory processing sensitivity. Methods: A quantitative, quasi-experimental, single-gro …

12.08.2026journal-article

Cancer Biome and Targeted Therapy

Patient-derived organoids in pancreatic cancer: Advances and applications in precision oncology

Hee Seung Lee, Bon-Kyoung Koo

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies owing to late diagnosis, extensive intratumoral heterogeneity, a dense desmoplastic tumor microenvironment, and limited therapeutic responsiveness. Although current treatment regimens, including FOLFIRINOX and gemcitabine plus nab-paclitaxel, have modestly improved survival, chemoresistance and the lack of reliable predictive biomarkers continue to hinder precision oncology. Conventional two-dimensional cell lines and many in vivo mod …

12.08.2026journal-article

Polish Journal of Radiology

Endovascular therapy for acute non-terminal internal carotid artery occlusions

Milena Miszczuk, Christoph Riegler, Christian H. Nolte, Georg Bohner, Eberhard Siebert

Purpose Acute stroke from non-terminal internal carotid artery (non-T ICA) occlusions presents with variable symptoms. Although collaterals influence stroke severity, their role in non-T ICA occlusions remains unclear. This study evaluated the safety and efficacy of endovascular therapy (EVT) for isolated non-T ICA occlusions and examined the impact of collateral status. Material and methods Patients treated with EVT for acute isolated non-T ICA occlusion between August 2015 and February 2023 were retrospectively a …

12.08.2026journal-article

International Journal of Evidence Based Coaching and Mentoring

Coaching Versus Therapy: A Quantitative, Qualitative and Conceptual Analysis

Iain McCormick, Stewart Forsyth

Coaching is widely employed in organisations, which has led to a debate about the differences between coaching and therapy. This study used quantitative, qualitative and conceptual analyses to examine this. The qualitative data suggested that coaches have a clear idea of the differences between modalities. Qualitative data indicated that coaching is seen as having six features: performance versus emotional outcomes, future versus past focus, emphasis on action-based experimentation, the work context, higher client …

12.08.2026journal-article

Frontiers in Medical Technology

Intelligent data governance and quality control for chest Bi syndrome/coronary heart disease across the prevention–treatment–rehabilitation continuum: integrating a standardized framework, adversarially-optimized trigger engine, and domain-adaptive AI

Huisi Hong, Guiyuan Yang, Weihan Shen, Shiqi Luo, Yiming Yuan, Yong Zhao, Hong Zhang, Shuangyan Li, Juhua Wu, Wenge Chen, Shaoyang Men, Kaixuan Lin

Background Digital transformation in Traditional Chinese Medicine (TCM) is hindered by data silos, poor standardization, and inefficient quality control. This study developed and validated an intelligent data governance system to address these gaps. Methods Using Chest Bi syndrome (coronary heart disease) as a model, we established a standardized data system (9 subsets, 352 elements; 42.6% TCM-specific) based on the “Triple-Loop Coupling” theory and HL7 FHIR (Fast Healthcare Interoperability Resources)/SNOMED CT st …

12.08.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

Radiolabelled somatostatin receptor antagonist versus agonist for peptide receptor radionuclide therapy in patients with metastatic pheochromocytoma or paraganglioma: a retrospective pilot study

Felix Schmidt, Sofia-Maria Lider, Lisa McDougall, Christopher Eigler, Peter Bernhardt, Abdulrafee Mushaweh, Andreas Bauman, Melpomeni Fani, Emanuel Christ, Damian Wild

Abstract Purpose Metastatic pheochromocytomas and paragangliomas (mPPGLs) are rare neuroendocrine tumours with limited therapeutic options. Peptide receptor radionuclide therapy (PRRT) using somatostatin receptor (SSTR) antagonists (e.g. [ 177 Lu]Lu-DOTA-JR11) may achieve higher tumour and organ absorbed doses compared with standard SSTR agonist therapy (e.g. [ 177 Lu]Lu-DOTA-TOC). This study aimed to perform an intra-patient comparison of tumour and organ dosimetry between [ 177 Lu]Lu-DOTA-TOC and [ 177 Lu]Lu-DOTA …