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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

Jurnal Kejuruteraan

Influence of Bitumen Chemistry and Crumb Rubber Pre-Treatment on the Storage Stability and Rheological Performance of Modified Binders

Naeem Aziz Memon, Nur Izzi Md. Yusoff, Ahmed Suliman B. Ali, Warid Wazien, Aawag Mohsen Alawag, Zubair Ahmed Memon, Shabir Hussain Khahro

The incorporation of crumb rubber (CR) into bitumen offers significant performance and sustainability advantages, yet its widespread adoption is impeded by poor storage stability caused by thermodynamic incompatibility. To address this fundamental challenge, this study investigates the role of bitumen chemistry, specifically the balance of fractions determined via SARA analysis, and the efficacy of crumb rubber pre-treatment in creating a stable binder system. Two base bitumen with distinct chemical compositions (P …

30.08.2026journal-article

European Heart Journal

Antithrombotic therapy after percutaneous coronary intervention in patients with atrial fibrillation: an individual patient data network meta-analysis

Mauro Chiarito, Roxana Mehran, Michael C Gibson, Christopher P Cannon, Renato D Lopes, Samantha Sartori, Angelo Oliva, Kenneth Smith, Yihan Feng, Joshua Lampert, Andreas Goette, Adnan Kastrati, Ruth Owen, Jurrien M ten Berg, Freek W A Verheugt, Pascal Vranckx, Marco Valgimigli, Deepak L Bhatt, John Alexander, Stuart Pocock

Abstract Background and aims Randomized trials demonstrated that in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) direct oral anticoagulants (DOAC) and a P2Y12 inhibitor reduce bleeding compared with vitamin K antagonist (VKA) plus dual antiplatelet therapy (DAPT) with no increase in ischemic risk; however, important gaps in knowledge remain, limiting certainty and generalizability of these findings. Methods In this patient-level meta-analysis of randomized trials evalua …

30.08.2026journal-article

Frontiers on Healthcare Research

Effect of Preoperative Lactobacillus acidophilus Supplementation on Postoperative Gastric Residual Volume after Lower Digestive Laparotomy: A Randomized, Double-Blind, Controlled Trial

Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Indonesia, Christophorus Simadibrata Christophorus, Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Rudyanto Sedono Rudyanto, Sidharta Kusuma Manggala Sidharta Kusuma, Wifanto Saditya Jeo Wifanto Saditya

<p style="font-weight: 400;"><strong>Background:</strong> Gastrointestinal dysmotility is among the most common complications after abdominal surgery and is reflected clinically by an elevated gastric residual volume (GRV), which increases the risk of aspiration and delays enteral feeding. Lactobacillus acidophilus is thought to improve gut motility through luminal acidification, competitive exclusion of pathogens, and direct stimulation of smooth-muscle contractility, but whether this translates into a lower GRV a …

30.08.2026journal-article

Applied Sciences

A Rolling Bearing Fault Diagnosis Method Based on S-LE-EGWO Jointly Optimizing VMD, MCKD and SVM

Fuqiuxuan Liu, Xiaofeng Yue

To overcome the nonlinear and non-stationary characteristics of rolling bearing vibration signals and the challenge of extracting incipient weak fault features, this paper proposes a joint fault diagnosis method based on Variational Mode Decomposition (VMD), Maximum Correlated Kurtosis Deconvolution (MCKD) and Support Vector Machine (SVM). Different from most existing studies that separately optimize individual stages of the fault diagnosis workflow, the proposed method adopts a multi-strategy enhanced grey wolf al …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Research Progress on the Use of Yue ju Pill in the Treatment of Functional Dyspepsia

Jianing Ma, Hui Ding

Yueju Pill are derived from *Danxi Xinfa*; the formula comprises Atractylodes lancea, Cyperus rotundus, Ligusticum chuanxiong, Shenqu and Gardenia jasminoides, and is primarily indicated for relieving various forms of stagnation. Later generations of medical practitioners have also extended its use to treat disorders of the digestive and nervous systems, amongst others. This article provides a systematic review of the progress made in clinical and basic research on Yueju pill in the treatment of functional dyspepsi …

30.08.2026journal-article

Annals of Clinical and Translational Neurology

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù

ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease pathogenesis. Patients showed increased cerebrospinal fluid levels of neurofilament light chain and chitinases, along with hypermetabolism in the medulla oblongata. C …

30.08.2026journal-article

Iraqi Journal of Science

Estimating Scabies Severity by Epidemiological and Clinical Survey of Baghdad Governorate Patients and Assessing Blood Immune Antibody Levels

Wasan Addai Al-marsomy

Scabies is a parasitic infestation caused by tiny mites Sarcoptes scabiei. Scabies can lead to skin ulcers and serious complications such as septicemia (bloodstream infection), heart disease and kidney problems. Therefore, scabies is considered a dangerous infectious disease that must be treated when diagnosed. The current study aimed to conduct a survey of scabies patients of both genders, examining the role of humoral immunity by estimating certain immunoglobulins (IgM and IgG) and their effect on the patients. H …

30.08.2026journal-article

Medical Science and Discovery

Clinical and Methodological Considerations in Evaluating Amelogenesis Imperfecta as a Systemic Marker: A Critical Commentary

Edgar García-Torres, Oscar Eduardo Almeda-Ojeda, José Manuel Salas-Pacheco

Background and Objective: Recent literature frequently explores the clinical intersections between localized dental enamel variations and systemic health conditions. While multidisciplinary evaluations offer valuable clinical insights, premature conclusions regarding genetic etiologies can introduce significant clinical bias if acquired, pharmacological, and environmental confounders are overlooked. This commentary aims to critically examine a recent case report by highlighting key methodological and pathophysiolog …

30.08.2026journal-article

Open Access Public Health and Health Administration Review

Investigating the Confounding Role of Artificial Intelligence on the Relationship between Patient Safety and Infection Control Practices in Enhancing Patient Satisfaction in Healthcare

Ghulam Muhammad Kundi, Tanya Marie Torres, Syed Arif Pasha

This study aimed to investigate how AI mediates the relationship between infection control, patient safety, and patient satisfaction. The study used an exploratory sequential research design with two phases. In the first phase, 25 qualitative studies were analyzed using PRISMA (2009–2024), which were supplemented by quantitative analysis of 384 samples. A cross-sectional survey was conducted among physicians, nurses, and paramedics. The scales were found to be reliable and valid in PLS-SEM measurement models. The s …

30.08.2026journal-article

Journal of Vascular Societies Great Britain & Ireland

Developing a vision and strategy for global vascular surgery within the Vascular Society of Great Britain & Ireland

N Moody, T Kirengo, N Al-Saadi, B Sandford, R Davenport, A Garnham, K Sritharan

Global surgery is a field encompassing research, education and advocacy, which aims to improve health outcomes and achieve equitable surgical and anaesthetic care for all.1 Within the field of global surgery there is a special emphasis on underserved populations such as those in low- and middle-income countries (LMICs) and those facing a humanitarian crisis.2 The 2015 Lancet Commission on Global Surgery brought the scale of surgical inequity into focus, demonstrating that the poorest third of the world receive only …

30.08.2026journal-article

Clinical EEG and Neuroscience

Neuroelectrophysiological Characteristics of the Attention Network in Children with Obstructive Sleep Apnea Accompanied by ADHD-Like Symptoms

Yunxiao Wu, Changming Wang, Dandi Ma, Zhifei Xu, Xiao-lin Ning

Objective To investigate the neuroelectrophysiological characteristics of children with obstructive sleep apnea (OSA) accompanied by attention deficit hyperactivity disorder (ADHD)-like symptoms using attention network test (ANT) task-state electroencephalography analysis. Methods All participants completed the Attention Deficit Hyperactivity Disorder rating scale. Electroencephalography data were collected using 32 leads while the participants performed the ANT, followed by polysomnography. Results Of the 87 child …

30.08.2026journal-article

Journal of Translational Medicine

SLC7A11-associated astrocyte states are linked to redox imbalance and synaptic microenvironment remodeling in multiple sclerosis: translational implications

Jian Liu, Jun-Jun Yin, Meng Pu, Di Guo, Zhen Mao, Yu Guo, Ying Xiao, Qing Wang

Abstract Background Multiple sclerosis (MS) is characterized by inflammatory demyelination, oxidative stress, and neurological dysfunction. Despite disease-modifying therapies, chronic active lesions and ongoing neurodegeneration remain largely untreated, highlighting the need for mechanistically informed translational targets. Methods We analyzed a human single-nucleus RNA-sequencing dataset (GSE279180) including healthy controls and MS samples. Astrocyte subpopulations were examined using reclustering, pseudotime …

30.08.2026journal-article

Journal of Personalized Medicine

Body Mass Index and Body Fat Percentage Are Associated with Clinical Outcomes in Patients Receiving PD-1/PD-L1 Inhibitors: A Prospective Exploratory Study

Ángela Morell, Alberto Morell, Ainhoa Aranguren, Jacobo Rogado, Miguel Sampedro, Rebeca Mondéjar, Ramón Colomer, M. Paz Lorenzo, Esther Ramírez

Background/Objectives: Immunotherapy using immune checkpoint inhibitors has transformed the treatment of multiple solid tumours. However, the clinical response to programmed death receptor (PD-1) and its ligand (PD-L1) inhibitors remains heterogeneous. We have previously shown that host-related factors such as body mass index (BMI) may modulate the efficacy of immunotherapy. The aim of this study was to determine whether body composition, measured with bioelectrical impedance analysis (BIA) before treatment initiat …

30.08.2026journal-article

Journal of Clinical Medicine

Persistent Unilateral Nephrolithiasis: Do 24-h Urine Parameters Account for It?

Orel Hemo, Miki Haifler, Asaf Shvero, Nir Kleinmann, Dorit E. Zilberman

Background: Bilateral nephrolithiasis is typically attributed to systemic metabolic abnormalities reflected in 24 h urine studies. Yet, some individuals form stones exclusively in one kidney over long-term follow-up, while the contralateral kidney remains unaffected. This study aimed to determine whether differences in urinary metabolites can explain persistent unilateral stone formation. Methods: We retrospectively reviewed our 2011–2024 nephrolithiasis database and analyzed 24 h urine compositions obtained under …

30.08.2026journal-article

Diabetic Medicine

DiaActive protocol: A randomized controlled trial of cognitive‐motor multicomponent exercise to reduce fall rate in older adults with diabetes

Aksayan Arunanthy Mahalingasivam, Asger Ahlmann Bech, Peter Vestergaard, Martin Grønbech Jørgensen, Nicklas Højgaard‐Hessellund Rasmussen

Abstract Introduction Older adults with diabetes have an increased risk of falls due to neuropathy, impaired bone health and cardiovascular disease, resulting in significant morbidity and mortality. Conventional fall‐prevention programmes primarily target strength and balance, while cognitive‐motor integration, essential for safe mobility in complex environments, is often overlooked. Multicomponent exercise combining physical and cognitive training may therefore provide additional benefits in this population. Metho …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

Machine learning in the analysis of medical profiles of patients with coronary heart disease in the context of unbalanced data

Evgeniya A. Mikishanina, Elsa V. Ivanova, Alexey Yu. Makarov, Elena V. Preobrazhenskaya, Nikolay V. Belovoschev

Background. Using machine learning (ML) techniques in addition to traditional methods can make disease diagnosis more reliable and unbiased. The aim of the study is to compare the efficacy of machine learning methods on imbalanced data for identifying dominant diagnostic features that form the clinical profile of a patient with coronary artery disease (CAD). Materials and Methods. A retrospective, single-center, continuous comparative study was performed with a predominance of patients without CAD (n2 = 3023) over …

30.08.2026journal-article

Bipolar Disorders

Optimizing Ketamine Infusion Therapy for Treatment‐Resistant Bipolar Depression: Commentary on Zhou et al. (2023)

Chih‐Cheng Lin, Lien‐Chung Wei

ABSTRACT Objectives To contextualize the real‐world findings of repeated intravenous ketamine infusions for treatment‐resistant bipolar depression (TRBPD) and identify priorities for safer, more durable clinical implementation. Methods We provide a focused commentary on Zhou et al. (2023) and integrate selected evidence concerning inflammatory and metabolic correlates, neurocognitive outcomes, and continuation‐phase ketamine treatment. Results Repeated subanesthetic ketamine infusions may rapidly improve depressive …

30.08.2026journal-article

Journal of Hospital Medicine

Sharing unwritten rules of negotiation: An effort to help leaders thrive

Julie Byerley, Kenya McNeal‐Trice, Nancy D. Spector

Abstract Negotiation is a skill essential for leader success yet not often trained in the academic pathway. Ideal negotiation is between at least two parties with overlapping goals where mutual benefit is achieved in a solidified agreement. For long‐term success in partnership, integrity, shared value, mutual respect, and clarity should be demonstrated during negotiation, propelling the professional relationship going forward. Negotiation is a skill often addressed in senior leadership development programs. For exa …

30.08.2026journal-article

Artificial Organs

SURGELLA: A Scoping Review of Impella‐Assisted Hemodynamic Support in High‐Risk Non‐Cardiac Surgery

Hussein Elghazaly, Mohammed Allaf, Areeb Mian, Hanad Ahmed, Alex Gordon‐Weeks, Alexander Tindale, Vasileios Panoulas

ABSTRACT Background Patients with advanced heart failure or severe ventricular dysfunction are often considered prohibitively high risk for non‐cardiac surgery. Impella may provide temporary perioperative hemodynamic support by augmenting cardiac output and unloading the left ventricle, but evidence for this strategy remains limited and largely case based. Methods We conducted a scoping review of Impella use for adult high‐risk non‐cardiac surgery. MEDLINE and Embase were searched from inception to April 2026, with …

30.08.2026journal-article

Ukrainian Heart Journal

Оцінка ефективності й безпечності використання аксилярної канюляції при хірургічному лікуванні патології грудної аорти

O. V. Zelenchuk

The aim – to evaluate the efficacy and safety of direct axillary artery cannulation during reconstructive surgery for thoracic aortic disease by comparing intraoperative parameters, early clinical outcomes, and the incidence of neurological and local complications with those of femoral artery cannulation.Materials and methods. The study included 110 patients who underwent reconstructive surgery for thoracic aortic disease between 2016 and 2025 using peripheral arterial cannulation. Femoral artery cannulation was pe …

30.08.2026journal-article

World Journal of Surgery

Correlation Between Anastomotic Leakage and the Anastomotic Position of the Gastric Conduit After Esophagectomy Using ICG Fluorescence Imaging Stratification

Yamato Ninomiya, Kazuo Koyanagi, Rie Nakashima, Kohei Tajima, Kohei Kanamori, Mika Ogimi, Yoshiaki Shoji, Akihito Kazuno, Miho Yamamoto, Masaki Mori

ABSTRACT Background This study aimed to clarify the correlation between anastomotic leakage and anastomotic position after esophagectomy for esophageal cancer, stratified by gastric conduit blood flow assessed using indocyanine green (ICG) fluorescence imaging. Methods A total of 136 patients who underwent esophagectomy with retrosternal gastric conduit reconstruction were included. After creating the gastric conduit, three points were identified: point A (anastomotic site), point B (terminal end of the gastroepipl …

30.08.2026journal-article

Journal of Clinical Medicine

Population Decline May Affect the Incidence of Pulmonary Tuberculosis in Japan

Akihiro Miyauchi, Mizuki Inaba, Takatoshi Tetsuka, Noritaka Sakamoto, Yushi Nomura, Otohiro Katsube, Hirokuni Hirata, Hiroshige Yoshioka, Seiji Niho, Kumiya Sugiyama

Background/Objectives: Pulmonary tuberculosis in Japan had been decreasing as a result of the country’s anti-tuberculosis policy. The decreased number of patients with tuberculosis has led to many tuberculosis units being downsized. However, the decreasing trend in incidence ended in 2022. To resume this trend, it is important to clarify which populations are at higher risk of developing tuberculosis. Methods: This study analyzed annual reports on tuberculosis published by the Japanese government from 2015 to 2024. …

30.08.2026journal-article

Machines

Imbalanced Fault Diagnosis of Harmonic Reducers Using Vibration Signals Based on an Auxiliary Classifier WGAN-GP with Spectral Normalization

Lingdong Wang, Ronggang Yang, Jianlong Wang, Kai Li, Jiawei Xiang, Lishan Gao

Class imbalance is common in vibration-based fault diagnosis because normal-condition data are generally more abundant than fault data. This study proposes an auxiliary-classifier Wasserstein generative adversarial network with gradient penalty and spectral normalization, termed ACWGAN-SG, for fault-sample generation and progressive dataset augmentation. The method combines class-conditioned generation, Wasserstein adversarial learning, gradient penalty, spectral normalization, and PCC-CS-based sample screening. Ex …

30.08.2026journal-article

Journal of Pastoral Care & Counseling: Advancing theory and professional practice through scholarly and reflective publications

Van Gogh, Cowper, and Unfinished Suffering: Narrative Hope in Clinical Chaplaincy

Hyewon Kim

This clinical pastoral reflection explores how historical and artistic narratives may support meaning-making in chaplaincy encounters. During a pastoral visit with a patient experiencing advanced cancer and depression, the lives of Vincent van Gogh and William Cowper became interpretive resources through which suffering was reframed as spiritually continuous rather than spiritually disqualifying. The encounter illustrates how narrative engagement can foster renewed hope while suffering remains unresolved within cli …