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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
12.08.2026journal-article

Pharmacoepidemiology

Virologic Outcomes of Predominantly Tenofovir-Based First-Line Antiretroviral Therapy Among Treatment-Naïve HIV Patients in Davao City, Philippines

Alfredo A. Hinay, Avee Joy B. Dayaganon, Aprilyn F. Francisco-Breva, Jennifer Ashley H. Reyes, Reigner Jay B. Escartin

Background/Objectives: Tenofovir disoproxil fumarate (TDF)-containing regimens remain the cornerstone of first-line antiretroviral therapy (ART) in many low- and middle-income countries. However, concerns regarding treatment failure and antiretroviral resistance highlight the need to evaluate the effectiveness of treatments under routine clinical conditions. This study evaluated the virologic outcomes of treatment-naïve individuals living with HIV who received predominantly TDF-based first-line ART in Davao City, P …

12.08.2026journal-article

Journal of Clinical Medicine

Ethnic Differences in Cardiac Rehabilitation Enrolment, Participation, and Mortality: A Retrospective Cohort Study from Auckland, New Zealand

Paul W. Marshall, Alana McCambridge, Sasha Douglas, Tia Kendal-Lindbom, Wendy Marshall, Michael O’Sullivan, Gayatri Ganesh, Cameron Walker, Nikki J. Earle, Stacey Reading, Jocelyne Benatar, Michael Kingsley

Background/Objectives: Ethnic inequities in cardiovascular disease and healthcare access are well recognised worldwide, but it is unclear whether these inequities translate into differences in cardiac rehabilitation participation and subsequent clinical outcomes. This study examined ethnic differences in cardiac rehabilitation enrolment, participation, and mortality outcomes within a large multi-ethnic cohort to determine whether the association between rehabilitation exposure and mortality differed across ethnic g …

12.08.2026journal-article

Смоленский медицинский альманах

ЧАСТОТА ИСПОЛЬЗОВАНИЯ КОМБИНИРОВАННОЙ АНТИСКЛЕРОТИЧЕСКОЙ ТЕРАПИИ У БОЛЬНЫХ, ГОСПИТАЛИЗИРОВАННЫХ В СТАЦИОНАР С ОСТРЫМ КОРОНАРНЫМ СИНДРОМОМ

И. А. Литвинова, А. Д. Лагунова, Н. Н. Лапик, А. А. Петров

В статье проанализированы клинико-лабораторные характеристики, структура коморбидной патологии и особенности гиполипидемической терапии у пациентов с острым коронарным синдромом в условиях реальной клинической практики. В анализ и включены данные пациентов с подтвержденным диагнозом острый коронарный синдром, госпитализированных в кардиологическое отделение. Изучались демографические показатели, характер основного и фоновых заболеваний, уровни глюкозы, печеночных ферментов, показатели липидограммы, а также проводим …

12.08.2026journal-article

Hong Kong Physiotherapy Journal

Effects of trunk lean on lower-limb muscle activity ratios during single-leg squat in individuals with patellofemoral pain syndrome

Jong Min Kim, Geon Dong Lee, Tae Ho Kim

Background: Patellofemoral pain syndrome (PFPS) is associated with altered activation of the lower-limb muscles during functional tasks such as the single-leg squat (SLS). Although trunk position can influence the recruitment of the hip and knee muscles, the effects of different trunk lean angles on muscle activation ratios in individuals with PFPS remain unclear. Objective: This study aimed to examine how trunk lean angles of 0°, 15°, and 30° affect lower-limb muscle activation ratios during SLS in individuals wit …

12.08.2026journal-article

International Journal of Drug Delivery Technology

Impact of Long-Term Statin Therapy on the Severity and Treatment of Diabetic Retinopathy in Type 2 Diabetes Mellitus

Navya D, Swathi G, Dhanush H C

Background: Diabetic retinopathy (DR) is one of the leading microvascular complications of type 2 diabetes mellitus (T2DM) and remains a major cause of preventable vision loss worldwide. In addition to glycemic control, dyslipidemia has been implicated in the progression of retinal vascular damage. Statins, widely prescribed for lipid-lowering therapy, may provide additional protective effects against the development and progression of diabetic retinopathy. Aim: To assess the role of statin therapy in diabetic reti …

12.08.2026journal-article

Journal of Hypertension

Theoretical foundations of bloodletting therapy for primary hypertension in the southern school of Tibetan medicine: insights from Qinghai-Tibet Plateau medical theory

Wujin Danzeng, Ciwang Duoji, Gama Gele, Ga Wu

Primary hypertension (PH) remains a significant contributor to global morbidity and mortality. While contemporary biomedical treatments are widely utilized, traditional medical systems such as Tibetan medicine provide distinctive diagnostic frameworks and therapeutic modalities. Among these, venesection therapy constitutes a key external intervention, frequently employed in managing conditions corresponding to PH, referred to in classical texts as Trak lung tö tsang (khrag rlung stod ‘tshangs, blood-wind proliferat …

12.08.2026journal-article

Journal of Nursing Scholarship

Virtual Reality–Based Rehabilitation to Improve Mobility and Prevent Falls in Older People With Diabetic Peripheral Neuropathy: Evidence Synthesis and Development of a Geriatric‐Specific Framework

Leodoro J. Labrague, David M. Ha, Liza Visbal‐Dionaldo, Kacy L. Aderhold, Anna Nguyen

ABSTRACT Introduction Diabetic peripheral neuropathy (DPN) among older people is associated with significant gait and balance impairments, postural instability, and an increased fall risk. Virtual reality (VR)‐based interventions have been shown to be effective in improving balance and mobility; however, their design features and applicability for older people with DPN remain unclear. This systematic review was conducted to examine the effectiveness of VR systems on clinical outcomes in individuals with DPN and tra …

12.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Artificial intelligence awareness and employment expectations among university students: Evidence from Turkey

Yahya Algül, İkram Yusuf Yarbaşı

Background The rapid advancement of artificial intelligence (AI) technologies generates concerns about potential job losses in certain occupational groups. In this context, developing effective policy tools in higher education and skill transformation has become essential to ensure that university graduates can adapt to technological change. Objective While the literature mainly focuses on the effects of AI and robotics on employment, limited research examines university students’ awareness of AI and its relationsh …

12.08.2026journal-article

Frontiers in Neuroscience

Beyond speech perception: contemporary landscape of language agnostic hearing assessment

Archer Race Schaeffer, Yinglun Bi, William J. Bologna, Frederick J. Gallun, Tiffany Peng Hwa

Speech perception testing remains the dominant framework for cochlear implant (CI) outcomes assessment, yet its reliance on language introduces two fundamental limitations. Mechanistically, speech recognition performance reflects a composite of peripheral auditory encoding, cognitive processing, and linguistic knowledge, obscuring the contribution of each. Practically, language-dependent testing systematically underserves patients with limited English proficiency, prelingually deafened children, and others for whom …

12.08.2026journal-article

Advanced Research Journal

Hate speech and its conflict potentials among youths in Kenema City

Alhaji Ibrahim Konneh

Hate speech has emerged as a significant issue in contemporary society, with social media amplifying its spread and impact. In Sierra Leone, particularly in Kenema City, hate speech among youths has become a pressing concern, often exacerbating political and ethnic tensions. This study examines the forms, causes, and conflict potential of hate speech among youths in Kenema City, focusing on the role of social media in its proliferation. The research employs a mixed-methods approach, incorporating surveys and interv …

12.08.2026journal-article

Royal Society Open Science

Analysing Korean children's speech data for early childhood educational services: age-specific insights from text and audio analysis

Haein Lee, Hae Sun Jung, Keon Chul Park

Abstract As speech-based artificial intelligence (AI) becomes integrated into educational contexts, attention is growing towards its role in supporting child-centred learning environments. This study offers insights for developing child-friendly conversational AI systems by analysing age-specific linguistic and acoustic features in the speech of Korean-speaking children aged 4–9 years. The study was conducted in three phases: linguistic analysis of transcribed text, acoustic analysis of recorded utterances and auto …

12.08.2026journal-article

Смоленский медицинский альманах

СООТНОШЕНИЕ УДОВЛЕТВОРЁННОСТИ БОТУЛИНОТЕРАПИЕЙ С УРОВНЕМ ТРЕВОГИ У ПАЦИЕНТОВ С ЦЕРВИКАЛЬНОЙ ДИСТОНИЕЙ

Е. А. Кислякова, А. В. Матусевич

Цель. Установить характер соотношения между уровнем ситуативной и личностной тревожности по шкале Спилбергера-Ханина и степенью удовлетворённости ботулинотерапией у пациентов с цервикальной дистонией. Методика. В исследование включено 23 пациента с цервикальной дистонией, находящихся на лечении ботулотоксином типа А. Для сбора данных использовалась специально разработанная анкета по оценке субъективной эффективности ботулинотерапии и удовлетворенности лечением, а также шкала самооценки тревожности Спилбергера в ада …

12.08.2026journal-article

Photobiomodulation, Photomedicine, and Laser Surgery

Systematic Review on the Effectiveness of Photobiomodulation Therapy on Enhancing Musculoskeletal Rehabilitation Outcomes after Total Knee and Hip Arthroplasty

Hadaya Mosaad Eladl, Saja Nashmi Alrashedi, Nesma M. Allam, Dalia Mahmoud Abdelmonem Elsherbini, Mohamed El-Sherbiny, Mohamed Mahmoud Abdelfattah Abdelrahman, Moaz Abulfaraj

Background: Total knee and hip arthroplasty (TKA/THA) effectively alleviate chronic pain and improve joint function and quality of life. However, postoperative recovery is often hindered by pain, edema, restricted range of motion (ROM), and muscle weakness, necessitating structured physical rehabilitation. Photobiomodulation Therapy (PBMT) has been proposed as an adjunct modality to enhance rehabilitation outcomes. This systematic review evaluates the efficacy of PBMT in reducing postoperative pain and edema as wel …

12.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Worldwide survey on artificial intelligence in occupational therapy

Jana Cason, Liat Gafni-Lachter, Tammy Richmond, Karen Jacobs, World Federation of Occupational Therapists

Background Rapid AI integration into healthcare necessitates proactive action to leverage benefits and reduce risks to clients and occupational therapy. Research on AI integration in occupational therapy shows promising outcomes. Objective This study assessed knowledge, use, and attitudes regarding AI in occupational therapy worldwide to inform development of guidance documents and resources for future policy, professional development, and practice in occupational therapy. Methods This cross-sectional descriptive s …

12.08.2026journal-article

Journal of the American Chemical Society

Nonconjugated Side-Chain Engineering Enables Through-Space Interactions for Stimuli-Responsive Photodynamic Therapy

Zining Ge, Zhong-Hong Zhu, Yubo Liu, Qiaoyang Tang, Guangxue Feng, Ben Zhong Tang

Abstract Efficient and stimulus-modulated intersystem crossing (ISC) in photodynamic therapy (PDT) is usually designed via molecular engineering of π-conjugated core structures. Herein, we report that nonconjugated protonatable imide side chains of perylene diimide (PDI) photosensitizers can function as through-space electrostatic regulators of ISC, enabling acid-responsive reactive oxygen species (ROS) generation. Incorporation of a conformationally flexible dimethylamine chain at the imide position enables acid-t …

12.08.2026journal-article

Neonatology

Association of antenatal corticosteroid therapy on women with clinical chorioamnionitis: A nationwide cohort study in Japan

Kana Saito, Hiroyuki Furuya, Atsushi Uchiyama, Fumihiko Namba

Introduction: Antenatal corticosteroids (ACS) prevent neonatal complications and mortality in women at risk of preterm birth. However, the benefits and risks of ACS in chorioamnionitis (CAM) remain debated. This study evaluated whether ACS in women with clinical CAM was associated with adverse neonatal outcomes. Methods: This population-based retrospective study included neonates born before 34 weeks of gestation to women with clinical CAM in Japan between April 2010 and March 2023. Data were obtained from the Neon …

12.08.2026journal-article

Livers

Longitudinal Changes in Utility Scores and Health-Related Quality of Life During Interferon-Free Direct-Acting Antiviral Therapy for Chronic Hepatitis C in Japan: Implications for Cost–Utility Analysis

Maki Hirao, Hiroki Sugimori, Ataru Igarashi, Hiroshi Yatsuhashi, Toshihiko Satoh, Shunya Ikeda, Naohiko Masaki, Hiroshi Yotsuyanagi, Tomoyuki Takura, Takeshi Yoda, Manabu Akazawa, Machi Suka, Naoko Ito, Takeshi Odajima, Tomohiro Hirao

Background/Objectives: Interferon-free direct-acting antiviral (DAA) therapy cures chronic hepatitis C virus (HCV) infection, but its short-term effects on health-related quality of life (HRQoL) are captured differently by generic and disease-specific instruments. We examined longitudinal changes in utility scores and HRQoL in a multicenter Japanese cohort. Methods: Adults with chronic HCV completed the EuroQol 5-Dimension 5-Level questionnaire (EQ-5D-5L), the 8-Item Short-Form Health Survey (SF-8), and the Chronic …

12.08.2026journal-article

Cancer Biome and Targeted Therapy

Targeting Immune Cell Metabolism for Cancer Immunotherapy

Yi-Qing Jiang, Yan-Ling Wu, Tian-Lei Ying

Metabolic reprogramming is a fundamental regulator of immune cell fate and function in the tumor microenvironment (TME), though the relative contributions of individual metabolic pathways vary across immune cell subsets, tumor types, and disease stages. Competition for nutrients, hypoxia, and the accumulation of immunosuppressive metabolites reshape the TME's metabolic landscape, driving functional exhaustion of antitumor immune cells while promoting the persistence of immunosuppressive populations. These metabolic …

12.08.2026journal-article

Journal of Dental Health and Oral Research

In-Office Clear Aligner Therapy in Orthodontics: A Systematic Review of Digital Workflows, Clinical Effectiveness and Cost-Efficiency

Amilkar Cárdenas

Objective: To systematically review and appraise the available evidence regarding the clinical effectiveness, digital workflows, manufacturing processes and cost-efficiency of in-office clear aligner therapy compared with commercially outsourced aligner systems and conventional fixed orthodontic appliances. Methods: A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL) and Google Scholar for publications up to Marc …

12.08.2026journal-article

Human Factors and Ergonomics in Manufacturing & Service Industries

Occupational Accidents in Industrial Maintenance: A Systematic Review of Typologies and Causal Factors

Jonas Leonardo Gomes de Araújo, Ruan Eduardo Carneiro Lucas, Jader Morais Borges

ABSTRACT Industrial maintenance, as it involves direct contact with the internal components of machinery and equipment, entails a high level of exposure to occupational risks, requiring integrated analyses that correlate accident types, causal agents, and maintenance strategies. The aim of this study was to systematically map these associations, offering a fresh perspective on how specific maintenance strategies dictate accident causality. To this end, a systematic literature review (SLR) was conducted following th …

12.08.2026journal-article

Neuroprotection

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang

Abstract Current evidence indicates that antiplatelet therapy as a cornerstone for secondary prevention of cerebral infarction. However, ischemic or bleeding events arising from antiplatelet drug resistance or excessive platelet inhibition can diminish its clinical benefit. These challenges have laid the foundation for individualized antiplatelet treatment. Although cytochrome P450 family 2 subfamily C member 19 ( CYP2C19 ) genetic polymorphisms have partially addressed the issue of drug resistance in these patient …

12.08.2026journal-article

Cancer Biome and Targeted Therapy

The Role and Mechanistic Effects of Gut Microbiota Metabolites in Immunotherapy for Hepatocellular Carcinoma

Yau-Tuen Chan, Pengde Lu, Jiaqi Zou, Zhuofeng Jiang, Lin Xu, Ning Wang

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced hepatocellular carcinoma (HCC), but low response rates and drug resistance remain major clinical challenges. Recent data underscore the gut-liver axis as a major determinant of therapeutic outcomes, particularly amid an epidemiological transition towards chronic liver diseases. In this review, we summarize the effects of gut microbiota-derived metabolites on the hepatic tumor immune microenvironment (TIME) and the efficacy of ICIs. Be …

12.08.2026journal-article

Stem Cell Research & Therapy

Gestational age–associated differences in human umbilical cord mesenchymal stem cells: biological, paracrine, and neuroprotective properties

Xirui Peng, Yuhang Zhang, Yizhuo Li, Yangyang Cao, Lingling Zhang, Ju Wang, Xiaoli Zhang, Yiran Xu, Yu Yang, Jiajia Duan, Yuyang Yue, Juan Song, Changlian Zhu

Abstract Background Human umbilical cord mesenchymal stem cells (UCMSCs) have shown considerable therapeutic promise for neonatal brain injury. However, whether gestational age influences UCMSC biological characteristics and therapeutic efficacy remains unclear. This study investigated the potential functional and molecular differences between UCMSCs derived from preterm and full-term infants to inform future autologous and allogeneic cell-based therapies. Methods UCMSCs were isolated from full-term and preterm umb …

12.08.2026journal-article

Frontiers in Digital Health

Automatic analysis of speech representations to assess psychological distress

Sara Fernández-Velasco, Jose Moreno-Mesa, Daniel Escobar-Grisales, Diego M. Lopez, Juan Rafael Orozco-Arroyave

Background Current mental health diagnostic methods are limited by subjective clinical interpretation. Automatic speech analysis is a promising technology for objective assessment. Objective To evaluate and compare different speech-based representations (acoustic, phonetic, and time-frequency) and deep learning-based embeddings for discriminating symptoms associated with psychological distress. Methods A secondary analysis of the Distress Analysis Interview Corpus (DAIC-WOZ) was conducted using recordings from 125 …