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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

IPS Journal of Basic and Clinical Medicine

Navigating the Gap: A Review of Time to Treatment Intervals and Cervical Cancer Survival in Sub-Saharan Africa

Bright Odinaka Okorocha, Chigaemezu Remmy-Martin Akubuo, Abdulhafeez Opeyemi Busari, Lovelyn Chiamaka Nnanyereugo, John Perpetual Chimazuru, Confidence Chinaza Ogbomade, Victory Mmerichukwu Ogbatuo

Background: While cervical cancer is highly preventable through the HPV vaccine, early detection, and treatment, it continues to be a significant contributor to the morbidity and mortality of women in Sub-Saharan Africa (SSA). Poorer survival outcomes in SSA compared to high-income countries can, to a large extent, be attributed to patients being unable or unwilling to present to the health system to obtain curative treatment in a timely manner. Time-to-treatment interval (TTI) has gained traction as a key measure …

30.08.2026journal-article

Journal of Cardiovascular Electrophysiology

Clinical Outcomes After Catheter Ablation in Patients With Structural Heart Disease and Ventricular Fibrillation

Kenji Hashimoto, Samual Turnbull, Saurabh Kumar

ABSTRACT Introduction In patients with ischemic cardiomyopathy (ICM), recurrent VF may be treated with catheter ablation by targeting triggering premature ventricular complexes (PVCs) and/or ventricular scar homogenization. Data on optimal ablation strategies in patients with non‐ischemic cardiomyopathy (NICM) remain limited. This study aimed to compare ablation strategies and outcomes in patients with recurrent VF due to ICM versus NICM. Methods and Results We retrospectively analyzed consecutive patients with str …

30.08.2026journal-article

IECCMEXICO

Occult Osteochondral Injuries in Athletes: Advanced Imaging, Clinical Evolution, and Criteria for Safe Return to Sport

Jose Gregorio Requena Rodriguez, Loys Eliana Tello Caldas, Edunice Beatriz Mora López, Juan Pablo Monroy Moreno, Angie Michelle Junco Aguaiza, Juan José Dorado Victoria, Fabián Patricio Miranda Yáñez, Jorge Roberto Gandarilla San Luis, Nicolás Camilo Rivera Calvo, Eduardo Andres Castillo González

Occult osteochondral lesions represent an important challenge in sports medicine because they may remain undetected during initial assessment despite persistent pain, swelling, mechanical symptoms, and functional limitation. This study analyzed the role of diagnostic imaging, clinical and structural evolution, and return-to-sport criteria in athletes with osteochondral injuries, with particular emphasis on the knee and ankle. An integrative descriptive and analytical review was conducted using the Scientific Method …

30.08.2026journal-article

Journal of the American Heart Association

Natriuretic Peptide and Transthyretin and Their Relationship With Clinical Outcomes: Results From ATTRIBUTE‐CM, a Randomized Controlled Trial

Onyedika John Ilonze, Daniel Philip Judge, Ahmad Masri, Prem Soman, Francesco Cappelli, Michel Georges Khouri, Nitasha Sarswat, Mazen Hanna, Yuxi Liu, Gillian Murtagh, Kuangnan Xiong, Adam Castaño, Jean‐François Tamby, Jonathan C. Fox, Uma Sinha, Jan Marie Griffin, Julian D. Gillmore, James Louis Januzzi

Background Transthyretin amyloid cardiomyopathy (ATTR‐CM) carries high risk for all‐cause mortality (ACM), cardiovascular mortality (CVM), and cardiovascular hospitalization (CVH). NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) and serum TTR (sTTR) are prognostic biomarkers in transthyretin amyloid cardiomyopathy, but their combined value for integrated risk stratification remains unknown. We evaluated the relationship between baseline NT‐proBNP and sTTR and their prognostic value in ATTRIBUTE‐CM (Efficacy a …

30.08.2026journal-article

Biomedicines

Long-Duration Response to Levodopa in Patients with Early Parkinson’s Disease: Pharmacodynamics, Neuroplasticity, and Clinical Implications

Giorgia Sciacca

Background: The most effective pharmacological treatment for Parkinson’s disease (PD) remains levodopa, whose responsiveness is distinguished into two temporally and mechanistically distinct components: the short-duration response (SDR), which lasts hours, closely paralleling drug plasma concentration, and the long-duration response (LDR), which derives from prolonged administration of levodopa and persists for days to weeks after drug discontinuation. The mechanisms underlying the LDR and, in particular, the behav …

30.08.2026journal-article

JAMA

Low-Voltage Ablation in Persistent Atrial Fibrillation

Astrid Paul Nordin, Emmanouil Charitakis, Carina Carnlöf, Finn Åkerström, Ott Saluveer, Henrik Almroth, Lars O. Karlsson, Anders Hassel Jönsson, Csaba Herczku, Jari Tapanainen, Niklas Höglund, Emma Svennberg, Frieder Braunschweig, Tara Bourke, Jonas Schwieler, Hamid Bastani, Serkan Saygi, Fahd Asaad, Yusuf Türkmen, Mats Jensen-Urstad, Nikola Drca

Importance Pulmonary vein isolation remains the foundational ablation approach for atrial fibrillation (AF), yet outcomes in persistent AF remain suboptimal. Targeting low-voltage zones identified by electroanatomical mapping offers a promising strategy for enhancing ablation success. Objective To determine whether adjunctive individualized low-voltage zone ablation improves arrhythmia outcomes and health-related quality of life beyond pulmonary vein isolation alone in patients with persistent AF and significant lo …

30.08.2026journal-article

Clinical Case Reports

Malaria‐Associated Secondary Hematophagocytic Lymphohistocytosis—A Case Report and Comprehensive Literature Review (sHLH)

Indresh Yadav, Sulav Kumar Jha, Sweta Singh, Dipesh Kumar Mandal, Saurav Jha

ABSTRACT Malaria‐associated secondary HLH, though rare, is often overlooked. Clinicians should maintain a high‐index of suspicion in travelers returning from malaria‐endemic regions who develop severe to rapidly worsening inflammatory illness, as early recognition is critical for survival.

30.08.2026journal-article

International Journal of Molecular Sciences

Natriuretic Peptides as Predictors for the Diagnosis of Pulmonary Hypertension Secondary to Left Heart Disease and for the Assessment of Its Severity

Filip Sawczak, Agata Kukfisz, Aleksandra Soloch, Kamila Kurkiewicz-Sawczak, Magdalena Dudek, Ewa Straburzyńska-Migaj, Marta Kałużna-Oleksy

Pulmonary hypertension (PH) frequently complicates heart failure with reduced ejection fraction (HFrEF) and worsens prognosis. Right heart catheterization (RHC) remains the diagnostic gold standard, but natriuretic peptides may help identify patients requiring invasive assessment. We retrospectively analyzed 563 HFrEF patients who underwent RHC. Patients with and without PH were compared. Associations between B-type natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and RHC parameters …

30.08.2026journal-article

JAMA Internal Medicine

Specialist Referral for Cardiovascular Risk in Patients With Prostate Cancer

Darryl P. Leong, Celestia Higano, Cristina Cano Garcia, Vincent Fradet, D. Robert Siemens, Tamim Niazi, Bobby Shayegan, Avirup Guha, Filipe Cirne, Joseph B. Selvanayagam, Philippe D. Violette, Felipe H. Valle, Luke T. Lavallée, Emmanuelle Duceppe, Patrick Anderson, Denis Xavier, Jose Patricio Lopez-Lopez, Nicolas Villareal Trujillo, Ariel Galapo Kann, Rafaela K. Piccoli, Marina Mourtzakis, David Sarid, Srivatsa Narasimha, Patrick P.W. Luke, Ludhmila A. Hajjar, Himu Lukka, Laurence Klotz, Kumar Balasubramanian, Rajibul Mian, Steven Agapay, Sumathy Rangarajan, Sarah Karampatos, Kelvin K. H. Ng, Alvaro Avezum, P. J. Devereaux, Jehonathan H. Pinthus, RADICAL PC Investigators, Alanna Hall, Meghan Cagnin, Maheen Farooqi

Importance Patients with prostate cancer have a high burden of cardiovascular risk factors, often suboptimally controlled, and adverse cardiovascular outcomes. Objective To determine whether the routine referral of patients with prostate cancer to a cardiovascular specialist to implement a systematic risk factor strategy is more likely to reduce adverse cardiovascular outcomes and improve risk factor control than usual care. Design, Settings, and Participants This randomized clinical trial included patients with pr …

1 Zitationen
30.08.2026journal-article

Wilderness & Environmental Medicine

Epinephrine Autoinjectors as an Improvised Treatment for Severe Asthma in Austere Settings

Kenneth V. Iserson

Severe asthma exacerbations may rapidly become fatal when bronchodilator therapy is unavailable. In wilderness and disaster environments, inhaled β 2 -agonists—the standard treatment—may be lost, depleted, or otherwise inaccessible. Epinephrine has been used for more than a century as a bronchodilator and was historically administered subcutaneously or intramuscularly for acute asthma before selective β 2 -agonists became widely available. In emergency medicine, parenteral epinephrine remains an accepted rescue the …

30.08.2026journal-article

Arthroscopy

Editorial Commentary : Use of Glenoid Labral Augmentation as an Effective Treatment for Subcritical Glenoid Bone Loss

Anthony Zacharias

Abstract Restoration of joint function and mechanics is the goal of every shoulder stabilization surgery. Achieving this goal in the setting of altered anatomy and bone loss is easier said than done. In restoring a joint, it is important to understand what native tissue can be repaired, what can be augmented, or what needs to be reconstructed. For this, we rely on biomechanical research, patient outcomes, and long‐term follow‐up of patients. Bone augmentation procedures have provided a crucial role in shoulder inst …

30.08.2026journal-article

International Journal of Medical Sciences and Pharma Research

Implementing Enhanced Recovery After Surgery (ERAS) Protocols in Resource-Limited Environments: A Critical Review for Nigerian Surgical Patients

Fagbohun Omolola, Oshunpidan Adekunbi, Eke Ngozi

Background: Enhanced Recovery After Surgery (ERAS) protocols have been shown to improve perioperative outcomes and reduce healthcare costs in various settings. However, their implementation in resource-limited environments, such as Nigeria, remains constrained due to infrastructural, economic, and sociocultural barriers. Methods: This critical review synthesizes current literature on the application of ERAS protocols in resource-constrained environments, with a focus on Nigeria. A comprehensive search of PubMed, Sc …

30.08.2026journal-article

Revista ft

Detecção e diagnóstico de falhas em sistemas HVAC e sua relação com o desempenho energético de edificações: uma análise bibliométrica

Bruno de Oliveira Schneider, Guilherme Agues Emerick, Matheus Alves Lima, Rodrigo de Souza, Thales Rodrigues Barboza

Heating, ventilation, and air conditioning systems (HVAC) play an important role in the energy performance of buildings and faults in their components can compromise operational efficiency, increasing energy consumption. This study analyzed the scientific literature on fault detection and diagnosis (FDD) in HVAC systems and its relationship with building energy performance, seeking to understand the evolution of the topic and its main trends. A bibliometric analysis was conducted using publications indexed in the W …

30.08.2026journal-article

International Journal of Medical Science and Dental Health

Comorbidity Patterns Associated with Renal Dysfunction Across COPD Severity Stages and Clinical Phenotypes

Abdigaffar G. Gadaev, Muborak S. Salaeva, Dinora A. Parpibaeva, Nargiza D. Salimova, Fazilat R. Ismoilova, Abdisalim K. Kulkarayev

Background: Chronic obstructive pulmonary disease (COPD) is frequently accompanied by cardiovascular, metabolic, haematological and urinary system comorbidities. The presence of renal dysfunction may further modify the clinical profile and prognostic significance of these comorbid conditions. Objective: To comparatively evaluate comorbidities associated with renal dysfunction in patients with COPD across different disease severity stages and clinical phenotypes. Methods: A total of 609 patients with COPD were inclu …

30.08.2026journal-article

Journal of Clinical Medicine

Restoration of Radial Bowing After Elastic Stable Intramedullary Nailing in Pediatric Forearm Fractures: The Importance of Bowing Location in Addition to Magnitude

Osman Görkem Muratoğlu, Hasan Ceylan, Gökhan Güzel, Fatih Günaydın, Fevzi Mehmet Kuyumcu, Mehmet Ali Talmaç, Cem Yıldırım

Background/Objectives: Elastic stable intramedullary nailing (ESIN) is widely used for the treatment of pediatric diaphyseal forearm fractures. Although fracture union is commonly achieved, restoration of physiological radial bowing is essential for optimal forearm biomechanics. Most previous studies have focused on bowing magnitude, whereas the anatomical location of maximal radial bowing has received limited attention. Methods: This retrospective observational study included pediatric patients aged 4–16 years who …

30.08.2026journal-article

Clinical Cardiology

Comparison of Guideline‐Directed Medical Therapy in Black versus White Patients With Heart Failure With Reduced Ejection Fraction in a Large, Integrated Health Care System

Natalia C. Berry, Yi‐Shin Sheu, Karen Chesbrough, R. Clayton Bishop, Suma Vupputuri

ABSTRACT Background Guideline‐directed medical therapy (GDMT) improves clinical outcomes for patients with heart failure with reduced ejection fraction (HFrEF). While GDMT treatment differences have been described for Black patients, data are limited. Aims We sought to evaluate, among Black and White HFrEF patients, differences in GDMT use and target dosing by race. Materials & Methods We examined health records of Black and White patients with HFrEF between 2015 and 2022. GDMT was defined by four medication classe …

30.08.2026journal-article

European Journal of Medical Research

Intelligent diagnosis of vocal cord lesions via multimodal deep learning: integrating laryngoscopy, voice, and biomarkers

Xue Zhao, Shuang Li, Linlin Zheng, Tuanjie Wang, Haixian Guo, Dan Yu

Abstract Background Accurate pre‑operative diagnosis of vocal cord lesions remains challenging. We developed a multimodal deep learning model that integrates laryngoscopic images, voice recordings, and biochemical markers to improve diagnostic accuracy. Methods In this retrospective study (2020–2025), a total of 425 patients were enrolled. Of these, 374 patients treated between January 2020 and May 2025 formed the development cohort (contributing 1,947 aligned multimodal samples), and the remaining 51 consecutive c …

30.08.2026journal-article

Journal of Vascular Societies Great Britain & Ireland

The effect of preoperative natriuretic peptide testing on outcome in vascular surgery: a systematic review and meta-analysis

G Imperatore, N Bradley, L Hanna, J Gudgeon, P Chong

Objective: The aim of this systematic review and meta-analysis was to evaluate the prognostic utility of natriuretic peptide testing for predicting adverse postoperative outcomes in patients undergoing vascular surgery, and to assess their incremental value within established perioperative risk stratification frameworks. Specific endpoints included mortality, myocardial infarction, stroke and prolonged hospitalisation. A secondary objective was to determine whether natriuretic peptide testing offers incremental pro …

30.08.2026journal-article

Journal of Clinical Medicine

Comparison of the Effects of Sorafenib and Stem Cell Secretome on HepG2 Cancer Cells with Respect to the Ras/Raf/MEK/ERK Pathway

Aleksandra Gładyś, Aleksandra Skubis-Sikora, Bartosz Sikora, Kinga Pogoda-Mieszczak, Patrycja Wieczorek, Edyta Bogunia, Piotr Czekaj

Background/Objective: Liver cancer is a global health challenge due to its resistance to most systemic therapies. Human mesenchymal and epithelial stem cells exhibit anti-proliferative and pro-apoptotic effects on some cancer cell lines, which can be used to support standard therapy. The aim of this study was to investigate the effects of conditioned media (CM) derived from mesenchymal adipose tissue-derived stem cells (hADSCs) and amniotic membrane-derived cells expressing both mesenchymal and epithelial markers ( …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

Causes of pulmonary bleeding in cancer patients

Roman S. Kiselev, Evgeniy A. Tarabrin, Z. G. Berikkhanov, S. Yu. Muravev, M. Yu. Ivanova

Objective. To analyze the causes of pulmonary hemorrhage (PH) in cancer patients. Material and methods. During the period 2010–2022, pulmonary hemorrhage was treated in cancer patients. The causes of PH were analyzed based on the nosology of cancer diseases. The involvement of the great circle of circulation (GCC) was determined based on the presence of direct or indirect radiological signs of bronchial angiography, the clinical outcome of endovascular treatment for PH, and the results of autopsy. CT of the chest w …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

Secondary haemophagocytic lymphohistiocytosis in blood malignancies. The multicentre retrospective study

Vsevolod G. Potapenko, Alina S. Antipova3, Julia A. Zhuravleva, Yulia V. Zabutova, Alina Yu. Zavyalova, Irina V. Ishmatova, Elena V. Karyagina, Natalia A. Kotova, Valeria V. Kozyro, Tatiana G. Kulibaba, Daniil A. Manaenkov, Nadezhda V. Medvedeva, Natalia B. Mikhailova, Olga V. Nebelitskaya, Elena S. Pavlyuchenko, Victoria V. Ryabchikova, Irina A. Samorodova, Alexander V. Serkov, Irina A. Skorokhod, Kseniya A. Skoryukova, Tatiana V. Fedorenko, Darya A. Chaginskaya, Vasily A. Shuvaev, Vadim I. Mazurov

Haemophagocytic syndrome (HPS) or haemophagocytic lymphohistiocytosis is a reaction of severe but ineffective inflammation. Blood malignancies (BlM) are among the frequent causes of HPS in adults. Objective. To analyse survival, causing trigger haemoblastosis, relationship with tumor and efficacy of including etoposide in chemotherapy of patients with secondary HPS-BlM. Material and methods. A retrospective analysis of case histories of patients with BlM complicated by SHPS was performed. The diagnosis of SHPS was …

30.08.2026journal-article

ANZ Journal of Surgery

Managing Outliers in Australian Surgical Clinical Quality Registries

Alun Cameron, Konstance Nicolopoulos, R. James Aitken, Helena Kopunic, Wendy Babidge, Guy J. Maddern

ABSTRACT Clinical quality registries (CQRs) are central to improving surgical safety and quality by enabling systematic monitoring of outcomes and proactive identification of outliers. Published guidelines provide important advice on methods and activities for CQRs. Guideline flexibility allows for the varied and unique requirements of each CQR, but some aspects around guideline implementation are less certain, particularly for outlier management. In order to describe activities in Australia and the UK, searches we …

30.08.2026journal-article

Journal of the American Heart Association

Sex Differences in Treatment Effect of Adjunctive Intra‐Arterial Urokinase After Successful Thrombectomy: A Post Hoc Secondary Analysis of the POST‐UK Randomized Clinical Trial

Xuanyu Chen, Linyu Li, Gaoming Li, Lingyu Zhang, Haoxuan Zhu, Xu Xu, Jinfu Ma, Lilan Wang, Zhixi Wang, Jiayu Li, Qiuyi Yang, Yian Chen, Mingyang Chen, Yihui Yang, Yuhan Fan, Kaiyuan Feng, Chunye Chen, Jiaxing Song, Wenjie Zi, Kunxin Lin

Background Whether adjunct intra‐arterial urokinase has differential effectiveness and safety by sex among patients with acute ischemic stroke who achieve near‐complete to complete reperfusion after endovascular thrombectomy (EVT) remains unknown. Methods This post hoc analysis of the POST‐UK (Adjunctive Intra‐Arterial Urokinase After Successful Endovascular Thrombectomy in Patients With Large‐Vessel Occlusion Stroke) multicenter randomized clinical trial included 534 patients with proximal intracranial large‐vesse …

30.08.2026journal-article

Journal of International Medical Research

Clinical features of primary intestinal follicular lymphoma: A single-center retrospective study

Chun-Lin Ying, Tian-Qi Zhao, Qin-Xue Pu, Han-Cheng Huang, Wei Liu

Objective To characterize the clinical features of primary intestinal follicular lymphoma and provide insights into its diagnosis and management. Methods We retrospectively analyzed the clinical, endoscopic, imaging, pathological, and long-term follow-up data of eight patients with primary intestinal follicular lymphoma who were admitted between January 2019 and August 2025. Results The mean patient age was 58.13 years, and 75.00% of patients were women. Abdominal pain (62.50%) was the most common clinical manifest …