Journal of Mid-life Health
Cancer Risk in Premature Ovarian Insufficiency: Current Evidence and Clinical Implications
A BSTRACT Premature ovarian insufficiency (POI), defined as loss of ovarian function before 40 years with elevated gonadotropins and oligo/amenorrhea, is increasingly recognized as a systemic condition with long-term health consequences. While cardiovascular, skeletal, and neurocognitive risks are well established, the relationship between POI and cancer risk remains less clearly understood. This mini-review summarizes current evidence on site-specific malignancy risks in women with POI and evaluates the influence …