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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
12.08.2026journal-article

International Journal For Multidisciplinary Research

Biomass-Derived Nanocarbons for Antimicrobial Therapy: A Sustainable Pathway for Developing Health Infrastructure

Hezam Dhaif Allah

Nanocarbon-based drug delivery systems have gained increasing attention as advanced platforms for enhancing antimicrobial therapy, particularly in low-resource settings where drug resistance and limited healthcare infrastructure remain critical challenges. Among various nanocarbon materials, biomass-derived nanocarbon and carbon-based nanoparticles offer a unique combination of low-cost production, high surface area, tunable surface chemistry, and efficient drug loading capacity, making them especially suitable for …

12.08.2026journal-article

The Egyptian Journal of Otolaryngology

Adult aural rehabilitation practices among audiologists in India – a cross-sectional survey

Aparna Nandurkar

Abstract Background Adult hearing loss is a major global health concern. Adult aural rehabilitation (AR) is a comprehensive intervention that extends beyond hearing aid fitting to address communication, psychosocial well-being, and participation. Despite its recognized importance, information regarding adult AR practices among audiologists in India is limited. Objectives To investigate the current practices, service delivery models, assessment approaches, barriers, and perceptions related to adult AR among audiolog …

12.08.2026journal-article

Frontiers in Digital Health

Speech analysis for acute decompensated heart failure: reporting a pilot study in Germany

Andreas Triantafyllopoulos, Wolfgang Mayr, Anton Batliner, Lana Lempkens, Björn W. Schuller, Thomas M. Berghaus

Acute decompensated heart failure (ADHF) has been shown to affect breathing and speech production. We present a new German speech dataset and conduct a pilot study to show the feasibility of using speech to distinguish between decompensated and recompensated ADHF. We achieve accuracy rates of 77 % for this binary classification using read speech, with the use of segmented phrases scoring at 75% and sustained vowels trailing far behind at 52%. Our feature analysis shows a reduction in breathiness and an increase in …

12.08.2026journal-article

Frontiers in Oncology

Case Report: Synchronous cutaneous and pineal metastases from gastric adenocarcinoma—inter-lesion biomarker heterogeneity and multi-line targeted therapy

Qing Shen, Wanqian Zhang, Ying Chen

Gastric adenocarcinoma simultaneously metastasizing to the skin and pineal gland represents an extraordinarily rare clinical manifestation. Pineal metastases account for less than 1% of all adult intracranial tumors and seldom originate from gastrointestinal primary lesions, and this atypical metastatic combination frequently results in delayed diagnosis and complicated clinical decision-making. Distinct molecular profiles between primary and metastatic lesions create additional obstacles to personalized treatment, …

12.08.2026journal-article

Frontiers in Oncology

Evolution from KRAS G12C-mutant to ALK fusion-positive stage IV lung adenocarcinoma following immune checkpoint inhibitor therapy: a case report

Feng Xu, Hongli Pu, Na Yan, Yunhui Wei

Background Immune checkpoint inhibitors (ICIs) have become standard treatment for KRAS-mutant lung adenocarcinoma, but acquired resistance inevitably develops. Tumor clonal evolution under therapeutic pressure is a key resistance mechanism. The emergence of a new oncogenic driver mutually exclusive with the original one is rare. Case report We report a 51-year-old female with stage IV lung adenocarcinoma harboring a KRAS G12C mutation along with TP53 and RB1 alterations. She received first-line therapy including th …

12.08.2026journal-article

Journal of Clinical Medicine

Changes in Serum C-Reactive Protein Following Nonsurgical Periodontal Therapy: A Systematic Review and Meta-Analysis

José María Montoya-Carralero, Rebeca Ávila-Villasmil, María Fernanda Romo-García, Alfonso Jornet-García, Arturo Sánchez-Pérez, María José Moya-Villaescusa

Background: Periodontitis is associated with elevated circulating C-reactive protein (CRP), but the extent to which CRP changes after nonsurgical periodontal therapy remains uncertain. This systematic review and meta-analysis examined within-participant changes in serum CRP and considered controlled evidence separately. Methods: PubMed/MEDLINE, the Cochrane Library, and SciELO were searched through August 2025. For uncontrolled pre-post studies reporting periodontitis-specific paired data, mean CRP reductions in mg …

12.08.2026journal-article

Pharmaceuticals

Gold Nanoparticles in Prostate Cancer: Advances in Targeted Therapy, Diagnostics, and Precision Nanomedicine

Umme Hani, Mona Al Hamod, Noura Al Hamood, Yahya Alhamhoom, Mohammed Ghazwani, Fahad AlQahtani, Helal A. Helal, Riyaz Ali M. Osmani

Prostate cancer (PC) is one of the most common cancers in men globally and there is an urgent need for new immune-based approaches because many traditional therapies, including chemotherapy, radiotherapy, and anti-androgens, have limitations. Due to their distinct physicochemical and biological features, gold nanoparticles (AuNPs) are emerging as a potential nanoplatform for the development of strategies in prostate cancer therapy. These features include tunable size, shape, and surface plasmon resonance (SPR) and …

12.08.2026journal-article

Clinical Rehabilitation

Physical and mental health-related quality of life outcomes of non-pharmacological interventions in early multiple sclerosis: A systematic review and meta-analysis

Adam Dawidziuk, Delfina Popiel

Objective To determine the effect of non-pharmacological interventions on physical and mental health-related quality of life among adults with early diagnosed multiple sclerosis. Data sources PubMed, EMBASE, Cochrane CENTRAL, ClinicalTrials.gov and APA PsycINFO were searched from database inception to 8 July 2026. Review methods We conducted a systematic review and meta-analysis of randomised controlled trials comparing non-pharmacological interventions with control conditions in adults with early-stage multiple sc …

12.08.2026journal-article

Cognitive Therapy and Research

Does Verbal Crystallized Intelligence Predict Efficacy of Psychological Therapies for PTSD? Results from a Randomized Controlled Trial Comparing Dialectical Behavior Therapy for PTSD (DBT-PTSD) and Cognitive Processing Therapy (CPT)

Regina Steil, Kathlen Priebe, Meike Müller-Engelmann, Tara Faust, Thomas Fydrich, Frank Enning, Nikolaus Kleindienst

Abstract Background Treatment response in posttraumatic stress disorder (PTSD) varies widely. Intelligence has been proposed as a potential predictor, particularly in cognitively demanding interventions such as Cognitive Processing Therapy (CPT), but evidence remains limited and mixed. Objective To examine whether pretreatment verbal crystallized IQ (cIQ) is associated with treatment outcome and dropout in individuals with childhood abuse-related PTSD receiving CPT or Dialectical Behavior Therapy for PTSD (DBT-PTSD …

12.08.2026journal-article

Stem Cell Research & Therapy

A single-donor proof-of-concept single-cell analysis maps heterogeneous differentiation trajectories toward cartilage-like states in human urine-derived stem cells

Alexander Schulz, Emily M. Brockmann, Miriam Zentgraf, Andreas S. Baur, Steffen Uebe, Arif B. Ekici, Mark Dedden, Sebastian Zundler, Christian T. Thiel

Abstract Background Urine-derived stem cells (USCs) represent an accessible and non-invasive cell source with reported chondrogenic differentiation potential. However, the cellular heterogeneity and transcriptional dynamics underlying USC differentiation remain incompletely understood, limiting their translational interpretation. Methods We combined functional differentiation assays with single-cell RNA sequencing to characterize USC differentiation at both phenotypic and transcriptional levels. Chondrogenic and os …

12.08.2026journal-article

Frontiers in Immunology

Contrasting outcomes of visceral leishmaniasis in two patients with membranous nephropathy receiving immunosuppressive therapy: a case report

Xiu Sun, Yan Wang, Ruixian Duan

Background Visceral leishmaniasis (VL) often presents with an atypical and fulminant course in immunocompromised hosts, and treatment faces multiple challenges including drug toxicity, immunosuppressive status, and complications. Case presentation Here we report two cases of VL in patients with membranous nephropathy(MN) who developed the infection after long-term immunosuppressive therapy. Both patients presented with fever, pancytopenia, and markedly elevated inflammatory markers. Case 1 had relapsed VL complicat …

12.08.2026journal-article

Antioxidants

Current Study of Alpha-Mangostin in Breast Cancer Therapy: Antioxidant Mechanisms and Redox Modulation from In Silico to In Vivo Studies

Muchtaridi Muchtaridi, Bintang Satrio Mahardika, Luthfi Utami Setyawati, Dhania Novitasari, Jasimah Jasimah, Febby Pratama, Nur Kusaira Khairul Ikram

Breast cancer remains a major disease burden and a leading cause of cancer-related morbidity and mortality among women, while current therapies are often limited by toxicity, drug resistance, and recurrence. α-Mangostin (AM), a prenylated xanthone derived from Garcinia mangostana L., has attracted considerable interest because of its antioxidant, redox-modulating, and anticancer properties, which may contribute to improved health outcomes and patient well-being. This study systematically reviewed the therapeutic po …

11.08.2026journal-article

Australian and New Zealand Journal of Family Therapy

Conversations With Dr Walter H. Smith Jr: Systems Thinking and Family Dynamics and Its Application in Child Welfare and Other Human Services

Kumudu Rathnayaka, Walter H. Smith, Linda MacKay

ABSTRACT This interview with Dr Walter H. Smith Jr explores the application of Bowen family systems theory to child welfare practice and organisational leadership. Dr Smith stands at the intersection of clinical psychology, systemic leadership and social advocacy. His personal experiences within his own family of origin sparked a lifelong enquiry into human adaptation, suffering and resilience, pursued rigorously through the lens of Bowen family systems theory. Dr Smith's engagement with Bowen theory, including pos …

11.08.2026journal-article

Occupational and Environmental Medicine

Occupational exposure to noise and depression incidence: a nationwide cohort study of workers in Denmark, 2000–2017

Anne Marie Kirkegaard, Aslak Harbo Poulsen, Zara Ann Stokholm, Henrik Albert Kolstad, Lau Caspar Thygesen, Jenny Selander, Karin Sørig Hougaard, Ida E H Madsen, Mette Sørensen

Objectives Research on the association between occupational noise and incident depression is limited. We investigated whether long-term occupational noise was associated with depression risk, both independently and in combination with other stress-related factors. Methods In a Danish nationwide register-based cohort of 2 424 542 workers aged 25–64 years, individual-level occupational histories were linked to noise exposure using a job exposure matrix. Noise exposure was aggregated as 5-year running means. During fo …

11.08.2026journal-article

Journal of Cardiopulmonary Rehabilitation and Prevention

Post-Traumatic Stress Disorder Severity and Cardiac Rehabilitation Utilization Following Myocardial Infarction

Pranav Sreekumar, Joanne Salas, Allan S. Jaffe, Beth E. Cohen, Kenneth E. Freedland, Paula P. Schnurr, Patrick J. Lustman, Matthew Friedman, Jeffrey F. Scherrer

Purpose: Post-traumatic stress disorder (PTSD) is associated with poor health behaviors and risk for cardiovascular disease, and PTSD may impair cardiovascular disease recovery. Whether PTSD severity is a barrier to cardiac rehabilitation (CR) use following a new myocardial infarction (MI) or revascularization (percutaneous coronary intervention or coronary artery bypass grafting) is uncertain. Methods: Eligible patients were identified from Veterans Health Administration historical medical record data. Patients (N …

11.08.2026journal-article

Journal of Deaf Studies and Deaf Education

Speech-language pathologists’ perceptions of common myths related to deaf and hard of hearing children who use signed language

Kristen Secora, Brittany Lee, Kym Meyer

Abstract Speech-language pathologists (SLPs) have little formal education related to the needs of deaf and hard of hearing (DHH) children who use a signed language and often report feeling underprepared to work with this population. Although a small subset of SLPs specialize in working with DHH children, the majority of DHH children are served by generalist SLPs without specialized training. We surveyed 50 SLPs (26 self-reported DHH specialists) to better understand SLPs’ awareness of common myths or misunderstandi …

11.08.2026journal-article

Journal of Applied Pharmaceutical Science

Medicinal Plants for Hemorrhoid Therapy: Mechanistic Insights, Bioactive Compounds, and Preclinical-to-Clinical Evidence

Muhammad Rizal Januardi, Finna Setiawan, Ridho Islamie, Johan Sukweenadhi, Boonsong Wungsintaweekul, Kartini Kartini

Hemorrhoid is a multifactorial condition involving inflammation, venous stasis, degeneration of supporting tissue, and vascular fragility. It requires safer adjunctive therapy options for long-term use. This narrative review seeks to comprehensively examine potential anti-hemorrhoidal medicinal plants by linking bioactive compounds, pharmacological targets, and evidence from in vitro , in vivo , and clinical trials. Literature searches were conducted using PubMed, Scopus, Web of Science, ScienceDirect, and Google S …

11.08.2026journal-article

European Journal of Preventive Cardiology

Beta-blocker therapy and physical activity after myocardial infarction: a preplanned sub-study of the BETAMI trial

Erik Madssen, Elise Sverre, Johanne E Nyen, Therese L F Holmager, Anna M D Kristensen, Arnhild Bakken, Jarle Jortveit, Thor Edvardsen, Terje Steigen, Sigrun Halvorsen, Dan Atar, Rune Wiseth, John Munkhaugen

Abstract Aims To investigate the effect of long-term beta-blocker therapy on physical activity (PA) level after myocardial infarction (MI) in patients without heart failure. Methods and results The BETAMI trial randomized patients hospitalized with a MI without heart failure (LVEF ≥40%) to beta-blocker or no beta-blocker. In this preplanned sub-study, PA level was assessed by guideline-recommended PA level (≥30 min moderate activity ≥5 days/week) or not and self-reported hours/week with light to moderate and vigoro …

11.08.2026journal-article

Meditsinskiy sovet = Medical Council

Psychotropic adverse event during transition from elexacaftor/tezacaftor/ivacaftor to vanzacaftor/ tezacaftor/deutivacaftor therapy in a patient with cystic fibrosis

E. L. Amelina, R. U. Kagazezhev, M. M. Pichugina, N. Yu. Kashirskaya

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have dramatically improved outcomes in people with cystic fibrosis (CF), but their use is associated with a class-specific risk of neuropsychiatric adverse events (AEs), including anxiety, depression, suicidal ideation, and sleep disturbance. We report the case of a 45-year-old woman with a rare CFTR genotype (N1303K/G461E) who had been successfully treated with ivacaftor (since 2016) and subsequently elexacaftor/tezacaftor/ivacaftor (ETI, since …

11.08.2026journal-article

Orthopaedic Surgery

A Rare Pseudoaneurysm of the Popliteal Artery Induced by Acute‐Phase Rehabilitation Following Total Knee Replacement: A Case Report and Literature Review

Xiang Zhao, Haobo Wu, Jiajiang Jiang, Shigui Yan, Sihao Li

ABSTRACT Background Early rehabilitation programs are often considered essential for optimizing patient recovery after total knee replacement. Popliteal artery pseudoaneurysm, an infrequent but recognized risk during total knee replacement associated with early postoperative rehabilitation, is relatively rare. Case Presentation We report a case of severe knee inversion deformity in a 56‐year‐old male patient with traumatic arthritis of the right knee. The man complained that the pain has gradually worsened over the …

11.08.2026journal-article

Journal of Occupational & Environmental Medicine

Association Between Objective and Subjective Indoor Coldness During Winter and Presenteeism: A Cross-Sectional Study in Japan

Yuma Uchida, Wataru Umishio, Shintaro Ando, Kazuomi Kario, Shuzo Murakami, Toshiharu Ikaga, Yoshihisa Fujino

Objective: To investigate the associations of room temperature (objective coldness) and the frequency of feeling cold (subjective coldness) with presenteeism. Methods: This cross-sectional study analyzed 2,568 Japanese workers (1,735 households). Room temperature was measured for two weeks in winter. The frequency of feeling cold was assessed using a four-point scale. Presenteeism was evaluated using the Work Functioning Impairment Scale (WFun). Generalized linear models adjusted for age, sex and other confounders. …

11.08.2026journal-article

Scientific Reports

Effectiveness of web-based cognitive behavioral therapy for perfectionism in reducing symptoms of social anxiety disorder

Masoumeh Barani, Hamid Poursharifi, Hamid Yaghubi, Behrooz Dolatshahi, Abbas Pourshahbaz

Abstract This study examined the effectiveness of web-based cognitive behavioral therapy for perfectionism (WCBT-P) in reducing symptoms of social anxiety disorder (SAD) and indices of perfectionism in individuals with SAD. A total of 40 participants diagnosed with SAD and maladaptive perfectionism were randomly assigned to an intervention or waitlist control group. The intervention group received one online session per week for eight weeks, while the control group received no treatment. Outcome measures included t …

11.08.2026journal-article

Molecules

Research Progress and Future Perspectives of Orexin Receptor Antagonists in Insomnia Therapy

Zirui Zhang, Lina Zhu, Yue Gao, Caoqing Ji, Yong Ling

Insomnia is a common sleep disorder that significantly impairs quality of life and increases the risk of various chronic diseases. Although conventional sedative–hypnotic agents are effective, their clinical use is limited by tolerance, dependence, and residual next-day effects. The orexin system plays a critical role in sleep–wake regulation through orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R), with OX2R serving as the primary mediator of wakefulness. Based on this mechanism, orexin receptor antagonists ( …

11.08.2026journal-article

International Journal of Physiotherapy and Research

Effect of Lee Silverman Voice Treatment-Big Vs Hibalance on Gait and Balance in Patients with Parkinson’s Disease

Ketaki Kathe, Sabah Thaver

Background: Parkinson’s disease is a progressive neurodegenerative disorder that commonly leads to impairments in gait and balance, and increasing the risk of falls by affecting mobility and quality of life. As these deficits emerge early in the disease course, they therefore require timely assessment and appropriate targeted intervention. Aims and Objectives: This study aims to compare the effects of LSVT-BIG and the Hibalance program on gait and balance in individuals with Parkinson’s disease and to determine whi …