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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

CNS Neuroscience & Therapeutics

PPARγ ‐Dependent Pioglitazone Treatment Suppresses Neuroinflammation and Improves Cognition in Sepsis‐Associated Encephalopathy in Mice

Jing Zhang, Peng Wang, Nan Li, Yan Gao

ABSTRACT Objective To assess whether pioglitazone (Pio) protects against sepsis‐associated encephalopathy (SAE) and to probe underlying mechanisms. Methods Sepsis was induced in male C57BL/6 mice by caecal ligation and puncture (CLP). At 24 h post‐CLP, mice received Pio and/or the PPAR‐γ antagonist GW9662 and were followed for 14‐day survival. Cognitive and affective behaviors were evaluated using a behavioral battery. Blood–brain barrier (BBB) permeability was assessed by Evans blue extravasation, and hippocampal …

30.08.2026journal-article

Annals of Clinical and Translational Neurology

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio

ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging. Methods We analysed baseline ALSFRS‐R item responses from 866 PRO‐ACT participants. Ordinal SuStaIn inferred subtype‐specific sequences of functional deterioration and assigned each participant to a subtype and a SuStaIn‐derived functional stage. Longitu …

30.08.2026journal-article

Clinical and Translational Medicine

CDO1 as a prognostic biomarker and therapeutic target in gastric cancer: Mechanistic insights into the PI3K/AKT‐THBS1 axis and epigenetic reactivation by decitabine

Fazhi Wang, Runkai Zhou, Jinfeng Cai, Jiazhe Wen, Abudushalamu Yalikun, Yang Yu, Yugang Wen

Abstract Background As a pivotal metabolic enzyme, cysteine dioxygenase type 1 (CDO1) exerts tumour‐suppressive effects across diverse tumour types, and its expression is strongly correlated with clinical prognosis. However, the molecular mechanisms underlying CDO1‐mediated tumour suppression in gastric cancer (GC), its relationship with the tumour‐associated immune microenvironment, and pharmacological strategies to restore its expression remain poorly understood. Methods CDO1 expression and prognosis were evaluat …

30.08.2026journal-article

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218

PERFIL EPIDEMIOLÓGICO, CLÍNICO E VARIAÇÃO DA ACUIDADE VISUAL EM PACIENTES COM RETINOSE PIGMENTAR: ESTUDO LONGITUDINAL RETROSPECTIVO EM UM HOSPITAL OFTALMOLÓGICO DO SUL DO BRASIL

Lilian Zaki, Licia Deon Weirich, Cassio Tokuji Tsujiguchi, Clodomir Salgueiro Cordeiro de Carvalho, Marcos Solano Vale, Camila Marinelli Martins

A retinose pigmentar é a distrofia hereditária da retina mais prevalente, caracterizada pela degeneração progressiva dos fotorreceptores e comprometimento visual de evolução variável. Este estudo teve como objetivo descrever o perfil epidemiológico, clínico e oftalmológico e avaliar a variação da acuidade visual de pacientes com retinose pigmentar acompanhados em um hospital oftalmológico do Sul do Brasil. Foi realizado um estudo observacional longitudinal retrospectivo, baseado em prontuários eletrônicos de pacien …

30.08.2026journal-article

Revista ft

Hipertensão arterial e doença renal crônica em idosos: revisão das evidências sobre evolução clínica e tratamento

Beatriz Aguiar Medeiros, Julia Gauer Gomides Tavares, Nicolly Cristine Nobre Bredun, Michel Hosananh Vasconcelos

Systemic arterial hypertension (SAH) and chronic kidney disease (CKD) are among the most prevalent chronic conditions in the elderly, frequently coexisting and mutually exacerbating their outcomes. This interaction compromises quality of life and increases the risk of cardiovascular and renal complications, making its management a significant challenge. This study analyzed the influence of hypertension on the progression of kidney disease in the elderly and evaluated the effectiveness of available therapeutic strat …

30.08.2026journal-article

Clinical Case Reports

A Rare Finding of Retroperitoneal Sepsis Following Robot‐Assisted Transanal Minimally Invasive Surgery ( TAMIS ): A Case Report and Review of the Literature

Jonathan Tiong, Khang Duy Ricky Le, Annie Jiao Wang, Jean Flanagan, Dilshan Udayasiri

ABSTRACT Robot‐assisted transanal minimally invasive surgery (TAMIS) is a safe and effective platform for the local excision of early rectal lesions. While postoperative complications such as bleeding or contained perforation are recognized, rapidly progressive retroperitoneal sepsis remains an exceedingly rare occurrence. A 56‐year‐old male underwent robot‐assisted TAMIS for a pT1 grade 1 rectal neuroendocrine tumor (NET). Despite successful circumferential excision and defect closure with sutures, the patient dev …

30.08.2026journal-article

Veterinary and Comparative Orthopaedics and Traumatology

Race Performance Following Arthroscopic Surgery for Femoropatellar and Tarsocrural Osteochondrosis in Juvenile Thoroughbreds

Federico Pepe, Francesca Beccati, Francesca Bonaspetti, Marco Pepe, Maria Chiara Pressanto

Abstract The objective of this study is to evaluate racing performance of Thoroughbred yearlings following arthroscopic surgery for osteochondrosis (OC) of the femoropatellar (FP) and tarsocrural (TC) joints. This is a retrospective study of Thoroughbreds < 2 years old undergoing arthroscopic surgery for OC in the FP or TC joint (2010–2022). For each case, two age- and sex-matched controls from the same stud farm were selected. Lesions were graded on preoperative radiographs and described. Racing outcomes (number o …

30.08.2026journal-article

Exercise Medicine

High-Intensity Exercise Induced Changes in Oxidative Stress and Skeletal Muscle Damage in Male Endurance and Resistance Trained Athletes: A Comparative Study

Debdatta Saha, Tamalica Hore, Debajyoti Mukherjee, Ananda Kisor Pal, Santiranjan Dasgupta, Rubia Mondal, Amit Bandyopadhyay

Objectives: High-intensity exercise (HIE) can induce skeletal muscle damage and oxidative stress not only in sedentary individuals but also in trained athletes. This study aimed to evaluate and compare oxidative stress levels and muscle damage markers following high-intensity exercise among male resistance-trained athletes (RA, n = 18), endurance-trained athletes (EA, n = 18), and sedentary controls (SC, n = 30) aged 20–30 years.Methods: A familiarization trial was performed for each participant to determine the tr …

30.08.2026journal-article

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY

Reducing Potentially Harmful Drug‐Related Problems in Outpatient Prescribing: A Quasi‐Experimental Evaluation of a Multifaceted Clinical Pharmacist Intervention in Vietnam

Thanh‐Tam Le, Thang Nguyen, Minh‐Thy Tran‐Doan, Huong‐Thao Nguyen

ABSTRACT Background Drug‐related problems (DRPs) are common in ambulatory prescribing and can cause preventable harm, yet evidence that pharmacist‐led interventions reduce clinically meaningful DRPs in Vietnam remains limited. This study evaluated a multifaceted clinical pharmacist intervention to reduce the prevalence and potential clinical harm of DRPs in adult outpatient prescriptions. Methods We conducted a quasi‐experimental pre‐post study of electronic adult outpatient prescription records at a tertiary hospi …

30.08.2026journal-article

Journal of Internal Medicine

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede

Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine and metabolic disorder with prominent reproductive, psychological, dermatological, and cardiometabolic consequences. Once considered primarily a reproductive disorder …

30.08.2026journal-article

Veterinary Record Case Reports

Treatment of separation anxiety and fear of noises, confinement and unfamiliar people in a dog using escitalopram and clonidine

Erica Grier

Abstract A 3‐year‐old, 8.9 kg, neutered male dachshund was presented for fear and anxiety that significantly affected his daily quality of life. Distressing situations included being separated from his owner, confined in crates, exposed to noises and introduced to unfamiliar people. Clinical signs frequently included trembling, barking, hypersalivation, urination and attempts to escape or hide, with a recovery time of 20–40 minutes. Previous treatment with fluoxetine, a cannabidiol supplement and trazodone, alongsi …

30.08.2026journal-article

International Journal of Dental Hygiene

Evaluation of Dyclonine Hydrochloride Mucilage for Pain Control in Plaque Control‐Oriented Periodontal Therapy: A Double‐Blind Randomised Clinical Trial

Zeng Yi, Zhou Hangfan, Huang Rongli, Wu Zixiang, Chu Xiangyuan, Yang Jiantang, Yang Kun, Yan Fuhua, Ge Song

ABSTRACT Objective To evaluate the effectiveness of dyclonine hydrochloride mucilage (DYC) in controlling pain during guided biofilm therapy (GBT) and its potential to improve patient comfort and adherence to regular supportive periodontal treatment. Methods Patients aged 18–65 years undergoing GBT were enrolled in this randomised, double‐blind, split‐mouth placebo‐controlled study. The left and right sides of the mouth were randomly assigned to the control or experimental group using a coin toss. The Modified Dent …

30.08.2026journal-article

Tomography

Anatomy-Weighted CTDIvol from Routine CT Metadata: A Patient-Specific, Multi-Vendor Study Using Deep-Learning Segmentation

Shuji Yamamoto

Background/Objectives: The volume computed tomography (CT) dose index (CTDIvol) is a scanner output, not an organ dose, and cannot express how tube-current modulation varies along a patient. An organ-specific weighted CTDIvol addressing this has been reported before, in single-institution cohorts and often from inputs routine archives do not retain. New here is not the quantity but what an open, multi-vendor operationalisation reveals: whether its inputs survive archive curation and what the fallback costs when the …

30.08.2026journal-article

Wilderness & Environmental Medicine

Read It and Weep: An Evaluation of People Involved in Avalanches and Their Forecast Reading Habits

Sarah Petelinsek, Rowan Kelner, Jamal Jones, Nikki Champion, Michael Morgan, Patrick G. Hughes

Introduction The aim of this investigation is to gain insight into how humans interact with the avalanche forecast and better understand the role that the avalanche forecast plays in prevention of human-triggered avalanche incidents. Methods Using a 5-y cross-sectional study of self-reported survey data of participants involved in avalanches, we performed a secondary analysis to identify trends and patterns in avalanche forecast reading habits. The study assessed avalanche forecast reading habits, perceptions, and …

30.08.2026journal-article

Scientific Reports

Regional disparities in osteosarcoma and soft tissue sarcoma treatment across Northwest China: a cross-sectional multicenter survey

Wenpeng Yang, Junshen Wu, Maierdanjiang Maihemuti, Suzhi Ji, Renbing Jiang

Abstract Osteosarcoma and soft tissue sarcoma are rare but aggressive malignancies requiring multidisciplinary care. Despite consensus guidelines, real-world treatment patterns across Northwest China remain poorly characterized. We conducted a cross-sectional, questionnaire-based multicenter survey of 67 hospitals treating osteosarcoma and 60 treating soft tissue sarcoma across three regional clusters in Northwest China (Xinjiang-Qinghai, Gansu-Ningxia, Shaanxi-Shanxi). The survey instrument, developed through lite …

30.08.2026journal-article

International Journal of Sexual Science

Treatment Options in Erectile Dysfunction

Arda Tongal, Hakan Türk

Erectile dysfunction is a common and important health problem that affects the quality of life of individuals and their partners. Although its etiology includes various factors, the majority of cases have organic causes. In cases of organic ED, lifestyle modification remains the main approach, and oral phosphodiesterase type 5 (PDE5) inhibitors make up the main part of non-invasive management. Additionally, intraurethral suppositories, extracorporeal shock wave therapy (ESWT), and vacuum erection devices are also e …

29.08.2026journal-article

Translational Medicine

Assessment of fertility and reproductive potential in the arctic regions of the Russian Federation from 2014 to 2023

E. D. Mayskaya, T. M. Duryagina, A. N. Smolinets, M. D. Sukharev, A. L. Sannikov, A. G. Kalinin

Background. Assessment of the reproductive potential of the subarctic territories of Russia is of high significance due to the specific climatic, geographical, socio-economic and ethno-demographic conditions that affect fertility. Despite national demographic trends, regional variability in fertility rates, infertility, reproductive behaviour and accessibility of assisted reproductive technologies remains insufficiently studied, which limits the development of targeted management decisions. Aim. To conduct a compre …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Time to Antibiotics and Clinical Outcomes in Pediatric Cancer Patients with Fever: Evaluating the "Golden Hour" Concept

Medalit Luna Vilchez, Grisell Leonor Portilla Uribe, Mitsi Lorraine Santiago Abal, Victoria Angélica Godoy Vila, Alicia Janeth Mafaldo Rengifo, Gloria Francia Oscanoa

Abstract Background In low- andmiddle-income countries, infections remain the leading cause of treatment-related mortality in pediatric patients with cancer. The "Golden Hour" concept advocates antibiotic administration within 60 minutes of emergency department (ED) triage to reduce sepsis and ICU admission. We evaluated whether time to antibiotic administration (TTA) &gt;60 min versus ≤60 min impacts adverse clinical outcomes in children with cancer and fever. Methods We conducted a prospective longitudinal at the …

29.08.2026journal-article

Bioelectronic Medicine

Teaching through technology: comparing student experiences of VR and computer simulations in orthoptics education

Michael Batterley, Georg Meyer, Jignasa Mehta, Simon Campion, Ryan Ward

Abstract Background Virtual Reality (VR) has previously been found to provide both an effective and enjoyable learning environment for users to develop a wide range of skills. However, despite uptake in fields such as medicine and veterinary medicine, there is little research into the use of VR for diagnostics training with Orthoptists. Methods This study compared students’ experiences of a collaborative VR learning environment with the Strabismus desktop computer simulation for practicing the diagnosis of ocular d …

29.08.2026journal-article

European Spine Journal

Trends and postoperative complications of spinal metastasis surgery in Thailand between 2015 and 2024: a nationwide retrospective cohort study

Sarunya Poolpol, Borriwat Santipas, Korawish Mekariya, Sirichai Wilartratsami, Panya Luksanapruksa

Abstract Study design Nationwide retrospective cohort study. Objective To evaluate 10-year national trends, postoperative complications of spinal metastasis surgery in Thailand. Methods Individual-level data were obtained from five national healthcare databases covering the Thai population, with spinal metastasis patients identified using ICD-10 TM (C79.5, C79.8) and ICD-9 CM codes (03.0, 03.09, 03.4, 81.00–81.08). The index surgical utilization rate was calculated by selecting only first-time surgeries, whereas th …

29.08.2026journal-article

Scientific Reports

Analysis of sex and BMI influence on power delivery in high-power RF ablation for atrial fibrillation using virtual patient simulations

Minha Anees, Zoraida Moreno Weidmann, David Viladés Medel, Aurel Neic, Edward J. Vigmond, Jose M. Guerra, Luca Gerardo-Giorda, Argyrios Petras

Abstract Radiofrequency Ablation (RFA) is an effective treatment for atrial fibrillation (AF), in which thermal energy is delivered to eliminate abnormal cardiac tissue and restore normal electrical conduction. The aim of this study is to assess the extent to which procedural variability is influenced by patient-specific anatomical characteristics, with particular emphasis on Body Mass Index (BMI) and sex-based differences. To address this, we developed patient-specific in-silico models to simulate the ablation pro …

29.08.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

Variational autoencoders can detect coronary artery disease in myocardial perfusion SPECT images

Koichi Okuda, Kenichi Nakajima, Takeshi Hara, Hiroto Yoneyama, Seigo Kinuya

Abstract Purpose Variational autoencoders (VAEs) can detect unsupervised anomalies in medical images. We aimed to determine whether a VAE could automatically detect anomalies in myocardial perfusion SPECT (MPS) images. We then interpreted the training and generative processes of the VAE. Methods We trained a VAE on polar maps to learn the variability of normal myocardial perfusion profiles in latent space. The training dataset comprised 3,432 polar map images (49% male) without coronary artery disease (CAD) and the …

29.08.2026journal-article

International Journal of Medical Science and Pharmaceutical Research

Benefits of Using Hydroxychloroquine/Chloroquine in the Treatment of Immunomediated Rheumatic Diseases

Jozelio Freire de Carvalho, Mariana Fernandes Carneiro

Antimalarial drugs, particularly hydroxychloroquine (HCQ) and chloroquine (CQ), have been used for decades as cornerstone therapies in the management of immune‑mediated rheumatic diseases (IMRDs). Beyond their classical role in disease activity control, these agents exert pleiotropic effects encompassing immunomodulation, anti‑inflammatory signaling, antithrombotic activity, and metabolic and cardiovascular protection. Robust clinical evidence supports their ability to reduce disease flares, limit cumulative organ …

29.08.2026journal-article

Journal of Clinical Medicine

Gut Dysbiosis in Selected Gynecological Diseases Associated with Female Infertility: A Scoping Review

Łukasz Nowakowski, Katarzyna Warchoł, Agnieszka Kuźniar, Barbara Zimoń, Michał M. Skoczylas, Paweł Marzec, Grzegorz Krawczyk, Dorota Jegorow, Robert Pankiewicz, Andrew Z. Warchoł, Maciej Banach, Kinga Kuranty, Piotr Olcha

Background/Objectives: Female infertility represents a significant public health issue. Available evidence supports the hypothesis that the gut microbiota may play an essential role in women’s reproductive health and may serve as a diagnostic or prognostic biomarker in specific gynecological disorders. A substantial part of current research concerns disturbed communication between the hypothalamic–pituitary–ovarian axis and the gut microbiota, providing the basis for analyzing this phenomenon as the gut–ovary axis …