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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

OTJR: Occupational Therapy Journal of Research

Factors Impacting Quality of Life in People Living With Complex Regional Pain Syndrome

Gretchen L. Bachman, Tara Packham, Dana S. Mills, Margo Kreger

Relationships among pain, sleep, and occupational engagement are well known; however, evidence on these relationships relative to quality of life (QOL) remains limited. This study examines pain, sleep, and occupational engagement (including social-emotional contexts) as predictors of QOL in persons with complex regional pain syndrome (CRPS). This descriptive survey research was conducted over 5 months. Participants were recruited through three organizations and were aged 18 or older, diagnosed with CRPS, English-sp …

25.08.2026journal-article

Psychogeriatrics

Apathy as a Predictor of Functional Recovery in Older Adults With Hip Fracture: A Multicentre Prospective Study

Kazuya Takeda, Mineko Wada, Ryouichi Nakamura, Junko Okajima, Manami Harada, Yuiko Nishiguchi, Hideaki Sakai, Masaru Sakai, Yuri Kanemoto, Miwako Tsunematsu, Hideaki Hanaoka

ABSTRACT Background In older patients with hip fractures, delirium and behavioural and psychological symptoms of dementia (BPSD) during hospitalisation have been reported to impede recovery of activities of daily living (ADL). As delirium and BPSD may fluctuate throughout hospitalisation, improving ADL requires longitudinal assessment of these symptoms and clarification of factors influencing functional recovery. This study aimed to evaluate delirium and BPSD longitudinally during hospitalisation in older patients …

25.08.2026journal-article

Frontiers in Cardiovascular Medicine

Cardiac and systemic biological age capture complementary aging signals associated with cardiovascular disease

Yiming Wang, Hao Zhu, Xiaotong Liu, Chenwen Yuan, Jing Liu, Xiaodong Wang, Yu Duan

Background Biological ages capture aging signatures associated with aging-related outcomes, but most models use systemic and unimodal indices. The added value of organ-specific and multimodal information for assessing organ-specific disease associations remains unclear. Methods We enrolled 1,830 participants (77.81% male; age 55.87 ± 11.07 years) undergoing blood chemistry testing and echocardiography. Cardiac, systemic, and multimodal biological age models were trained using supervised machine learning with 20-fol …

25.08.2026journal-article

Universal Access in the Information Society

Three paths, one target group: comparison of recruitment methods for people with disabilities

Anne Stöcker, Zaza Zindel

Abstract This paper examines strategies for recruiting people with disabilities to participate in quantitative social research. Using a mixed-methods approach, three recruitment pathways were compared in North Rhine-Westphalia, Germany from August 2023 to March 2024: Online convenience sampling via social media, Community-based organizational sampling (CBO), and Time-location sampling (TLS) in sheltered workshops for people with disabilities. The study recruited 1,211 participants across the three methods. Results …

25.08.2026journal-article

BioScience

The case of the missing midstorey: urban park design for people and nature

Nicola J Sockhill, Richard A Fuller, Sarah Bekessy, Brenda B Lin

Abstract Urban park design globally prioritises open spaces with some shade trees, with complex midstorey vegetation frequently missing. However, complex vegetation is crucial for healthy ecosystems, increased biodiversity, and human health and wellbeing. In this paper we assess the historical influences that led to this ubiquitous and enduring savanna-style park design, as well as often-cited contemporary barriers to including complex vegetation. We show that omitting complex midstory vegetation is outdated, and t …

25.08.2026journal-article

Journal of Interpersonal Violence

Emotion Regulation is Associated with Symptoms of Racial Trauma Among Minoritized People

Cossette A. Canovas, Lorraine T. Benuto

Race-based traumatic stress (RBTS) can develop after prolonged exposure to racial discrimination and shares similar symptoms to post-traumatic stress disorder (PTSD). However, there is a scarcity of research investigating specific psychological processes associated with RBTS that may inform intervention development. As PTSD and RBTS have shared symptomology, it is possible that psychological processes implicated in PTSD may also be implicated in RBTS. The current study examined if mindfulness, distress tolerance, a …

25.08.2026journal-article

Viruses

Eating Habits and Possible Effects of Mediterranean Diet on Body Composition in Ageing People Living with HIV in Two Italian Centres

Maria Mazzitelli, Giacomo Berti, Valentina Camozzi, Elisa Mazza, Samuele Gardin, Chiara Davoli, Chiara Costa, Vincenzo Scaglione, Tiziana Montalcini, Enrico Maria Trecarichi, Annamaria Cattelan, Carlo Torti

Background: The relationship between diet and body composition in people with HIV (PWH) is still not well defined. Therefore, our primary objective was to assess the association between Mediterranean diet (MD) adherence and body composition measured by whole-body dual-energy X-ray absorptiometry (DXA). Secondly, we aimed to assess differences between people living in the north (Padua, Veneto Region, Italy) vs. those living in the south of Italy (Catanzaro, Calabria Region, Italy) and with respect to ethnicity. Meth …

25.08.2026journal-article

Reports

The Utilization of Inclisiran for the Optimization of Lipid Management in People Living with HIV: A Clinical Case Series and Comprehensive Review

Vasileios Petrakis, Maria Panopoulou, Anastasia Grapsa, Andreas G. Tsantes, Periklis Panagopoulos

Background and Clinical Significance: People with HIV (PWH) experience an elevated risk of atherosclerotic cardiovascular disease (ASCVD), driven by chronic immune activation, metabolic toxicities of antiretroviral therapy (ART), and traditional risk factors. Achieving target low-density lipoprotein cholesterol (LDL-C) levels is frequently impeded by adherence barriers, pharmacokinetic drug interactions, or muscle-related symptoms. Inclisiran is a hepatocyte-targeted small interfering RNA that halts proprotein conv …

25.08.2026journal-article

Journal of Neuropsychology

Co‐design and preliminary evaluation of a quality measure for informational resources for people with disability

Megan Topping, Stacey Oliver, Kate D'Cruz, Jacinta Douglas

Abstract Access to clear, accurate and accessible information is essential for people with disability to exercise choice and control, as outlined in the UN Convention on the Rights of Persons with Disabilities. However, few tools exist to evaluate the quality of informational resources from the perspective of people with disability. This study aimed to co‐design a pilot measure to assess the quality of informational resources for people with disability and to conduct a preliminary evaluation of its content validity …

25.08.2026journal-article

Buildings

The Impact of Perceived Community Environmental Quality on Residents’ Psychological Well-Being from the Perspective of Homo Urbanicus Theory: The Mediating Role of Perceived Environmental Restorativeness and Age Differences Among Older Adults

Chenda Guo, Jiale Fei, Wenjia Li, Lujie Liu, Liusha Chen

With the advancement of healthy city development and community renewal practices, the influence of perceived community environmental quality on residents’ psychological well-being has attracted increasing attention. Previous research has shown that the built environment is closely related to residents’ well-being; however, most studies have focused on objective spatial elements or facility provision and have paid insufficient attention to the mechanisms through which subjective environmental perceptions operate in …

25.08.2026journal-article

Alzheimer Disease & Associated Disorders

Using a Survey to Monitor Participant Experience in a Population-Based Study of Older Adults

Isabella Wood, Erin Jacobsen, Tiffany Hughes, Mary Ganguli

Consumer surveys are increasingly used in business and clinical practice, but less so in human subjects research. Within a longitudinal, population-based study of older adults, we administered a survey to monitor participants' experiences and address potential challenges. We invited participants to provide feedback on their study experience following their annual interviews, using a survey with Likert-scale questions and open-ended comments. In the first round of surveys between 2022 and 2024, 82% responded who wer …

25.08.2026journal-article

Nutrients

Associations of Meal Timing and Temporal Eating Patterns with Cardiovascular Disease Among Chinese Older Adults

Lingfang Wang, Jinghai Li, Jiaming Fang, Shulei Chen, Jingle Peng, Huiqing Ye, Hongying Shi

Background: Direct evidence linking meal timing to cardiovascular disease (CVD) remains limited. This study examined the associations of meal timing and temporal eating patterns with prevalent CVD among Chinese older adults. Methods: From September 2021 to October 2025, 1386 community-dwelling adults aged ≥60 years from various socioeconomic regions of China were interviewed face-to-face. Meal timing (breakfast, lunch, and dinner timing) and sleep–wake schedules (wake-up and bedtime) were collected using standardiz …

25.08.2026journal-article

Psychological Reports

The Role of Family Functioning and Sense of Coherence in the Relationship Between Social Support and Perceived Stress in Community-Dwelling Older Adults

Leandro da Silva-Sauer, André Luiz de Carvalho Braule Pinto, Gustavo Souza Zanatta, Andresa Cortez Guimarães, Ana Cláudia de Souza Pinto Oliveira, Bernardino Fernández-Calvo

This study examined how social support influences perceived stress in older adults, testing family functioning and sense of coherence (SOC) as serial mediators within a theoretically grounded model. Given the cross-sectional design, the analysis adopted an exploratory framework, conceptualizing SOC as a cognitive-emotional resource shaped by relational factors and instrumental in regulating individuals’ stress responses. Participants were 361 community-dwelling older adults in Brazil ( M = 67.32, SD = 5.77). Social …

25.08.2026journal-article

Frontiers in Aging

Adaptive immune cells and kidney function in older adults: sex-specific associations in the health and retirement study (HRS)

Shannon M. Sullivan, Bibin Joseph, Shweta Sharma, Weihua Guan, Amy B. Karger, Jessica Faul, Bharat Thyagarajan

Background Chronic kidney disease (CKD) is characterized by chronic inflammation and immune dysregulation. Aging of the adaptive immune system, marked by a shift from naïve to memory T-cell phenotypes, is associated with systemic “inflammaging”, but sex-specific associations between these immunophenotypes and kidney function in older adults remain poorly understood. Methods We analyzed cross-sectional data from 8,970 participants (aged ≥56 years) in the 2016 Health and Retirement Study (HRS) Venous Blood Study. Sev …

25.08.2026journal-article

The Journal of Cardiovascular Aging

CARD10 deficiency attenuates myocardial infarction associated with enhanced cardiac fibroblast senescence

Yueyue Xu, Yiwei Yao, Yueyun Zhou, Ganyi Chen, Yafeng Liu, Yunfei Jiang, Xu Cao, Wanlin Li, Yide Cao, Wen Chen, Xin Chen

Aim: Myocardial infarction (MI) causes cardiomyocyte death and triggers tissue repair and remodeling processes orchestrated by multiple cell types, particularly cardiac fibroblasts (CFs). Caspase recruitment domain-containing protein 10 (CARD10) has been implicated in mitochondrial function and aneurysm formation; however, its role in MI is not clear. To investigate the potential role of CARD10 in MI and the underlying mechanisms. Methods: CARD10 expression and localization were analyzed by Western blot and immunof …

25.08.2026journal-article

European Journal of Health Law

The Directiveness of Advance Directives. Performing Euthanasia on Individuals with Severe Dementia

Jasper Doomen

Abstract This paper inquires whether performing euthanasia in accordance with an advance directive is acceptable in the case of individuals with severe dementia. Specifically, the Convention on the rights of persons with disabilities is examined to determine whether it provides the basis to perform euthanasia in these cases. The meaning of certain values in particular is analysed, namely, equality, (legal) personhood, autonomy, freedom, dignity and physical and mental integrity. The intricate aspect of the identity …

25.08.2026journal-article

Uluslararası Sağlık Bilimlerinde Disiplinler Arası Etkileşim Dergisi

The Role of NLRP3 Inflammasome in Aging and Age-Related Diseases

Ayşe BAŞARAN

The world's population is rapidly aging, and the number of age-related diseases is increasing. Researchers are focusing particularly on chronic low-grade inflammation as they strive to understand and address the complex mechanisms of aging. NOD-like receptor protein 3 (NLRP3), a key regulator of the innate immune response, initiates inflammation by recognizing pathogens and damage-related molecular patterns. Functional NLRP3 plays a role in age-related diseases. Investigating the mechanisms that regulate the NLRP3 …

25.08.2026journal-article

Current Oncology

Tumor Characteristics and Event Free Survival in Older and Younger Women with Early Breast Cancer

Samantha Kodikara, Alexis C. Wardell, Allison M. Deal, Annie Page, Hyman B. Muss, Kirsten A. Nyrop

Background: Age, race, body mass index (BMI), breast density, parity, smoking and alcohol use are associated with increased risk for breast cancer. These factors, as well as tumor characteristics, treatment regimens and comorbidities, are analyzed for associations with five-year event free survival (EFS) in a sample of women with Stage I-III breast cancer who received chemotherapy with curative intent. Methods: EFS was defined in terms of breast cancer recurrence, second primary, metastasis, and overall survival. A …

25.08.2026journal-article

Frontiers in Public Health

Mental health implications in the older adults of internet access in China

Chi Zhang, Lue Zhou, Xiaoyu Cheng

Social isolation is a significant factor contributing to mental health issues among the older adults, particularly in societies experiencing rapid population aging. Notably, digital technology offers an effective means to address this issue. However, little is known that how access to internet affects the mental health of the older adults. Based on the China Longitudinal Aging Social Survey (2018–2020) data, a national representative data, this study explored the impact of internet access on the older adults mental …

25.08.2026journal-article

Communicable Diseases Intelligence

ATAGI targeted review 2025: Immunisation considerations for immunocompromised people in Australia

Xia Wang, Phoebe Williams, Ketaki Sharma, Helen Quinn, Sanjay Jayasinghe, Clayton Chiu, Kristine Macartney, Katie Flanagan, Kristy Cooper, Benjamin Teh, Michelle Giles, Nigel Crawford

Vaccination plays a pivotal role in protecting people who are immunocompromised, and who may therefore be at increased risk of infectious diseases, including vaccine preventable diseases (VPDs). However, there are special challenges in clinical practice and the development of immunisation policies to accurately address the vaccination needs of this heterogeneous population. This review aims to highlight the immunisation needs and challenges of immunocompromised populations, and to summarise the rationale behind the …

25.08.2026journal-article

BJPsych Open

Insight into cannabis use disorder in people with psychotic disorders

Edward Chesney, Millie Lloyd, Sebastien Brodeur, Arsime Demjaha, Lisa Conlan, Ikram Slimani, Ayşe Doğa Lamper, Ananya Sarma, Will Lawn, Dominic Oliver, Tom P. Freeman, Robin Murray, Marta Di Forti, Amir Englund, John Strang, Philip McGuire

Background Cannabis use is common in people with psychosis and is associated with poor outcomes. Aims To assess insight into cannabis use disorder, perceptions about how cannabis use influences mental health and the desire to change cannabis use among people with psychotic disorders. Method Adults with a psychotic disorder and comorbid cannabis use disorder were asked about the impact of cannabis use on their illness and their desire to change cannabis use. Cannabis use disorder was determined using DSM-5 criteria. …

25.08.2026journal-article

Frontiers in Sports and Active Living

Effect of wearables with behavioral prompts on physical and cognitive outcomes in community-dwelling older adults: preliminary results of a pilot randomized controlled trial

Kar Yin Lee, Savannah Siew, Tat Lee Teo, Kuang Chua Chua, Junhong Yu, Rathi Mahendran, Iris Rawtaer

Introduction The global rise in life expectancy has driven research into aging-related vulnerabilities, particularly cognitive frailty. Physical activity interventions have been identified as a protective factor, and technology, such as wearable devices, may enhance engagement. This pilot RCT explores mobile phone applications and smartwatch-based interventions to promote physical activity and improve cognitive health in older adults. Methods This single-blind pilot RCT enrolled 53 adults aged 60–85 in Singapore th …

25.08.2026journal-article

Pain Medicine

Central Sensitization and Cognitive Vulnerability: A Neurobiological Framework for CNS Resilience and Brain Aging

Kevin V Hackshaw

Abstract Objective Preservation of central nervous system (CNS) resilience during midlife is increasingly recognized as an important determinant of healthy cognitive aging, as biological processes contributing to Alzheimer's disease and related dementias (ADRD) may begin decades before clinically apparent impairment. Identifying measurable physiological states associated with diminished CNS resilience during this period is therefore an important objective of brain-aging research. Central sensitization is a neurophy …

25.08.2026journal-article

International Journal of Molecular Sciences

Safety and Efficacy of Mesenchymal Stem Cell Therapy in Aging Frailty: A Systematic Review

Eleni Poutouri, Maria Sotiropoulou, Michael Potoupnis, Georgios Koliakos, Evanthia Kassi, Symeon Tournis, Panagiotis Anagnostis

Aging frailty is a multifactorial geriatric syndrome characterized by reduced physiological reserve across multiple interrelated systems, leading to increased vulnerability to adverse health outcomes. Mesenchymal stem cells (MSCs) have emerged as a potential therapeutic intervention due to their immunomodulatory and regenerative properties. This systematic review aimed to evaluate the available clinical evidence regarding the safety and efficacy of MSC administration in individuals with aging frailty. A systematic …