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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

International Journal of Cancer

The Africa We Want : A Perspective on the African Code Against Cancer To Be Developed for Sub‐Saharan Africa

Anthony Kityo, Phyllis Ohene‐Agyei, Felix M. Onyije, Hannah Simba, Annet Nakaganda, Denis Chopera, Kofi Mensah Nyarko, Benido Impouma, Mary Nyangasi, Blandina Mmbaga, Valerie McCormack, Cesaltina Lorenzoni, Miriam Mutebi, Joachim Schüz, Carolina Espina

ABSTRACT Sub‐Saharan Africa (SSA) faces a unique cancer burden, characterized by a disproportionately high mortality‐to‐incidence ratio, a large share of infection‐related cancers, and distinct environmental exposures. Implementation of national policies on primary prevention is limited, and public literacy regarding cancer risk and curability remains low. Furthermore, the implementation of existing prevention and treatment interventions is hindered by resource constraints and deeply rooted cultural beliefs. Thus, …

27.08.2026journal-article

Inquiry@Queen's Undergraduate Research Conference Proceedings

The Cancer-Related Experiences of Visible Minorities in Canada

Rishta Bhusal, Falaq Mansuri

Background: Cancer care is multifaceted, encompassing screening, diagnosis, treatment, and survivorship. While advances in research have led to improved cancer care experiences, social determinants of health influence health outcomes, revealing disparities among marginalized populations. Of note, visible minorities experience socio-contextual and systemic barriers to care. Despite increased attention to these inequities, relevant literature has not been synthesized, revealing a need for a comprehensive review. This …

27.08.2026journal-article

BJUI Compass

Salvage prostate therapies for local pelvic recurrence after primary radiation for prostate cancer

Jamie Michael, Kathryn Fink, Vivian Wan, Sai K. S. R. Kaushik, Clayton Neill, Yutai Li, Ridwan Alam, David J. VanderWeele, Shilajit Kundu, Ashley E. Ross

Abstract Objectives The purpose of this study is to evaluate salvage treatment after primary radiation therapy (RT) for prostate cancer within our hospital system. Specifically, we aim to evaluate treatment patterns, oncologic outcomes and complications. Materials and methods We retrospectively identified men with post‐RT recurrence treated with salvage radical prostatectomy (sRP), seminal vesiculectomy, cryoablation, high‐dose‐rate brachytherapy (HDR) or irreversible electroporation (IRE). Salvage failure was defi …

27.08.2026journal-article

Neuro-Oncology

25 Imaging Tumour-Associated Macrophages in Gliomas and Vestibular Schwannomas Using Ferumoxytol-Enhanced MRI

James Breese, Daniel Lewis, William Lloyd, Rainer Hinz, Andrew Tyler, Xiaoping Zhu, Ka-Loh Li, Bandar Alfaifi, Ibahim Djoukhadar, Andrew King, Alan Jackson, David Coope

Abstract Introduction Tumour-associated macrophages (TAMs) play a central role in brain tumour growth, immune evasion and therapeutic resistance, with a paucity of clinically translatable, non-invasive methods to assess TAM-related inflammation in vivo. One promising approach is ultrasmall superparamagnetic iron oxide nanoparticle (USPIO)-enhanced MRI. Ferumoxytol, a commercially available USPIO, is used off label as an MRI contrast agent and exhibits prolonged intravascular circulation prior to extravasation and s …

27.08.2026journal-article

Neuro-Oncology

43 Determinants of Survival Following Re-resection for Recurrent High-Grade Glioma: A Single-Centre Retrospective Cohort Study

Zekai Qiang, Ji-Young Park, Francesco Magni, Anisa Sharif, Deborah Oduguwa, Yahia Al-Tamimi, Veejay Bagga, Andrea Cavalli, Kishor Choudhari, Daniel Gatt, Geza Mezei, Jerry Phillip

Abstract Introduction Evidence is limited to define which patients derive meaningful survival benefit from re-resection of recurrent high-grade glioma (HGG). This study aimed to identify clinical determinants of overall survival (OS) in a cohort of patients undergoing surgical resection for HGG, with secondary analysis of the re-resection subgroup. Methods A retrospective single-centre analysis was performed on consecutive patients undergoing HGG resection from 2020-2021. OS was calculated from the date of first re …

27.08.2026journal-article

Neuro-Oncology

35 Access to Vorasidenib for Low-Grade Glioma in the UK: Voices of Patients, Carers and Clinicians

Rachel Roberts, Shannon Winslade, Clare Jackson, Anita Harries, Kiran Cheema, Cameron Miller

Abstract Introduction Low-grade gliomas (LGG) often affect younger adults with patients often experiencing prolonged uncertainty, cognitive difficulties, and loss of independence. Methods Following a draft decision by the National Institute for Health and Care Excellence not to recommend vorasidenib for NHS use, The Brain Tumour Charity conducted an online UK-wide survey to capture community perspectives on access, unmet need, and lived experience. The survey, open from 15 October to 22 November 2025, received 1,31 …

27.08.2026journal-article

Neuro-Oncology

56 The evolving challenges and opportunities in adult brain tumour imaging: Insights from a review of United Kingdom neuro-oncology centres (2021-2024)

Adam Waldman, Samantha Mills, Andrew Wright, Camille Goetz, Nicky Huskens

Abstract Introduction Brain tumour imaging is rapidly changing: while new technologies promise clinical advances, centres report growing staff shortages and burnout at a time of increasing demand. We examined how these trends have evolved since 2021 in United Kingdom (UK) neuro-oncology centres. Method Data were collected from 21 UK neuro-oncology centres (covering ∼84% of the population) in 2021 and 2024 via the Tessa Jowell Centre of Excellence for Adults programme. Anonymised data were analysed to identify trend …

27.08.2026journal-article

Qualitative Health Research

Praise as Pathway: Caregiver Language and Identity Construction in Pediatric Cancer Narratives

Isha Jayakumar, Hannah Taylor

This qualitative interpretive study examines how praise functions in pediatric cancer narratives, focusing on two caregiver-authored blogs, Dominic’s Journey with AML and Superman Sam. The analysis identifies a longitudinal progression in which praise evolves from process-focused coping language into heroic, communal, and elegiac identity framing across treatment, crisis, and loss. These findings extend developmental and clinical work on praise, mindset, and metaphor into the underexplored domain of pediatric recov …

27.08.2026journal-article

Scientific Reports

Isolation, in vitro cytotoxicity and in silico analysis of methoxylated flavone derivatives from Kaempferia parviflora on breast cancer cell lines

Mohammad Aidiel, Maisarah Abdul Mutalib

Abstract Kaempferia parviflora ( K. parviflora ) is a plant native to Southeast Asia known to contain bioactive methoxylated flavone derivatives, including polymethoxyflavones (PMFs) and hydroxy-substituted methoxyflavones. This study aims to isolate and characterize methoxylated flavone derivatives from K. parviflora , evaluate their cytotoxic activity against breast cancer cell lines, and perform in silico analyses to predict their possible molecular interactions with selected cancer-related targets. PMFs were is …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Non-surgical magnetic-electrical biofeedback improves anterior resection syndrome after sphincter-preserving surgery for low rectal cancer

Xia-Hui Weng, Yin Huang

BACKGROUND Sphincter-preserving surgery is a common procedure for rectal cancer, but anterior resection syndrome (ARS) remains a frequent complication. AIM To evaluate the efficacy of combined magnetic-electrical biofeedback therapy in patients with ARS after sphincter-preserving surgery for low rectal cancer. METHODS Sixty patients with ARS following sphincter-preserving surgery for low rectal cancer admitted to our hospital between August 2024 to March 2026, were selected. Based on the chronological order of surg …

27.08.2026journal-article

Cell Communication and Signaling

SIRT3 determines the sensitivity of cancer cells to mitochondrial targeting

Maria A. Yapryntseva, Matvey A. Vinogradov, Pavel I. Volik, Anastasiia V. Melnikova, Sofia E. Kiseleva, Anastasiya V. Poteryakhina, Alexey V. Zamaraev, Gelina S. Kopeina, Boris Zhivotovsky, Vladimir Gogvadze

Abstract SIRT3 is a mitochondria-localized member of the sirtuin family, playing a key role in cellular antioxidant defense. Its function in carcinogenesis and therapy response remains uncertain. In the present study, we sought to identify the role of SIRT3 in regulating cell death induced by conventional DNA-damaging anticancer drugs or mitochondria-targeting compounds using bioinformatic analysis, western blot analysis, viability, and clonogenic assays. High SIRT3 levels were associated with higher sensitivity to …

27.08.2026journal-article

JAMA Network Open

A Clinically Aligned 18-Item Instrument for Measuring Inflammatory Breast Cancer Knowledge

Anh N. Tran, Alexandra Bennion, Kalyani Sonawane, Samantha M. Thomas, Alisa N. Blumenthaler, Katherine Reddy, Beau Blass, Jennifer K. Plichta, Gayathri R. Devi

This survey study evaluates preliminary, clinically informed exploratory indices to evaluate inflammatory breast cancer knowledge, including symptom and risk-factor recognition.

27.08.2026journal-article

BMJ Supportive & Palliative Care

Objective assessment of activities of daily living and prognosis in patients with terminal cancer in the palliative care unit: a retrospective cohort study

Shunsuke Nakanishi, Riki Sakata, Ayaka Nishimura, Keiko Onishi, Tomoo Okumura, Yasushi Miura

Objectives Rehabilitation in patients with terminal cancer plays an essential role in maintaining quality of life. However, limited consensus exists regarding rehabilitation in the palliative care unit (PCU). This study aimed to support the setting of appropriate goals in the rehabilitation of patients with terminal cancer in a PCU. Methods In this retrospective cohort study, 224 patients with terminal cancer admitted to a PCU were analysed. Participants were classified based on total Functional Independence Measur …

27.08.2026journal-article

Molecules

Cytotoxic Triterpenes from Argan Pulp (Argania spinosa): Isolation, In Vitro Evaluation on Cancer Cell Lines, and In Silico Studies

Asma El Kaourat, Badr Eddine Kartah, Mohamed El Fadili, Noura Bentarhlia, Hamza Tachallait, Yassine Jaouhari, Matteo Bordiga, Zineb Ourradi, Younes Zaid, Zoubida Charrouf, Hanae El Monfalouti

This study focuses on the isolation, characterization, and evaluation of cytotoxicity of triterpenes extracted from argan pulp. The unsaponifiable lipids extracted from argan pulp are separated into five fractions, two of which are triterpene fractions F2 (composed of α-amyrin, β-amyrin, lupeol, ψ-taraxasterol, taraxasterol) and F4 (erythrodiol). The extraction process utilized solvent-based methods followed by purification through column chromatography. Structural elucidation was carried out using GC-MS and NMR te …

27.08.2026journal-article

Current Oncology Reports

Role of Interventional Oncology in the Management of Neuroendocrine Tumors: 2026 Update

Daniel M. DePietro, Michael C. Soulen

Abstract Purpose of Review Summarize recent advances in interventional oncology for the management of neuroendocrine tumor liver metastases (NETLMs), with a focus on evolving evidence for embolization and ablation, integration with systemic therapies, and emerging approaches. Recent Findings Recent studies have strengthened the role of liver-directed therapies within multidisciplinary NET care. Long-term data supports transarterial chemoembolization as an effective and repeatable line of therapy. Improved dosimetry …

27.08.2026journal-article

BMC Cancer

Real-world outcomes of second-line therapy in advanced thymic carcinoma: a multicenter Turkish Oncology Group (TOG) study

Fatih Kus, Fatih Atalah, Gokhan Sahin, Caner Kapar, Damla Gunenc, Erkut Demirciler, Alper Topal, Halil Goksel Guzel, Yakup Duzkopru, Mert Erciyestepe, Ilgin Koc Kus, Omer Denizhan Tatar, Firat Sirvan, Gozde Agdas, Bilgesah Kilictas, Irem Ugurlu, Abdussamet Celebi, Goncagul Akdag, Dogan Bayram, Aysegul Merc Cetinkaya, Ilknur Deliktas Onur, Taliha Guclu, Omer Faruk Elcicek, Sendag Yaslikaya, Elif Sahin, Pinar Gursoy, Ozturk Ates, Abdullah Sakin, Harun Muglu, Murad Guliyev, Nigar Rustamova Cennet, Melike Ozcelik, Melek Karakurt Eryilmaz, Ahmet Bilici, Nebi Serkan Demirci, Mehmet Ali Sendur, Saadettin Kilickap, Derya Kivrak Salim, Ozlem Er, Gamze Gokoz Dogu

Abstract Background Thymic carcinoma (TC) is a rare and aggressive malignancy with limited evidence guiding second-line treatment after prior systemic therapy. We evaluated real-world outcomes of second-line systemic therapy in a multicenter cohort. Methods Adults with unresectable, recurrent, or metastatic TC who received second-line systemic therapy after prior systemic therapy between 2010 and 2023 were retrospectively analyzed. Treatments were categorized as multidrug chemotherapy, gemcitabine monotherapy, PD-1 …

27.08.2026journal-article

Diagnostics

Digital Patient-Reported Monitoring of Functional Recovery After Robot-Assisted Radical Prostatectomy in High-Risk Prostate Cancer Treated With or Without Perioperative Hormonal Therapy

Bogdan Adrian Buhas, Alessandro Uleri, Giorgio Calleris, Guilhem Roubaud, Marine Lesourd, Benjamin Pradère, Christophe Tollon, Damien Pouessel, Bernard Malavaud, Loïc Mourey, Guillaume Ploussard

Background/Objectives: Perioperative androgen-deprivation therapy (ADT) and androgen-receptor pathway inhibitors (ARPIs) are increasingly used in high-risk prostate cancer, yet patient-centred functional-recovery data after radical prostatectomy are scarce and rarely standardized. We assessed whether a smartphone-based digital monitoring pathway could characterize social-continence recovery and capture differences associated with a perioperative hormonal therapy (PHT) strategy after robot-assisted radical prostatec …

27.08.2026journal-article

Journal of Pediatric Hematology/Oncology Nursing

Challenges of Treatment Decisions for Children With Hematological Malignancies Who Relapse After Hematopoietic Stem Cell Transplant: A Health Care Provider Perspective

Deborah Tomlinson, Sonia Lucchetta, Sarah Alexander, Sumit Gupta, Erilda Kapllani, Tal Schechter-Finkelstein, Jane Lowry, Joerg Krueger

Background When a child or adolescent's disease relapses following hematopoietic stem cell transplantation (HSCT), families are often presented with the complex decision to pursue further treatment with curative intent. This study aims to describe the experiences of health care professionals (HCPs) regarding choices after the first HSCT and factors influencing decision-making. Method This qualitative study included staff and trainee physicians, nurse practitioners, and nurse coordinators. All participants had exper …

27.08.2026journal-article

Neuro-Oncology

6 Radiogenomics of circumscribed versus diffuse grade 4 gliomas based on standard molecular markers

Adnan Hammad, John McNamee, Tom Flannery

Abstract Introduction The two main types of adult grade 4 gliomas are IDH1-wildtype glioblastomas and IDH-mutant astrocytomas. Each have their own molecular hallmarks. We sought to determine if there are differences in molecular markers between radiologically circumscribed and diffuse grade 4 gliomas. Method We carried out a retrospective analysis of a single surgeon’s experience of adult patients undergoing surgery for grade 4 gliomas at our institution between January 2019 and July 2024. Results We identified 145 …

27.08.2026journal-article

Neuro-Oncology

71 Hypertrophic olivary degeneration after dentate nucleus involvement in two patients with Central Nervous System Lymphoma: a potential mimic of relapse

Valentina Fenech, Laura Preston, Emanuela Molinari

Abstract Introduction Hypertrophic olivary degeneration (HOD) is a rare transsynaptic degeneration caused by disruption of the Guillain-Mollaret triangle. In neuro-oncology, it may mimic tumour recurrence, particularly during post-treatment surveillance of posterior fossa disease. We describe two cases of contralateral HOD following dentate nucleus involvement in central nervous system lymphoma (CNSL), highlighting an important diagnostic pitfall. Method We reviewed clinical, radiological and follow-up data from tw …

27.08.2026journal-article

Genes

Integrating Multi-Omics and Machine Learning to Reveal a Prognostic Model for Prostate Cancer Metastatic Recurrence Associated with Epithelial–Mesenchymal Transition Features

Xueqian Zhang, Wei Zhang, Zheng Wang, Xinyang Shi, Chenghao Zhang, Yan Gao, Yiheng Deng, Tianyu Shen, Ziyan An, Weijun Fu

Background: Prostate cancer (PCa) is a leading cause of cancer-related mortality worldwide, highlighting the need for improved prognostic tools. The integration of artificial intelligence (AI) and machine learning (ML) with multi-omics data offers new opportunities for biomarker discovery and risk stratification. Methods: We integrated bulk transcriptomic data from GSE116918 (training, n = 248) and three cross-cohort consistency evaluation cohorts (TCGA-PRAD, GSE70769, GSE46602), focusing on 1087 epithelial–mesench …

27.08.2026journal-article

The Oncologist

Osimertinib plus anlotinib in untreated, EGFR-mutated, advanced non-small-cell lung cancer with concurrent alterations: a multicenter phase II study

Xiaojun Yang, Qinquan Tan, Shiyuan Chen, Jieyun Xie, Yihong Zeng, Ruinian Zheng, Qinglin Tan, Wan Zhang, Churen Yu, Ziying Hong, Xinpei Yu, Guanming Jiang

Abstract Background The standard first-line treatment for advanced EGFR-mutated non-small cell lung cancer (NSCLC) is EGFR tyrosine kinase inhibitors. However, concurrent mutations facilitate resistance evolution in EGFR-mutant lung adenocarcinoma and combination therapies may offer a superior approach. This study explores the efficacy and safety of osimertinib plus anlotinib as first-line treatment for advanced NSCLC with EGFR co-mutations. Materials and Methods This study prospectively enrolled patients with adva …

27.08.2026journal-article

Inquiry@Queen's Undergraduate Research Conference Proceedings

The Quality of Research Methods in Studies Quantifying the Association Between Cancer Diagnosis to Treatment Interval and Overall Survival

Vidhi Patel

Background and Objective: Studies examining the association between cancer diagnosis to treatment interval (DTI) and overall survival (OS) are important to help inform clinical practice guidelines. Recent international consensus-based recommendations defined best practices for this area of research and raised concerns about the poor validity and inconsistent methodologies in the available literature. Our objective is to systematically assess the quality of studies investigating the association between DTI and OS us …

27.08.2026journal-article

BMC Cancer

miR-451a is a differentially expressed blood-based microRNA in newly diagnosed CML identified by high-throughput profiling

Surbhi Gupta, Nitu Nigam, Abdullah H. Maad, Ninar AlJerf, S. P. Verma, Swasti Sinha, Rashmi Kushwaha, Manish Kumar Singh, Arun Kumar Trivedi, Soniya Nityanand, Muaaz Alajlani, Loai Aljerf

Abstract Background microRNAs (miRNAs) are emerging as promising biomarkers in hematological malignancies due to their stability in blood. This study aimed to investigate the differential expression of miRNAs in chronic myeloid leukemia (CML) and evaluate the potential of miR-451a as a candidate whole-blood miRNA marker. Methodology We collected whole blood samples from 77 newly diagnosed CML patients before TKI therapy and 77 healthy controls. A subset of samples underwent miRNA sequencing to identify dysregulated …