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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Current Oncology

Patient-Controlled Real-Time Transcutaneous Electrical Acupoint Stimulation at Neiguan (PC6) for Chemotherapy-Induced Nausea and Vomiting in Breast Cancer: An Exploratory Single-Arm Two-Stage Trial

Huiting Liu, Jie Zhou, Junying Du, Qiongying Shen, Chao Lu, Jianxing Zhang, Weiping Zhang, Ran Ran, Jianqiao Fang, Jiongyao Ye, Hong Gao, Junfan Fang

Chemotherapy-induced nausea and vomiting (CINV) remain difficult to control after discharge despite guideline-based antiemetics. This multicenter exploratory single-arm two-stage trial evaluated patient-controlled, real-time transcutaneous electrical acupoint stimulation (TEAS) at Neiguan (PC6) as an adjunct to standard antiemetic therapy in patients with breast cancer. Forty-eight patients who had experienced CINV and were scheduled at enrollment to receive the same chemotherapy and antiemetic regimens during two …

31.08.2026journal-article

Korean Journal of Clinical Oncology

Suppression of MCM2 reduces cancer stem cells and epithelial-mesenchymal transition-related phenotypes in breast cancer cells

Rae-Kwon Kim

Purpose: Minichromosome maintenance protein 2 (MCM2) is a key regulator of DNA replication and has been implicated in tumor progression. While previous studies have demonstrated its role in lung cancer stem cells (CSCs), its role in breast cancer remains unclear. This study aimed to investigate whether MCM2 regulates CSCs and epithelial-mesenchymal transition (EMT) in breast cancer.Methods: MCM2 expression and its prognostic significance were analyzed using public breast cancer datasets. MDA-MB-231 breast cancer ce …

31.08.2026journal-article

ASEAN Journal on Hospitality and Tourism

Inclusive Tourism in Public Spaces: An Accessibility and Visitor Experience Study of Mobility-Impaired Individuals on Malioboro Street

Zachary Ryan, Mohamad Rachmadian Narotama, Iswan Bahri, Hikmah Kamarudin

Everyone has the right to tourism, including individuals with disabilities. Unfortunately, not all tourist destinations can ensure a positive experience for disabled travelers. For instance, even popular sites like Malioboro Street in Yogyakarta may fail to provide an accessible and inclusive experience for people with disabilities. This study investigates the experiences of wheelchair users regarding facilities, culinary areas, and community responses in the Malioboro Street area. The research methodology employed …

31.08.2026journal-article

Global Spine Journal

Discrepancy Between Clinician- and Patient-Reported Definitions of Mild Degenerative Cervical Myelopathy and Surgical Outcomes

Takahiro Kitagawa, Narihito Nagoshi, Junichi Yamane, Toshiki Okubo, Reo Shibata, Yoshiomi Kobayashi, Kanehiro Fujiyoshi, Yoshiyuki Yato, Tatsuya Yamamoto, Kazuya Kitamura, Takeshi Ikegami, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe

Study Design Prospective multicenter observational cohort study. Objective To redefine mild degenerative cervical myelopathy (DCM) using a patient-reported severity framework derived from Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ) and to compare surgical outcomes with the conventional clinician-reported definition. Methods Patients with DCM undergoing surgery at 10 spine centers were enrolled. Mild DCM was defined using two criteria: a clinician-reported definition based …

31.08.2026journal-article

Bioinformation

Biological susceptibility to root resorption in clear aligner therapy: A mini review

Mariana Lourdes Barrionuevo

External apical root resorption (EARR) persists in clear aligner therapy and reflects individual biological susceptibility more than appliance type. Polymorphisms in inflammatory and vitamin D pathway genes, including IL1B, RANK and VDR, shift individual EARR risk. Gingival crevicular fluid biomarkers, such as interleukin-6, interleukin-8 and matrix metalloproteinase-8, track the active resorptive phase. AI-assisted three-dimensional imaging quantifies apical loss objectively, near 0.6 to 0.8 mm and comparable to f …

31.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

INTELIGÊNCIA ARTIFICIAL COGNITIVA COMO VETOR DE GOVERNANÇA E PRONTIDÃO OPERACIONAL: PROPOSIÇÃO DE UM MODELO INTEGRADO PARA A POLÍCIA MILITAR DO PARANÁ

Antonio Rogerio Custodio dos Santos

A crescente complexidade regulatória da Administração Pública impõe às organizações policiais o desafio de conciliar segurança jurídica, eficiência administrativa e fortalecimento da prontidão operacional. Nesse contexto, o presente estudo propõe o Modelo Integrado de Inteligência Artificial Cognitiva (MIIA), concebido como uma arquitetura de governança organizacional destinada à aplicação estratégica da Inteligência Artificial em processos administrativos complexos da Polícia Militar do Paraná. Trata-se de pesquis …

31.08.2026journal-article

Blockchain in Healthcare Today

Lightweight Privacy-Preserving Blockchain Framework for Healthcare: A Simulation-Based Approach to Reducing Computational Overhead

MD. Asrar Ahmed, Mohammed Abid Ali Sameer, Mousmi Ajay Chaurasia, S. Nallusamy

Background: The privacy and security of electronic health records (HER) in blockchain-based systems remains a major research problem because of high computational overhead and scalability restrictions. Privacy-preserving techniques such as encryption and zero-knowledge proofs strengthen blockchain’s transparency and immutability but often add significant latency and resource use. This study proposes a lightweight, simulation-based blockchain model balancing privacy protection and computational efficiency for health …

31.08.2026journal-article

AFRICAN JOURNAL OF REPRODUCTIVE HEALTH

Assessment of anxiety levels and marital relationships among women undergoing infertility treatment: A descriptive observational study

Naima M. Elsayed, Nabila S. Mohamed, Rabab S. Hassan, Eshrak S. Hashem, Randa M. Abobaker

This study aimed to assess anxiety levels and marital relationships among women undergoing infertility treatment. A descriptive observational design was conducted involving 300 infertile women over nine months at Zagazig University Hospital. Data were collected using a Structured Interview Questionnaire, the Female Sexual Function Index (FSFI), and the Taylor Anxiety Scale. Reliability analysis showed high internal consistency (Cronbach's alpha: 0.923 for FSFI; 0.845 for Taylor Scale). Results indicated that 32.6% …

31.08.2026journal-article

GSC Advanced Research and Reviews

HEALTH LOCUS OF CONTROL, MEDICATION ADHERENCE AND QUALITY OF LIFE AS PREDICTORS OF DEATH ANXIETY AMONG PEOPLE LIVING WITH HIV/AIDS

Ojie Owen Isa, Joshua Edet Ifere, Peter Odey, Regina Onung Odey

Introduction: The diagnosis of an incurable disease can trigger a profound existential crisis as everyday life and the future are threatened for both patients and their families. As an existential issue, death anxiety stems from the conscious awareness of our own mortality. Aim: The study therefore attempts to examine the potential influence that health locus of control, medication adherence, and quality of life could have on death anxiety among HIV/AIDS patients. Methodology: The study utilized a cross sectional s …

31.08.2026journal-article

European Journal of Multidisciplinary Health Sciences

A Bibliometric Analysis of Research on Depression and Exercise in Older Adults

Canan Yüksel Haji, Emine Nacar, Sinem Suner-Keklik

Depression is a common mental disorder worldwide and significantly affects older adults. Considering the potential role of exercise in depression management, examining research trends in this field using bibliometric methods is important. Accordingly, this study aimed to provide a systematic overview of the development of the literature by analysing English-language publications indexed in the Web of Science Core Collection using search terms related to depression, exercise, and older adults, without applying publi …

31.08.2026journal-article

Military Medicine

Detection of Occult Patent Ductus Arteriosus Through Teleradiology in a Forward-Deployed Setting

Ryan Dinnen, Anthony Cossetti, Oskar Kizhner

Abstract Patent ductus arteriosus (PDA) is a congenital cardiac anomaly most often diagnosed in infancy or childhood and infrequently detected in adulthood. In young adults, clinical and radiographic manifestations may be subtle and nonspecific, leading to delayed diagnosis. We report a case involving a 22-year-old previously healthy active duty female service member who presented with pleuritic chest pain at a forward-deployed medical facility in Djibouti, Africa. Chest radiographs were transmitted via teleradiolo …

31.08.2026journal-article

Frontiers in Medicine

Association between smoking and the clinical status of adult patients with moderate-severe atopic dermatitis in the China Atopic Dermatitis Registry (ChinaSTAD): a cross-sectional study

Yingzhe Yu, Lu Cao, Xin Fan, Lingyi Lu, Sihan Wang, Jianzhong Zhang, Bingjiang Lin

Background Atopic dermatitis (AD) is a common inflammatory skin disease influenced by multiple factors such as genetic, environmental and lifestyle factors. This study explored the association between smoking and AD. Methods The China Atopic Dermatitis Registry (ChinaSTAD) is a nationwide observational registry of patients with moderate to severe AD in China. We conducted a cross-sectional analysis of adult patients enrolled from July 2021 to April 2023 across 26 provinces. Patients were categorized as ever-smokers …

31.08.2026journal-article

Frontiers in Endocrinology

Combined cord blood metabolomic and clinical signatures discriminate small for gestational age neonates in preeclampsia

Luhan Zhang, Weibo Huang, Shuyuan Xue, Xiaolan Chi, Gang Guo, Guifeng Ding

Background Preeclampsia (PE) subjects the fetus to a hostile intrauterine environment and elevates the risk of small for gestational age (SGA). The link between cord blood metabolic signs and PE exposure is still unclear. This connection may affect fetal growth. Methods We did untargeted metabolomics profiling of cord blood. This involved 37 pregnancies with preeclampsia (PE) and 48 control pregnancies. We used liquid chromatography-mass spectrometry for the analysis. Researchers examined metabolites that showed di …

31.08.2026journal-article

Orphanet Journal of Rare Diseases

Clinical and genetic landscape of neuronopathic gaucher disease in Ukraine: hepatosplenomegaly and diagnostic delay

Nataliia Samonenko, Nataliia Olkhovych, Olena Okhotnikova, Nataliia Gorovenko

Abstract Background Neuronopathic Gaucher disease (GD types II and III) represents rare and severe phenotypes of glucocerebrosidase deficiency, characterized by neurological involvement and variable systemic manifestations. Data on clinical presentation and genotype–phenotype patterns in Eastern European populations remain limited. Methods We conducted a retrospective cohort study of 92 patients with confirmed Gaucher disease followed at the National Children’s Specialized Hospital “Okhmatdyt” (Kyiv, Ukraine) betwe …

31.08.2026journal-article

Public Health Journal

The Effect of Basil Leaf (Ocimum basilicum) Decoction on Vaginal Discharge Among Women of Reproductive Age (WRA) at TPMB Midwife L, Cikampek, 2026

Liana Bintang Permata, Dita Humaeroh, Maulida Lathifah

Vaginal discharge is one of the reproductive health problems frequently experienced by women of reproductive age (WRA), particularly when accompanied by changes in color, odor, itching, or other complaints. Basil leaves (Ocimum basilicum) contain bioactive compounds such as flavonoids, saponins, tannins, eugenol, and essential oils, which have been associated in previous studies with antibacterial, antifungal, and anti-inflammatory activities. This study aimed to determine the effect of basil leaf decoction on vagi …

31.08.2026journal-article

International Journal of Pharmaceutical and Bio Medical Science

Pursed-Lip Breathing as a Belief-Based Nursing Intervention to Reduce Respiratory Rate in Patients with Pulmonary Tuberculosis: A Narrative Literature Review

Fernando Da Costa Fernandes, Indah Sri Wahyuningsih, Dwi Heppy Rochmawati, Erna Melastuti

Background: Pulmonary tuberculosis remains a major global health concern and is frequently accompanied by increased respiratory rate due to impaired lung function. Non-pharmacological nursing interventions that incorporate patients’ belief systems may enhance physiological and psychological outcomes. Objective: This review aims to examine the effectiveness of pursed-lip breathing as a belief-based nursing intervention in reducing respiratory rate among patients with pulmonary tuberculosis. Methods: A narrative lite …

31.08.2026journal-article

Greenation International Journal of Law and Social Sciences

Beyond "No Viral, No Justice": Rebuilding Institutional Legitimacy in Indonesia's Digital Society Public Trust, the Rule of Law, and Access to Justice in the Age of Digital Public Pressure

Anas Lutfi, Aris Mahmud

This research examines the significance of standard language in agreements and its impact using a qualitative descriptive method. The qualitative descriptive method was selected to provide a comprehensive and in-depth understanding of the complexities between language and the law. This study analyzes agreements to identify the use of standard language and its effect on legal interpretation. The study demonstrates the importance of standard language in agreements, as language influences legal consequences through wo …

31.08.2026journal-article

Journal of Pharmaciest Pharmaceutical Research and Science STIKes Panti Waluya Malang

EVALUASI EFEK SAMPING MMS (MULTIPLE MICRONUTRIENT SUPPLEMENT) PADA IBU HAMIL DI PUSKESMAS PROPPO KABUPATEN PAMEKASAN

Khofifah Dian Safitry, Naili Uswatun Hasanah, Akhmad Fathir

Pendahuluan: Kekurangan mikronutrien selama kehamilan masih menjadi masalah kesehatan yang dapat meningkatkan risiko anemia pada ibu serta berbagai komplikasi kehamilan. Multiple Micronutrient Supplement (MMS) diberikan untuk memenuhi kebutuhan vitamin dan mineral selama kehamilan, namun penggunaannya dapat menimbulkan beberapa efek samping. Tujuan: Penelitian ini bertujuan untuk mengevaluasi efek samping penggunaan Multiple Micronutrient Supplement (MMS) pada ibu hamil di Puskesmas Proppo Kabupaten Pamekasan. Meto …

31.08.2026journal-article

Life

Sarcopenia in Inflammatory Bowel Disease: Prevalence, Mechanisms, Detection, Adverse Clinical Impact and Targetable Care Gaps—A Narrative Review Supported by a Structured Literature Search

Alexandra-Ioana Vasilachi-Lulache, Petruta Violeta Filip, Cosmin Alexandru Ciora, Eugen-Florin Georgescu, Laura Sorina Diaconu, Anca Roxana Băleanu, Corina Silvia Pop

Sarcopenia is increasingly recognized as a systemic complication of inflammatory bowel disease (IBD)—more accurately described as an IBD-associated muscle disorder than as a classical extraintestinal manifestation—but it remains inconsistently defined and rarely integrated into routine care. Consensus frameworks require low muscle strength confirmed by low muscle quantity or quality, so studies reporting only computed tomography (CT)-derived muscle area describe low muscle mass rather than consensus-defined sarcope …

31.08.2026journal-article

Indian Journal of Aerospace Medicine

Incidence of otitic barotrauma during decompression chamber test in Indian armed forces between 2019 and 2022

Avishek Sharma, G Harshavardhan, Karthikeyan Sankaran

Objectives: Combat free-fall (CFF) jumps are undertaken by special forces of the Armed Forces for the conduct of various operations. These jumps expose paratroopers to barometric changes, making them prone to various types of barotrauma. Indoctrination on middle ear pressure equalization techniques in the Decompression Chamber (DC) before the actual training helps the personnel to understand the physiological changes and thereby helps in reducing the probability of barotrauma. However, simulation of these barometri …

31.08.2026journal-article

Frontiers in Radiology

Slice-level vs. volumetric radiomics for molecular subtyping of breast cancer: impact of patient-level data partitioning on model performance

Laila El Jiani, Zouheir Banou, Fatima Zahra Alaoui, Hasnae Sakhi, El Habib Benlahmar, Sanaa El Filali

Introduction Molecular subtyping of breast cancer, particularly the discrimination between Luminal A and Basal-like tumours, is critical for guiding treatment decisions and establishing prognosis. Radiomics offers a promising complementary, non-invasive imaging biomarker to support biopsy-based subtyping; however, two methodological gaps limit the validity of existing studies: the absence of controlled 2D-vs.-3D feature comparisons, and the systematic underreporting of patient-level data leakage in multi-slice pipe …

31.08.2026journal-article

Frontiers in Medicine

Short-term clinical and radiographic outcomes of a 3D-printed trabecular titanium acetabular cup in primary total hip arthroplasty for Crowe type I–III developmental dysplasia of the hip with limited acetabular bone defects: a retrospective comparative study

Chengxiao Li, Lilei Song, Junheng Zhang, Bo Liu, Zhaolong Wang, Yongqiang Fan, Binquan Zhang, Yiding Liu, Kun Xiang, Yifan Niu, Guangyang Lu, Huijie Li

Objective To compare the short-term clinical and radiographic outcomes of a 3D-printed trabecular titanium acetabular cup system (AK Medical, Beijing, China) with a conventional porous titanium-coated acetabular cup system (Pinnacle Gription Sector Acetabular System, DePuy Synthes/Johnson & Johnson, USA) in primary total hip arthroplasty (THA) for Crowe type I–III developmental dysplasia of the hip (DDH) with limited acetabular bone defects not requiring metal augments or structural bone grafting. Methods This …

31.08.2026journal-article

Health Policy and Planning

The One Health national policy network to combat antimicrobial resistance in Senegal

Léo Delpy, Mouhamadou Moustapha Sow, Mamadou Ciss, Assane Gueye Fall, Marion Bordier

Abstract Antimicrobial resistance (AMR) is a health threat globally and particularly in low- and middle-income countries. Senegal, like many other African countries, faces significant challenges in addressing the AMR crisis. This article aims to investigate the policy-making process that supports efforts to combat AMR in Senegal since the adoption of the country’s 2017 National Multisectoral Action Plan Against Antimicrobial Resistance. A survey was conducted between January and August 2023 with key organizations i …

31.08.2026journal-article

Supportive Care in Cancer

Evidence supporting endodontic therapy as a safe strategy in patients previously treated with head and neck radiotherapy: a scoping review

Álvaro Souza Wanderley, Wesley Viana de Sousa, Maria Olívia da Costa, Alícia Marcelly Souza de Mendonça Silva, Raylane Farias de Albuquerque, Igor Henrique Morais Silva, Lucas Nascimento Ribeiro, Diana Santana Albuquerque, Marlos Barbosa-Ribeiro

Abstract Purpose To map and synthesize the available scientific evidence supporting the effectiveness and safety of endodontic therapy in patients who underwent head and neck radiotherapy, considering clinical and radiographic outcomes and treatment-related complications, particularly osteoradionecrosis (ORN). Methods This scoping review followed the Arksey and O’Malley framework, informed by the Joanna Briggs Institute Manual for Evidence Synthesis, and was reported according to PRISMA-ScR guidelines. Comprehensiv …